{"id":13802,"date":"2020-06-23T09:50:41","date_gmt":"2020-06-23T13:50:41","guid":{"rendered":"https:\/\/engineering.jhu.edu\/magazine-archive\/?p=13802"},"modified":"2020-08-10T10:43:32","modified_gmt":"2020-08-10T14:43:32","slug":"a-solution-to-vision-loss-in-canines","status":"publish","type":"post","link":"https:\/\/engineering.jhu.edu\/magazine-archive\/2020\/06\/a-solution-to-vision-loss-in-canines\/","title":{"rendered":"A Solution to Vision Loss in Canines"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-13994\" src=\"https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2020\/06\/corneal-transplant.jpeg\" alt=\"Corneal Transplant\" width=\"339\" height=\"222\" srcset=\"https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2020\/06\/corneal-transplant.jpeg 339w, https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2020\/06\/corneal-transplant-300x196.jpeg 300w\" sizes=\"auto, (max-width: 339px) 100vw, 339px\" \/>In 2017, a Boston terrier named Lucky became the first client-owned dog to receive a partial corneal transplant to restore his vision in one eye. Although the transplant was a success, it did come with challenges\u2014which inspired a team of <a href=\"https:\/\/www.bme.jhu.edu\/\" target=\"_blank\" rel=\"noopener noreferrer\">Johns Hopkins biomedical engineering<\/a> students and alumni to develop a device to make it easier for surgeons to perform partial corneal transplants on dogs.<\/p>\n<p>Using the device, veterinary ophthalmologist Micki Armour has since performed 18 partial corneal transplants at Friendship Hospital for Animals in Washington, D.C. \u201cThis device simplifies and streamlines our ability to provide this service to our canine patients,\u201d says Armour, who is now training other veterinarians from around the world to perform the surgery.<\/p>\n<p>The genesis for this advance goes back four years, when Akash Chaurasia, then a first-year student at the Whiting School, was part of an eight-person design team that began researching problems in the human ophthalmology field that could be solved through innovation. The team learned that Descemet\u2019s Membrane Endothelial Keratoplasty, a type of corneal transplant that can produce excellent outcomes for human patients, is also challenging for surgeons to perform. One of the primary issues is that the donor cornea\u2019s thin, fragile tissue can roll up after being injected into the eye, leaving surgeons with the difficult task of unrolling the tissue without damaging it.<\/p>\n<p>Working with Allen Eghrari, an ophthalmologist at Johns Hopkins\u2019 <a href=\"https:\/\/www.hopkinsmedicine.org\/wilmer\/\" target=\"_blank\" rel=\"noopener noreferrer\">Wilmer Eye Institute<\/a>, Chaurasia and his classmates created a device to help surgeons address this problem. After folding the corneal tissue in a specific manner, the tissue roll is loaded into the student-designed device, which is then provided to the surgeon. When the surgeon injects the graft into the recipient\u2019s eye, it unrolls instead of curling up. In 2017, Chaurasia, along with several other students and alumni, co-founded <a href=\"http:\/\/treye.tech\/\" target=\"_blank\" rel=\"noopener noreferrer\">Treyetech<\/a>, a startup company, to bring the device to the market. As of February, it was awaiting FDA approval.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-14066\" src=\"https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2020\/06\/Lucky-Corneal-Transplant.jpeg\" alt=\"Lucky\" width=\"346\" height=\"352\" srcset=\"https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2020\/06\/Lucky-Corneal-Transplant.jpeg 346w, https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2020\/06\/Lucky-Corneal-Transplant-295x300.jpeg 295w\" sizes=\"auto, (max-width: 346px) 100vw, 346px\" \/>But the team also wanted to help other potential recipients. \u201cDuring our research, we learned about the veterinary market,\u201d Chaurasia says. Eghrari told them that the field of canine ophthalmology was ripe for innovation. The students zeroed in on developing a device to help enable partial corneal transplants to dogs with corneal endothelial dystrophy. A condition similar to Fuchs\u2019 dystrophy in humans, it is marked by a declining number of endothelial cells, which pump water from the cornea to keep it clear. With fewer cells, a dog\u2019s cornea becomes cloudy and covered in a blue haze, vision loss can occur, and painful ulcers may develop, potentially necessitating removal of the affected eye. Veterinarians have been able to treat the symptoms, but until now, there hasn\u2019t been an easy way to perform a partial corneal transplant to restore vision.<\/p>\n<p>\u201cThat\u2019s the problem the team had to solve,\u201d says Steven Solar, a sophomore working on the canine project.<\/p>\n<p>Along with Chaurasia and Solar, sophomore Batya Wiener, first-year Satya Baliga, Conan Chen \u201918, Eric Chiang \u201918, and Kali Barnes \u201918 created the device, of which there are two versions: the Luna inserter and the Lucky inserter. Although it has been scaled for dogs\u2019 corneas, which are larger and floppier than those of humans, the device works like its counterpart for humans. To address the challenge of the graft curling up in the eye after injection, the team leveraged a trifold technique\u2014the same one used with the device for humans\u2014in which surgeons fold the graft against the way it naturally curls before inserting it into the device. \u201cThen when you put it in the eye and let go, it will naturally open up and flatten out, which can simplify the surgery,\u201d Solar says. The endothelial cells also face one another inside the device, which prevents them from getting lost\u2014the potential challenge with Lucky\u2019s transplant \u2014when they are inserted into the eye.<\/p>\n<p>Chaurasia\u2019s proudest moment was when he saw a video of Armour using the device to insert a graft into a dog\u2019s eye. \u201cSometimes you lose sight of the bigger picture because you\u2019re staring at Google Docs or reading literature all day,\u201d he says. \u201cThen you see your device actually having an impact. That was a real moment for me.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team of Johns Hopkins biomedical engineering students and alumni developed a device to make it easier for surgeons to perform partial corneal transplants on dogs.<\/p>\n","protected":false},"author":4,"featured_media":13902,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[25],"tags":[3480,5027],"class_list":["post-13802","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-students","tag-corneal-transplant","tag-ophtalmology","issue-summer-2020"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A Solution to Vision Loss in Canines - JHU Engineering Magazine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/engineering.jhu.edu\/magazine-archive\/2020\/06\/a-solution-to-vision-loss-in-canines\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Solution to Vision Loss in Canines - JHU Engineering Magazine\" \/>\n<meta property=\"og:description\" content=\"A team of Johns Hopkins engineers developed a device to make it easier for surgeons to perform partial corneal transplants on dogs.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/engineering.jhu.edu\/magazine-archive\/2020\/06\/a-solution-to-vision-loss-in-canines\/\" \/>\n<meta property=\"og:site_name\" content=\"JHU Engineering Magazine\" \/>\n<meta property=\"article:published_time\" content=\"2020-06-23T13:50:41+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-08-10T14:43:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/engineering.jhu.edu\/magazine-archive\/wp-content\/uploads\/2020\/06\/Lucky-Corneal-Transplant.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"346\" \/>\n\t<meta property=\"og:image:height\" content=\"352\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Abby Lattes\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Abby Lattes\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/engineering.jhu.edu\\\/magazine-archive\\\/2020\\\/06\\\/a-solution-to-vision-loss-in-canines\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/engineering.jhu.edu\\\/magazine-archive\\\/2020\\\/06\\\/a-solution-to-vision-loss-in-canines\\\/\"},\"author\":{\"name\":\"Abby Lattes\",\"@id\":\"https:\\\/\\\/engineering.jhu.edu\\\/magazine-archive\\\/#\\\/schema\\\/person\\\/0244393be370fbc3ead8ec26062e9742\"},\"headline\":\"A Solution to Vision Loss in Canines\",\"datePublished\":\"2020-06-23T13:50:41+00:00\",\"dateModified\":\"2020-08-10T14:43:32+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/engineering.jhu.edu\\\/magazine-archive\\\/2020\\\/06\\\/a-solution-to-vision-loss-in-canines\\\/\"},\"wordCount\":710,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/engineering.jhu.edu\\\/magazine-archive\\\/2020\\\/06\\\/a-solution-to-vision-loss-in-canines\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/engineering.jhu.edu\\\/magazine-archive\\\/wp-content\\\/uploads\\\/2020\\\/06\\\/thumb-students-canine.jpg\",\"keywords\":[\"Corneal Transplant\",\"Ophtalmology\"],\"articleSection\":[\"Students\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/engineering.jhu.edu\\\/magazine-archive\\\/2020\\\/06\\\/a-solution-to-vision-loss-in-canines\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/engineering.jhu.edu\\\/magazine-archive\\\/2020\\\/06\\\/a-solution-to-vision-loss-in-canines\\\/\",\"url\":\"https:\\\/\\\/engineering.jhu.edu\\\/magazine-archive\\\/2020\\\/06\\\/a-solution-to-vision-loss-in-canines\\\/\",\"name\":\"A Solution to Vision Loss in Canines - 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