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Oxygen8: Minimizing Recurrence of Glioblastoma Multiforme

Project Description:

Glioblastoma multiforme (GBM) is the most common malignant brain tumor and remains highly lethal due to its invasive nature and resistance to treatment. Its development of oxygen-poor regions reduces the effectiveness of radiation, limiting current therapeutic outcomes. We propose a new treatment strategy that delivers oxygen to tumor cells to enhance their sensitivity to radiation and improve patient prognosis.

Project Photo:

Diagram depicting glioblastoma treatment resistance. On the left, a tumor is treated with radiotherapy and medication, while on the right, the tumor grows larger, representing resistance to treatment. Both treatment methods are marked with an 'X', indicating their ineffectiveness in halting tumor progression.

The current standard of care for GBM involves a series of ineffective treatments that ultimately enable the tumor to proliferate to a fatal level within 12-15 months from initial resection.

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