Lymph nodes mediate the co-mingling of cells of the adaptive system to coordinate adaptive immune response. Drug delivery principles and technologies our group has developed to leverage the potential of lymph nodes as immunotherapeutic drug targets to augment anti-cancer therapeutic effects will be described
Continuous oozing is the number one bleeding problem in the surgical operating rooms, occurring in more than 50% of all surgeries, across different specialties all over the world. SURGICEL® Powder Absorbable Hemostat, a Class III medical device, was developed to control broad continuous oozing efficiently and effectively in open or minimal invasive surgeries when ligation or other methods of bleeding control are not possible. This presentation will walk you through how team brought a medical device to market, including identification of unmet needs, concept generations, new product development, commercialization, and teamwork.
Dr. Allen Y. Wang is currently a Global Technical Lead in New Product Development at Ethicon Biosurgery, a medical device subsidiary of Johnson & Johnson. In 2008, after obtaining his PhD from Johns Hopkins University, Allen joined Johnson & Johnson Wound Management R&D and quickly set the standard of excellence, holding over 70 patents and 45 patent applications worldwide and several peer‐reviewed publications, and developing several new surgical products to help more patients. His most recent Class III medical device invention, SURGICEL Powder Absorbable Hemostat, has served numerous patients in more than 45 countries since its launch in late 2017 and led to Allen and his team being awarded the 2020 Johnson Medal (a.k.a. Johnson & Johnson Nobel Prize) and several prestigious international awards such as the Gold Medical Design Excellence Award (MDEA) in the Drug‐Delivery Devices and Combination Products and the R&D 100 Award. Currently, he continues to work with J&J divisions globally to expand the Biosurgery product portfolio and generate novel surgical products for their future pipeline to address unmet surgical needs to enhance the health of people all over the world.
Hosted by Mingwei Chen
Abstract: Electrolytes are critical enabling components for Li-ion batteries to safely operate within a wide temperature range, under extreme fast charging, and under intense abuse conditions without sacrificing energy density and cycle life. Current electrolytes cannot satisfy these requirements. We developed advanced all-fluorinated electrolytes, water-in-sale (WIS) electrolytes and solid-state electrolytes aiming to simultaneously enhance cell energy density and safety. Guided by the electrolyte design principle for high-capacity electrodes with large volume changes, we developed serval organic liquid electrolytes suitable for micro-sized Si and Li metal anodes and NMC cathodes. We also reduced the salt concentration of water-in-salt electrolytes from 21 m to 4.5m and extended the electrochemical stability window from 3.0V of WIS to 3.4V. These improved electrolytes enable LiMn2O4/Li4Ti5O12 pouch cells with an areal capacity of 2.5 mAh/cm2 and a P/N capacity ratio of 1.14 to achieve a long cycle life of 500. For solid state electrolyte Li metal batteries, we suppressed the Li dendrite growth and reduced the interface resistance by constructing a lithionphobic-lithiophoilic interlayer between solid electrolyte and Li metal anodes. The critical role of solid electrolyte interphase in accommodating electrode volume changes was also investigated.
Bio: Dr. Wang is a Robert Franklin and Frances Riggs Wright distinguished chair professor at the University of Maryland College Park. He is a co-founder and UMD Director of The UMD-ARL Center for Research in Extreme Battery, and associate editor of ACS Applied Energy Materials. His current research focuses on Li-ion battery electrolytes and developed a water-in-salt electrolyte and a transition metal free LiBr-LiCl-Graphite cathode for Li-ion batteries. He has published more than 300 papers and has been tanked as a Highly Cited Researcher by Clarivate. He is the recipient of University of Maryland’s 2016 and 2021 Invention of the Year Award. His battery technologies have been licensed by the Aqualith Advanced Materials. He also received award of ECS Battery Division Research Award in 2021.