{"id":15794,"date":"2022-01-20T08:55:12","date_gmt":"2022-01-20T13:55:12","guid":{"rendered":"https:\/\/engineering.jhu.edu\/magazine-archive\/?p=15794"},"modified":"2022-01-20T08:55:12","modified_gmt":"2022-01-20T13:55:12","slug":"tech-tools-less-costly-couriers","status":"publish","type":"post","link":"https:\/\/engineering.jhu.edu\/magazine-archive\/2022\/01\/tech-tools-less-costly-couriers\/","title":{"rendered":"Tech Tools: Less Costly Couriers"},"content":{"rendered":"
\"Viral
This particle manufacturing technology improves production of lentiviral vectors, used to generate CAR T cells (red) that recognize and kill cancer cells (blue) in patients.<\/figcaption><\/figure>\n

A new particle assembly technology created by Johns Hopkins engineers in partnership with experts from a biotechnology company is making it easier and more cost-efficient to produce viral vectors: engineered viruses that have been used to modify therapeutic cells to treat congenital and acquired diseases.<\/p>\n

A team led by Hai-Quan Mao<\/a>, professor of materials science and engineering<\/a> and of biomedical engineering<\/a>, and associate director for the Institute for NanoBioTechnology<\/a>, in collaboration with scientists from bluebird bio, has developed shelf-stable and size-controlled DNA particles that not only improve the quality and consistency of viral vectors but also their yield.<\/p>\n

\u201cViruses are experts at targeting and infecting specific cells, and viral vectors take advantage of this, but producing them is time-consuming and costly,\u201d Mao says. \u201cThis work represents a great example of how we can partner with corporate collaborators to accelerate the translation of discoveries on the bench to the industry.\u201d<\/p>\n

Team members believe the new technology will find a wide range of applications in the manufacture of a variety of viral vectors for gene and cell therapy applications.<\/p>\n","protected":false},"excerpt":{"rendered":"

A new particle assembly technology created by Johns Hopkins engineers in partnership with experts from a biotechnology company is making it easier and more cost-efficient to produce viral vectors: engineered viruses that have been used to modify therapeutic cells to treat congenital and acquired diseases.<\/p>\n","protected":false},"author":4,"featured_media":15798,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[24],"tags":[],"class_list":["post-15794","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-impact","issue-winter-2022"],"acf":[],"yoast_head":"\nTech Tools: Less Costly Couriers - JHU Engineering Magazine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/engineering.jhu.edu\/magazine-archive\/2022\/01\/tech-tools-less-costly-couriers\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tech Tools: Less Costly Couriers - 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