{"id":4220,"date":"2016-01-12T17:18:40","date_gmt":"2016-01-12T22:18:40","guid":{"rendered":"https:\/\/engineering.jhu.edu\/magazine-archive\/?p=4220"},"modified":"2017-10-09T10:03:19","modified_gmt":"2017-10-09T14:03:19","slug":"the-cells-dont-lie","status":"publish","type":"post","link":"https:\/\/engineering.jhu.edu\/magazine-archive\/2016\/01\/the-cells-dont-lie\/","title":{"rendered":"The Cells Don\u2019t Lie"},"content":{"rendered":"<p><a href=\"https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2016\/01\/JHU0702_d.jpg\" rel=\"attachment wp-att-4335\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-4335\" src=\"https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2016\/01\/JHU0702_d-682x1024.jpg\" alt=\"The Cells Don't Lie\" width=\"300\" height=\"451\" srcset=\"https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2016\/01\/JHU0702_d-682x1024.jpg 682w, https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2016\/01\/JHU0702_d-200x300.jpg 200w, https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2016\/01\/JHU0702_d-768x1154.jpg 768w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>You may look younger than your years, but your cells won\u2019t lie about your age, according to researchers in the <a href=\"http:\/\/engineering.jhu.edu\/chembe\/\" target=\"_blank\" rel=\"noopener\">Department of Chemical and Biomolecular Engineering<\/a>.<\/p>\n<p>\u201cBeing able to determine an individual\u2019s biological age as determined by measurements on the cellular level allows us to gain a better understanding of aging, both as a function of healthy, \u2018normal\u2019 aging and in the context of disease,\u201d says Jude Phillip, PhD \u201915, lead author on a study determining new benchmarks for aging patterns.<\/p>\n<p>\u201cBiological age is a better predictor of health and longevity than chronological age. By knowing our biological age, we can make the appropriate changes with regard to lifestyle or therapeutic interventions,\u201d adds Phillip, who worked in the lab of <a href=\"http:\/\/engineering.jhu.edu\/chembe\/faculty\/denis-wirtz\/\" target=\"_blank\" rel=\"noopener\">Denis Wirtz<\/a>, the Theophilus Halley Smoot Professor of Engineering and Johns Hopkins University vice provost for research.<\/p>\n<p>Previous cell biological age tests focused on biochemistry, such as genetic makeup and epigenetics. Phillip\u2019s tests focused on biophysical measures, such as how cells moved, gripped their surroundings, or self-repaired, or their general appearance. He used human dermal fibroblasts, cells below the skin\u2019s surface responsible for repair.<\/p>\n<p>\u201cA combination of biophysical features better predicted biological age than two biochemical features,\u201d Phillip says.<\/p>\n<p>The study also suggested that correlations between biological cell age and chronological age in men and women differ. In men, biological age was closely correlated to chronological age throughout their life spans. In women, that correlation lasted until women reached their early 30s, when biological age shot up above chronological age. By their 70s, though, the two age measures were once again more closely correlated.<\/p>\n<p>\u201cUsing this tool in collaboration with <a href=\"http:\/\/www.hopkinsmedicine.org\/profiles\/results\/directory\/profile\/0005058\/jeremy-walston?clearpagecache=false&amp;pagecount=10&amp;modalpref=false&amp;currpage=1\" target=\"_blank\" rel=\"noopener\">Jeremy Walston<\/a> of the <a href=\"http:\/\/www.hopkinsmedicine.org\/som\/\" target=\"_blank\" rel=\"noopener\">Johns Hopkins University School of Medicine<\/a>, we are now working on identifying early cell markers of frailty, which involves the progressive decline of multiple organ functions,\u201d Wirtz says.<\/p>\n<p>Phillip\u2019s work could also help improve skin graft matching and provide a more accurate prescreening platform for therapeutics or cosmetics. Both Phillip and Wirtz are affiliated with the Johns Hopkins <a href=\"http:\/\/inbt.jhu.edu\/\" target=\"_blank\" rel=\"noopener\">Institute for NanoBioTechnology<\/a>.<\/p>\n<p>Listen to a <a href=\"https:\/\/www.mixcloud.com\/JHU_INBT\/jude-philip-your-cells-will-never-lie-about-your-age\/\" target=\"_blank\" rel=\"noopener\">podcast<\/a> of Jude Phillip explaining this research.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>You may look younger than your years, but your cells won\u2019t lie about your age, according to researchers in the Department of Chemical and Biomolecular Engineering. \u201cBeing able to determine an individual\u2019s biological age as determined by measurements on the cellular level allows us to gain a better understanding of aging, both as a function&#8230;<\/p>\n","protected":false},"author":6,"featured_media":4338,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[25],"tags":[212,208,213,174,211,210,209],"class_list":["post-4220","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-students","tag-jeremy-walston","tag-jude-phillip","tag-johns-hopkins-university-school-of-medicine","tag-department-of-chemical-and-biomolecular-engineering","tag-denis-wirtz","tag-institute-for-nanobiotechnology","tag-inbt","issue-winter-2016"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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