Drug delivery systems
Developing strategies for engineering liposome-based and peptide-based systems to improve tumor accumulation and uptake in target tissues, with a focus on delivering drugs to the brain.
In vitro models of the tumor microenvironment
Developing tissue-engineered models of the tumor microenvironment including tumor vasculature, post-capillary venules, and capillary networks, for use testing and imaging drug and gene delivery vehicles.
The blood-brain barrier (BBB)
Using tissue engineering, stem cell technology, and microfabrication to reverse engineer the blood-brain barrier.
Development of Biodegradable Mg Alloys for Bone Fixation and Bone Scaffolds
In this project, Professor Weihs and multiple collaborators are conducting in vitro and in vivo experiments to characterize and optimize the mechanical properties, corrosion properties, and biocompatibility of biodegradable Mg alloys.
Model Membranes to Probe the Interactions of Transmembrane Helices
Developing novel methods to probe the interactions of TM helices in various lipid bilayer systems.
Molecular Mechanism of Receptor Tyrosine Kinase Associated Pathogenesis
Exploring membrane model systems composed of lipids and peptides corresponding to the transmembrane domain of wild-type and mutant RTKs.
Quantitative Measurements of Protein Interactions in Cells
Developing experimental methods that yield a quantitative description of protein interactions in cellular membranes.