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Applied Mathematics and Statistics Presents The Distinguished Goldman Lecture | Amit Singer
November 14, 2024 @ 1:30 pm - 2:30 pm
Location: Gilman 50
When: November 14th at 1:30 p.m.
Title: Mathematics of Cryo-Electron Microscopy
Abstract: Single particle cryo-EM is an increasingly popular technique for determining 3-D molecular structures at high resolution. The 2017 Nobel Prize in Chemistry was awarded to three of the pioneers of cryo-EM, and already in the early stages of the global pandemic, cryo-EM was successfully applied to image the SARS-CoV-2 spike protein. We will discuss the mathematical principles and computational methods for reconstruction using cryo-EM, focusing on its sample complexity (i.e., the number images required for reconstruction as a function of the signal-to-noise ratio) and reconstruction of flexible molecules.
Bio: Amit Singer is a Professor of Mathematics, the Director of the Program in Applied and Computational Mathematics (PACM), and a member of the Executive Committee for the Center for Statistics and Machine Learning (CSML) at Princeton University. He joined Princeton as an Assistant Professor in 2008. From 2005 to 2008 he was a Gibbs Assistant Professor in Applied Mathematics at the Department of Mathematics, Yale University. Singer received the BSc degree in Physics and Mathematics and the PhD degree in Applied Mathematics from Tel Aviv University (Israel), in 1997 and 2005, respectively. His list of awards includes SIAM Fellow (2022), the Simons Math+X Investigator Award (2017), a National Finalist for Blavatnik Awards for Young Scientists (2016), Moore Investigator in Data-Driven Discovery (2014), Simons Investigator Award (2012), Presidential Early Career Award for Scientists and Engineers (2010), the Alfred P. Sloan Research Fellowship (2010) and the Haim Nessyahu Prize for Best PhD in Mathematics in Israel (2007). His current research in applied mathematics focuses on theoretical and computational aspects of data science, and on developing computational methods for structural biology.
Zoom link: https://wse.zoom.us/j/96299385386?pwd=HvOzDnw7A2SOQkMrbBbr5AXjqurdj0.1