NeuroFilm is an innovative implantable electrospun substrate designed to address musculoskeletal disorders by stimulating muscle repair, promoting reinnervation, and enabling continuous monitoring through EMG signal acquisition. Composed of sodium alginate, poly (vinyl alcohol), PEDOT:PSS, and glutaraldehyde, NeuroFilm mimics the extracellular matrix to support cell attachment and regeneration. The substrate’s electrospun fibers provide high porosity and hydrophilicity, essential for efficient muscle interaction. Through rodent studies, including subcutaneous and epimysial implants, the project investigates the material’s structural integrity, mechanical properties, and in vivo performance. Early results show promising electrical conductivity and potential for long-term biocompatibility, paving the way for future clinical applications in rehabilitation. Ongoing studies aim to refine the material’s performance and explore its combination with nerve cuff systems to create a dual-purpose treatment and monitoring device. 

Team Members: Raeann Kalinowski, Pierce Perkins, Nitish Thakor

Department: Materials Science and Engineering

Course: EN.510.439 Biomaterials Senior Design