Winslow, Raimond L.

Professor
Som Biomedical Engineering

Hackerman Hall Ste 208
(410) 516-4116
rwinslow@jhu.edu

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About

Education
  • Ph.D. 1986, JOHNS HOPKINS SCHOOL OF MEDICINE
Experience
  • 2013 - Present:  JOINT/SECONDARY FACULTY, SOM Medicine
  • 2003 - Present:  Professor, SOM Medicine
  • 2001 - Present:  Joint, SOM Health Sciences Informatics

Publications

Journal Articles
  • Walker MA, Gurev V, Rice JJ, Greenstein JL, Winslow RL (2017).  Estimating the probabilities of rare arrhythmic events in multiscale computational models of cardiac cells and tissue.  PLoS Computational Biology.  13(11).
  • Zhao CY, Greenstein JL, Winslow RL (2017).  Mechanisms of the cyclic nucleotide cross-talk signaling network in cardiac L-type calcium channel regulation.  Journal of Molecular and Cellular Cardiology.  106.
  • Chu L, Greenstein JL, Winslow RL (2016).  Modeling Na+-Ca2 + exchange in the heart: Allosteric activation, spatial localization, sparks and excitation-contraction coupling.  Journal of Molecular and Cellular Cardiology.  99.
  • Winslow RL, Granite S, Jurado C (2016).  WaveformECG: A platform for visualizing, annotating, and analyzing ECG data.  Computing in Science and Engineering.  18(5).
  • Ardekani S, Jain S, Sanzi A, Corona-Villalobos CP, Abraham TP, Abraham MR, Zimmerman SL, Wu KC, Winslow RL, Miller MI, Younes L (2016).  Shape analysis of hypertrophic and hypertensive heart disease using MRI-based 3D surface models of left ventricular geometry.  Medical Image Analysis.  29.
  • Walker MA, Madduri R, Rodriguez A, Greenstein JL, Winslow RL (2016).  Models and Simulations as a Service: Exploring the Use of Galaxy for Delivering Computational Models.  Biophysical Journal.  110(5).
  • Zhao CY, Greenstein JL, Winslow RL (2016).  Roles of phosphodiesterases in the regulation of the cardiac cyclic nucleotide cross-talk signaling network.  Journal of Molecular and Cellular Cardiology.  91.
  • Winslow RL, Walker MA, Greenstein JL (2016).  Modeling calcium regulation of contraction, energetics, signaling, and transcription in the cardiac myocyte.  Wiley Interdisciplinary Reviews: Systems Biology and Medicine.  8(1).
  • Walker MA, Kohl T, Lehnart SE, Greenstein JL, Lederer WJ, Winslow RL (2015).  On the Adjacency Matrix of RyR2 Cluster Structures.  PLoS Computational Biology.  11(11).
  • Zhao CY, Greenstein JL, Winslow RL (2015).  Interaction between phosphodiesterases in the regulation of the cardiac β-adrenergic pathway.  Journal of Molecular and Cellular Cardiology.  88.
  • Foteinou PT, Greenstein JL, Winslow RL (2015).  Mechanistic Investigation of the Arrhythmogenic Role of Oxidized CaMKII in the Heart.  Biophysical Journal.  109(4).
  • Volpe GJ, Rizzi P, Nacif MS, Ricketts EP, Venkatesh BA, Liu CY, Gomes AS, Hundley WG, Prince MR, Carr JC, McClelland RL, Liu K, Eng J, Johnson WC, Winslow RL, Bluemke DA, Lima JAC (2015).  Lessons on Quality Control in Large Scale Imaging Trials: the Multi-Ethnic Study of Atherosclerosis (MESA).  Current Cardiovascular Imaging Reports.  8(5).
  • Walker MA, Williams GSB, Kohl T, Lehnart SE, Jafri MS, Greenstein JL, Lederer WJ, Winslow RL (2014).  Superresolution Modeling of Calcium Release in the Heart.  Biophysical Journal.  107(12).
  • Santaniello S, Granite SJ, Sarma SV, Winslow RL (2014).  Computing network-based features from physiological time series: Application to sepsis detection.  2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014.
  • Winslow RL (2014).  Systems biology approaches to understanding the cause and treatment of heart, lung, blood, and sleep disorders.  Frontiers in Physiology.  5 MAR.
  • Greenstein JL, Foteinou PT, Hashambhoy-Ramsay YL, Winslow RL (2014).  Modeling CaMKII-mediated regulation of L-type Ca2+ channels and ryanodine receptors in the heart.  Frontiers in Pharmacology.  5 APR.
  • Gauthier LD, Greenstein JL, O'Rourke B, Winslow RL (2013).  An integrated mitochondrial ROS production and scavenging model: Implications for heart failure.  Biophysical Journal.  105(12).
  • Strauss DG, Mewton N, Verrier RL, Nearing BD, Marchlinski FE, Killian T, Moxley J, Tereshchenko LG, Wu KC, Winslow R, Cox C, Spooner PM, Lima JAC (2013).  Screening entire health system ecg databases to identify patients at increased risk of death.  Circulation: Arrhythmia and Electrophysiology.  6(6).
  • Gauthier LD, Greenstein JL, Cortassa S, O'Rourke B, Winslow RL (2013).  A Computational model of reactive oxygen species and redox balance in cardiac mitochondria.  Biophysical Journal.  105(4).
  • Aiba T, Barth AS, Hesketh GG, Hashambhoy YL, Chakir K, Tunin RS, Greenstein JL, Winslow RL, Kass DA, Tomaselli GF (2013).  Cardiac resynchronization therapy improves altered na channel gating in canine model of dyssynchronous heart failure.  Circulation: Arrhythmia and Electrophysiology.  6(3).
  • Winslow RL, Greenstein JL (2013).  Extinguishing the sparks.  Biophysical Journal.  104(10).
  • Kembro JM, Aon MA, Winslow RL, O'Rourke B, Cortassa S (2013).  Integrating mitochondrial energetics, redox and ROS metabolic networks: A two-compartment model.  Biophysical Journal.  104(2).
  • Winslow RL, Trayanova N, Geman D, Miller MI (2012).  Computational medicine: Translating models to clinical care.  Science Translational Medicine.  4(158).
  • Gauthier LD, Greenstein JL, Winslow RL (2012).  Toward an integrative computational model of the guinea pig cardiac myocyte.  Frontiers in Physiology.  3 JUL.
  • Wei AC, Liu T, Winslow RL, O'Rourke B (2012).  Dynamics of matrix-free Ca2+ in cardiac mitochondria: Two components of Ca2+ uptake and role of phosphate buffering.  Journal of General Physiology.  139(6).
  • Steinert-Threlkeld S, Ardekani S, Mejino JLV, Detwiler LT, Brinkley JF, Halle M, Kikinis R, Winslow RL, Miller MI, Ratnanather JT (2012).  Ontological labels for automated location of anatomical shape differences.  Journal of Biomedical Informatics.  45(3).
  • Ardekani S, Jain A, Jain S, Abraham TP, Abraham MR, Zimmerman S, Winslow RL, Miller MI, Younes L (2012).  Matching sparse sets of cardiac image cross-sections using large deformation diffeomorphic metric mapping algorithm.  Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics).  7085 LNCS.
  • Hashambhoy YL, Winslow RL, Greenstein JL (2011).  CaMKII-dependent activation of late I Na contributes to cellular arrhythmia in a model of the cardiac myocyte.  Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS.
  • Cortassa S, Aon MA, O'Rourke B, Winslow RL (2011).  Metabolic control analysis applied to mitochondrial networks.  Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS.
  • Winslow RL (2011).  Grand challenges in computational physiology and medicine.  Frontiers in Physiology.  2 NOV.
  • Hashambhoy YL, Winslow RL, Greenstein JL (2011).  CaMKII-dependent activation of late INa contributes to cellular arrhythmia in a model of the cardiac myocyte..  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference.  2011.
  • Cortassa S, Aon MA, O'Rourke B, Winslow RL (2011).  Metabolic control analysis applied to mitochondrial networks..  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference.  2011.
  • Kohl P, Hunter PJ, Winslow RL (2011).  Model interactions: 'It is the simple, which is so difficult'.  Progress in Biophysics and Molecular Biology.  107(1).
  • Quinn TA, Granite S, Allessie MA, Antzelevitch C, Bollensdorff C, Bub G, Burton RAB, Cerbai E, Chen PS, Delmar M, DiFrancesco D, Earm YE, Efimov IR, Egger M, Entcheva E, Fink M, Fischmeister R, Franz MR, Garny A, Giles WR, Hannes T, Harding SE, Hunter PJ, Iribe G, Jalife J, Johnson CR, Kass RS, Kodama I, Koren G, Lord P, Markhasin VS, Matsuoka S, McCulloch AD, Mirams GR, Morley GE, Nattel S, Noble D, Olesen SP, Panfilov AV, Trayanova NA, Ravens U, Richard S, Rosenbaum DS, Rudy Y, Sachs F, Sachse FB, Saint DA, Schotten U, Solovyova O, Taggart P, Tung L, Varró A, Volders PG, Wang K, Weiss JN, Wettwer E, White E, Wilders R, Winslow RL, Kohl P (2011).  Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing.  Progress in Biophysics and Molecular Biology.  107(1).
  • Winslow RL, Greenstein JL (2011).  Cardiac myocytes and local signaling in nano-domains.  Progress in Biophysics and Molecular Biology.  107(1).
  • Wei AC, Aon MA, O'Rourke B, Winslow RL, Cortassa S (2011).  Mitochondrial energetics, pH regulation, and ion dynamics: A computational-experimental approach.  Biophysical Journal.  100(12).
  • Winslow RL, Cortassa S, O'Rourke B, Hashambhoy YL, Rice JJ, Greenstein JL (2011).  Integrative modeling of the cardiac ventricular myocyte.  Wiley Interdisciplinary Reviews: Systems Biology and Medicine.  3(4).
  • Anderson T, Wulfkuhle J, Petricoin E, Winslow RL (2011).  High resolution mapping of the cardiac transmural proteome using reverse phase protein microarrays.  Molecular and Cellular Proteomics.  10(7).
  • Wei AC, Liu T, Cortassa S, Winslow RL, O'Rourke B (2011).  Mitochondrial Ca2+ influx and efflux rates in guinea pig cardiac mitochondria:Low and high affinity effects of cyclosporine A.  Biochimica et Biophysica Acta - Molecular Cell Research.  1813(7).
  • Greenstein JL, Winslow RL (2011).  Integrative systems models of cardiac excitation-contraction coupling.  Circulation Research.  108(1).
  • Hashambhoy YL, Greenstein JL, Winslow RL (2010).  Role of CaMKII in RyR leak, EC coupling and action potential duration: A computational model.  Journal of Molecular and Cellular Cardiology.  49(4).
  • Zhou L, Aon MA, Almas T, Cortassa S, Winslow RL, O'Rourke B (2010).  A reaction-diffusion model of ROS-induced ROS release in a mitochondrial network.  PLoS Computational Biology.  6(1).
  • Chen CS, Sullivan S, Anderson T, Tan AC, Alex PJ, Brant SR, Cuffari C, Bayless TM, Talor MV, Burek CL, Wang H, Li R, Datta LW, Wu Y, Winslow RL, Zhu H, Li X (2009).  Identification of novel serological biomarkers for inflammatory bowel disease using Escherichia coli proteome chip.  Molecular and Cellular Proteomics.  8(8).
  • Anderson T, Wulfkuhle J, Liotta L, Winslow RL, Petricoin E (2009).  Improved reproducibility of reverse-phase protein microarrays using array microenvironment normalization.  Proteomics.  9(24).
  • Ardekani S, Weiss RG, Lardo AC, George RT, Lima JAC, Wu KC, Miller MI, Winslow RL, Younes L (2009).  Cardiac motion analysis in ischemic and non-ischemic cardiomyopathy using parallel transport.  Proceedings - 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009.
  • Zhou L, Cortassa S, Wei AC, Aon MA, Winslow RL, O'Rourke B (2009).  Modeling cardiac action potential shortening driven by oxidative stress-induced mitochondrial oscillations in guinea pig cardiomyocytes.  Biophysical Journal.  97(7).
  • Cortassa S, O'Rourke B, Winslow RL, Aon MA (2009).  Control and regulation of mitochondrial energetics in an integrated model of cardiomyocyte function.  Biophysical Journal.  96(6).
  • Hashambhoy YL, Winslow RL, Greenstein JL (2009).  CaMKII-induced shift in modal gating explains L-type Ca2+ current facilitation: A modeling study.  Biophysical Journal.  96(5).
  • Ardekani S, Weiss RG, Lardo AC, George RT, Lima JAC, Wu KC, Miller MI, Winslow RL, Younes L (2009).  Computational Method for Identifying and Quantifying Shape Features of Human Left Ventricular Remodeling.  Annals of Biomedical Engineering.  37(6).
  • Cortassa S, O'Rourke B, Winslow RL, Aon MA (2009).  Control and regulation of integrated mitochondrial function in metabolic and transport networks.  International Journal of Molecular Sciences.  10(4).
  • Gao Z, Barth AS, DiSilvestre D, Akar FG, Tian Y, Tanskanen A, Kass DA, Winslow RL, Tomaselli GF (2008).  Key pathways associated with heart failure development revealed by gene networks correlated with cardiac remodeling.  Physiological Genomics.  35(3).
  • Plank G, Zhou L, Greenstein JL, Cortassa S, Winslow RL, O'Rourke B, Trayanova NA (2008).  From mitochondrial ion channels to arrhythmias in the heart: Computational techniques to bridge the spatio-temporal scales.  Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.  366(1879).
  • Younes L, Qiu A, Winslow RL, Miller MI (2008).  Transport of relational structures in groups of diffeomorphisms.  Journal of Mathematical Imaging and Vision.  32(1).
  • Xu L, Tan AC, Winslow RL, Geman D (2008).  Merging microarray data from separate breast cancer studies provides a robust prognostic test.  BMC Bioinformatics.  9.
  • Aik CT, Fan JB, Karikari C, Bibikova M, Garcia EW, Zhou L, Barker D, Serre D, Feldmann G, Hruban RH, Klein AP, Goggins M, Couch FJ, Hudson TJ, Winslow RL, Maitra A, Chakravarti A (2008).  Allele-specific expression in the germline of patients with familial pancreatic cancer: An unbiased approach to cancer gene discovery.  Cancer Biology and Therapy.  7(1).
  • Xu L, Geman D, Winslow RL (2007).  Large-scale integration of cancer microarray data identifies a robust common cancer signature.  BMC Bioinformatics.  8.
  • Tanskanen AJ, Greenstein JL, Chen A, Sun SX, Winslow RL (2007).  Protein geometry and placement in the cardiac dyad influence macroscopic properties of calcium-induced calcium release.  Biophysical Journal.  92(10).
  • Anderson TJ, Tchernyshyov I, Diez R, Cole RN, Geman D, Dang CV, Winslow RL (2007).  Discovering robust protein biomarkers for disease from relative expression reversals in 2-D DIGE data.  Proteomics.  7(8).
  • Bober MB, Winslow R (2007).  Developing computational resources in cardiac gene expression.  Methods in Molecular Biology.  366.
  • Cao Y, Miller MI, Mori S, Winslow RL, Younes L (2006).  Diffeomorphic matching of diffusion tensor images.  Proceedings of the IEEE Computer Society Conference on Computer Vision and Pattern Recognition.  2006.
  • Tanskanen AJ, Winslow RL (2006).  Integrative structurally detailed model of calcium dynamics in the cardiac diad.  Multiscale Modeling and Simulation.  5(4).
  • Yang CG, Granite SJ, Van Eyk JE, Winslow RL (2006).  MASCOT HTML and XML parser: An implementation of a novel object model for protein identification data.  Proteomics.  6(21).
  • Winslow RL, Tanskanen A, Chen M, Greenstein JL (2006).  Multiscale modeling of calcium signaling in the cardiac dyad.  Annals of the New York Academy of Sciences.  1080.
  • Cortassa S, Aon MA, O'Rourke B, Jacques R, Tseng HJ, Marbán E, Winslow RL (2006).  A computational model integrating electrophysiology, contraction, and mitochondrial bioenergetics in the ventricular myocyte.  Biophysical Journal.  91(4).
  • Gao Z, Tomaselli G, Wei C, Winslow R (2006).  Constructing gene expression-based diagnostic rules for understanding individualized etiology of heart failure.  Journal of Cardiothoracic-Renal Research.  1(1).
  • Ideker T, Winslow LR, Lauffenburger AD (2006).  Bioengineering and systems biology.  Annals of Biomedical Engineering.  34(2).
  • Helm PA, Younes L, Beg MF, Ennis DB, Leclercq C, Faris OP, McVeigh E, Kass D, Miller MI, Winslow RL (2006).  Evidence of structural remodeling in the dyssynchronous failing heart.  Circulation Research.  98(1).
  • Hinch R, Greenstein JL, Winslow RL (2006).  Multi-scale models of local control of calcium induced calcium release.  Progress in Biophysics and Molecular Biology.  90(1-3).
  • Gao Z, Xu H, DiSilvestre D, Halperin VL, Tunin R, Tian Y, Yu W, Winslow RL, Tomaselli GF (2006).  Transcriptomic profiling of the canine tachycardia-induced heart failure model: Global comparison to human and murine heart failure.  Journal of Molecular and Cellular Cardiology.  40(1).
  • Greenstein JL, Hinch R, Winslow RL (2006).  Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte.  Biophysical Journal.  90(1).
  • Cao Y, Miller MI, Winslow RL, Younes L (2005).  Large deformation diffeomorphic metric mapping of fiber orientations.  Proceedings of the IEEE International Conference on Computer Vision.  II.
  • Winslow RL, Hinch R, Greenstein JL (2005).  Mechanisms and models of cardiac excitation-contraction coupling.  Lecture Notes in Mathematics.  1867.
  • Tan AC, Naiman DQ, Xu L, Winslow RL, Geman D (2005).  Simple decision rules for classifying human cancers from gene expression profiles.  Bioinformatics.  21(20).
  • Xu L, Tan AC, Naiman DQ, Geman D, Winslow RL (2005).  Robust prostate cancer marker genes emerge from direct integration of inter-study microarray data.  Bioinformatics.  21(20).
  • Helm PA, Tseng HJ, Younes L, McVeigh ER, Winslow RL (2005).  Ex vivo 3D diffusion tensor imaging and quantification of cardiac laminar structure.  Magnetic Resonance in Medicine.  54(4).
  • Cao Y, Miller MI, Winslow RL, Younes L (2005).  Large deformation diffeomorphic metric mapping of vector fields.  IEEE Transactions on Medical Imaging.  24(9).
  • Helm P, Beg MF, Miller MI, Winslow RL (2005).  Measuring and mapping cardiac fiber and laminar architecture using diffusion tensor MR imaging.  Annals of the New York Academy of Sciences.  1047.
  • Winslow RL, Gao Z (2005).  Candidate gene discovery in cardiovascular disease.  Circulation Research.  96(6).
  • Winslow RL, Cortassa S, Greenstein JL (2005).  Using models of the myocyte for functional interpretation of cardiac proteomic data.  Journal of Physiology.  563(1).
  • Tanskanen AJ, Greenstein JL, O'Rourke B, Winslow RL (2005).  The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations.  Biophysical Journal.  88(1).
  • Winslow RL, Greenstein JL (2004).  The ongoing journey to understand heart function through integrative modeling.  Circulation Research.  95(12).
  • Geman D, D'Avignon C, Naiman DQ, Winslow RL (2004).  Classifying gene expression profiles from pairwise mRNA comparisons.  Statistical Applications in Genetics and Molecular Biology.  3(1).
  • Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL (2004).  A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes.  Biophysical Journal.  87(6).
  • Beg MF, Helm PA, McVeigh E, Miller MI, Winslow RL (2004).  Computational cardiac anatomy Using MRI.  Magnetic Resonance in Medicine.  52(5).
  • Cortassa S, Aon MA, Winslow RL, O'Rourke B (2004).  A mitochondrial oscillator dependent on reactive oxygen species.  Biophysical Journal.  87(3).
  • Iyer V, Mazhari R, Winslow RL (2004).  A computational model of the human left-ventricular epicardial myocyte.  Biophysical Journal.  87(3).
  • Greenstein JL, Tanskanen AJ, Winslow RL (2004).  Modeling the actions of β-adrenergic signaling on excitation- contraction coupling processes.  Annals of the New York Academy of Sciences.  1015.
  • Yung CK, Halperin VL, Tomaselli GF, Winslow RL (2004).  Gene expression profiles in end-stage human idiopathic dilated cardiomyopathy: Altered expression of apoptotic and cytoskeletal genes.  Genomics.  83(2).
  • Dos Remedios CG, Liew CC, Allen PD, Winslow RL, Van Eyk JE, Dunn MJ (2003).  Genomics, proteomics and bioinformatics of human heart failure.  Journal of Muscle Research and Cell Motility.  24(4-6).
  • Armoundas AA, Hobai IA, Tomaselli GF, Winslow RL, O'Rourke B (2003).  Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts.  Circulation Research.  93(1).
  • Winslow RL, Boguski MS (2003).  Genome informatics: Current status and future prospects.  Circulation Research.  92(9).
  • Cortassa S, Aon MA, Marbán E, Winslow RL, O'Rourke B (2003).  An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics.  Biophysical Journal.  84(4).
  • Mazhari R, Marbán E, Winslow RL (2002).  Regulation of cardiac repolarization by adenoviral gene transfer rationalized by computational modeling.  Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings.  3.
  • Winslow RL, Helm P, Baumgartner W, Peddi S, Ratnanather T, McVeigh E, Miller MI, Hunter, McCulloch (2002).  Imaging-based integrative models of the heart: Closing the loop between experiment and simulation.  Novartis Foundation Symposium.  247.
  • Greenstein JL, Winslow RL (2002).  An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release.  Biophysical Journal.  83(6).
  • Bober M, Wiehe K, Yung C, Suzek TO, Lin M, Baumgartner W, Winslow R (2002).  CaGE: Cardiac gene expression knowledgebase.  Bioinformatics.  18(7).
  • Mazhari R, Bradley Nuss H, Armoundas AA, Winslow RL, Marbán E (2002).  Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval.  Journal of Clinical Investigation.  109(8).
  • Higgins G, Athey B, Bassingthwaighte J, Burgess J, Champion H, Cleary K, Dev P, Duncan J, Hopmeier M, Jenkins D, Johnson C, Kelly H, Leitch R, Lorensen W, Metaxas D, Spitzer V, Vaidehi N, Vosburgh K, Winslow R (2001).  Final report of the meeting "modeling & simulation in medicine: Towards an integrated framework".  Computer Aided Surgery.  6(1).
  • Winslow RL, Scollan DF, Greenstein JL, Yung CK, Baumgartner W. J, Bhanot G, Gresh DL, Rogowitz BE (2001).  Mapping, modeling, and visual exploration of structure-function relationships in the heart.  IBM Systems Journal.  40(2).
  • Mazhari R, Greenstein JL, Winslow RL, Marbán E, Nuss HB (2001).  Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis.  Circulation Research.  89(1).
  • Winslow RL, Greenstein JL, Tomaselli GF, O'Rourke B (2001).  Computational models of the failing myocyte: Relating altered gene expression to cellular function.  Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.  359(1783).
  • Winslow R, Greenstein J, Delmar P (2000).  Modulation of the cardiac ventricular myocyte action potential by intracellular calcium.  Annals of Biomedical Engineering.  28(SUPPL. 1).
  • Rice JJ, Jafri MS, Winslow R (2000).  Computational modeling of short-term interval-force relations in single cardiac myocytes.  Annals of Biomedical Engineering.  28(SUPPL. 1).
  • Scollan DF, Holmes A, Zhang J, Winslow RL (2000).  Reconstruction of cardiac ventricular geometry and fiber orientation using magnetic resonance imaging.  Annals of Biomedical Engineering.  28(8).
  • Entcheva E, Colecraft HM, Yue D, Winslow R, Tung L (2000).  Genetic augmentation of Ca2+ channels in cell monolayers: comparing optical recordings and computer simulations of modulated action potentials.  Annals of Biomedical Engineering.  28(SUPPL. 1).
  • Winslow RL, Scollan DF, Holmes A, Yung CK, Zhang J, Jafri MS (2000).  Electrophysiological modeling of cardiac ventricular function: From cell to organ.  Annual Review of Biomedical Engineering.  2(2000).
  • Kohl P, Noble D, Winslow RL, Hunter PJ (2000).  Computational modelling of biological systems: Tools and visions.  Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.  358(1766).
  • Greenstein J, Delmar P, Winslow R (2000).  Combining stochastic and deterministic methods to simulate local control by diadic Ca2+ during a ventricular action potential.  Annals of Biomedical Engineering.  28(SUPPL. 1).
  • Gresh DL, Rogowitz BE, Winslow RL, Scollan DF, Yung CK (2000).  WEAVE: A system for visually linking 3-D and statistical visualizations, applied to cardiac simulation and measurement data.  Proceedings of the IEEE Visualization Conference.
  • Greenstein JL, Wu R, Po S, Tomaselli GF, Winslow RL (2000).  Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration.  Circulation Research.  87(11).
  • Holmes AA, Scollan DF, Winslow RL (2000).  Direct histological validation of diffusion tensor MRI in formaldehyde- fixed myocardium.  Magnetic Resonance in Medicine.  44(1).
  • Rice JJ, Jafri MS, Winslow RL (2000).  Modeling short-term interval-force relations in cardiac muscle.  American Journal of Physiology - Heart and Circulatory Physiology.  278(3 47-3).
  • Scollan DF, Holmes AA, Zhang J, Winslow RL (1999).  Reconstruction of myocardial architecture at high resolution using diffusion tensor MRI.  Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings.  2.
  • Winslow RL (1999).  Integrative modeling of cardiac arrhythmia: Relating gene expression to cell and tissue function.  Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings.  2.
  • Rice JJ, Jafri MS, Winslow RL (1999).  Modeling gain and gradedness of Ca2+ release in the functional unit of the cardiac diadic space.  Biophysical Journal.  77(4).
  • Steinmetz PN, Winslow RL (1999).  Optimal detection of flash intensity differences using rod photocurrent observations.  Neural Computation.  11(5).
  • Irvine LA, Jafri MS, Winslow RL (1999).  Cardiac sodium channel Markov model with temperature dependence and recovery from inactivation.  Biophysical Journal.  76(4).
  • Rice JJ, Winslow RL, Hunter WC (1999).  Comparison of putative cooperative mechanisms in cardiac muscle: Length dependence and dynamic responses.  American Journal of Physiology - Heart and Circulatory Physiology.  276(5 45-5).
  • Winslow RL, Rice J, Jafri S, Marbán E, O'Rourke B (1999).  Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: Model studies.  Circulation Research.  84(5).
  • Scollan DF, Holmes A, Winslow R, Forder J (1998).  Histological validation of myocardial microstructure obtained from diffusion tensor magnetic resonance imaging.  American Journal of Physiology - Heart and Circulatory Physiology.  44(6).
  • Scollan DF, Holmes A, Winslow R, Forder J (1998).  Histological validation of myocardial microstructure obtained from diffusion tensor magnetic resonance imaging.  American Journal of Physiology - Heart and Circulatory Physiology.  275(6 44-6).
  • Maryak JL, Smith RH, Winslow RL (1998).  Modeling cardiac ion channel conductivity: Model fitting via simulation.  Winter Simulation Conference Proceedings.  2.
  • Zhang H, Winslow RW, Holden AV (1998).  Re-entrant excitation initiated in models of inhomogeneous atrial tissue.  Journal of Theoretical Biology.  191(3).
  • Jafri MS, Rice JJ, Winslow RL (1998).  Cardiac Ca2+ dynamics: The roles of ryanodine receptor adaptation and sarcoplasmic reticulum load.  Biophysical Journal.  74(3).
  • Winslow RL, Rice J, Jafri S (1998).  Modeling the cellular basis of altered excitation-contraction coupling in heart failure.  Progress in Biophysics and Molecular Biology.  69(2-3).
  • Rice JJ, Winslow RL, Dekanski J, McVeigh E (1998).  Model studies of the role of mechano-sensitive currents in the generation of cardiac arrhythmias.  Journal of Theoretical Biology.  190(4).
  • Rice JJ, Jafri MS, Winslow RL (1998).  Modeling short-term interval-force relations in cardiac muscle.  Annals of the New York Academy of Sciences.  853.
  • Demir SS, O'Rourke B, Tomaselli GF, Marban E, Winslow RL (1996).  Action potential variation in canine ventricle: A modeling study.  Computers in Cardiology.  0(0).
  • Irvine LA, Winslow RL (1996).  Numerical studies of use-dependent block of cardiac sodium channels by quinidine on spiral wave reentry.  Computers in Cardiology.  0(0).
  • Noble D, Leguennec JY, Winslow R (1996).  Functional roles of sodium-calcium exchange in normal and abnormal cardiac rhythm.  Annals of the New York Academy of Sciences.  779.
  • Winslow RL (1995).  Propagation of electrical activity in the SA node.  Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings.  17(1).
  • Lai YC, Winslow RL (1995).  Geometric properties of the chaotic saddle responsible for supertransients in spatiotemporal chaotic systems.  Physical Review Letters.  74(26).
  • Winslow RL, Cai D, Varghese A, Lai YC (1995).  Generation and propagation of normal and abnormal pacemaker activity in network models of cardiac sinus node and atrium.  Chaos, Solitons and Fractals.  5(3-4).
  • Winslow RL, Cai D, Lai YC (1994).  Factors controlling generation and propagation of pacemaker potentials in network models of mammalian SA node.  Proceedings of the ACM/IEEE Supercomputing Conference.
  • Lai YC, Winslow RL, Sachs MB (1994).  A model of selective processing of auditory-nerve inputs by stellate cells of the antero-ventral cochlear nucleus.  Journal of Computational Neuroscience.  1(3).
  • Lai YC, Winslow RL (1994).  Extreme sensitive dependence on parameters and initial conditions in spatio-temporal chaotic dynamical systems.  Physica D: Nonlinear Phenomena.  74(3-4).
  • Varghese A, Winslow RL (1994).  Dynamics of Abnormal Pacemaking Activity in Cardiac Purkinje Fibers.  Journal of Theoretical Biology.  168(4).
  • Lai YC, Winslow RL (1994).  Riddled parameter space in spatiotemporal chaotic dynamical systems.  Physical Review Letters.  72(11).
  • Cai D, Winslow RL, Noble D (1994).  Effects of Gap Junction Conductance on Dynamics of Sinoatrial Node Cells: Two-Cell and Large-Scale Network Models.  IEEE Transactions on Biomedical Engineering.  41(3).
  • Lai YC, Winslow RL (1994).  Fractal basin boundaries in coupled map lattices.  Physical Review E.  50(5).
  • Cai D, Lai YC, Winslow RL (1993).  Periodicity, quasiperiodicity, and chaos in coupled cardiac pacemaker cells.  Proceedings of SPIE - The International Society for Optical Engineering.  2036.
  • Winslow RL, Varghese A, Noble D, Adlakha G, Hoythya A (1993).  Generation and propagation of ectopic beats induced by spatially localized Na-K pump inhibition in atrial network models.  Proceedings of the Royal Society B: Biological Sciences.  253(1339).
  • Varghese A, Winslow RL (1993).  Dynamics of the calcium subsystem in cardiac Purkinje fibers.  Physica D: Nonlinear Phenomena.  68(3-4).
  • Winslow RL, Kimball AL, Varghese A, Noble D (1993).  Simulating cardiac sinus and atrial network dynamics on the connection machine.  Physica D: Nonlinear Phenomena.  64(1-3).
  • Cai D, Lai YC, Winslow RL (1993).  Complex dynamics in coupled cardiac pacemaker cells.  Physical Review Letters.  71(15).
  • Winslow R, Varghese A, Noble D, Denyer JC, Kimball A (1992).  Modelling large SA node-atrial cell networks on a massively parallel computer.  Journal of Physiology.  446.
  • Winslow RL, Knapp AG (1991).  Dynamic models of the retinal horizontal cell network.  Progress in Biophysics and Molecular Biology.  56(2).
  • Winslow RL, Ma S (1990).  Bifurcation analysis of nonlinear retinal horizontal cell models. II. Network properties.  Journal of Neurophysiology.  64(1).
  • Winslow RL, Miller RF, Ogden TE (1989).  Functional role of spines in the retinal horizontal cell network.  Proceedings of the National Academy of Sciences of the United States of America.  86(1).
  • Sachs MB, Winslow RL, Sokolowski BHA (1989).  A computational model for rate-level functions from cat auditory-nerve fibers.  Hearing Research.  41(1).
  • Winslow RL, Miller RF (1989).  A theoretical and experimental study of the effects of non-uniform membrane resistance on the shape of single-cell charging curves.  Neuroscience.  29(3).
  • Winslow RL (1989).  Bifurcation analysis of nonlinear retinal horizontal cell models. I. Properties of isolated cells.  Journal of Neurophysiology.  62(3).
  • Winslow RL, Sachs MB (1988).  Single-tone intensity discrimination based on auditory-nerve rate responses in backgrounds of quiet, noise, and with stimulation of the crossed olivocochlear bundle.  Hearing Research.  35(2-3).
  • Winslow RL, Sachs MB (1987).  Effect of electrical stimulation of the crossed olivocochlear bundle on auditory nerve response to tones in noise.  Journal of Neurophysiology.  57(4).
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