{"id":2020,"date":"2005-09-16T11:52:04","date_gmt":"2005-09-16T15:52:04","guid":{"rendered":"https:\/\/engineering.jhu.edu\/magazine-archive\/?p=2020"},"modified":"2014-12-16T11:52:40","modified_gmt":"2014-12-16T16:52:40","slug":"late","status":"publish","type":"post","link":"https:\/\/engineering.jhu.edu\/magazine-archive\/2005\/09\/late\/","title":{"rendered":"Before It\u2019s Too Late"},"content":{"rendered":"<p><strong>Through studying cardiac electrical abnormalities, Samuel Hahn \u201905 analyzed the data that could improve the prognosis for patients with heart failure.<\/strong><\/p>\n<figure id=\"attachment_2021\" class=\"wp-caption aligncenter\" style=\"width: 522px\"><a href=\"https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2014\/07\/29_3203.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-2021\" src=\"https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2014\/07\/29_3203.jpg\" alt=\"\u201cIn the lab, we\u2019re dealing with the big picture,\u201d notes Samuel Hahn \u201905. A Biomedical Engineering major, the undergraduate was part of a research team whose goal was to understand the exact mechanisms underlying heart disease.\" width=\"512\" height=\"323\" srcset=\"https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2014\/07\/29_3203.jpg 512w, https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2014\/07\/29_3203-300x189.jpg 300w\" sizes=\"auto, (max-width: 512px) 100vw, 512px\" \/><\/a><figcaption class=\"wp-caption-text\"><strong>\u201cIn the lab, we\u2019re dealing with the big picture,\u201d notes Samuel Hahn \u201905. A Biomedical Engineering major, the undergraduate was part of a research team whose goal was to understand the exact mechanisms underlying heart disease.<\/strong><\/figcaption><\/figure>\n<p>Samuel Hahn \u201905 is both philosopher and scientist when describing his role in a ground-breaking research study identifying the electrical changes that lead to heart failure. As an undergraduate in the Whiting School of Engineering, the Biomedical Engineering major contributed to research that for the first time described the time-course and nature of the electrical abnormalities that are present long before a patient has any clinical signs of heart failure.<\/p>\n<p>Some 5 million Americans suffer from heart failure, and more than 250,000 a year die. \u201cOf the deaths in patients with heart failure, up to 50 percent are sudden and unexpected, and the result of lethal arrhythmias,\u201d Hahn notes. \u201cBy defining the early electrical changes,\u201d he observes, \u201cwe hope to identify new targets for therapy that can either reverse, or at the very least, hinder the progression of the vicious cycle of events that ultimately leads to death.\u201d Hahn conducted his research under the guidance of Fadi G. Akar, a research assistant professor at the Johns Hopkins School of Medicine, Division of Cardiology. Hahn and Akar, who have submitted their research to a peer-reviewed journal, worked in the laboratory of Gordon F. Tomaselli, professor of Medicine and a cardiologist at Johns Hopkins Hospital.<\/p>\n<p>\u201cIn the lab, we\u2019re dealing with the big picture,\u201d says Hahn, who is 21. Their goal is to understand the exact mechanisms underlying heart disease. \u201cOur work with optical mapping doesn\u2019t deal with the minute genes, but how they work together and what changes they produce,\u201d Hahn explains. The technique of optical mapping involves staining heart tissue samples with voltage-sensitive dyes, shining light on the samples, collecting the emitted light in an optical detection system, and then converting it to current for computer analysis. Hahn\u2019s role came in analyzing the data and helping to perform the experiments on the two phases of electrical disturbances that lead to lethal arrhythmia.<\/p>\n<blockquote><p>\u201cI love designing things and getting them to work, Being an engineer teaches you to think analytically.\u201d <cite>Samual Hahn \u201905<\/cite><\/p><\/blockquote>\n<p>This fall, Hahn has taken his big-picture research experience to the University of Pennsylvania School of Medicine, where he is pursuing an MD. Though he\u2019s always wanted to be a physician, Hahn chose majoring in Biomedical Engineering over pre-med, and hopes to do further research. \u201cI love designing things and getting them to work,\u201d he explains. \u201cBeing an engineer teaches you to think analytically.\u201d<\/p>\n<p>Hahn\u2019s father, Suk-kyun Hahn, MD, is an internist in private practice. His sister Sarah, a Hopkins sophomore, also has her sights set on medical school. It was their brother, David who, perhaps, has had the biggest influence on Hahn\u2019s approach to his chosen career. In 2002, David, 15, who has Down syndrome, wanted to take part in Special Olympics. Hahn, who played intramural basketball at Hopkins, jumped at the chance to coach his brother in basketball, track, and soccer. He spent most weekends with David at the family\u2019s home in Lutherville, Maryland. \u201cBy being with him and getting to know others in Special Olympics, I really developed a desire to help people,\u201d Hahn says. \u201cIt\u2019s rewarding to help him achieve his goals, however simple those goals are. I hope that I will have the same compassion and empathy when I practice medicine.\u201d<\/p>\n<p>When Hahn entered Hopkins in fall 2001, he was very interested in genetics because of David and because it was \u201ca field just waiting to be explored,\u201d he says. A few months prior, he had worked as a paid technician in the genetics lab of Andrew P. Feinberg, professor of Medical Genetics at Hopkins and Hahn\u2019s next-door neighbor. Recalling his cardiology study in the Physiological Foundations course, a core Biomedical Engineering class, Hahn says, \u201cI had seen EKGs before, but had never seen action potentials, which are electrical signals of how the ion channels in your heart work and produce contractions.\u201d Feinberg mentioned to Hahn that Tomaselli was researching cardiac rhythms, and that led to Tomaselli\u2019s offering the junior a for-credit position in his lab.<\/p>\n<p>Akar also spotted Hahn\u2019s talent right from the start. He recalls how Hahn \u201cdistinguished himself early on as a gifted, forwardthinking, and meticulous scientist. He learned how to approach scientific questions, identify gaps in knowledge, and design experimental procedures that would specifically answer those questions in the most effective manner.\u201d Hahn politely deflects such compliments. Akar \u201cgives me a lot more credit than I think I deserve. He put a lot of trust in me and trusted my work,\u201d Hahn says. \u201cThe great thing about Hopkins is that you get to see the research aspect of medicine. I can say I was part of something bigger.\u201d<\/p>\n<p><strong>Special thanks to Karen Blum for her contributions to this article. To learn more about the Department of Biomedical Engineering in the Whitaker Institute at Johns Hopkins, visit www.bme.jhu.edu.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Through studying cardiac electrical abnormalities, Samuel Hahn \u201905 analyzed the data that could improve the prognosis for patients with heart failure. Samuel Hahn \u201905 is both philosopher and scientist when describing his role in a ground-breaking research study identifying the electrical changes that lead to heart failure. As an undergraduate in the Whiting School of&#8230;<\/p>\n","protected":false},"author":4,"featured_media":2021,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[77],"tags":[],"class_list":["post-2020","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-making-waves","issue-fall-2005"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Before It\u2019s Too Late - JHU Engineering Magazine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/engineering.jhu.edu\/magazine-archive\/2005\/09\/late\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Before It\u2019s Too Late - JHU Engineering Magazine\" \/>\n<meta property=\"og:description\" content=\"Through studying cardiac electrical abnormalities, Samuel Hahn \u201905 analyzed the data that could improve the prognosis for patients with heart failure. 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