Course Description

The field of computational neuroscience explores the neural code that allows the brain to solve various problems such as information representation, learning, and decision-making. This year, the course will survey current literature in auditory systems neuroscience, including topics of sensory processing, perception, attention and learning as pertaining to speech and sound processing and language representation. This course has a seminar format. Students are expected to review and critique papers, give presentations and participate in discussions.

Schedule of Discussions

Week Topic Team Reading
Jan 27 Introduction - Physics of sound - Ear/Auditory nerve
Feb 3 Cochlear nucleus Kailash / Michael ・ Young, ED, Spirou, GA, Rice, JJ, and HF Voigt (1992) "Neural organization and responses to complex stimuli in the dorsal cochlear nucleus," Phil. Trans. R. Soc. Lond. B, 336, 407-413.
・ Yu JJ and ED Young (2000) “Linear and nonlinear pathways of spectral information transmission in the cochlear nucleus,” Proc Natl Acad Sci, 97, 11780-11786.
Feb 10 Brainstem and midbrain Corey / Ming ・ Joris P. and TCT Yin (2007) “A matter of time: internal delays in binaural processing,” Trends Neurosci, 30, 70-78.
・ Harper NS and D McAlpine (2004) “Optimal neural population coding of an auditory spatial cue,” Nature, 430, 682-686.
Feb 17 Auditory Cortex Charley / Sivaram ・ Nelken I (2004) "Processing of complex stimuli and natural scenes in the auditory cortex." Curr Opin Neurobiol, 14, 474-80.
・ Fritz J, S Shamma, M Elhilali, and D Klein (2003) "Rapid task-related plasticity of spectrotemporal receptive fields in primary auditory cortex. " Nat Neurosci, 6, 1216-23.
Feb 24 Receptive fields in the auditory system Michael / Sivaram ・ Klein et al. (2000) "Robust spectro-temporal reverse correlation or the auditory system: optimizing stimulus design", J. Comp. Neuroscience, vol 9, pp. 85--111
・ Elhilali et al. (2007) "Auditory Cortical Receptive Fields: Stable Entities with Plastic Abilities". J. Neuroscience, (27)39, pp.10372--10382
Mar 3 Receptive fields in the auditory system Ben / Ming ・ Bitterman et al. (2008) "Ultra-fine frequency tuning revealed in single neurons of human auditory cortex", Nature, 10; 451(7175):197--201
・ Sahani M, Linden JF(2003) "How linear are auditory cortical responses?" chapter in "Advances in neural information processing systems", 15th ed. Cambridge: MIT, pp. 125-132
Mar 10 Computational models of auditory processing Charley / Corey / Samuel ・ Dau T, Kollmeier B, Kohlrauch A (1997) "Modeling auditory processing of amplitude modulation. I. Detection and masking with narrow-band carriers," J. Acoust. Soc. Am., 102:2892-2905.
・ Chi T. , Ru P, Shamma SA (2005) "Multiresolution spectrotemporal analysis of complex sounds," J. Acoust. Soc. Am., 118:887-906.
Mar 17 SPRING BREAK
Mar 31 Auditory scene analysis Ming / Sivaram ・ Carlyon RP (2004). "How the brain separates sounds," Trends Cogn Sci, 8, 465-71
・ Grossberg, S, KK Govindarajan, LL Wyse, and MA Cohen (2004). "ARTSTREAM: A neural network model of auditory scene analysis and source segregation," Neural Networks, 17, 511-536
Apr 7 Auditory scene analysis (2) Ben / Kailash / Samuel ・ Micheyl C, Tian B, Carlyon RP, and Rauschecker JP (2005) “Perceptual organization of tone sequences in the auditory cortex of awake macaques”, Neuron, 48, 139?148.
・ Elhilali M, Ma L, Micheyl C, Oxenham AJ, and Shamma SA (2009) “Temporal Coherence in the Perceptual Organization and Cortical Representation of Auditory Scenes” Neuron, 61(2), 317-329.
Apr 14 Pitch and timbre Kailash / Patrick ・ Hartmann, WM. (1996) "Pitch, periodicity, and auditory organization." J. Acoust. Soc. Am. 100 (6), 3491-3501
・ Andrew J. Oxenham, Joshua G. W. Bernstein, and Hector Penagos (2004) "Correct tonotopic representation is necessary for complex pitch perception", PNAS 101, 1421-1425.
・ Shihab A. Shamma "Topographic organization is essential for pitch perception" (2004) PNAS 101, 1114-1115.
Apr 21 Speech perception Charley / Corey ・ Formisano, E, De Martino, F, Bonte, M, Goebel, R, ""Who" Is Saying "What"? Brain-Based Decoding of Human Voice and Speech," Science, 2008 vol. 322 (5903) pp. 970-973
・ Mesgarani, N, David, S, Fritz, J, Shamma, S, "Phoneme representation and classification in primary auditory cortex," The Journal of the Acoustical Society of America 123, 899 (2008)
Apr 23 Computational models of auditory processing (2) Ben / Michael / Patrick ・ Nelson, P. C. and Carney, L. H. (2004) "A phenomenological model of peripheral and central neural responses to amplitude-modulated tones," J. Acoust. Soc. Am., 116, pp. 2173--2186.
・ Bruce, I. et al. (2003) "An auditory-periphery model of the effects of acoustic trauma on auditory nerve responses," J. Acoust. Soc. Am. 113, pp. 369--388.
Apr 28 Speech perception (2) Patrick / Samuel ・ Moore, B.C.J. (2008), "Basic auditory processes involved in the analysis of speech sounds," Philosophical Transactions of the Royal Society B 363, pp. 947- 963.
・ Lorenzi, C., Gilbert G, Carn, H, and Moore B.C.J. (2006), "Speech perception problems of the hearing impaired reflect inability to use temporal fine structure", Proceedings of the National Academy of Sciences, 103(49), pp. 18866-18869.
Term paper:
- Progress report due Tuesday, March 24, 2009.
- Final paper due Thursday May 14, 2009.