Michael J. Betenbaugh
Ph.D. Chemical Engineering, University of Delaware (’88)
- Metabolic Engineering
- Cell Line Optimization
- Mammalian Cell and Microalgae Genetic Engineering
- Green Energy (Biofuels Production)
Professor Betenbaugh serves as the Chair of Engineering for Professionals (ChemBE). He received his Ph.D. in Chemical Engineering from the University of Delaware in 1988 and his B.S. in Chemical Engineering from the University of Virginia in 1981.
His research group integrates systems biology with cellular, metabolic and biochemical engineering for eukaryotic biotechnology applications. The goal is to optimize cell lines to produce high quality and quantities of proteins of biopharmaceutical interest as well as biochemicals of medical and energy interest. The Mammalian Cell Engineering Group focuses on inhibition of programmed cell death (apoptosis) and glycoengineering using genetic engineering strategies. By blocking certain metabolic pathways which initiate the apoptosis program, we have been able to delay cell death and increased protein production. By modifying glycosylation pathways, they have been able to increase the therapeutic quality of recombinant glycoproteins generated by mammalian cells. In concert, they are examining metabolic and biochemical engineering strategies to manipulate microalgae for the improved production of biochemical and biofuels precursors in order to develop sustainable bioprocesses for the next generation of green chemistry.