Research
Our lab develops metabolic intervention strategies for cancer treatment and organ transplantation:
Target metabolism for more effective cancer treatment
Reprogram metabolism in suboptimal donor organs to make them more suitable for transplantation
Develop sensing technologies for metabolic and immune diseases
Our lab has three unique interdisciplinary expertise to achieve our research goals:
Metabolism
Extracellular vesicles (EVs)
Device engineering
News
Mar. 19, 2025 – Our probiotics paper demonstrating “Probiotics-In-Egg (PIE)” is published in Advanced Healthcare Materials. Check this Link!
Nov. 22, 2024 – Kevin Chen, Luis Flores, and Mallikarjun Reddy join our lab for their exciting PhD journey! Welcome!
Sep. 24, 2024 – Our metabolism paper demonstrating how E-cadherin (a cell-to-cell junction molecule) reprograms breast cancer metabolism is published in Cancer Research. Check this Link!
Jun. 20, 2024 – Our lab received the 2024 JHU Catalyst Award. This will help us develop a novel sensing technology for rapid, quantitative, and sensitive detection of cytokines in aqueous humor samples for personalized treatment for vascular eye diseases.
Apr. 16, 2024 – Our lab received the CDMRP Reconstructive Transplant Research Program (RTRP) Idea Discovery Award. This will help us develop a novel therapeutic strategy for establishing the immune tolerance in vascularized composite allografts.
May 9, 2023 – Our lab received the Maryland Stem Cell Research Fund Launch Award . This will help us develop a novel therapeutic strategy for extending the preservation time of a donor organ in transplantation using extracellular vesicles.
Dec. 21, 2022 – THE FIRST paper is published! Click this Link!
Nov. 12, 2022 – Jeong lab & Jung lab have a joint Fall party!
Oct. 13, 2022 – Michaela Bhoorasingh, Jeongyun Kim, and Rodger Black join our lab as THE SECOND generation of PhD students!
Sep. 12, 2022 – Dr. Sohyeon Park joins our lab as THE SECOND postdoctoral researcher!
Aug 11, 2022 – Today is the last day for Peyton to work in our lab. Peyton did amazing jobs (under excellent guidance from Alli) over the last 10 weeks. We wish you all the best for your next journey!!!
Aug 4, 2022 – Our lab received the 2022 Cancer Invasion and Metastasis Pilot Grant from Sidney Kimmel Comprehensive Cancer Center. This will help us investigate the interplay between intercellular adhesion protein, E-cadherin, and metabolism in breast cancer models.
July 26, 2022 – Our lab received the Maximizing Investigators’ Research Award (MIRA) from NIGMS, NIH! This 5-year grant will help us investigate how cellular metabolism regulates the exosome biogenesis.
Jun. 8, 2022 – Peyton Panovich joins our lab as THE FIRST REU student during this Summer! She is a rising senior at University of Kansas with spectacular GPA and research experience! Welcome, Peyton!
Feb. 21, 2022 – Anna Cho joins our lab as THE FIRST visiting undergraduate researcher!
Feb. 1, 2022 – Lab renovation has finally started! We expect to have a fancy lab space at the end of Summer!
Oct. 13, 2021 – Alli Abolarin joins our lab as THE FIRST PhD graduate student!
Oct. 1, 2021 – Alex Correa joins our lab as THE FIRST undergraduate researcher!
July 1, 2021 – Our lab received THE FIRST foundation grant (the Leukemia Research Foundation)! [Link]
Jan. 17, 2021 – Claudia Wong joins our lab as THE FIRST research technician!
Jan. 1, 2021 – Dr. Geonhui Lee joins our lab as THE FIRST postdoctoral researcher!
Jan. 1, 2021 – Our lab is officially launched! At the same time, our lab received the NIH Pathway to Independence Award (R00) to jump up our start!
Members
We are actively hiring postdoctoral researchers with expertise in metabolism, molecular sensor, and EVs. Candidates should contact Dr. Jeong by e-mail with a CV, a 1-page summary of research experience and interests, and contact information of at least two references (if not, it would not be considered.)
Sangmoo Jeong (Principal Investigator)
Ph.D. Stanford Univ.
Cooking & Fund raising
Michaela Bhoorasingh (3rd-Yr Ph.D. Student)
B.S. Univ. of Toronto
EVs for in vivo gene therapy & EV biogenesis
Jeongyun Kim (3rd-Yr Ph.D. Student)
M.S. Carnegie Melon Univ.
Point-of-care biosensors for vascular and immune disorders
Rodger Black (3rd-Yr Ph.D. Student)
B.S. Kansas State Univ.
EVs for reducing graft damage & EV biogenesis
Yebin Im (2nd-Yr Ph.D. Student)
M.S. Seoul National Univ.
Single-cell meta-analysis of heart ischemic injury
Evan Vail (2nd-Yr Ph.D. Student)
B.S. UC Berkeley
EVs for reducing graft damage & Synthetic biology for cancer treatment
Kevin Chen (1st-Yr Ph.D. Student)
B.S. Univ. of Michigan
Single-cell meta-analysis of heart ischemic injury
Luis Flores (1st-Yr Ph.D. Student)
B.S. UT San Antonio
Biosensor for real-time assessment of donor organs
Mallikarjun Reddy (1st-Yr Ph.D. Student)
M.S. IIT
Metabolic intervention for cancer treatment
Alumni
Geonhui Lee (Postdoctoral researcher / 2021. Jan – 2024. Aug)
Alli Abolarin (Masters / 2021. Sep – 2024. Jun)
Sohyeon Park (Postdoctoral researcher / 2022. Jan – 2023. Jul)
Anna Cho (Visiting undergrad student from Handong Global University / 2022. Mar – 2022. Dec)
Claudia Wong (Research Technician / 2021. Jan – 2022. Dec)
Publications
2025
Park S, Jung S, Lee G, Lee E, Black R, Hong J, Jeong S. Self-Nourishing and Armored Probiotics via Egg-Inspired Encapsulation. Advanced Healthcare Materials Accepted [Link]
2024Hwang JS, Song HB, Lee G, Jeong S, Ma DJ. Extracellular Vesicles Derived from Adipose-Derived Mesenchymal Stem Cells Alleviate Apoptosis and Oxidative Stress of Retinal Pigment Epithelial Cells Through Activation of Nrf2 Signaling Pathway. Journal of Ocular Pharmacology and Therapeutics. 2024, 40:688-701. [Link]
Lee G, Wong C, Cho A, West JJ, Crawford AJ, Russo GC, Si, BR, Kim J, Hoffner L, Jang C, Jung M, Leone RD, Konstantopoulos K, Ewald AJ, Wirtz D, Jeong S. E-Cadherin Induces Serine Synthesis to Support Progression and Metastasis of Breast Cancer. Cancer Research 2024, 84(17):2820-2835. [Link]
Lee G, Han S-B, Kim S, Jeong S*, Kim D-H*. Stretching of porous poly (l-lactide-co-ε-caprolactone) membranes regulates the differentiation of mesenchymal stem cells. Frontiers in Cell and Developmental Biology 2024, 12:1303688. [Link]
2023Lee G, Ruan T, Wong C, Deh K, Abolarin A, Correa A, Keshari KR, Jeong S. Micro-Slab Coil Design for Hyperpolarized Metabolic Flux Analysis in Multiple Samples. Bioengineering 2023, 10(1), 14. [Link]
2022Tee SS, Kim N, Cullen Q, Eskandari R, Mamakhanyan A, Srouji RM, Chirayil R, Jeong S, Shakiba M, Kastenhuber E, Chen S, Sigel C, Lowe S, Jarnagin WR, Thompson CB, Schietinger A, and Keshari KR. Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging. Science Advances 2022, 8(14):eabm7985. [Link]
2021Jeong S, Savino AM, Chiray R, Barin E, Cheng Y, Park S-M, Schurer A, Mullarky E, Cantley LC, Kharas MG, Keshari KR. High fructose drives the serine synthesis pathway in acute myeloid leukemic cells. Cell Metabolism 2021, 33(1):145-159.E6. [Link]
2020Lees H, Millan M, Ahamed F, Eskandari R, Granlund KL, Jeong S, Keshari KR. Multi‐sample measurement of hyperpolarized pyruvate‐to‐lactate flux in melanoma cells. NMR in Biomedicine 2020, 34(3):e4447. [Link]
2019Dong Y, Eskandari R, Ray C, Granlund KL, Santos-Cunha LD, Miloushev VZ, Tee SS, Jeong S, Aras O, Chen YB, Cheng EH, Hsieh JJ, Keshari KR. Hyperpolarized MRI Visualizes Warburg Effects and Predicts Treatment Response to mTOR Inhibitors in Patient-Derived ccRCC Xenograft Models. Cancer Research 2019, 79(1):242-250. [Link]
2018Tee SS, Suster I, Truong S, Jeong S, Eskandari R, DiGialleonardo V, Alvarez JA, Aldeborgh HN, Keshari KR. Targeted AKT Inhibition in Prostate Cancer Cells and Spheroids Reduces Aerobic Glycolysis and Generation of Hyperpolarized [1-13C] Lactate. Molecular Cancer Research 2018, 16(3):453-460. [Link]
2017Park J, Lin HY, Assaker JP, Jeong S, Huang CH, Kurdi T, Lee K, Fraser K, Min C, Eskandari S, Routray S, Tannous B, Abdi R, Riella L, Chandraker A, Castro CM, Weissleder R, Lee H, Azzi JR. Integrated Kidney Exosome Analysis for the Detection of Kidney Transplant Rejection. ACS Nano 2017, 11(11):11041-11046. [Link]
Jeong S, Eskandari R, Park SM, Alvarez J, Tee SS, Weissleder R, Kharas MG, Lee H, Keshari KR. Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer. Science Advances 2017, 3(6):e1700341. [Link]
2016Tee SS, DiGialleonardo V, Eskandari R, Jeong S, Granlund KL, Miloushev V, Poot AJ, Truong S, Alvarez JA, Aldeborgh HN, Keshari KR. Sampling Hyperpolarized Molecules Utilizing a 1 Tesla Permanent Magnetic Field. Scientific Reports 2016, 6:32846. [Link]
Song J, Leon Swisher C, Im H, Jeong S, Pathania D, Iwamoto Y, Pivovarov M, Weissleder R, Lee H. Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography. Scientific Reports 2016, 6:24681. [Link]
Jeong S, Park J, Pathania D, Castro CM, Weissleder R, Lee H. Integrated Magneto-Electrochemical Sensor for Exosome Analysis. ACS Nano 2016, 10(2):1802-1809. [Link]
Contact us
The Jeong Lab
Croft Hall, Rm 1103400 N Charles Street
Baltimore, MD 21218
Tel: 410-516-0633
Email: [email protected]