Research

Metabolism regulates every single piece of our daily living, and its dysfunctions are directly linked with major diseases, including cancer and autoimmune diseases. A deeper understanding of the interplay between metabolic dysfunctions and pathologies will lead to novel biomarkers and therapeutic targets. 

Our lab has unique interdisciplinary expertise in metabolism, extracellular vesicles (EVs), and device, based on which we are pursuing exciting and impactful research topics:

  • Identify how abnormal metabolism promotes cancer metastasis and drug resistance development

  • Develop technologies for sensitive detection of metabolic biomarkers for cancer and autoimmune diseases

  • Engineer metabolism of mesenchymal stem cells to mass-produce therapeutic EVs

We are committed to creating and fostering a diverse, equitable, and inclusive research environment where people of all backgrounds and identities are valued and respected. We, as One Team, endeavor to achieve our full potential and scientific innovations together.

Device

exosome (or EV)

metabolism

Jeong S, et al. ACS Nano (2016)
Park J, et al. ACS Nano (2017)
Jeong S, et al. Cell Metabolism (2020)

News

May. 24, 2023 – You can download a preprint of our exciting work “E-cad-mediated metabolic reprogramming in breast cancer” from this Link!
May. 9, 2023 – Our lab received the Maryland Stem Cell Research Fund Launch Award . This will help us develop a novel therapeutic strategy for extending the preservation time of a donor organ in transplantation using extracellular vesicles.
Dec. 21, 2022 – THE FIRST paper is published! Click this Link!
Nov. 12, 2022 – Jeong lab & Jung lab have a joint Fall party!
  Jeong Lab & Jung Lab Joint Party
Oct. 13, 2022 – Michaela Bhoorasingh, Jeongyun Kim, and Rodger Black join our lab as THE SECOND generation of PhD students!
Sep. 12, 2022 – Dr. Sohyeon Park joins our lab as THE SECOND postdoctoral researcher!
Aug 11, 2022 – Today is the last day for Peyton to work in our lab. Peyton did amazing jobs (under excellent guidance from Alli) over the last 10 weeks. We wish you all the best for your next journey!!!
 
Aug 4, 2022 – Our lab received the 2022 Cancer Invasion and Metastasis Pilot Grant from Sidney Kimmel Comprehensive Cancer Center. This will help us investigate the interplay between intercellular adhesion protein, E-cadherin, and metabolism in breast cancer models.
July 26, 2022 – Our lab received the Maximizing Investigators’ Research Award (MIRA) from NIGMS, NIH! This 5-year grant will help us investigate how cellular metabolism regulates the exosome biogenesis.
Jun. 8, 2022 – Peyton Panovich joins our lab as THE FIRST REU student during this Summer! She is a rising senior at University of Kansas with spectacular GPA and research experience! Welcome, Peyton!
Feb. 21, 2022 – Anna Cho joins our lab as THE FIRST visiting undergraduate researcher!
Feb. 1, 2022 – Lab renovation has finally started! We expect to have a fancy lab space at the end of Summer!
Oct. 13, 2021 – Alli Abolarin  joins our lab as THE FIRST PhD graduate student!
Oct. 1, 2021 – Alex Correa joins our lab as THE FIRST undergraduate researcher!
July 1, 2021 – Our lab received THE FIRST foundation grant (the Leukemia Research Foundation)! [Link]
Jan. 17, 2021 – Claudia Wong joins our lab as THE FIRST research technician!
Jan. 1, 2021 – Dr. Geonhui Lee joins our lab as THE FIRST postdoctoral researcher!
Jan. 1, 2021 – Our lab is officially launched! At the same time, our lab received the NIH Pathway to Independence Award (R00) to jump up our start!

Members

We are actively hiring postdoctoral researchers with expertise in metabolism, molecular sensor, and EVs. Candidates should contact Dr. Jeong by e-mail with a CV, a 1-page summary of research experience and interests, and contact information of at least two references (if not, it would not be considered.)

Sangmoo jeong

Principal Investigator
Ph.D. Stanford University

geonhui lee

Postdoctoral Researcher
Ph.D. Korea University

alli abolarin

Ph.D. Student
B.S. UW Madison

SOHYeon park

Postdoctoral Researcher
Ph.D. Yonsei University​

michaela Bhoorasingh

Ph.D. Student
B.S. University of Toronto

erin lee

Undergrad Student

jeongyun kim

Ph.D. Student
M.S. Carnegie Melon University

rodger black

Ph.D. Student
B.S. Kansas State University

jasmine kim

Undergrad Student

Alumni

Claudia Wong  (Research Technician / 2021. Jan – 2022. Dec)
Anna Cho  (Visiting undergrad student from Handong Global University / 2022. Mar – 2022. Dec)

Publications

See publications on Pubmed
2023
Lee G, Wong C, Cho A, West JJ, Crawford AJ, Russo GC, Si, BR, Kim J, Hoffner L, Jang C, Jung M, Leone RD, Konstantopoulos K, Ewald AJ, Wirtz D, Jeong S. Serine synthesis pathway upregulated by E-cadherin is essential for the proliferation and metastasis of breast cancers . bioRxiv 2023, doi:10.1101/2023.05.24.541452. [Link]
Lee G, Ruan T, Wong C, Deh K, Abolarin A, Correa A, Keshari KR, Jeong S. Micro-Slab Coil Design for Hyperpolarized Metabolic Flux Analysis in Multiple Samples. Bioengineering 2023, 10(1), 14. [Link]
2022
Tee SS, Kim N, Cullen Q, Eskandari R, Mamakhanyan A, Srouji RM, Chirayil R, Jeong S, Shakiba M, Kastenhuber E, Chen S, Sigel C, Lowe S, Jarnagin WR, Thompson CB, Schietinger A, and Keshari KR. Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging. Science Advances 2022, 8(14):eabm7985. [Link]
2021
Jeong S, Savino AM, Chiray R, Barin E, Cheng Y, Park S-M, Schurer A, Mullarky E, Cantley LC, Kharas MG, Keshari KR. High fructose drives the serine synthesis pathway in acute myeloid leukemic cells. Cell Metabolism 2021, 33(1):145-159.E6. [Link]
2020
Lees H, Millan M, Ahamed F, Eskandari R, Granlund KL, Jeong S, Keshari KR. Multi‐sample measurement of hyperpolarized pyruvate‐to‐lactate flux in melanoma cells. NMR in Biomedicine 2020, 34(3):e4447. [Link]
2019
Dong Y, Eskandari R, Ray C, Granlund KL, Santos-Cunha LD, Miloushev VZ, Tee SS, Jeong S, Aras O, Chen YB, Cheng EH, Hsieh JJ, Keshari KR. Hyperpolarized MRI Visualizes Warburg Effects and Predicts Treatment Response to mTOR Inhibitors in Patient-Derived ccRCC Xenograft Models. Cancer Research 2019, 79(1):242-250. [Link]
2018
Tee SS, Suster I, Truong S, Jeong S, Eskandari R, DiGialleonardo V, Alvarez JA, Aldeborgh HN, Keshari KR. Targeted AKT Inhibition in Prostate Cancer Cells and Spheroids Reduces Aerobic Glycolysis and Generation of Hyperpolarized [1-13C] Lactate. Molecular Cancer Research 2018, 16(3):453-460. [Link]
2017
Park J, Lin HY, Assaker JP, Jeong S, Huang CH, Kurdi T, Lee K, Fraser K, Min C, Eskandari S, Routray S, Tannous B, Abdi R, Riella L, Chandraker A, Castro CM, Weissleder R, Lee H, Azzi JR. Integrated Kidney Exosome Analysis for the Detection of Kidney Transplant Rejection. ACS Nano 2017, 11(11):11041-11046. [Link]
Jeong S, Eskandari R, Park SM, Alvarez J, Tee SS, Weissleder R, Kharas MG, Lee H, Keshari KR. Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer. Science Advances 2017, 3(6):e1700341. [Link]
2016
Tee SS, DiGialleonardo V, Eskandari R, Jeong S, Granlund KL, Miloushev V, Poot AJ, Truong S, Alvarez JA, Aldeborgh HN, Keshari KR. Sampling Hyperpolarized Molecules Utilizing a 1 Tesla Permanent Magnetic Field. Scientific Reports 2016, 6:32846. [Link]
Song J, Leon Swisher C, Im H, Jeong S, Pathania D, Iwamoto Y, Pivovarov M, Weissleder R, Lee H. Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography. Scientific Reports 2016, 6:24681. [Link]
Jeong S, Park J, Pathania D, Castro CM, Weissleder R, Lee H. Integrated Magneto-Electrochemical Sensor for Exosome Analysis. ACS Nano 2016, 10(2):1802-1809. [Link]

Contact us

The Jeong Lab

Shaffer Hall, Rm. 103K
3400 N Charles Street, Baltimore, MD 21218
Tel: 410-516-0633
Email: [email protected]