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The Institute for NanoBioTechnology Seminar Series will present Vipul Periwal from the National Institutes of Health and his discussion on “Quantitatively predicting the effects of therapeutic intervention in human disease.”
Periwal is a senior investigator at the National Institutes of Health in the Intramural Research Program. His focus is on computational medicine and biological modeling with a goal to use biological modeling to predict systemic responses to perturbations. His current research includes data-driven large-scale biological modeling of disease, model of reactive oxygen species in mitochondria, and adipocyte development and insulin resistance.
Light refreshments will be provided.
Sharon Gerecht will deliver a lecture as part of the Don P. Giddens Inaugural Lecture Series. Gerecht is a professor in the Department of Chemical and Biomolecular Engineering and the Kent Gordon Croft Investment Management Faculty Scholar. She is also director of the Institute for NanoBioTechnology. Below are the title and abstract for her presentation.
The development and growth of blood vessels take place in an intricate milieu. This unique microenvironment is situated throughout the body in diverse types of both healthy and diseased tissues, yet it seems to involve similar cellular mechanisms. Two parameters of this microenvironment seem critical for blood vessel growth and stabilization: (i) the extracellular matrix (ECM), which provides critical support for the vascular cells, and (ii) low oxygen concentrations (hypoxia), which is a critical factor promoting vascularization during embryonic development and tumor growth. In this talk, Gerecht will present her team’s recent efforts to understand how these physicochemical cues and downstream signaling events impact blood vascular fate and assembly, from progenitors and pluripotent stem cells.
The Don P. Giddens Inaugural Professorial Lecture Series began in 1993 as a way to honor newly promoted full professors. Professor Giddens, originator of the series, served as the fifth dean of Engineering at Johns Hopkins.