Projects

Drug delivery systems

Developing strategies for engineering liposome-based and peptide-based systems to improve tumor accumulation and uptake in target tissues, with a focus on delivering drugs to the brain.

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In vitro models of the tumor microenvironment

Developing tissue-engineered models of the tumor microenvironment including tumor vasculature, post-capillary venules, and capillary networks, for use testing and imaging drug and gene delivery vehicles.

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The blood-brain barrier (BBB)

Using tissue engineering, stem cell technology, and microfabrication to reverse engineer the blood-brain barrier.


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Bioagent Defeat Using Gaseous Biocidals

A Defense of Threat Reduction Agency (DTRA) project developing a combination of reactive materials and biocidal compounds for the purpose of bioagent defeat.


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Model Membranes to Probe the Interactions of Transmembrane Helices

Developing novel methods to probe the interactions of TM helices in various lipid bilayer systems.


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Molecular Mechanism of Receptor Tyrosine Kinase Associated Pathogenesis

Exploring membrane model systems composed of lipids and peptides corresponding to the transmembrane domain of wild-type and mutant RTKs.


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Quantitative Measurements of Protein Interactions in Cells

Developing experimental methods that yield a quantitative description of protein interactions in cellular membranes.


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