Marsha Wills-Karp

Department Chair

Research Interests

Allergy, Asthma, Immunology, Pulmonary Biology, Environmental Health, Air Pollution, Microbiome, Early life determinants of immune disease    


Ph.D, University of California, Santa Barbara, 1986
MS, Southwest Texas State University, 1982


Professional Experience
Post-doctoral Fellowship, Yale University
Post-doctoral Fellowship, Johns Hopkins University
Research Associate, Johns Hopkins University, Baltimore, Maryland
Assistant Professor, Johns Hopkins University, Baltimore, Maryland
Associate Professor, Johns Hopkins University, Baltimore, Maryland
Tenured Professor of Pediatrics, Director, Division of Immunobiology, Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio
Founder and Director, Immunobiology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, Ohio
Director of Center for Immunological Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
Associate Dean for Basic Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio
Rieveschl Professor of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
Chair, Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland


Research Summary

My research activities focus on defining the environmental and genetic determinants of allergic airway diseases such as asthma. My lab members and I have specifically explored the role of CD4+ Th2 cells and cytokines (IL-13), and innate immune pathways (complement activation pathways, TLRs, CLRs), in the pathogenesis of asthma. I have made substantial contributions to our understanding of the molecular mechanisms underlying allergenicity of common allergens-specifically how allergens and airborne pollutants activate innate immune pathways through molecular mimicry (Nature). More recently, I have turned my attention to how the gut microbiome alters susceptibility to allergen and PM-induced asthma.


Research Areas




Pulmonary disease

Environmental health

Air pollution


Early life determinants of immune disease


Honors and Awards

2016:  Chair, NIAID ZRG1 IMM-S (90)S Study Section
2011 – 2015:  Chair, NIH AITRC Study Section
2015:  Chair, Special Emphasis Review NIAID Panel
2015:  Kleinerman Distinguished Lecture in Pulmonary Pathobiology
2014:  Intramural NHLBI Review Committee
2014:  Delta Omega Honor Society for Public Health
2012 – 2016:  Scientific Board, Trudeau Institute
2012 – present:  Deputy Editor, Mucosal Immunology
2012:  Distinguished Lectureship, Center for Immunology & Microbial Defense Disease, Albany Medical College
2012:  Rebecca Buckely Lectureship, American Academy of Allergy and Immunology
2012:  Marsha Wills-Karp Immunobiology Student Award established at CCHMC
2011 – 2012:  Member of Clinical Immunology Committee of AAI
2010 – present:  Elected Member American Society of Pediatrics
2010:  Keystone Advisory Council Member
2009 – 2011:  Permanent Member NIH AITRC Study Section
2007 – 2008:  Executive Leadership for Academic Medicine (ELAM) Fellow
2005 – 2016:  FDA, Allergenic Products Advisory Committee
2005:  Distinguished Immunology Professor Award, NIAID
2005:  Distinguished Lectureship, Japan
2004 – 2006:  Member of Finance Committee, American Association of Immunology
2000 – 2004:  Permanent Member, NIH LCMI Study Section
2002:  Distinguished Alumni Award, Southwest Texas State University
2001:  John Salvaggio Memorial Lectureship
2000 – 2005:  Faculty of 1000
1994:  Faculty Development Award, Johns Hopkins University
1998 – 2000, 2005, 2007:  Wellcome Trust Review Committee
1987 – 1989:  NIH Post-doctoral Training Grant
1989:  First Award, National Heart, Lung and Blood Institute
1981, 1982:  Achievement and Leadership Award, Southwest Texas State University
1980, 1981, 1982:  Academic Excellence
1979 – 1982:  Beta Beta Beta Biological Honor Society



Roche Bioscience (1997-1998)
Department of Energy, Beryllium Lung Disease (1998)
Millennium (1997)
Genetics Institute (1998-2000)
Dynavax Pharmaceuticals (1999-2004)
Merck Frosst (2002-2004)
Abgenix, Inc. (2003-2006)
Centocor (2003-2006)
Amgen (2005-2008)
Abbott (2006-2007)
Merck (2007-2012)
Omeros Corporation (2010-2011)
Genentech (2010-2012)
Johnson & Johnson Pharmaceutical R&D (2011-2012)
F. Hoffman-La Roche Ltd (2011-2012)
Isis Pharmaceuticals, Inc. (2011-present)
Janssen Pharmaceuticals (2013-2015)
Apellis (2015-present)


  • Ph.D. 1986, University of California, Santa Barbara
  • 2014 - 2021:  Professor, SPH Biochemistry and Molecular Biology
Journal Articles
  • Smole U, Gour N, Phelan J, Hofer G, Köhler C, Kratzer B, Tauber PA, Xiao X, Yao N, Dvorak J, Caraballo L, Puerta L, Rosskopf S, Chakir J, Malle E, Lane AP, Pickl WF, Lajoie S, Wills-Karp M (2020).  Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity.  Nature Immunology.  21(7).  756-765.
  • Kuiper JR, Stapleton HM, Wills-Karp M, Wang X, Burd I, Buckley JP (2020).  Predictors and reproducibility of urinary organophosphate ester metabolite concentrations during pregnancy and associations with birth outcomes in an urban population.  Environmental Health: A Global Access Science Source.  19(1).
  • DeKruyff RH, Zhang W, Nadeau KC, Leung DYM, Wills-Karp M (2020).  Summary of the Keystone Symposium “Origins of allergic disease: Microbial, epithelial and immune interactions,” March 24-27, Tahoe City, California.  Journal of Allergy and Clinical Immunology.  145(4).  1072-1081.e1.
  • Wills-Karp M (2020).  At last-linking ORMDL3 polymorphisms, decreased sphingolipid synthesis, and asthma susceptibility.  Journal of Clinical Investigation.  130(2).  604-607.
  • Wang G, Dibari J, Bind E, Steffens AM, Mukherjee J, Bartell TR, Bellinger DC, Hong X, Ji Y, Wang MC, Wills-Karp M, Cheng TL, Wang X (2019).  In utero exposure to mercury and childhood overweight or obesity: Counteracting effect of maternal folate status.  BMC Medicine.  17(1).
  • Eloundou SN, Lee JY, Wu D, Lei J, Feller MC, Ozen M, Zhu Y, Hwang M, Jia B, Xie H, Clemens JL, McLane MW, AlSaggaf S, Nair N, Wills-Karp M, Wang X, Graham EM, Baschat A, Burd I (2019).  Placental malperfusion in response to intrauterine inflammation and its connection to fetal sequelae.  PLoS ONE.  14(4).
  • Koehler K, Latshaw M, Matte T, Kass D, Frumkin H, Fox M, Hobbs BF, Wills-Karp M, Burke TA (2018).  Building Healthy Community Environments: A Public Health Approach.  Public health reports (Washington, D.C. : 1974).  133(1).  35S-43S.
  • Gour N, Smole U, Yong HM, Lewkowich IP, Yao N, Singh A, Gabrielson E, Wills-Karp M, Lajoie S (2018).  C3a is required for ILC2 function in allergic airway inflammation.  Mucosal Immunology.  11(6).  1653-1662.
  • Gour N, Lajoie S, Smole U, White M, Hu D, Goddard P, Huntsman S, Eng C, Mak A, Oh S, Kim JH, Sharma A, Plante S, Salem IH, Resch Y, Xiao X, Yao N, Singh A, Vrtala S, Chakir J, Burchard EG, Lane AP, Wills-Karp M (2018).  Dysregulated invertebrate tropomyosin–dectin-1 interaction confers susceptibility to allergic diseases.  Science Immunology.  3(20).
  • Wills-Karp M (2018).  Neutrophil ghosts worsen asthma.  Science Immunology.  3(26).
  • Wills-Karp M (2017).  Histamine-releasing factor: A promising therapeutic target for food allergy.  Journal of Clinical Investigation.  127(12).  4238-4241.
  • Mao G, Nachman RM, Sun Q, Zhang X, Koehler K, Chen Z, Hong X, Wang G, Caruso D, Zong G, Pearson C, Ji H, Biswal S, Zuckerman B, Wills-Karp M, Wang X (2017).  Individual and joint effects of early-life ambient PM2.5 exposure and maternal prepregnancy obesity on childhood overweight or obesity.  Environmental Health Perspectives.  125(6).
  • Hall SL, Baker T, Lajoie S, Richgels PK, Yang Y, McAlees JW, van Lier A, Wills-Karp M, Sivaprasad U, Acciani TH, LeCras TD, Myers JB, Kovacic MB, Lewkowich IP (2017).  IL-17A enhances IL-13 activity by enhancing IL-13–induced signal transducer and activator of transcription 6 activation.  Journal of Allergy and Clinical Immunology.  139(2).  462-471.e14.
  • Sussan TE, Sudini K, Talbot CC, Wang X, Wills-Karp M, Burd I, Biswal S (2017).  Nrf2 regulates gene-environment interactions in an animal model of intrauterine inflammation: Implications for preterm birth and prematurity.  Scientific Reports.  7.
  • Becerra-Díaz M, Wills-Karp M, Heller NM (2017).  New perspectives on the regulation of type II inflammation in asthma.  F1000Research.  6.
  • Nachman RM, Mao G, Zhang X, Hong X, Chen Z, Soria CS, He H, Wang G, Caruso D, Pearson C, Biswal S, Zuckerman B, Wills-Karp M, Wang X (2016).  Intrauterine inflammation and maternal exposure to ambient pm2.5 during preconception and specific periods of pregnancy: The boston birth cohort.  Environmental Health Perspectives.  124(10).  1608-1615.
  • Chavez-Valdez R, Ahlawat R, Wills-Karp M, Gauda EB (2016).  Mechanisms of modulation of cytokine release by human cord blood monocytes exposed to high concentrations of caffeine.  Pediatric Research.  80(1).  101-109.
  • Mpollo MSEM, Brandt EB, Shanmukhappa SK, Arumugam PI, Tiwari S, Loberg A, Pillis D, Rizvi T, Lindsey M, Jonck B, Carmeliet P, Kalra VK, Le Cras TD, Ratner N, Wills-Karp M, Khurana Hershey GK, Malik P (2016).  Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13.  Journal of Clinical Investigation.  126(2).  571-584.
  • Burgess SL, Saleh M, Cowardin CA, Buonomo E, Noor Z, Watanabe K, Abhyankar M, Lajoie S, Wills-Karp M, Petri WA (2016).  Role of serum amyloid A, granulocyte-macrophage colony-stimulating factor, and bone marrow granulocyte-monocyte precursor expansion in segmented filamentous bacterium-mediated protection from Entamoeba histolytica.  Infection and Immunity.  84(10).  2824-2832.
  • Gour N, Wills-Karp M (2015).  IL-4 and IL-13 signaling in allergic airway disease.  Cytokine.  75(1).  68-78.
  • Mcalees JW, Lajoie S, Dienger K, Sproles AA, Richgels PK, Yang Y, Khodoun M, Azuma M, Yagita H, Fulkerson PC, Wills-Karp M, Lewkowich IP (2015).  Differential control of CD4+ T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma.  European Journal of Immunology.  45(4).  1019-1029.
  • Mcalees JW, Whitehead GS, Harley ITW, Cappelletti M, Rewerts CL, Holdcroft AM, Divanovic S, Wills-Karp M, Finkelman FD, Karp CL, Cook DN (2015).  Distinct Tlr4-expressing cell compartments control neutrophilic and eosinophilic airway inflammation.  Mucosal Immunology.  8(4).  863-873.
  • Yang L, Lewkowich I, Apsley K, Fritz JM, Wills-Karp M, Weaver TE (2015).  Haploinsufficiency for Stard7 is associated with enhanced allergic responses in lung and skin.  Journal of Immunology.  194(12).  5635-5643.
  • Chung BM, Arutyunov A, Ilagan E, Yao N, Wills-Karp M, Coulombe PA (2015).  Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes.  Journal of Cell Biology.  208(5).  613-627.
  • Yang D, Sun YY, Bhaumik SK, Li Y, Baumann JM, Lin X, Zhang Y, Lin SH, Dunn RS, Liu CY, Shie FS, Lee YH, Wills-Karp M, Chougnet CA, Kallapur SG, Lewkowich IP, Lindquist DM, Murali-Krishna K, Kuan CY (2014).  Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns.  Journal of Neuroscience.  34(49).  16467-16481.
  • Burgess SL, Buonomo E, Carey M, Cowardin C, Naylor C, Noor Z, Wills-Karp M, Petri WA (2014).  Bone marrow dendritic cells from mice with an altered microbiota provide interleukin 17A-dependent protection against Entamoeba histolytica colitis.  mBio.  5(6).
  • Sussan TE, Ingole V, Kim JH, McCormick S, Negherbon J, Fallica J, Akulian J, Yarmus L, Feller-Kopman D, Wills-Karp M, Horton MR, Breysse PN, Agrawal A, Juvekar S, Salvi S, Biswal S (2014).  Source of biomass cooking fuel determines pulmonary response to household air pollution.  American Journal of Respiratory Cell and Molecular Biology.  50(3).  538-548.
  • Lajoie S, Lewkowich I, Herman NS, Sproles A, Pesce JT, Wynn TA, Grusby MJ, Hamid Q, Wills-Karp M (2014).  IL-21 receptor signalling partially mediates Th2-mediated allergic airway responses.  Clinical and Experimental Allergy.  44(7).  976-985.
  • Harley ITW, Giles DA, Pfluger PT, Burgess SL, Walters S, Hembree J, Raver C, Rewerts CL, Downey J, Flick LM, Stankiewicz TE, McAlees JW, Wills-Karp M, Balfour Sartor R, Divanovic S, Tschöp MH, Karp CL (2013).  Differential colonization with segmented filamentous bacteria and Lactobacillus murinus do not drive divergent development of diet-induced obesity in C57BL/6 mice.  Molecular Metabolism.  2(3).  171-183.
  • Ziyab AH, Davies GA, Ewart S, Hopkin JM, Schauberger EM, Wills-Karp M, Holloway JW, Arshad SH, Zhang H, Karmaus W (2013).  Interactive effect of STAT6 and IL13 gene polymorphisms on eczema status: Results from a longitudinal and a cross-sectional study.  BMC Medical Genetics.  14(1).
  • Lewkowich IP, Lajoie S, Stoffers SL, Suzuki Y, Richgels PK, Dienger K, Sproles AA, Yagita H, Hamid Q, Wills-Karp M (2013).  PD-L2 modulates asthma severity by directly decreasing dendritic cell IL-12 production.  Mucosal Immunology.  6(4).  728-739.
  • Yang D, Sun YY, Nemkul N, Baumann JM, Shereen A, Dunn RS, Wills-Karp M, Lawrence DA, Lindquist DM, Kuan CY (2013).  Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia.  Cerebral Cortex.  23(5).  1218-1229.
  • Chavez-Valdez R, Kovell L, Ahlawat R, McLemore GL, Wills-Karp M, Gauda EB (2013).  Opioids and clonidine modulate cytokine production and opioid receptor expression in neonatal immune cells.  Journal of Perinatology.  33(5).  374-382.
  • Chen W, Sivaprasad U, Gibson AM, Ericksen MB, Cunningham CM, Bass SA, Kinker KG, Finkelman FD, Wills-Karp M, Khurana Hershey GK (2013).  IL-13 receptor α2 contributes to development of experimental allergic asthma.  Journal of Allergy and Clinical Immunology.  132(4).
  • Wills-Karp M, Rani R, Dienger K, Lewkowich I, Fox JG, Perkins C, Lewis L, Finkelman FD, Smith DE, Bryce PJ, Kurt-Jones EA, Wang TC, Sivaprasad U, Hershey GK, Herbert DR (2012).  Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection.  Journal of Experimental Medicine.  209(3).  607-622.
  • Wang YH, Wills-Karp M (2011).  The potential role of interleukin-17 in severe asthma.  Current Allergy and Asthma Reports.  11(5).  388-394.
  • Lewkowich IP, Day SB, Ledford JR, Zhou P, Dienger K, Wills-Karp M, Page K (2011).  Protease-activated receptor 2 activation of myeloid dendritic cells regulates allergic airway inflammation.  Respiratory Research.  12.
  • Schroer KT, Gibson AM, Sivaprasad U, Bass SA, Ericksen MB, Wills-Karp M, Lecras T, Fitzpatrick AM, Brown LAS, Stringer KF, Hershey GKK (2011).  Downregulation of glutathione S-transferase pi in asthma contributes to enhanced oxidative stress.  Journal of Allergy and Clinical Immunology.  128(3).  539-548.
  • Izuhara K, Holgate ST, Wills-Karp M (2011).  Preface.  Inflammation and Allergy Drug Design.
  • Mohammed JP, Fusakio ME, Rainbow DB, Moule C, Fraser HI, Clark J, Todd JA, Peterson LB, Savage PB, Wills-Karp M, Ridgway WM, Wicker LS, Mattner J (2011).  Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity.  Journal of Immunology.  187(1).  337-349.
  • Stefater JA, Lewkowich I, Rao S, Mariggi G, Carpenter AC, Burr AR, Fan J, Ajima R, Molkentin JD, Williams BO, Wills-Karp M, Pollard JW, Yamaguchi T, Ferrara N, Gerhardt H, Lang RA (2011).  Regulation of angiogenesis by a non-canonical Wnt - Flt1 pathway in myeloid cells.  Nature.  474(7352).  511-516.
  • Perkins C, Yanase N, Smulian G, Gildea L, Orekov T, Potter C, Brombacher F, Aronow B, Wills-Karp M, Finkelman FD (2011).  Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice.  Journal of Experimental Medicine.  208(4).  853-867.
  • McCormack MC, Breysse PN, Matsui EC, Hansel NN, Peng RD, Curtin-Brosnan J, Williams DL, Wills-Karp M, Diette GB (2011).  Indoor particulate matter increases asthma morbidity in children with non-atopic and atopic asthma.  Annals of Allergy, Asthma and Immunology.  106(4).  308-315.
  • Guo F, Zhang S, Tripathi P, Mattner J, Phelan J, Sproles A, Mo J, Wills-Karp M, Grimes HL, Hildeman D, Zheng Y (2011).  Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation.  PLoS ONE.  6(3).
  • Baye TM, Kovacic MB, Myers JM, Martin LJ, Lindsey M, Patterson TL, He H, Ericksen MB, Gupta J, Tsoras AM, Lindsley A, Rothenberg ME, Wills-Karp M, Eissa NT, Borish L, Hershey GKK (2011).  Differences in candidate gene association between European ancestry and African American asthmatic children.  PLoS ONE.  6(2).
  • Sivaprasad U, Askew DJ, Ericksen MB, Gibson AM, Stier MT, Brandt EB, Bass SA, Daines MO, Chakir J, Stringer KF, Wert SE, Whitsett JA, Le Cras TD, Wills-Karp M, Silverman GA, Khurana Hershey GK (2011).  A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma.  Journal of Allergy and Clinical Immunology.  127(1).
  • Chavez Valdez R, Ahlawat R, Wills-Karp M, Nathan A, Ezell T, Gauda EB (2011).  Correlation between serum caffeine levels and changes in cytokine profile in a cohort of preterm infants.  Journal of Pediatrics.  158(1).  57-64.e1.
  • Schauberger EM, Ewart SL, Arshad SH, Huebner M, Karmaus W, Holloway JW, Friderici KH, Ziegler JT, Zhang H, Rose-Zerilli MJ, Barton SJ, Holgate ST, Kilpatrick JR, Harley JB, Lajoie-Kadoch S, Harley ITW, Hamid Q, Kurukulaaratchy RJ, Seibold MA, Avila PC, Rodriguez-Cintrón W, Rodriguez-Santana JR, Hu D, Gignoux C, Romieu I, London SJ, Burchard EG, Langefeld CD, Wills-Karp M (2011).  Identification of ATPAF1 as a novel candidate gene for asthma in children.  Journal of Allergy and Clinical Immunology.  128(4).
  • Wills-Karp M (2010).  Allergen-specific pattern recognition receptor pathways.  Current Opinion in Immunology.  22(6).  777-782.
  • Xun Z, Schmudde I, Laumonnier Y, Pandey MJK, Clark JR, König P, Gerard NP, Gerard C, Wills-Karp M, Köhl J (2010).  A critical role for C5L2 in the pathogenesis of experimental allergic asthma.  Journal of Immunology.  185(11).  6741-6752.
  • Wills-Karp M, Kapsenberg M (2010).  Allergy and hypersensitivity.  Current Opinion in Immunology.  22(6).  775-776.
  • Lajoie S, Lewkowich IP, Suzuki Y, Clark JR, Sproles AA, Dienger K, Budelsky AL, Wills-Karp M (2010).  Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma.  Nature Immunology.  11(10).  928-935.
  • Lages CS, Lewkowich I, Sproles A, Wills-Karp M, Chougnet C (2010).  Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/PD-L1 pathway.  Aging Cell.  9(5).  785-798.
  • Chen G, Wan H, Luo F, Zhang L, Xu Y, Lewkowich I, Wills-Karp M, Whitsett JA (2010).  Foxa2 programs Th2 cell-mediated innate immunity in the developing lung.  Journal of Immunology.  184(11).  6133-6141.
  • Page K, Ledford JR, Zhou P, Dienger K, Wills-Karp M (2010).  Mucosal sensitization to German cockroach involves protease-activated receptor-2.  Respiratory Research.  11.
  • Saunders V, Breysse P, Clark J, Sproles A, Davila M, Wills-Karp M (2010).  Particulate matter-induced airway hyperresponsiveness is lymphocyte dependent.  Environmental Health Perspectives.  118(5).  640-646.
  • Wills-Karp M, Nathan A, Page K, Karp CL (2010).  New insights into innate immune mechanisms underlying allergenicity.  Mucosal Immunology.  3(2).  104-110.
  • Finkelman FD, Hogan SP, Khurana Hershey GK, Rothenberg ME, Wills-Karp M (2010).  Importance of cytokines in murine allergic airway disease and human asthma.  Journal of Immunology.  184(4).  1663-1674.
  • Page K, Ledford JR, Zhou P, Wills-Karp M (2009).  A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in mice.  Journal of Immunology.  183(5).  3400-3408.
  • Niese KA, Collier AR, Hajek AR, Cederbaum SD, O'Brien WE, Wills-Karp M, Rothenberg ME, Zimmermann N (2009).  Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice.  BMC Immunology.  10.
  • Gu Y, Harley ITW, Henderson LB, Aronow BJ, Vietor I, Huber LA, Harley JB, Kilpatrick JR, Langefeld CD, Williams AH, Jegga AG, Chen J, Wills-Karp M, Arshad SH, Ewart SL, Thio CL, Flick LM, Filippi MD, Grimes HL, Drumm ML, Cutting GR, Knowles MR, Karp CL (2009).  Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease.  Nature.  458(7241).  1039-1042.
  • Zhang X, Lewkowich IP, Köhl G, Clark JR, Wills-Karp M, Köhl J (2009).  A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells.  Journal of Immunology.  182(8).  5123-5130.
  • Nathan AT, Peterson EA, Chakir J, Wills-Karp M (2009).  Innate immune responses of airway epithelium to house dust mite are mediated through β-glucan-dependent pathways.  Journal of Allergy and Clinical Immunology.  123(3).  612-618.
  • Chavez-Valdez R, Wills-Karp M, Ahlawat R, Cristofalo EA, Nathan A, Gauda EB (2009).  Caffeine modulates TNF-α production by cord blood monocytes: The role of adenosine receptors.  Pediatric Research.  65(2).  203-208.
  • Trompette A, Divanovic S, Visintin A, Blanchard C, Hegde RS, Madan R, Thorne PS, Wills-Karp M, Gioannini TL, Weiss JP, Karp CL (2009).  Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein.  Nature.  457(7229).  585-588.
  • Lewis CC, Aronow B, Hutton J, Santeliz J, Dienger K, Herman N, Finkelman FD, Wills-Karp M (2009).  Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung.  Journal of Allergy and Clinical Immunology.  123(4).
  • Wills-Karp M, Finkelman FD (2008).  Untangling the complex web of IL-4-and IL-13-mediated signaling pathways.  Science Signaling.  1(51).
  • Lewkowich IP, Lajoie S, Clark JR, Herman NS, Sproles AA, Wills-Karp M (2008).  Allergen uptake, activation, and IL-23 production by pulmonary myeloid DCs drives airway hyperresponsiveness in asthma-susceptible mice.  PLoS ONE.  3(12).
  • Chen W, Tabata Y, Gibson AM, Daines MO, Warrier MR, Wills-Karp M, Khurana Hershey GK (2008).  Matrix metalloproteinase 8 contributes to solubilization of IL-13 receptor α2 in vivo.  Journal of Allergy and Clinical Immunology.  122(3).  625-632.
  • Page K, Lierl KM, Hughes VS, Zhou P, Ledford JR, Wills-Karp M (2008).  TLR2-mediated activation of neutrophils in response to German cockroach frass.  Journal of Immunology.  180(9).  6317-6324.
  • Finkelman FD, Wills-Karp M (2008).  Usefulness and optimization of mouse models of allergic airway disease.  Journal of Allergy and Clinical Immunology.  121(3).  603-606.
  • Page K, Lierl KM, Herman N, Wills-Karp M (2007).  Differences in susceptibility to German cockroach frass and its associated proteases in induced allergic inflammation in mice.  Respiratory Research.  8.
  • Khodoun M, Lewis C, Yang JQ, Orekov T, Potter C, Wynn T, Mentink-Kane M, Khurana Hershey GK, Wills-Karp M, Finkelman FD (2007).  Differences in expression, affinity, and function of soluble (s)IL-4Rα and sIL-13Rα2 suggest opposite effects on allergic responses.  Journal of Immunology.  179(10).  6429-6438.
  • Wills-Karp M (2007).  Complement activation pathways: A bridge between innate and adaptive immune responses in asthma.  Proceedings of the American Thoracic Society.  4(3).  247-251.
  • Köhl J, Wills-Karp M (2007).  A dual role for complement in allergic asthma.  Current Opinion in Pharmacology.  7(3).  283-289.
  • Abdala-Valencia H, Earwood J, Bansal S, Jansen M, Babcock G, Garvy B, Wills-Karp M, Cook-Mills JM (2007).  Nonhematopoietic NADPH oxidase regulation of lung eosinophilia and airway hyperresponsiveness in experimentally induced asthma.  American Journal of Physiology - Lung Cellular and Molecular Physiology.  292(5).
  • Köhl J, Wills-Karp M (2007).  Complement regulates inhalation tolerance at the dendritic cell/T cell interface.  Molecular Immunology.  44(1-3).  44-56.
  • Ramadas RA, Li X, Shubitowski DM, Samineni S, Wills-Karp M, Ewart SL (2006).  IL-1 Receptor antagonist as a positional candidate gene in a murine model of allergic asthma.  Immunogenetics.  58(10).  851-855.
  • Li X, Wills-Karp M, Ewart S (2006).  Investigating Gata3 as a positional candidate gene for allergic asthma in a murine model.  International Journal of Immunogenetics.  33(5).  333-337.
  • Perkins C, Wills-Karp M, Finkelman FD (2006).  IL-4 induces IL-13-independent allergic airway inflammation.  Journal of Allergy and Clinical Immunology.  118(2).  410-419.
  • Barnes KC, Grant A, Gao P, Baltadjieva D, Berg T, Chi P, Zhang S, Zambelli-Weiner A, Ehrlich E, Zardkoohi O, Brummet ME, Stockton M, Watkins T, Gao L, Gittens M, Wills-Karp M, Cheadle C, Beck LA, Beaty TH, Becker KG, Garcia JGN, Mathias RA (2006).  Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypes.  Journal of Allergy and Clinical Immunology.  118(1).  70-77.
  • Köhl J, Baelder R, Lewkowich IP, Pandey MK, Hawlisch H, Wang L, Best J, Herman NS, Sproles AA, Zwirner J, Whitsett JA, Gerard C, Sfyroera G, Lambris JD, Wills-Karp M (2006).  A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma.  Journal of Clinical Investigation.  116(3).  783-796.
  • Molloy CA, Morrow AL, Meinzen-Derr J, Schleifer K, Dienger K, Manning-Courtney P, Altaye M, Wills-Karp M (2006).  Elevated cytokine levels in children with autism spectrum disorder.  Journal of Neuroimmunology.  172(1-2).  198-205.
  • Follettie MT, Ellis DK, Donaldson DD, Hill AA, Diesl V, DeClercq C, Sypek JP, Dorner AJ, Wills-Karp M (2006).  Gene expression analysis in a murine model of allergic asthma reveals overlapping disease and therapy dependent pathways in the lung.  Pharmacogenomics Journal.  6(2).  141-152.
  • Keen JC, Cianferoni A, Florio G, Guo J, Chen R, Roman J, Wills-Karp M, Casolaro V, Georas SN (2006).  Characterization of a novel PMA-inducible pathway of interleukin-13 gene expression in T cells.  Immunology.  117(1).  29-37.
  • Adhami F, Liao G, Morozov YM, Schloemer A, Schmithorst VJ, Lorenz JN, Dunn RS, Vorhees CV, Wills-Karp M, Degen JL, Davis RJ, Mizushima N, Rakic P, Dardzinski BJ, Holland SK, Sharp FR, Kuan CY (2006).  Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy.  American Journal of Pathology.  169(2).  566-583.
  • Goebel J, Forrest K, Wills-Karp M, Roszman TL (2006).  Tubulin polymerization modulates interleukin-2 receptor signal transduction in human T cells.  Journal of Receptors and Signal Transduction.  26(1-2).  87-106.
  • Barnes KC, Grant AV, Baltadzhieva D, Zhang S, Berg T, Shao L, Zambelli-Weiner A, Anderson W, Nelsen A, Pillai S, Yarnall DP, Dienger K, Ingersoll RG, Scott AF, Fallin MD, Mathias RA, Beaty TH, Garcia JGN, Wills-Karp M (2006).  Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families.  Genes and Immunity.  7(1).  27-35.
  • Hessel EM, Chu M, Lizcano JO, Chang B, Herman N, Kell SA, Wills-Karp M, Coffman RL (2005).  Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction.  Journal of Experimental Medicine.  202(11).  1563-1573.
  • Lewkowich IP, Herman NS, Schleifer KW, Dance MP, Chen BL, Dienger KM, Sproles AA, Shah JS, Köhl J, Belkaid Y, Wills-Karp M (2005).  CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function.  Journal of Experimental Medicine.  202(11).  1549-1561.
  • Zimmermann N, Doepker MP, Witte DP, Stringer KF, Fulkerson PC, Pope SM, Brandt EB, Mishra A, King NE, Nikolaidis NM, Wills-Karp M, Finkelman FD, Rothenberg ME (2005).  Expression and regulation of small proline-rich protein 2 in allergic inflammation.  American Journal of Respiratory Cell and Molecular Biology.  32(5).  428-435.
  • Finkelman FD, Yang M, Perkins C, Schleifer K, Sproles A, Santeliz JA, Bernstein JA, Rothenberg ME, Morris SC, Wills-Karp M (2005).  Suppressive effect of IL-4 on IL-13-induced genes in mouse lung.  Journal of Immunology.  174(8).  4630-4638.
  • Guajardo JR, Schleifer KW, Daines MO, Ruddy RM, Aronow BJ, Wills-Karp M, Hershey GKK (2005).  Altered gene expression profiles in nasal respiratory epithelium reflect stable versus acute childhood asthma.  Journal of Allergy and Clinical Immunology.  115(2).  243-251.
  • Goebel J, Logan B, Forrest K, Mieczkowski A, Roszman TL, Wills-Karp M (2005).  Atorvastatin affects interleukin-2 signaling by altering the lipid raft enrichment of the interleukin-2 receptor β chain.  Journal of Investigative Medicine.  53(6).  322-328.
  • Wills-Karp M, Koehl J (2005).  New insights into the role of the complement pathway in allergy and asthma.  Current Allergy and Asthma Reports.  5(5).  362-369.
  • Wills-Karp M (2004).  Interleukin-13 in asthma pathogenesis.  Immunological Reviews.  202.  175-190.
  • Wills-Karp M, Karp CL (2004).  Chitin checking - Novel insights into asthma.  New England Journal of Medicine.  351(14).  1455-1457.
  • Wills-Karp M, Karp CL (2004).  Eosinophils in asthma: Remodeling a tangled tale.  Science.  305(5691).  1726-1729.
  • Hawlisch H, Wills-Karp M, Karp CL, Köhl J (2004).  The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma.  Molecular Immunology.  41(2-3).  123-131.
  • Wills-Karp M, Ewart SL (2004).  Time to draw breath: Asthma-susceptibility genes are identified.  Nature Reviews Genetics.  5(5).  376-387.
  • Barnes KC, Caraballo L, Muñoz M, Zambelli-Weiner A, Ehrlich E, Burki M, Jimenez S, Mathias RA, Stockton ML, Deindl P, Mendoza L, Hershey GK, Nickel R, Wills-Karp M (2004).  A novel promoter polymorphism in the gene encoding complement component 5 receptor 1 on chromosome 19q13.3 is not associated with asthma and atopy in three independent populations.  Clinical and Experimental Allergy.  34(5).  736-744.
  • Karp CL, Flick LM, Park KW, Softic S, Greer TM, Keledjian R, Yang R, Uddin J, Guggino WB, Atabani SF, Belkaid Y, Xu Y, Whitsett JA, Accurso FJ, Wills-Karp M, Petasis NA (2004).  Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway.  Nature Immunology.  5(4).  388-392.
  • Wills-Karp M (2004).  Interleukin-13 in asthma pathogenesis.  Current Allergy and Asthma Reports.  4(2).  123-131.
  • Wills-Karp M, Brandt D, Morrow AL (2004).  Understanding the origin of asthma and its relationship to breastfeeding.  Advances in Experimental Medicine and Biology.  554.  171-191.
  • Wills-Karp M, Belkaid Y, Karp CL (2003).  I-Tim-izing the pathways of counter-regulation.  Nature Immunology.  4(11).  1050-1052.
  • Wills-Karp M, Chiaramonte M (2003).  Interleukin-13 in asthma.  Current Opinion in Pulmonary Medicine.  9(1).  21-27.
  • Shubitowski DM, Wills-Karp M, Ewart SL (2002).  The complement factor 5a receptor gene maps to murine chromosome 7.  Cytogenetic and Genome Research.  97(1-2).  133-135.
  • Polack FP, Teng MN, Collins PL, Prince GA, Exner M, Regele H, Lirman DD, Rabold R, Hoffman SJ, Karp CL, Kleeberger SR, Wills-Karp M, Karron RA (2002).  A role for immune complexes in enhanced respiratory syncytial virus disease.  Journal of Experimental Medicine.  196(6).  859-865.
  • Santeliz JV, Nest GV, Traquina P, Larsen E, Wills-Karp M (2002).  Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma.  Journal of Allergy and Clinical Immunology.  109(3).  455-462.
  • Walters DM, Breysse PN, Schofield B, Wills-Karp M (2002).  Complement factor 3 mediates particulate matter-induced airway hyperresponsiveness.  American Journal of Respiratory Cell and Molecular Biology.  27(4).  413-418.
  • Wills-Karp M (2001).  Asthma genetics: Not for the TIMid?.  Nature Immunology.  2(12).  1095-1096.
  • Vehmas AK, Troncoso JC, Borchelt DR, Price DL, McCarthy D, Wills-Karp M, Peper MJ, Rudow G, Luyinbazi J, Siew LT (2001).  β-amyloid peptide vaccination results in marked changes in serum and brain Aβ levels in APPswe/PS1ΔE9 mice, as detected by SELDI-TOF-based ProteinChip® technology.  DNA and Cell Biology.  20(11).  713-721.
  • Walters DM, Breysse PN, Wills-Karp M (2001).  Ambient urban Baltimore particulate-induced airway hyperresponsiveness and inflammation in mice.  American Journal of Respiratory and Critical Care Medicine.  164(8 I).  1438-1443.
  • Chen ES, Greenlee BM, Wills-Karp M, Moller DR (2001).  Attenuation of lung inflammation and fibrosis in interferon-γ-deficient mice after intratracheal bleomycin.  American Journal of Respiratory Cell and Molecular Biology.  24(5).  545-555.
  • Chen ES, Greenlee BM, Wills-Karp M, Moller DR (2001).  Bleomycin-induced pulmonary fibrosis is attenuated in interferon-γ knockout mice.  Chest.  120(SUPPL.).
  • Wills-Karp M (2001).  IL-12/IL-13 axis in allergic asthma.  Journal of Allergy and Clinical Immunology.  107(1).  9-18.
  • Keen JC, Sholl L, Wills-Karp M, Georas SN (2001).  Preferential activation of nuclear factor of activated T cells c correlates with mouse strain susceptibility to allergic responses and interleukin-4 gene expression.  American Journal of Respiratory Cell and Molecular Biology.  24(1).  58-65.
  • Wills-Karp M, Santeliz J, Karp CL (2001).  The germless theory of allergic disease: Revisiting the hygiene hypothesis.  Nature Reviews Immunology.  1(1).  69-75.
  • Karp CL, Wills-Karp M (2001).  Complement and IL-12: Yin and yang.  Microbes and Infection.  3(2).  109-119.
  • Wills-Karp M (2000).  The gene encoding interleukin-13: A susceptibility locus for asthma and related traits.  Respiratory Research.  1(1).  19-23.
  • Wills-Karp M (2000).  Murine models of asthma in understanding immune dysregulation in human asthma.  Immunopharmacology.  48(3).  263-268.
  • Ewart SL, Kuperman D, Schadt E, Tankersley C, Grupe A, Shubitowski DM, Peltz G, Wills-Karp M (2000).  Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice.  American Journal of Respiratory Cell and Molecular Biology.  23(4).  537-545.
  • Karp CL, Grupe A, Schadt E, Ewart SL, Keane-Moore M, Cuomo PJ, Köhl J, Wahl L, Kuperman D, Germer S, Aud D, Peltz G, Wills-Karp M (2000).  Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma.  Nature Immunology.  1(3).  221-226.
  • Walters DM, Wills-Karp M, Mitzner W (2000).  Assessment of cellular profile lung function with repeated bronchoalveolar lavage in individual mice.  Physiological Genomics.  2000(2).  29-36.
  • Wills-Karp M (2000).  Trophic slime, allergic slime.  American Journal of Respiratory Cell and Molecular Biology.  22(6).  637-639.
  • Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD (1999).  Interleukin-13: Central mediator of allergic asthma.  Pneumologie.  53(9).
  • Wills-Karp M (1999).  Immunologic basis of antigen-induced airway hyperresponsiveness.  Annual Review of Immunology.  17.  255-281.
  • Eggleston PA, Buckley TJ, Breysse PN, Wills-Karp M, Kleeberger SR, Jaakkola JJK (1999).  The environment and asthma in U.S. inner cities.  Environmental Health Perspectives.  107(SUPPL. 3).  439-450.
  • Mayer RJ, Wills-Karp M (1999).  Symposium of the Inflammation Research Association on Recent Insights into Pathogenesis and Control of Asthma and Atopic Diseases, New York Academy of Sciences, January 26, 1999.  Inflammation Research.  48(9).  469-470.
  • Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD (1998).  Interleukin-13: Central mediator of allergic asthma.  Science.  282(5397).  2258-2261.
  • Keane-Myers A, Wysocka M, Trinchieri G, Wills-Karp M (1998).  Resistance to antigen-induced airway hyperresponsiveness requires endogenous production of IL-12.  Journal of Immunology.  161(2).  919-926.
  • Kuperman D, Schofield B, Wills-Karp M, Grusby MJ (1998).  Signal transducer and activator of transcription factor 6 (Stat6)- deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production.  Journal of Experimental Medicine.  187(6).  939-948.
  • Keane-Myers AM, Gause WC, Finkelman FD, Xhou XD, Wills-Karp M (1998).  Development of murine allergic asthma is dependent upon B7-2 costimulation.  Journal of Immunology.  160(2).  1036-1043.
  • Wills-Karp M (1998).  Interleukin-12 as a target for modulation of the inflammatory response in asthma.  Allergy: European Journal of Allergy and Clinical Immunology.  53(2).  113-119.
  • Keane-Myers A, Gause WC, Linsley PS, Chen SJ, Wills-Karp M (1997).  B7-CD28/CTLA-4 Costimulatory Pathways Are Required for the Development of T Helper Cell 2-Mediated Allergic Airway Responses to Inhaled Antigens.  Journal of Immunology.  158(5).  2042-2049.
  • Wills-Karp M (1997).  Smooth muscle as a direct or indirect target accounting for bronchopulmonary hyperresponsiveness.  Research in Immunology.  148(1).  59-72.
  • Wills-Karp M, Ewart SL (1997).  The genetics of allergen-induced airway hyperresponsiveness in mice.  American Journal of Respiratory and Critical Care Medicine.  156(4 II SUPPL.).
  • Gavett SH, O'Hearn DJ, Karp CL, Patel EA, Schofield BH, Finkelman FD, Wills-Karp M (1997).  Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice.  American Journal of Physiology - Lung Cellular and Molecular Physiology.  272(2 16-2).
  • Li XM, Chopra RK, Chou TY, Schofield BH, Wills-Karp M, Huang SK (1996).  Mucosal IFN-γ Gene Transfer Inhibits Pulmonary Allergic Responses in Mice.  Journal of Immunology.  157(8).  3216-3219.
  • Ewart SL, Gavett SH, Margolick J, Wills-Karp M (1996).  Cyclosporin A Attenuates Genetic Airway Hyperresponsiveness in Mice but Not through Inhibition of CD4+ or CD8+ T Cells.  American Journal of Respiratory Cell and Molecular Biology.  14(6).  627-634.
  • Foster WM, Wills-Karp M, Tankersley CG, Chen X, Paquette NC (1996).  Bloodborne markers in humans during multiday exposure to ozone.  Journal of Applied Physiology.  81(2).  794-800.
  • Wills-Karp M, Gavett SH, Schofield B, Finkelman F (1996).  Role of interleukin-4 in the development of allergic airway inflammation and airway hyperresponsiveness.  Advances in Experimental Medicine and Biology.  409.  343-347.
  • Gavett SH, O’Hearn DJ, Li X, Huang SK, Finkelman FD, Wills-Karp M (1995).  Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice.  Journal of Experimental Medicine.  182(5).  1527-1536.
  • Chen X, Gavett SH, Wills-Karp M (1995).  CD4+ T lymphocyte modulation of ozone-induced murine pulmonary inflammation..  American journal of respiratory cell and molecular biology.  12(4).  396-403.
  • Gavett SH, Chen X, Finkelman F, Wills-Karp M (1994).  Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia..  American journal of respiratory cell and molecular biology.  10(6).  587-593.
  • Wills-Karp M, Uchida Y, Lee JY, Jinot J, Hirata A, Hirata F (1993).  Organ culture with proinflammatory cytokines reproduces impairment of the beta-adrenoceptor-mediated relaxation in tracheas of a guinea pig antigen model..  American journal of respiratory cell and molecular biology.  8(2).  153-159.
  • Wills-Karp M, Gilmour MI (1993).  Increased cholinergic antagonism underlies impaired β-adrenergic response in ovalbumin-sensitized guinea pigs.  Journal of Applied Physiology.  74(6).  2729-2735.
  • Wills-Karp M (1993).  Age-related changes in pulmonary muscarinic receptor binding properties.  American Journal of Physiology - Lung Cellular and Molecular Physiology.  265(2 9-2).
  • Gavett SH, Wills-Karp M (1993).  Elevated lung G protein levels and muscarinic receptor affinity in a mouse model of airway hyperreactivity.  American Journal of Physiology - Lung Cellular and Molecular Physiology.  265(5 9-5).
  • Fryer AD, Wills-Karp M (1991).  Dysfunction of M2-muscarinic receptors in pulmonary parasympathetic nerves after antigen challenge.  Journal of Applied Physiology.  71(6).  2255-2261.
  • Wills-Karp M (1991).  Effects of age on muscarinic agonist-induced contraction and IP accumulation in airway smooth muscle.  Life Sciences.  49(14).  1039-1045.
  • Wills-Karp M, Jinot J, Lee J, Hirata F (1990).  Interleukin 1 alters guinea pig tracheal smooth muscle responsiveness to β-adrenergic stimulation.  European Journal of Pharmacology.  183(4).  1185.
  • Baumgartner RA, Wills-Karp M, Kaufman MJ, Munakata M, Hirshman C (1990).  Serotonin induces constriction and relaxation of the guinea pig airway.  Journal of Pharmacology and Experimental Therapeutics.  255(1).  165-173.
  • Izuhara K, Holgate ST, Wills-Karp M (2011).  Inflammation and Allergy Drug Design.
Book Chapters
  • Downey J, Gour N, Wills-Karp M (2015).  Mechanisms of Experimental Mouse Models of Airway Hyperresponsiveness.  Mucosal Immunology: Fourth Edition.  2-2.  1783-1803.
  • Lloyd C, Lewkowich IP, Wills-Karp M, Saglani S (2014).  Mouse Models of Allergic Airways Disease.  Middleton's Allergy: Principles and Practice: Eighth Edition.  1-2.  842-860.
  • Wills-Karp M (2011).  Role of Th2 Cells in the Allergic Diathesis.  Inflammation and Allergy Drug Design.  15-25.
  • Wills-Karp M, Köhl J, Karp CL (2003).  Complement factor 5 in asthma.  Therapeutic Targets in Airway Inflammation.  699-714.
  • "Method and compositions for treating asthma", 2009.
  • "Cytokine receptor chain", 2009.
  • "Therapy for allergic diseases", 2000.
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