{"id":4988,"date":"2017-01-10T10:43:22","date_gmt":"2017-01-10T15:43:22","guid":{"rendered":"https:\/\/engineering.jhu.edu\/magazine-archive\/?p=4988"},"modified":"2017-01-11T09:43:23","modified_gmt":"2017-01-11T14:43:23","slug":"catching-alzheimers-early","status":"publish","type":"post","link":"https:\/\/engineering.jhu.edu\/magazine-archive\/2017\/01\/catching-alzheimers-early\/","title":{"rendered":"Catching Alzheimer&#8217;s Early"},"content":{"rendered":"<p>For a disease that\u2019s disturbingly prevalent\u2014an estimated 5.4 million people in the United States are affected\u2014Alzheimer\u2019s disease\u2019s cause and cure remains elusive. But researchers know that the brain changes of Alzheimer\u2019s start before symptoms such as memory loss show up. The same is true for other neurodegenerative diseases, such as Parkinson\u2019s and Huntington\u2019s disease.<\/p>\n<p>\u201cWe need to be looking at the brain before someone starts to complain of significant clinical symptoms,\u201d says <a href=\"http:\/\/www.bme.jhu.edu\/people\/primary.php?id=392\" target=\"_blank\">Michael I. Miller<\/a>, MS \u201979, PhD \u201984, the Herschel and Ruth Seder Professor of <a href=\"http:\/\/www.bme.jhu.edu\/\" target=\"_blank\">Biomedical Engineering<\/a> and university Gilman Scholar.<\/p>\n<p>Similar to his work to create a pediatric brain data bank, Miller is analyzing MRI brain images of the elderly. His goal: to unveil lurking signs of Alzheimer\u2019s that cognitive tests cannot detect. He is collaborating with <a href=\"http:\/\/www.hopkinsmedicine.org\/profiles\/results\/directory\/profile\/6044024\/marilyn-albert\" target=\"_blank\">Marilyn S. Albert<\/a>, director of the Division of Cognitive Neuroscience at the Johns Hopkins University School of Medicine, and <a href=\"http:\/\/engineering.jhu.edu\/ams\/faculty\/laurent-younes\/\" target=\"_blank\">Laurent Younes<\/a>, chair of <a href=\"http:\/\/engineering.jhu.edu\/ams\/\" target=\"_blank\">applied mathematics and statistics<\/a> at the Whiting School.<\/p>\n<p>Since 1995, Albert has been studying patients at risk for Alzheimer\u2019s based on genetics and family history. One-fifth of 360 individuals have developed full-blown Alzheimer\u2019s. Their brain scans are a critical window into the disease\u2019s evolution.<\/p>\n<figure id=\"attachment_6036\" class=\"wp-caption alignleft\" style=\"width: 310px\"><a href=\"https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2017\/01\/Untitled-1.jpg\" rel=\"attachment wp-att-6036\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-6036 size-medium\" src=\"https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2017\/01\/Untitled-1-300x191.jpg\" width=\"300\" height=\"191\" srcset=\"https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2017\/01\/Untitled-1-300x191.jpg 300w, https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2017\/01\/Untitled-1-768x489.jpg 768w, https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2017\/01\/Untitled-1-1024x652.jpg 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><figcaption class=\"wp-caption-text\">Researchers have found changes in the entorhinal cortex (red) 10 years prior to symptoms. The disease moves to the hippocampus (blue) and amygdala (green). (JHU CENTER FOR IMAGING SCIENCE)<\/figcaption><\/figure>\n<p>Now, using sophisticated computer models to study the shape and volume of three brain structures in the temporal lobe, associated with memory, the researchers have found significant changes in the entorhinal cortex 10 years before symptoms. Images show that the volume of gray matter shrinks, which is \u201cconsistent with losing neurons, which are the computing machinery associated with memory storage and retrieval,\u201d says Miller.<\/p>\n<p>The disease then moves to the hippocampus and the amygdala, which shrink to a smaller extent two to four years before symptom onset. Understanding these subtle brain changes could help design interventions that slow the disease. \u201cIf we find an important-enough-marker it could be used to diagnose and alter care,\u201d Miller says.<\/p>\n<p>Miller co-directs the <a href=\"http:\/\/www.kavlifoundation.org\/johns-hopkins-university\" target=\"_blank\">Kavli Neuroscience Discovery Institute<\/a> at Johns Hopkins with <a href=\"http:\/\/neuroscience.jhu.edu\/research\/faculty\/40\" target=\"_blank\">Richard Huganir<\/a>, director of the <a href=\"http:\/\/neuroscience.jhu.edu\/\" target=\"_blank\">Department of Neuroscience<\/a> at the School of Medicine.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>For a disease that\u2019s disturbingly prevalent, Alzheimer\u2019s disease\u2019s cause and cure remains elusive. But researchers know that the brain changes of Alzheimer\u2019s start before symptoms such as memory loss show up.<\/p>\n","protected":false},"author":4,"featured_media":6044,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[24],"tags":[121,213,271,976,980,984,988,992],"class_list":["post-4988","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-impact","tag-department-of-biomedical-engineering","tag-johns-hopkins-university-school-of-medicine","tag-kavli-neuroscience-discovery-institute","tag-michael-i-miller","tag-alzheimers-disease","tag-neurodegenerative-disease","tag-marilyn-s-albert","tag-richard-huganir","issue-winter-2017"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Catching Alzheimer&#039;s Early - JHU Engineering Magazine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/engineering.jhu.edu\/magazine-archive\/2017\/01\/catching-alzheimers-early\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Catching Alzheimer&#039;s Early - JHU Engineering Magazine\" \/>\n<meta property=\"og:description\" content=\"For a disease that\u2019s disturbingly prevalent, Alzheimer\u2019s disease\u2019s cause and cure remains elusive. 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