Projects
Drug delivery systems
Developing strategies for engineering liposome-based and peptide-based systems to improve tumor accumulation and uptake in target tissues, with a focus on delivering drugs to the brain.
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In vitro models of the tumor microenvironment
Developing tissue-engineered models of the tumor microenvironment including tumor vasculature, post-capillary venules, and capillary networks, for use testing and imaging drug and gene delivery vehicles.
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The blood-brain barrier (BBB)
Using tissue engineering, stem cell technology, and microfabrication to reverse engineer the blood-brain barrier.
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Bioagent Defeat Using Gaseous Biocidals
A Defense of Threat Reduction Agency (DTRA) project developing a combination of reactive materials and biocidal compounds for the purpose of bioagent defeat.
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Model Membranes to Probe the Interactions of Transmembrane Helices
Developing novel methods to probe the interactions of TM helices in various lipid bilayer systems.
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Molecular Mechanism of Receptor Tyrosine Kinase Associated Pathogenesis
Exploring membrane model systems composed of lipids and peptides corresponding to the transmembrane domain of wild-type and mutant RTKs.
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Quantitative Measurements of Protein Interactions in Cells
Developing experimental methods that yield a quantitative description of protein interactions in cellular membranes.
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