Title: Proximal Causal Inference
Abstract: Skepticism about the assumption of no unmeasured confounding – also known as exchangeability – is often warranted in making causal inferences from observational data, because exchangeability hinges on an investigator’s ability to accurately measure covariates that capture all potential sources of confounding. In practice, the most one can hope for is that covariate measurements are at best proxies of the true confounding mechanism, thus invalidating inferences made under exchangeability. In this talk, we consider the framework of proximal causal inference introduced by Tchetgen Tchetgen et al (2020), which while explicitly acknowledging covariate measurements as imperfect proxies of confounding mechanisms, offers an opportunity to learn about causal effects even if exchangeability on basis of measured covariates fails. We provide an overview of nonparametric identification conditions, as well as parametric, semi-parametric and nonparametric modes of inference in a variety of causal settings, including total effects, mediation analysis, interference on a network subject to homophily bias, Synthetic controls, and longitudinal analysis of time-varying treatment subject to time-varying unmeasured confounding. We illustrate the proximal framework via simulation studies and a variety of data applications in the health and social sciences.
Short bio: Dr. Eric Tchetgen Tchetgen is the Luddy Family President’s Distinguished Professor in the Department of Statistics and Data Science at University of Pennsylvania’s Wharton School. His primary area of interest is in semi-parametric efficiency theory with application to causal inference and missing data problems. He is known for his work in development of statistical and epidemiologic methods that make efficient use of the information in data collected by scientific investigators, while avoiding unnecessary assumptions about underlying data generating mechanisms. He received his B.S. in Electrical Engineering from Yale University in 1999, and completed his PhD in Biostatistics at Harvard University in 2006. From 2006 to 2018, he was with the Harvard T.H. Chan School of Public Health where he rose to the rank of Professor in the Department of Biostatistics and Department of Epidemiology.
Location: Hodson 110
Zoom: https://wse.zoom.us/j/91467375713?pwd=VjN3ekZTRFZIWS80NnpwZUFRUzRWUT09
Meeting ID: 914 6737 5713
Passcode: 272254