Jeffrey J. Gray

Ph.D. University of Texas at Austin (’00)

Research Interests

  • Protein Structure Prediction and Design
  • Protein-Protein Docking
  • Antibody Engineering
  • Biomineralization

Dr. Gray is the ChemBE Director of Graduate Admissions and Alumni Relations and has been named the F. Stuart Hodgson Faculty Scholar. He was a postdoctoral fellow in the Biochemistry Department at the University of Washington in 2002. Before that he received his Ph.D. at the University of Texas at Austin in 2000, and his B.S.E. from the University of Michigan, Ann Arbor in 1994.


Gray’s laboratory creates and applies protein structure prediction methods to address practical problems in biomolecular self-assembly and function. Recent problems they have studied include protein-protein docking (developing ensemble docking, pH-dependent side-chain packing, and binding affinity prediction), therapeutic antibodies (integrating knowledge-based homology modeling and high-resolution loop modeling, flexible loop docking, and immunome analysis), proteins interacting with solid surfaces (biomineralization, protein design to control crystal growth), and allostery (contact rearrangment networks, rigid-body motion networks.

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