Research

Metabolism is an ensemble of biochemical reactions, regulating every single piece of our living. Its dysfunctions are deeply implicated in major diseases, including cancer, diabetes and neurological disorders. Our lab is interested in developing technologies to deepen our understanding of the interplay between metabolic dysfunctions and disease initiation and progression, with a goal of identifying biomarkers and therapeutic targets.
Our research goals are:
i) developing microfluidic systems to determine how our diet affects disease progression, especially cancer,
ii) building bioreactors to investigate how cells reprogram their metabolism under varying metabolic conditions,
iii) developing analytical tools to identify the role of extracellular vesicles in metabolic homeostasis
Our lab principles are:
Own your research; Tell your story; Love your neighbor

Device

exosome

metabolism

Jeong S, et al. ACS Nano (2016)
Park J, et al. ACS Nano (2017)
Jeong S, et al. Cell Metabolism (2020)

News

Jan. 17, 2021 – Claudia Wong joins our lab as THE FIRST research technician!
Jan. 1, 2021 – Dr. Geonhui Lee joins our lab as THE FIRST postdoctoral researcher!
Jan. 1, 2021 – Our lab is officially launched!

Members

Sangmoo jeong

Principal Investigator
Ph.D. Stanford University

geonhui lee

Postdoctoral Researcher
Ph.D. Korea University

claudia wong

Research Technician
B.S. UC Berkeley

Publications

See publications on Pubmed
2020
Jeong S, Savino AM, Chiray R, Barin E, Cheng Y, Park S-M, Schurer A, Mullarky E, Cantley LC, Kharas MG, Keshari KR. High fructose drives the serine synthesis pathway in acute myeloid leukemic cells. Cell Metab. 2020 Accepted. [Link]
Lees H, Millan M, Ahamed F, Eskandari R, Granlund KL, Jeong S, Keshari KR. Multi‐sample measurement of hyperpolarized pyruvate‐to‐lactate flux in melanoma cells. NMR Biomed. 2020 Accepted. [Link]
2019
Dong Y, Eskandari R, Ray C, Granlund KL, Santos-Cunha LD, Miloushev VZ, Tee SS, Jeong S, Aras O, Chen YB, Cheng EH, Hsieh JJ, Keshari KR. Hyperpolarized MRI Visualizes Warburg Effects and Predicts Treatment Response to mTOR Inhibitors in Patient-Derived ccRCC Xenograft Models. Cancer Res. 2019 Jan 1;79(1):242-250. [Link]
2018
Tee SS, Suster I, Truong S, Jeong S, Eskandari R, DiGialleonardo V, Alvarez JA, Aldeborgh HN, Keshari KR. Targeted AKT Inhibition in Prostate Cancer Cells and Spheroids Reduces Aerobic Glycolysis and Generation of Hyperpolarized [1-13C] Lactate. Mol Cancer Res. 2018 Mar;16(3):453-460. [Link]
2017
Park J, Lin HY, Assaker JP, Jeong S, Huang CH, Kurdi T, Lee K, Fraser K, Min C, Eskandari S, Routray S, Tannous B, Abdi R, Riella L, Chandraker A, Castro CM, Weissleder R, Lee H, Azzi JR. Integrated Kidney Exosome Analysis for the Detection of Kidney Transplant Rejection. ACS Nano. 2017 Nov 28;11(11):11041-11046. [Link]
Jeong S, Eskandari R, Park SM, Alvarez J, Tee SS, Weissleder R, Kharas MG, Lee H, Keshari KR. Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer. Sci Adv. 2017 Jun;3(6):e1700341. [Link]
2016
Tee SS, DiGialleonardo V, Eskandari R, Jeong S, Granlund KL, Miloushev V, Poot AJ, Truong S, Alvarez JA, Aldeborgh HN, Keshari KR. Sampling Hyperpolarized Molecules Utilizing a 1 Tesla Permanent Magnetic Field. Sci Rep. 2016 Sep 6;6:32846. [Link]
Song J, Leon Swisher C, Im H, Jeong S, Pathania D, Iwamoto Y, Pivovarov M, Weissleder R, Lee H. Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography. Sci Rep. 2016 Apr 21;6:24681. [Link]
Jeong S, Park J, Pathania D, Castro CM, Weissleder R, Lee H. Integrated Magneto-Electrochemical Sensor for Exosome Analysis. ACS Nano. 2016 Feb 23;10(2):1802-9. [Link]

Contact us

The Jeong Lab

Shaffer Hall, Rm. 103K
3400 N Charles Street, Baltimore, MD 21218
Tel: 410-516-0633
Email: [email protected]