Sarah Preheim

Assistant Professor

Research Interests

environmental microbiology, microbial ecology, bioinformatics

  • Ph.D. February 01, 2010, Massachusetts Institute of Technology/ Woods Hole Oceanographic Institution
  • B.S. May 18, 1997, Carnegie Mellon University
Research Areas
  • Environmental Microbiology, Microbial Ecology, Bioinformatics
Journal Articles
  • King, A. J., Preheim, S., Bailey, K. L., Robeson, M. S., Roy Chowdhury, T., Crable, B. R., Hurt, R. A., Mehlhorn, T. L., Lowe, K. A., Phelps, T. J., Palumbo, A. V., Brandt, C. C., Brown, S. D., Podar, M., Zhang, P., Lancaster, W. A., Poole, F. L., Watson, D. B., Fields, M. W., Chandonia, J. M., Alm, E. J., Zhou, J., Adams, M. W., Hazen, T. C., Arkin, A. P., Elias, D. A. (2017).  Temporal Dynamics of In-Field Bioreactor Populations Reflect the Groundwater System and Respond Predictably to Perturbation..  Environmental science & technology.
  • Hehemann, J. H., Arevalo, P., Datta, M. S., Yu, X., Corzett, C. H., Henschel, A., Preheim, S., Timberlake, S., Alm, E. J., Polz, M. F. (2016).  Adaptive radiation by waves of gene transfer leads to fine-scale resource partitioning in marine microbes..  Nature communications.  7.  12860.
  • Preheim, S., Olesen, S. W., Spencer, S. J., Materna, A., Varadharajan, C., Blackburn, M., Friedman, J., Rodríguez, J., Hemond, H., Alm, E. J. (2016).  Surveys, simulation and single-cell assays relate function and phylogeny in a lake ecosystem..  Nature microbiology.  1(9).  16130.
  • Spencer, S. J., Tamminen, M. V., Preheim, S., Guo, M. T., Briggs, A. W., Brito, I. L., A Weitz, D., Pitkänen, L. K., Vigneault, F., Virta, M. P., Alm, E. J. (2016).  Massively parallel sequencing of single cells by epicPCR links functional genes with phylogenetic markers..  The ISME journal.  10(2).  427-436.
  • Smith, M. B., Rocha, A. M., Smillie, C. S., Olesen, S. W., Paradis, C., Wu, L., Campbell, J. H., Fortney, J. L., Mehlhorn, T. L., Lowe, K. A., Earles, J. E., Phillips, J., Techtmann, S. M., Joyner, D. C., Elias, D. A., Bailey, K. L., Hurt, Jr, R. A., Preheim, S., Sanders, M. C., Yang, J., Mueller, M. A., Brooks, S., Watson, D. B., Zhang, P., He, Z., Dubinsky, E. A., Adams, P. D., Arkin, A. P., Fields, M. W., Zhou, J., Alm, E. J., Hazen, T. C. (2015).  Natural bacterial communities serve as quantitative geochemical biosensors..  mBio.  6(3).  e00326-15.
  • Preheim, S., Perrotta, A. R., Friedman, J., Smilie, C., Brito, I., Smith, M. B., Alm, E., DeLong, E. (2013).  Computational Methods for High-Throughput Comparative Analyses of Natural Microbial Communities.  Microbial Metagenomics, Metatranscriptomics, and Metaproteomics.  531.  353-370.
  • Preheim, S., Perrotta, A. R., Martin-Platero, A. M., Gupta, A., Alm, E. J. (2013).  Distribution-Based Clustering: Using Ecology To Refine the Operational Taxonomic Unit.  Applied and Environmental Microbiology.  79(21).  6593-6603.
  • Szabo, G., Preheim, S., Kauffman, K. M., David, L. A., Shapiro, J., Alm, E. J., Polz, M. F. (2013).  Reproducibility of Vibrionaceae population structure in coastal bacterioplankton.  Isme Journal.  7(3).  509-519.
  • Papa, E., Docktor, M., Smillie, C., Weber, S., Preheim, S., Gevers, D., Giannoukos, G., Ciulla, D., Tabbaa, D., Ingram, J., Schauer, D. B., Ward, D. V., Korzenik, J. R., Xavier, R. J., Bousvaros, A., Alm, E. J. (2012).  Non-Invasive Mapping of the Gastrointestinal Microbiota Identifies Children with Inflammatory Bowel Disease.  Plos One.  7(6).
  • Wollenberg, M. S., Preheim, S., Polz, M. F., Ruby, E. G. (2012).  Polyphyly of non-bioluminescent Vibrio fischeri sharing a lux-locus deletion.  Environmental Microbiology.  14(3).  655-668.
  • Shapiro, B. J., Friedman, J., Cordero, O. X., Preheim, S., Timberlake, S. C., Szabo, G., Polz, M. F., Alm, E. J. (2012).  Population Genomics of Early Events in the Ecological Differentiation of Bacteria.  Science.  336(6077).  48-51.
  • Preheim, S., Timberlake, S., Polz, M. F. (2011).  Merging Taxonomy with Ecological Population Prediction in a Case Study of Vibrionaceae.  Applied and Environmental Microbiology.  77(20).  7195-7206.
  • Preheim, S., Boucher, Y., Wildschutte, H., David, L. A., Veneziano, D., Alm, E. J., Polz, M. F. (2011).  Metapopulation structure of Vibrionaceae among coastal marine invertebrates.  Environmental Microbiology.  13(1).  265-275.
  • Wildschutte, H., Preheim, S., Hernandez, Y., Polz, M. F. (2010).  O-antigen diversity and lateral transfer of the wbe region among Vibrio splendidus isolates.  Environmental Microbiology.  12(11).  2977-2987.
  • Birkeland, S. R., Preheim, S., Davids, B. J., Cipriano, M. J., Palm, D., Reiner, D. S., Svard, S. G., Gillin, F. D., McArthur, A. G. (2010).  Transcriptome analyses of the Giardia lamblia life cycle.  Molecular and Biochemical Parasitology.  174(1).  62-65.
  • Marcelino, L. A., Backman, V., Donaldson, A., Steadman, C., Thompson, J. R., Preheim, S., Lien, C., Lim, E., Veneziano, D., Polz, M. F. (2008).  Accurately quantifying low-abundant targets amid similar sequences by revealing hidden correlations in oligonucleotide microarray data (vol 103, pg 13629, 2006).  Proceedings of the National Academy of Sciences of the United States of America.  105(50).  20045-20045.
  • HUNT, D., DAVID, L., GEVERS, D., PREHEIM, S., ALM, E., POLZ, M. (2008).  Resource partitioning and sympatric differentiation among closely related bacterioplankton.  SCIENCE.  320(5879).  1081-1085.
  • LAUWAET, T., DAVIDS, B., TORRES-ESCOBAR, A., BIRKELAND, SR., CIPRIANO, M., PREHEIM, S., PALM, D., SVARD, S., MCARTHUR, A., GILLIN, F. (2007).  Protein phosphatase 2A plays a crucial role in Giardia lamblia differentiation.  MOLECULAR AND BIOCHEMICAL PARASITOLOGY.  152(1).  80-89.
  • DAVIDS, B., REINER, D., BIRKELAND, SR., PREHEIM, S., CIPRIANO, M., MCARTHUR, A., GILLIN, F. (2006).  A New Family of Giardial Cysteine-Rich Non-VSP Protein Genes and a Novel Cyst Protein.  PLOS ONE.  1(1).
  • MARCELINO, L., BACKMAN, V., DONALDSON, A., STEADMAN, C., THOMPSON, JR., PREHEIM, S., LIEN, C., LIM, E., VENEZIANO, D., POLZ, M. (2006).  Accurately quantifying low-abundant targets amid similar sequences by revealing hidden correlations in oligonucleotide microarray data.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  103(37).  13629-13634.
  • FAULKNER, S., OLI, M., KIEFT, R., COTLIN, L., WIDENER, J., SHIFLETT, A., CIPRIANO, M., PACOCHA, S., BIRKELAND, SR., HAJDUK, S., MCARTHUR, A. (2006).  In vitro generation of human high-density-lipoprotein-resistant Trypanosoma brucei brucei.  EUKARYOTIC CELL.  5(8).  1276-1286.
  • POLZ, M., HUNT, D., PREHEIM, S., WEINREICH, D. (2006).  Patterns and mechanisms of genetic and phenotypic differentiation in marine microbes.  PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES.  361(1475).  2009-2021.
  • PALM, D., WEILAND, M., MCARTHUR, A., WINIECKA-KRUSNELL, J., CIPRIANO, M., BIRKELAND, SR., PACOCHA, S., DAVIDS, B., GILLIN, F., LINDER, E., SVARD, S. (2005).  Developmental changes in the adhesive disk during Giardia differentiation.  MOLECULAR AND BIOCHEMICAL PARASITOLOGY.  141(2).  199-207.
  • THOMPSON, JR., PACOCHA, S., PHARINO, C., KLEPAC-CERAJ, V., HUNT, D., BENOIT, J., SARMA-RUPAVTARM, R., DISTEL, D., POLZ, M. (2005).  Genotypic diversity within a natural coastal bacterioplankton population.  SCIENCE.  307(5713).  1311-1313.
  • LI, X., ESSAYAN, D., PACOCHA, S., BEATY, T., HUANG, S. (2000).  Identification of differentially expressed genes in human Th2 cells.  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY.  105(1).  S154-S154.
  • PACOCHA, S., ORIENTE, A., LICHTENSTEIN, L., HUANG, S., ESSAYAN, D. (2000).  Interferon-beta induces selective enhancement of antigen-specific T cell responses.  JOURNAL OF INTERFERON AND CYTOKINE RESEARCH.  20(4).  383-389.
  • ORIENTE, A., FEDARKO, N., PACOCHA, S., HUANG, S., LICHTENSTEIN, L., ESSAYAN, D. (2000).  Interleukin-13 modulates collagen homeostasis in human skin and keloid fibroblasts.  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS.  292(3).  988-994.
  • PACOCHA, S., ORIENTE, A., KAGEY-SOBOTKA, A., LICHTENSTEIN, L., HUANG, S. (1999).  All in vitro efficacy of calcineurin antagonists on antigen-driven human Th0, Th1, and Th2 responses..  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY.  103(1).  S194-S194.
  • ORIENTE, A., FEDARKO, N., PACOCHA, S., HUANG, S., LICHTENSTEIN, L., ESSAYAN, D. (1999).  IL-13 induces collagen synthesis in normal (NF) and keloid fibroblasts (KF)..  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY.  103(1).  S239-S239.
  • KWON, J., PACOCHA, S., JORGENSEN, L., MURPHY, R. (1999).  Na+,K+-ATPsse beta 2 isoform expression and endosomal pH regulation.  MOLECULAR BIOLOGY OF THE CELL.  10.  113A-113A.
  • PACOCHA, S., ORIENTE, A., HUANG, S., ESSAYAN, D. (1999).  Regulation of antigen-induced human T-lymphocyte responses by calcineurin antagonists.  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY.  104(4).  828-835.
  • "Dynamics of Microbial Diversity and Biogeochemical Processes in the Chesapeake Bay Dead-Zone", Annual Meeting.  Portland, OR.  2017
  • "Using a Biogeochemical Model to Interpret the Spatial and Temproal Dynamics of Microorganisms in a Seasonally Stratified Lake", Aquatic Sciences Meeting.  Honolulu, HI.  February 28, 2017
  • "Bacteria Form Distinct Ecological Groups That May Impact Nutrient Cycling and Dead Zone Formation in the Chesapeake Bay", Mid-Atlantic Microbiome Meeting.  College Park, MD.  November 2, 2016
  • "Bacteria Form Distinct Ecological Groups That May Impact Nutrient Cycling and Dead Zone Formation in the Chesapeake Bay", ASM Microbe 2016.  Boston, MA.  June 18, 2016
  • "Modeling the Dynamics of Biogeochemical Processes and Bacterial Diversity in Aquatic Dead-Zones", Biology Department Seminar Series.  Baltimore, MD.  May 5, 2016
  • "Modeling the dynamic feedback between microbial communities and their environment", First Workshop on Challenges in Microbiome Data Analysis.  160 Fifth Ave., New York, NY.  February 26, 2016
  • "Ecology and the Environment", Naval Academy Science and Engineering Conference.  Annapolis, MD.  November 8, 2015
  • "Modeling the Dynamics of Biogeochemical Processes and Bacterial Diversity in Aquatic Dead-Zones", 9th Annual Genomics and Bioinformatics Symposium.  Baltimore, MD.  October 22, 2015
  • "Modeling the Dynamics of Biogeochemical Processes and Bacterial Diversity in Aquatic Dead-Zones", Bromery seminar series.  Baltimore, MD.  September 24, 2015
  • "Organizing diversity data into functional units to explain bacterial distribution patterns in a stratified lake", Microbiome Seminar Series.  April 9, 2015
  • "Quantitative modeling and single-cell gene fusion technique explains bacterial community structure in a dynamic ecosystem", Civil and Environmental Engineering Departmental Seminar.  Newark, DE.  April 3, 2015
  • "Distribution-based clustering: using ecology to refine the operational taxonomic unit", High-Resolution Microbiome Informatics Meeting.  Woods Hole, MA.  March 19, 2015
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