{"id":14659,"date":"2021-02-01T10:23:11","date_gmt":"2021-02-01T15:23:11","guid":{"rendered":"https:\/\/engineering.jhu.edu\/magazine-archive\/?p=14659"},"modified":"2021-02-01T10:36:48","modified_gmt":"2021-02-01T15:36:48","slug":"upstarts-a-one-two-punch-for-tumors","status":"publish","type":"post","link":"https:\/\/engineering.jhu.edu\/magazine-archive\/2021\/02\/upstarts-a-one-two-punch-for-tumors\/","title":{"rendered":"Upstarts: A One-Two Punch for Tumors"},"content":{"rendered":"\"\"\n

Traditional cancer therapies designed to stimulate the immune system or mimic its normal functions are often ineffective in defending against certain cancers.<\/p>\n

To solve this problem, Honggang Cui<\/a>, an associate professor of chemical and biomolecular engineering<\/a> and member of the Institute for NanoBioTechnology<\/a>, is leading a team in developing a dual chemo-immunotherapy treatment that is designed to create an immune-responsive environment through targeted, sustained release of a cancer immunotherapy drug.<\/p>\n

Cui\u2019s approach is to create a selfassembling hydrogel version of the chemotherapy drug camptothecin, which can be administered directly into a tumor and released over a two-month period. The hydrogel form enables Cui to incorporate cyclic dinucleotide c-di-AMP, a molecule that activates cell signaling pathways to stimulate an immune response. The CPT and CDA work synergistically to destroy the tumor, which causes inflammation, a natural immune response that attracts more immune cells to the tumor site to penetrate and further destroy it.<\/p>\n

This novel therapy already has been tested on mice with a variety of tumor types, and the results showed near tumor regression in most models, with no obvious side effects.<\/p>\n","protected":false},"excerpt":{"rendered":"

Associate Professor Honggang Cui is leading a team in developing a dual chemo-immunotherapy treatment that is designed to create an immune-responsive environment through targeted, sustained release of a cancer immunotherapy drug.<\/p>\n","protected":false},"author":4,"featured_media":14647,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[24],"tags":[1650],"class_list":["post-14659","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-impact","tag-cancer","issue-winter-2021"],"acf":[],"yoast_head":"\nUpstarts: A One-Two Punch for Tumors - JHU Engineering Magazine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/engineering.jhu.edu\/magazine-archive\/2021\/02\/upstarts-a-one-two-punch-for-tumors\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Upstarts: A One-Two Punch for Tumors - 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