Ph.D. Biological Engineering, MIT, (’11)
Joint Appointment: Department of Biomedical Engineering
- Structural and Molecular Immunology
- Protein Engineering
- Therapeutic Antibody Discovery and Design
- Targeted Drug Development
Dr. Spangler earned her B.S. in Biomedical Engineering from Johns Hopkins University in 2006 and Ph.D. in Biological Engineering from MIT in 2011. After completing postdoctoral training at Stanford University School of Medicine, Spangler joined the faculty at Johns Hopkins in 2017 as an assistant professor, jointly appointed between the departments of Chemical & Biomolecular Engineering and Biomedical Engineering.
Prof. Spangler’s research aims to expand the repertoire of protein therapeutics by redesigning naturally occurring proteins and engineering new molecules to overcome the deficiencies of existing drugs. Integrating cutting-edge tools from structural biophysics, biomolecular engineering, and translational immunology, her research focuses on developing innovative platforms for the discovery and design of proteins that recruit novel mechanisms for disease therapy. In particular, Spangler’s group is interested in engineering antibody-based molecules that reshape immune cell behavior for targeted treatment of cancer, infectious diseases, and autoimmune disorders. The overarching goal of her interdisciplinary research program is to establish new insights into protein behavior and the extent to which it can be manipulated for medically relevant applications.