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Apr
18
Thu
Inaugural Professorial Lecture: Rachel Karchin
Apr 18 @ 4:00 pm – 5:00 pm
Inaugural Professorial Lecture: Rachel Karchin @ Mason Hall Auditorium

Rachel Karchin will deliver a lecture titled “Computational modeling of cancer precursor lesion evolution” as part of the Don P. Giddens Inaugural Professorial Lecture Series. Karchin is a professor in the Department of Biomedical Engineering.

Genome sequencing studies of tumor samples from large patient cohorts have provided convincing support for the somatic mutation theory of cancer, which posits that neoplasms result from mutational activation of oncogenes and mutational inactivation of tumor suppressor genes. Tumor cells originating from the same ancestral lineage form clonal populations, and the size and time-ordering of the clones can be modeled by hierarchical tree structures. In this lecture, Professor Karchin will discuss her research group’s reconstructions of precursor lesion evolution in high grade serous ovarian cancer and pancreatic adenocarcinoma.


The Don P. Giddens Inaugural Professorial Lecture Series began in 1993 as a way to honor newly promoted full professors. Professor Giddens, originator of the series, served as the fifth dean of Engineering at Johns Hopkins.

Sep
25
Wed
Inaugural Professorial Lecture: Thao (Vicky) Nguyen
Sep 25 @ 4:30 pm – 6:30 pm
Inaugural Professorial Lecture: Thao (Vicky) Nguyen @ Mason Hall Auditorium

Thao (Vicky) Nguyen will deliver a lecture titled “Biomechanics of the optic nerve head in glaucoma” as part of the Don P. Giddens Inaugural Professorial Lecture Series. Nguyen is a professor in the Department of Mechanical Engineering and the Marlin U. Zimmerman, Jr. Faculty Scholar.

Glaucoma is a neurodegenerative disease characterized by damage to the optic nerve axons and remodeling of the connective tissues in the optic nerve head. High pressure in the the eye is a major risk factor for the disease, and lowering this pressure is currently the only effective way to slow the disease’s progression. Nguyen seeks to understand the fundamental biomechanical mechanisms through which changes in the intraocular pressure alter the physiological function of cells and remodel the collagen structures of the optic nerve head. In this presentation, she will describe ongoing work to measure the deformation response of the cellular and connective tissue structures of the optic nerve head to pressure, characterize alterations with age and glaucoma, model the effects of structural variations on the deformation and stress response, and investigate the mechanisms through which stress can direct connective tissue growth and remodeling.


The Don P. Giddens Inaugural Professorial Lecture Series began in 1993 as a way to honor newly promoted full professors. Professor Giddens, originator of the series, served as the fifth dean of Engineering at Johns Hopkins.

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