5011 Smith Building
Research Areas
Structural and molecular immunology
Protein engineering
Therapeutic antibody discovery and design
Targeted drug development

Jamie Spangler is the William R. Brody Faculty Scholar and an associate professor of biomedical engineering and chemical and biomolecular engineering at the Whiting School of Engineering and the director of the Spangler Lab at the Johns Hopkins School of Medicine.

Spangler’s research aims to expand the repertoire of protein therapeutics by redesigning naturally occurring proteins and engineering new molecules to overcome the deficiencies of existing drugs. Integrating cutting-edge tools from structural biophysics, biomolecular engineering, and translational immunology, her research focuses on developing innovative platforms for the discovery and design of proteins that recruit novel mechanisms for disease therapy.

In particular, Spangler’s lab is interested in engineering antibody-based molecules that reshape immune cell behavior for targeted treatment of cancer, infectious diseases, and autoimmune disorders. The overarching goal of her interdisciplinary research program is to establish new insights into protein behavior and the extent to which it can be manipulated for medically relevant applications.

Spangler earned her BS in biomedical engineering from Johns Hopkins University in 2006 and her Ph.D. in biological engineering from MIT in 2011. After completing postdoctoral training at Stanford University School of Medicine, she joined the faculty at Johns Hopkins in 2017.