Faculty

Margarita Herrera-Alonso

Assistant Research Scientist

Research Interests

Kinetic control of polymer-based solution assemblies, Polymer design and synthesis, Architecturally complex polymer amphiphiles, Molecular brushes, Nanoparticle surface chemistry, Drug delivery carriers, Biomimetics

Education
  • Ph.D. 2004, Univ of Massachusetts Amherst*
Experience
  • 2010 - Present:  Assistant Professor, Materials Science and Engineering, WSE Materials Science and Engineering
  • 2009 - 2010:  Lecturer, Chemical Engineering, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
  • 2008 - 2010:  Postdoctoral Fellow, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
  • 2004 - 2007:  Postdoctoral Fellow, Princeton University, Princeton, NJ
  • 1999 - 2004:  Research Assistant, University of Massachusetts, Amherst, MA
Research Areas
  • Architecturally complex polymer amphiphiles
  • Biomimetics
  • Drug delivery carriers
  • Kinetic control of polymer-based solution assemblies
  • Molecular brushes
  • Nanoparticle surface chemistry
  • Polymer design and synthesis
Awards
  • 2012:  NSF CAREER Faculty Young Investigator Award
  • 2008:  CONACYT (Consejo Nacional de Ciencia y Tecnologia) Postdoctoral Scholarship
  • 1999:  Solutia Fellowship
  • 1999:  Fulbright/Garcia-Robles Scholarship
  • 1997:  CONACYT (Consejo Nacional de Ciencia y Tecnologia) Graduate Scholarship
Journal Articles
  • Palacios-Hernandez T, Luo H, Garcia EA, Pacheco LA, Herrera-Alonso M (2018).  Nanoparticles from Amphiphilic Heterografted Macromolecular Brushes with Short Backbones.  Macromolecules.  51(8).
  • Szymusiak M, Kalkowski J, Luo H, Donovan AJ, Zhang P, Liu C, Shang W, Irving T, Herrera-Alonso M, Liu Y (2017).  Core-Shell Structure and Aggregation Number of Micelles Composed of Amphiphilic Block Copolymers and Amphiphilic Heterografted Polymer Brushes Determined by Small-Angle X-ray Scattering.  ACS Macro Letters.  6(9).
  • Luo H, Szymusiak M, Garcia EA, Lock LL, Cui H, Liu Y, Herrera-Alonso M (2017).  Solute-Triggered Morphological Transitions of an Amphiphilic Heterografted Brush Copolymer as a Single-Molecule Drug Carrier.  Macromolecules.  50(5).
  • Culver HR, Steichen SD, Herrera-Alonso M, Peppas NA (2016).  Versatile Route to Colloidal Stability and Surface Functionalization of Hydrophobic Nanomaterials.  Langmuir.  32(22).
  • Luo H, Raciti D, Wang C, Herrera-Alonso M (2016).  Macromolecular Brushes as Stabilizers of Hydrophobic Solute Nanoparticles.  Molecular Pharmaceutics.  13(6).
  • Culver HR, Steichen SD, Herrera-Alonso M, Peppas NA (2016).  Versatile Route to Colloidal Stability and Surface Functionalization of Hydrophobic Nanomaterials.  Langmuir.  32(22).  5629-5636.
  • Luo H, Raciti D, Wang C, Herrera-Alonso M (2016).  Macromolecular Brushes as Stabilizers of Hydrophobic Solute Nanoparticles.  Molecular Pharmaceutics.  13(6).  1855-1865.
  • Aguilar-Castillo BA, Santos JL, Luo H, Aguirre-Chagala YE, Palacios-Hernández T, Herrera-Alonso M (2015).  Nanoparticle stability in biologically relevant media: influence of polymer architecture.  Soft Matter.  11(37).
  • Aguilar-Castillo BA, Santos JL, Luo H, Aguirre-Chagala YE, Palacios-Hernandez T, Herrera-Alonso M (2015).  Nanoparticle stability in biologically relevant media: influence of polymer architecture.  Soft Matter.  11(37).  7296-7307.
  • Aguirre-Chagala YE, Santos JL, Huang Y, Herrera-Alonso M (2014).  Phenylboronic acid-installed polycarbonates for the pH-dependent release of diol-containing molecules.  ACS Macro Letters.  3(12).
  • Santos JL, Li Y, Culver HR, Yu MS, Herrera-Alonso M (2014).  Conducting polymer nanoparticles decorated with collagen mimetic peptides for collagen targeting.  Chemical Communications.  50(95).
  • Aguirre-Chagala YE, Santos JL, Aguilar-Castillo BA, Herrera-Alonso M (2014).  Synthesis of copolymers from phenylboronic acid-installed cyclic carbonates.  ACS Macro Letters.  3(4).
  • Luo H, Santos JL, Herrera-Alonso M (2014).  Toroidal structures from brush amphiphiles.  Chemical Communications.  50(5).
  • Santos JL, Herrera-Alonso M (2014).  Kinetically arrested assemblies of architecturally distinct block copolymers.  Macromolecules.  47(1).
  • Aguirre-Chagala YE, Santos JL, Aguilar-Castillo BA, Herrera-Alonso M (2014).  Synthesis of Copolymers from Phenylboronic Acid-Installed Cyclic Carbonates.  Acs Macro Letters.  3(4).  353-358.
  • Santos JL, Herrera-Alonso M (2014).  Kinetically Arrested Assemblies of Architecturally Distinct Block Copolymers.  Macromolecules.  47(1).  137-145.
  • Santos JL, Li Y, Culver HR, Yu M, Herrera-Alonso M (2014).  Conducting polymer nanoparticles decorated with collagen mimetic peptides for collagen targeting.  Chemical Communications.  50(95).  15045-15048.
  • Herrera-Alonso M, Aguirre-Chagala YE, Santos JL, Huang Y (2014).  Phenylboronic acid-installed polycarbonates for the pH-dependent release of diol-containing molecules.  ACS Macro Letters.  3(12).  1249-1253.
  • Luo H, Santos JL, Herrera-Alonso M (2014).  Toroidal structures from brush amphiphiles.  Chemical Communications.  50(5).  536-538.
  • Aguirre-Chagala YE, Santos JL, Herrera-Nájera R, Herrera-Alonso M (2013).  Organocatalytic copolymerization of a cyclic carbonate bearing protected 2,2-bis(hydroxymethyl) groups and d, l -lactide. Effect of hydrophobic block chemistry on nanoparticle properties.  Macromolecules.  46(15).
  • Herrera-Alonso M, Santos JL (2013).  "Patchy" nanoparticles via kinetically arrested co-assembly of block copolymers.  Abstracts of Papers of the American Chemical Society.  245.
  • Elised Aguirre-Chagala Y, Santos JL, Herrera-Najera R, Herrera-Alonso M (2013).  Organocatalytic Copolymerization of a Cyclic Carbonate Bearing Protected 2,2-bis(hydroxymethyl) Groups and D,L-lactide. Effect of Hydrophobic Block Chemistry on Nanoparticle Properties.  Macromolecules.  46(15).  5871-5881.
  • D'Addio SM, Saad W, Ansell SM, Squiers JJ, Adamson DH, Herrera-Alonso M, Wohl AR, Hoye TR, MacOsko CW, Mayer LD, Vauthier C, Prud'homme RK (2012).  Effects of block copolymer properties on nanocarrier protection from in vivo clearance.  Journal of Controlled Release.  162(1).
  • D’Addio SM, Saad W, Ansell SM, Squiers JJ, Adamson DH, Herrera-Alonso M, Wohl AR, Hoye TR, Macosko CW, Mayer LD, Vauthier C, Prud’homme RK (2012).  Effects of block copolymer properties on nanocarrier protection from in vivo clearance.  Journal of Controlled Release.  162(1).  208-217.
  • Martínez-Estrada A, Chávez-Castellanos AE, Herrera-Alonso M, Herrera-Nájera R (2010).  Comparative study of the effect of sulfur on the morphology and rheological properties of SB- and SBS-modified asphalt.  Journal of Applied Polymer Science.  115(6).
  • Martinez-Estrada A, Enrique Chavez-Castellanos A, Herrera-Alonso M, Herrera-Najera R (2010).  Comparative Study of the Effect of Sulfur on the Morphology and Rheological Properties of SB- and SBS-Modified Asphalt.  Journal of Applied Polymer Science.  115(6).  3409-3422.
  • Ramanathan T, Abdala AA, Stankovich S, Dikin DA, Herrera-Alonso M, Piner RD, Adamson DH, Schniepp HC, Chen X, Ruoff RS, Nguyen ST, Aksay IA, Prud'Homme RK, Brinson LC (2008).  Functionalized graphene sheets for polymer nanocomposites.  Nature Nanotechnology.  3(6).
  • Ramanathan T, Abdala AA, Stankovich S, Dikin DA, Herrera-Alonso M, Piner RD, Adamson DH, Schniepp HC, Chen X, Ruoff RS, Nguyen ST, Aksay IA, Prud’homme RK, Brinson LC (2008).  Functionalized graphene sheets for polymer nanocomposites.  Nature Nanotechnology.  3(6).  327-331.
  • Herrera-Alonso M, Abdala AA, McAllister MJ, Aksay IA, Prud'homme RK (2007).  Intercalation and stitching of graphite oxide with diaminoalkanes.  Langmuir.  23(21).
  • McAllister MJ, Li JL, Adamson DH, Schniepp HC, Abdala AA, Liu J, Herrera-Alonso M, Milius DL, Car R, Prud'homme RK, Aksay IA (2007).  Single sheet functionalized graphene by oxidation and thermal expansion of graphite.  Chemistry of Materials.  19(18).
  • McAllister MJ, Li J, Adamson DH, Schniepp HC, Abdala AA, Liu J, Herrera-Alonso M, Milius DL, Car R, Prud’homme RK, Aksay IA (2007).  Single sheet functionalized graphene by oxidation and thermal expansion of graphite.  Chemistry of Materials.  19(18).  4396-4404.
  • Herrera-Alonso M, Abdala AA, McAllister MJ, Aksay IA, Prud’homme RK (2007).  Intercalation and stitching of graphite oxide with diaminoalkanes.  Langmuir.  23(21).  10644-10649.
  • Jia X, Herrera-Alonso M, McCarthy TJ (2006).  Nylon surface modification. Part 1. Targeting the amide groups for selective introduction of reactive functionalities.  Polymer.  47(14).
  • Herrera-Alonso M, McCarthy TJ, Jia X (2006).  Nylon surface modification: 2. Nylon-supported composite films.  Langmuir.  22(4).
  • Jia X, Herrera-Alonso M, McCarthy TJ (2006).  Nylon surface modification. Part 1. Targeting the amide groups for selective introduction of reactive functionalities.  Polymer.  47(14).  4916-4924.
  • Herrera-Alonso M, McCarthy TJ, Jia XQ (2006).  Nylon surface modification: 2. Nylon-supported composite films.  Langmuir.  22(4).  1646-1651.
  • Schniepp HC, Li JL, McAllister MJ, Sai H, Herrera-Alonso M, Adamson DH, Prud’homme RK, Car R, Saville DA, Aksay IA (2006).  Functionalized single graphene sheets derived from splitting graphite oxide.  Journal of Physical Chemistry B.  110(17).  8535-8539.
  • Herrera-Alonso M, Prud’homme RK (2006).  POLY 684-Poly(ethylene glycol)-b-polycaprolactone nanoparticles and their use as drug delivery vehicles.  Abstracts of Papers of the American Chemical Society.  232.
  • Guo X, Herrera-Alonso M, Tinsley J, Prud'homme RK (2005).  How poly(1-olefin-co-maleic anhydride amide) improves flow of cold crude oils.  ACS National Meeting Book of Abstracts.  230.
  • Guo X, Herrera-Alonso M, Tinsley J, Prud'homme RK (2005).  How poly(1-olefin-co-maleic anhydride amide) improves flow of cold crude oils.  American Chemical Society, Division of Petroleum Chemistry, Preprints.  50(3).
  • Guo XH, Herrera-Alonso M, Tinsley L, Prud’homme RK (2005).  How poly(1-olefin-co-maleic anhydride amide) improves flow of cold crude oils.  Abstracts of Papers of the American Chemical Society.  230.  U2316-U2317.
  • Herrera-Alonso M, McCarthy TJ (2004).  Chemical surface modification of poly(p-xylylene) thin films.  Langmuir.  20(21).
  • Herrera-Alonso M, McCarthy TJ (2004).  Chemical surface modification of poly(p-xylylene) thin films.  Langmuir.  20(21).  9184-9189.
  • Herrera-Alonso M, McCarthy TJ (2002).  Surface modification of poly(p-xylylene) films.  American Chemical Society, Polymer Preprints, Division of Polymer Chemistry.  43(2).
Conference Proceedings
  • Herrera-Alonso M, Prud’homme RK (2006).  Poly(ethylene glycol)-b-polycaprolactone nanoparticles and their use as drug delivery vehicles.  Abstracts of Papers of the American Chemical Society.  232.  9-9.
  • Jia XQ, Herrera-Alonso M, McCarthy TJ (2005).  Nylon surface modification: Targeting the amide groups for selective introduction of reactive functionalities.  Abstracts of Papers of the American Chemical Society.  229.  U739-U739.
  • Herrera-Alonso M, McCarthy TJ (2004).  Chemical reduction of nylons: Synthesis of polyalkyleneimines with controlled charge density.  Abstracts of Papers of the American Chemical Society.  227.  U374-U374.
  • Herrera-Alonso M, Garcia-Leiner M, McCarthy TJ, Lesser AJ (2004).  Semicrystalline polymer nanocomposites using chemically designed compatibilizers and supercritical CO2-assisted polymer processing.  Abstracts of Papers of the American Chemical Society.  228.  U506-U506.
  • Herrera-Alonso M, McCarthy TJ (2003).  Adsorption of polyelectrolytes to surface-modified nylon films.  Abstracts of Papers of the American Chemical Society.  226.  U380-U380.
  • Herrera-Alonso M, McCarthy TJ (2002).  Surface modification of poly(p-xylylene) films.  Abstracts of Papers of the American Chemical Society.  224.  U479-U479.
Patents
  • Aksay IA, Herrera-Alonso M, Prud'homme RK  "Separation medium containing thermally exfoliated graphite oxide", 2012.
  • Aksay IA, Herrera-Alonso M, McAllister MJ, Prud'homme RK  "Bridged graphite oxide material for e.g. polymer composite material in article or selective adsorption medium in adsorption device, comprises graphite oxide sheets bridged to other graphite oxide sheet(s) by diamine bridging group(s)", 2010.
  • Fu L, Garcia-Leiner MA, Herrera-Alonso M, Mehlmann F, Prud'homme RK  "Use of cyclodextrins in controlled architecture polymer synthesis", 2008.
  • "Molecular and process parameters of solution based polymer self-assemblies".  February 20, 2018
  • "Solution assemblies of amphiphilic macromolecular brushes".  February 13, 2018
  • "Molecular and process parameters of solution based polymer self-assemblies".  January 29, 2018
  • "Solution assemblies of amphiphilic macromolecular brushes".  November 30, 2017
  • "Molecular and process parameters of solution based polymer self-assemblies".  September 1, 2017
  • "Functional polycarbonates as environmentally responsive materials", 53rd ACS National Meeting, Division of Polymer Chemistry: Carl S. Marvel creative polymer chemistry.  April 3, 2017
  • "Functional polycarbonates as environmentally responsive materials", 2016 Japan-USA seminar on polymer synthesis.  Hokkaido Japan.  June 28, 2016
  • "Functional polycarbonates as environmentally responsive materials".  Columbus, Ohio.  April 19, 2016
  • "Oxidative responsiveness of arylboronic acid-installed polycarbonate nanoparticles", 251st ACS National Meeting.  San Diego CA.  March 13, 2016
  • "Solute-induced morphological transitions of molecular brush amphiphiles", 251st ACS National Meeting and Exposition,.  San Diego, CA.  March 13, 2016
  • "Unimolecular-molecular brush nanoparticles as solute stabilizers", 251st ACS National Meeting.  San Diego, CA.  March 13, 2016
  • "Molecular and process determinants of solution based polymer self-assemblies".  Storrs, CT.  November 6, 2015
  • "Molecular brush amphiphiles", 250th ACS National Meeting.  Boston, MA.  August 19, 2015
  • "Molecular and process determinants of solution assemblies".  May 13, 2015
  • "Kinetic effects in solution assemblies for drug delivery applications".  January 23, 2015
  • "Molecular and process determinants of solution assemblies".  December 2, 2014
  • "Functional polycarbonates as environmentally responsive materials".  November 21, 2014
  • "Functional polycarbonates as environmentally responsive materials".  October 9, 2014
  • International Symposium on Polymer Chemistry 2014.  Shanghai, China.  June 4, 2014
  • "Polycarbonates with pendant boronic acids: nanoparticles for controlled drug release", 247th ACS National Meeting and Exposition, Division of Polymer Chemistry.  Dallax, TX.  March 18, 2014
  • "Targeting kinetically arrested states of polymer assembly for the formation of drug carriers", PMSE Young Investigator (biannual session), ACS Spring 2014 National Meeting.  Dallas, TX.  March 16, 2014
  • "Solvophobically-driven self-assembly: kinetics and structures from novel amphiphiles".  April 23, 2012
  • "Solvophobically-driven self-assembly: kinetics and structures from novel amphiphiles".  March 7, 2012
  • "Block copolymer nanoparticles by flash nanoprecipitation: prodrug strategies".  April 7, 2010
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