{"id":2982,"date":"2014-12-22T17:20:08","date_gmt":"2014-12-22T22:20:08","guid":{"rendered":"https:\/\/engineering.jhu.edu\/magazine-archive\/?p=2982"},"modified":"2017-08-10T10:47:35","modified_gmt":"2017-08-10T14:47:35","slug":"mapping-drosophilias-brain","status":"publish","type":"post","link":"https:\/\/engineering.jhu.edu\/magazine-archive\/2014\/12\/mapping-drosophilias-brain\/","title":{"rendered":"Mapping Drosophilia’s Brain"},"content":{"rendered":"

\"Mapping<\/a>They would seem unlikely allies: a mathematician and a neuroscientist who studies fruit fly larvae. But from the moment that Carey Priebe, a professor in the Department of Applied Mathematics and Statistics at the Whiting School, met Marta Zlatic, a group leader at Howard Hughes Medical Institute\u2019s Janelia Farm campus, Priebe says that he knew the two would have a long and productive relationship.<\/p>\n

\u201cWhat I thought I could do and what she thought she wanted done seemed to have significant overlap,\u201d he remembers.<\/p>\n

Priebe and Park have created a statistical tool that successfully mapped behaviors onto about 60 percent of the fruit fly larvae’s neurons.<\/p><\/blockquote>\n

Zlatic and her colleagues had taken on the daunting task of trying to create a sort of atlas that categorized the jobs of a fruit fly larva\u2019s approximately 10,000 neurons\u2014 information that could help elucidate how brains, including ours, work in general. By using a genetic technique that allows a few of these neurons at a time to be manipulated externally with blue light, the researchers were able to stimulate a variety of behaviors in nearly 40,000 individual larvae, catching these actions on video. Because this process was automated, they accomplished this feat in just a few months, generating a new problem: figuring out how to group the insects\u2019 complex behaviors into clusters that tied them to particular neurons.<\/p>\n

That\u2019s where Priebe came in. Combining two theories he\u2019d developed in earlier work, the applied mathematician created a statistical tool with his Whiting School colleague Youngser Park, a researcher in the Center for Imaging Science, that successfully mapped behaviors onto about 60 percent of the larvae\u2019s neurons. The researchers published their results in Science<\/em><\/a> last May.<\/p>\n

Now that this project is finished, the researchers are moving on to the next stage: using data from the genetic technique and electron microscope and calcium channel imaging to map functional connectivity between neurons\u2014work that\u2019s already been awarded a National Science Foundation EAGER award.<\/p>\n","protected":false},"excerpt":{"rendered":"

They would seem unlikely allies: a mathematician and a neuroscientist who studies fruit fly larvae. But from the moment that Carey Priebe, a professor in the Department of Applied Mathematics and Statistics at the Whiting School, met Marta Zlatic, a group leader at Howard Hughes Medical Institute\u2019s Janelia Farm campus, Priebe says that he knew…<\/p>\n","protected":false},"author":4,"featured_media":3554,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[24],"tags":[],"class_list":["post-2982","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-impact","issue-winter-2015"],"acf":[],"yoast_head":"\nMapping Drosophilia's Brain - JHU Engineering Magazine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/engineering.jhu.edu\/magazine-archive\/2014\/12\/mapping-drosophilias-brain\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mapping Drosophilia's Brain - JHU Engineering Magazine\" \/>\n<meta property=\"og:description\" content=\"They would seem unlikely allies: a mathematician and a neuroscientist who studies fruit fly larvae. 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