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Rachel Karchin will deliver a lecture titled “Computational modeling of cancer precursor lesion evolution” as part of the Don P. Giddens Inaugural Professorial Lecture Series. Karchin is a professor in the Department of Biomedical Engineering.
Genome sequencing studies of tumor samples from large patient cohorts have provided convincing support for the somatic mutation theory of cancer, which posits that neoplasms result from mutational activation of oncogenes and mutational inactivation of tumor suppressor genes. Tumor cells originating from the same ancestral lineage form clonal populations, and the size and time-ordering of the clones can be modeled by hierarchical tree structures. In this lecture, Professor Karchin will discuss her research group’s reconstructions of precursor lesion evolution in high grade serous ovarian cancer and pancreatic adenocarcinoma.
The Don P. Giddens Inaugural Professorial Lecture Series began in 1993 as a way to honor newly promoted full professors. Professor Giddens, originator of the series, served as the fifth dean of Engineering at Johns Hopkins.