EDWARD J. SCHAEFER PROFESSOR IN ENGINEERING
Director, Institute for NanoBio Technology (INBT)
Joint Appointment: Oncology, School of Medicine
Secondary Appointment: Materials Science and Engineering
Ph.D. Bioengineering, Israel Institute of Technology (’04)
- 3D Culture Environments
- Stem Cell Self Renewal and Differentiation
- Tissue Engineering
Sharon Gerecht, professor of chemical and biomolecular engineering, Kent Gordon Croft Investment Management Faculty Scholar, the Edward J. Schaefer Professor in Engineering, and director of the Johns Hopkins Institute for NanoBioTechnology (INBT), is an internationally recognized expert in vascular and stem cell biology and engineering. She is an internationally recognized expert in vascular and stem cell biology and engineering and a member of the National Academy of Medicine.
Gerecht’s research group studies the interactions between stem cells and their microenvironments with the long-term goal of engineering artificial cell microenvironments capable of guiding vascular differentiation, delivery, and regeneration. Her research program is based on the integrated and advanced use of tissue engineering system components and is grounded in the fundamentals of interfacial science and engineering and stem cell biology.
Gerecht pioneered the use of engineering fundamentals to understand and harness vascular fate decisions of stem cells, leading to both basic knowledge and future therapeutics. Her lab was the first to design/develop/engineer biomaterials to guide vascular morphogenesis through activation of cellular pathways required for vacuole formation and merging into large lumen, sprouting, and eventual network formation. In the area of hypoxia, her group developed a hydrogel to better control variations in oxygen levels. Her work has led to the establishment of a novel line of research dedicated to understanding how dissolved oxygen regulates stem cell differentiation and cancer growth.
What sets Gerecht’s approach apart is its emphasis on understanding cells and tissues and how they function, and using that information to engineer systems. While the typical tactic had been to design materials and then test them in cells, Gerecht’s research group came at the challenge from a different direction, studying how vasculature forms and how tissues interact with the extracellular matrix. She has been able to bioengineer materials to use similar signaling and mimic the interactions in vitro. This innovative approach has rippled across the field; more researchers are now striving first to understand the requirements of the tissues they work with, and then to translate those findings into the systems they engineer.
Gerecht is the recipient of the Allan C. Davis Medal from the Maryland Academy of Sciences (2008); the North America Vascular Biology Organization Junior Investigator Award (2009); the Basil O’Connor Starter Scholar Research Award from the March of Dimes Foundation (2009-2011); the National Scientist Development Award (2008-2012) and Established Investigator Award (2014-2019), both from the American Heart Association; the National Science Foundation CAREER Award (2011-2016); the W.W. Smith Charitable Trust Heart Award (2014-2017); and the JHU Inaugural President’s Frontier Award (2015). She was elected to the National Academy of Medicine (2019), and also is an elected Fellow of the American Institute for Medical and Biological Engineering (2016). She is the author of more than 140 papers, book chapters, and patents in her field. Gerecht is a co-founder of Gemstone Biotherapeutics, LLC, a spin-off company based on technologies developed in her lab, focusing on wound healing.
Gerecht earned her BA in biology at the Israel Institute of Technology, her MSc in medical sciences from Tel-Aviv University, and her PhD in bioengineering from the Israel Institute of Technology. She was a postdoctoral researcher at the Massachusetts Institute of Technology.