Join us as we welcome Kyung Sung from the FDA to speak about “Advanced analytical tools for assessing the functional activity of regenerative medicine cellular products” on Wednesday, April 10th, 2024 at 3pm in Maryland Hall Room 110.
Abstract: Advanced analytical tools for assessing the functional activity of regenerative medicine cellular products
Mesenchymal stromal cells (MSCs) have become popular sources for manufacturing regenerative medicine cellular products due to their ability to undergo lineage-specific differentiation. MSCs, on the other hand, are heterogeneous and responsive to their surroundings, resulting in distinct subpopulations of cells with potentially different properties required for product potency. Because there are numerous biochemical and biomechanical factors that influence MSC function, developing reliable high-throughput assays that allow for the efficient exploration of large and complex parameters for evaluating cellular function is critical. Advanced in vitro tools such as microphysiological systems offer a viable solution to this unmet need. This presentation will provide an overview of regenerative medicine cellular product regulation as well as advanced in vitro analytical tools that improve throughput, relevance, and reliability. How such tools could be used to evaluate the efficacy of regenerative medicine cellular products will be discussed.