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Joel Bader will deliver a lecture as part of the Don P. Giddens Inaugural Professorial Lecture Series. Bader is a professor in the Department of Biomedical Engineering.
Stopping Cancer Metastasis
Cancer’s lethality comes not from the growth of the original tumor, but from the spread of the disease to distant sites in the body. Professor Bader will describe ongoing work to dissect the gene and protein networks driving cancer metastasis, suggesting targets for therapeutic intervention.
Noah Cowan will deliver a lecture as part of the Don P. Giddens Inaugural Professorial Lecture Series. Cowan is a professor in the Department of Mechanical Engineering.
Neuroscience in The Matrix
Understanding how the nervous system encodes and processes sensory information, transforms it into meaningful intermediate representations in the brain, and computes motor output involves decoding a complex closed-loop control system. Professor Cowan will present research devoted to developing and applying ideas in engineering to decode closed-loop neuromechanical control in animals, including humans.
More than 100 high school students will put their skills to the test as they square off in a competition to build the strongest bridge out of a brittle substance: dry spaghetti.
The Spaghetti Bridge Competition is the culmination of the four-week Engineering Innovation program that attracts students from 18 states and 11 countries to Johns Hopkins.
Rachel Karchin will deliver a lecture titled “Computational modeling of cancer precursor lesion evolution” as part of the Don P. Giddens Inaugural Professorial Lecture Series. Karchin is a professor in the Department of Biomedical Engineering.
Genome sequencing studies of tumor samples from large patient cohorts have provided convincing support for the somatic mutation theory of cancer, which posits that neoplasms result from mutational activation of oncogenes and mutational inactivation of tumor suppressor genes. Tumor cells originating from the same ancestral lineage form clonal populations, and the size and time-ordering of the clones can be modeled by hierarchical tree structures. In this lecture, Professor Karchin will discuss her research group’s reconstructions of precursor lesion evolution in high grade serous ovarian cancer and pancreatic adenocarcinoma.
Thao (Vicky) Nguyen will deliver a lecture titled “Biomechanics of the optic nerve head in glaucoma” as part of the Don P. Giddens Inaugural Professorial Lecture Series. Nguyen is a professor in the Department of Mechanical Engineering and the Marlin U. Zimmerman, Jr. Faculty Scholar.
Glaucoma is a neurodegenerative disease characterized by damage to the optic nerve axons and remodeling of the connective tissues in the optic nerve head. High pressure in the the eye is a major risk factor for the disease, and lowering this pressure is currently the only effective way to slow the disease’s progression. Nguyen seeks to understand the fundamental biomechanical mechanisms through which changes in the intraocular pressure alter the physiological function of cells and remodel the collagen structures of the optic nerve head. In this presentation, she will describe ongoing work to measure the deformation response of the cellular and connective tissue structures of the optic nerve head to pressure, characterize alterations with age and glaucoma, model the effects of structural variations on the deformation and stress response, and investigate the mechanisms through which stress can direct connective tissue growth and remodeling.