Spector, Alexander

Research Professor
Biomedical Engineering

Traylor 411
(410) 502-6955
aspector@jhu.edu

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About

Education
  • Doctor of Science 1991, Russian Academy of Sciences
Experience
  • 2012 - Present:  LECTURER, WSE Engineering for Professionals (EP)
Awards
  • 2011:  Provost Undergraduate Research Award as faculty advisor to the undergraduate student R.J. Powers
  • 2010:  Elected as a Fellow of the American Society of Mechanical Engineerins (ASME)
  • 2010:  Served as a Member of the International Scientific Board of the 1st Congress on NanoMedicine - Beijing China
  • 2003:  Comcast Corporation Award in Auditory Sciences from National Organisation for Hearing Research Foundation
  • 2003:  Provost Undergraduate Research Award as faculty advisor to the undergraduate student W. Hsu

Publications

Journal Articles
  • Yuan D, Somers SM, Grayson WL, Spector AA (2018).  A Poroelastic Model of a Fibrous-Porous Tissue Engineering Scaffold.  Scientific Reports.  8(1).
  • Spector AA, Yuan D, Somers S, Grayson WL (2018).  Biomechanics of stem cells.  Journal of Physics: Conference Series.  991(1).
  • Spector AA, Grayson WL (2017).  Stem Cell Fate Decision Making: Modeling Approaches.  ACS Biomaterials Science and Engineering.  3(11).
  • Somers SM, Spector AA, Digirolamo DJ, Grayson WL (2017).  Biophysical stimulation for engineering functional skeletal muscle.  Tissue Engineering - Part B: Reviews.  23(4).
  • Deshpande RS, Spector AA (2017).  Modeling Stem Cell Myogenic Differentiation.  Scientific Reports.  7.
  • Deshpande RS, Grayson WL, Spector AA (2015).  A modeling insight into adipose-derived stem cell myogenesis.  PLoS ONE.  10(9).
  • Harland B, Lee Wh, Brownell WE, Sun SX, Spector AA (2015).  The potential and electric field in the cochlear outer hair cell membrane.  Medical and Biological Engineering and Computing.  53(5).
  • Powers RJ, Kulason S, Atilgan E, Brownell WE, Sun SX, Barr-Gillespie PG, Spector AA (2014).  The local forces acting on the mechanotransduction channel in hair cell stereocilia.  Biophysical Journal.  106(11).
  • Powers RJ, Kulason S, Atilgan E, Brownell WE, Sun S, Barr-Gillespie PG, Spector A (2014).  The Local Forces Acting on the Mechanotransduction Channel in Hair Cell Stereocilia.  Biophysical Journal.  106(11).  2519-2528.
  • Huri PY, Wang A, Spector AA, Grayson WL (2014).  Multistage Adipose-Derived Stem Cell Myogenesis: An Experimental and Modeling Study.  Cellular and Molecular Bioengineering.  7(4).
  • Khatibzadeh N, Spector AA, Brownell WE, Anvari B (2014).  Rate-dependent dynamics of cellular membranes probed by laser tweezers and optical displacement sensing.  Progress in Biomedical Optics and Imaging - Proceedings of SPIE.  8946.
  • Khatibzadeh N, Spector AA, Brownell WE, Anvari B (2013).  Effects of Plasma Membrane Cholesterol Level and Cytoskeleton F-Actin on Cell Protrusion Mechanics.  PLoS ONE.  8(2).
  • Roy S, Brownell WE, Spector AA (2012).  Modeling electrically active viscoelastic membranes.  PLoS ONE.  7(5).
  • Lau C, Brownell WE, Spector AA (2012).  Internal forces, tension and energy density in tethered cellular membranes.  Journal of Biomechanics.  45(7).
  • Powers RJ, Roy S, Atilgan E, Brownell WE, Sun SX, Gillespie PG, Spector AA (2012).  Stereocilia membrane deformation: Implications for the gating spring and mechanotransduction channel.  Biophysical Journal.  102(2).
  • Powers RJ, Roy S, Atilgan E, Brownell WE, Sun S, Gillespie PG, Spector A (2012).  Stereocilia Membrane Deformation: Implications for the Gating Spring and Mechanotransduction Channel.  Biophysical Journal.  102(2).  201-210.
  • Nilsen N, Brownell WE, Sun S, Spector A (2012).  Effect of membrane mechanics on charge transfer by the membrane protein prestin..  Biomech Model Mechanobiol.  11(1-2).  107-18.
  • Nilsen N, Brownell WE, Sun S, Spector A (2012).  Effect of membrane mechanics on charge transfer by the membrane protein prestin.  Biomechanics and Modeling in Mechanobiology.  11(1-2).  107-118.
  • Nilsen N, Brownell WE, Sun SX, Spector AA (2012).  Effect of membrane mechanics on charge transfer by the membrane protein prestin.  Biomechanics and Modeling in Mechanobiology.  11(1-2).
  • Spector A (2011).  Outer hair cell electromotility in vivo: Comments and discussion.  AIP Conference Proceedings.  1403.
  • Harland B, Brownell WE, Spector AA, Sun SX (2010).  Voltage-induced bending and electromechanical coupling in lipid bilayers.  Physical Review E - Statistical, Nonlinear, and Soft Matter Physics.  81(3).
  • Schumacher K, Popel A, Anvari B, Brownell W, Spector A (2009).  Computational analysis of the tether pulling experiment to probe cellular membranes.  Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009.  (PART A).
  • Schumacher KR, Popel AS, Anvari B, Brownell WE, Spector AA (2009).  Computational analysis of the tether-pulling experiment to probe plasma membrane-cytoskeleton interaction in cells.  Physical Review E - Statistical, Nonlinear, and Soft Matter Physics.  80(4).
  • Sun SX, Farrell B, Chana MS, Oster G, Brownell WE, Spector AA (2009).  Voltage and frequency dependence of prestin-associated charge transfer.  Journal of Theoretical Biology.  260(1).
  • Cheshire AM, Kerman BE, Zipfel WR, Spector AA, Andrew DJ (2008).  Kinetic and mechanical analysis of live tube morphogenesis.  Developmental Dynamics.  237(10).
  • Schumacher KR, Popel AS, Anvari B, Brownell WE, Spector AA (2008).  Modeling the mechanics of tethers pulled from the cochlear outer hair cell membrane.  Journal of Biomechanical Engineering.  130(3).
  • Liao Z, Feng S, Popel AS, Brownell WE, Spector AA (2007).  Outer hair cell active force generation in the cochlear environment.  Journal of the Acoustical Society of America.  122(4).
  • Spector A, DEO N, GROSH K, Ratnanather J, RAPHAEL R (2006).  Electromechanical models of the outer hair cell composite membrane.  Journal of Membrane Biology.  209(2-3).  135-152.
  • Spector AA, Deo N, Grosh K, Ratnanather JT, Raphael RM (2006).  Electromechanical models of the outer hair cell composite membrane.  Journal of Membrane Biology.  209(2-3).
  • Liao Z, Popel AS, Brownell WE, Spector AA (2005).  Effect of voltage-dependent membrane properties on active force generation in cochlear outer hair cell.  Journal of the Acoustical Society of America.  118(6).
  • Liao Z, Popel AS, Brownell WE, Spector AA (2005).  High-frequency force generation in the constrained cochlear outer hair cell: A model study.  JARO - Journal of the Association for Research in Otolaryngology.  6(4).
  • Spector AA, Popel AS, Eatock RA, Brownell WE (2005).  Mechanosensitive channels in the lateral wall can enhance the cochlear outer hair cell frequency response.  Annals of Biomedical Engineering.  33(8).
  • Nelson CM, Jean RP, Tan JL, Liu WF, Sniadecki NJ, Spector AA, Chen CS (2005).  Emergent patterns of growth controlled by multicellular form and mechanics.  Proceedings of the National Academy of Sciences of the United States of America.  102(33).
  • Jean RP, Chen CS, Spector AA (2005).  Finite-element analysis of the adhesion-cytoskeleton-nucleus mechanotransduction pathway during endothelial cell rounding: Axisymmetric model.  Journal of Biomechanical Engineering.  127(4).
  • Spector AA (2005).  Effectiveness, active energy produced by molecular motors, and nonlinear capacitance of the cochlear outer hair cell.  Journal of Biomechanical Engineering.  127(3).
  • Liao Z, Popel AS, Brownell WE, Spector AA (2005).  Modeling high-frequency electromotility of cochlear outer hair cell in microchamber experiment.  Journal of the Acoustical Society of America.  117(4 I).
  • Murdock DR, Ermilov SA, Spector AA, Popel AS, Brownell WE, Anvari B (2005).  Effects of chlorpromazine on mechanical properties of the outer hair cell plasma membrane.  Biophysical Journal.  89(6).
  • Jean RP, Gray DS, Spector AA, Chen CS (2004).  Characterization of the nuclear deformation caused by changes in endothelial cell shape.  Journal of Biomechanical Engineering.  126(5).
  • Spector AA, Jean RP (2004).  Modes and balance of energy in the piezoelectric cochlear outer hair cell wall.  Journal of Biomechanical Engineering.  126(1).
  • Spector AA, Brownell WE, Popel AS (2003).  Effect of outer hair cell piezoelectricity on high-frequency receptor potentials.  Journal of the Acoustical Society of America.  113(1).
  • Jean RP, Chen CS, Spector AA (2003).  Analysis of the deformation of the nucleus as a result of alterations of the cell adhesion area.  American Society of Mechanical Engineers, Bioengineering Division (Publication) BED.  55.
  • Spector AA, Jean RP (2003).  Elastic moduli of the piezoelectric cochlear outer hair cell membrane.  Experimental Mechanics.  43(3).
  • Spector AA, Jean RP (2002).  Balance and modes of energy in the piezoelectric cochlear outer hair cell wall.  Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings.  1.
  • Spector AA, Brownell WE, Popel AS (2002).  Effect of outer hair cell membrane piezoelectric properties on the receptor potential under high-frequency conditions.  Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings.  1.
  • Spector AA, Ameen M, Charalambides PG, Popel AS (2002).  Nanostructure, effective properties, and deformation pattern of the cochlear outer hair cell cytoskeleton.  Journal of Biomechanical Engineering.  124(2).
  • Brownell WE, Spector AA, Raphael RM, Popel AS (2001).  Micro- and nanomechanics of the cochlear outer hair cell.  Annual Review of Biomedical Engineering.  3.
  • Spector AA (2001).  Nonlinear electroelastic model of the auditory outer hair cell.  International Journal of Solids and Structures.  38(10-13).
  • Spector AA, Ameen M, Popel AS (2001).  Simulation of motor-driven cochlear outer hair cell electromotility.  Biophysical Journal.  81(1).
  • Spector A, Ameen M, Popel A (2000).  Simulation of cochlear outer hair cell electromotility.  Annals of Biomedical Engineering.  28(SUPPL. 1).
  • Spector A (2000).  Nonlinear electromechanical model for the cochlear outer hair cell.  Annals of Biomedical Engineering.  28(SUPPL. 1).
  • Spector A, Ameen M, Charalambides P, Popel A (2000).  Computational modeling of the cochlear outer hair cell cytoskeleton.  Annals of Biomedical Engineering.  28(SUPPL. 1).
  • Spector AA (2000).  On the mechanoelectrical coupling in the cochlear outer hair cell.  Journal of the Acoustical Society of America.  107(3).
  • Spector AA, Ameen M, Charalambides PG, Popel AS (1999).  Mechanical properties of the outer hair cell cytoskeleton: simulation of the microstructure and molecular organization.  American Society of Mechanical Engineers, Bioengineering Division (Publication) BED.  42.
  • Spector AA (1999).  Electroelastic model of the cochlear outer hair cell.  American Society of Mechanical Engineers, Bioengineering Division (Publication) BED.  42.
  • Spector AA (1999).  Nonlinear electroelastic model for the composite outer hair cell wall.  ORL.  61(5).
  • Spector AA, Brownell WE, Popel AS (1999).  Nonlinear active force generation by cochlear outer hair cell.  Journal of the Acoustical Society of America.  105(4).
  • Spector AA, Brownell WE, Popel AS (1999).  Mechanical and electromotile characteristics of auditory outer hair cells.  Medical and Biological Engineering and Computing.  37(2).
  • Spector AA, Brownell WE, Popel AS (1998).  Elastic properties of the composite outer hair cell wall.  Annals of Biomedical Engineering.  26(1).
  • Spector AA, Brownell WE, Popel AS (1998).  Estimation of elastic moduli and bending stiffness of the anisotropic outer hair cell wall.  Journal of the Acoustical Society of America.  103(2).
  • Spector AA, Brownell WE, Popel AS (1998).  Analysis of the micropipet experiment with the anisotropic outer hair cell wall.  Journal of the Acoustical Society of America.  103(2).
  • Sit PS, Spector AA, Lue AJC, Popel AS, Brownell WE (1997).  Micropipette aspiration on the outer hair cell lateral wall.  Biophysical Journal.  72(6).
  • Spector AA, Brownell WE, Popel AS (1997).  Estimation of elastic characteristics of the auditory outer hair cell.  American Society of Mechanical Engineers, Bioengineering Division (Publication) BED.  35.
  • Spector AA, Brownell WE, Popel AS (1996).  A model for cochlear outer hair cell deformations in micropipette aspiration experiments: An analytical solution.  Annals of Biomedical Engineering.  24(2).
  • Spector AA, Brownell WE, Popel AS (1996).  An elastic model of a composite cell membrane: interpretation and design of experiments.  American Society of Mechanical Engineers, Bioengineering Division (Publication) BED.  33.
  • Spector AA, Batra RC (1996).  On elastic joints containing interfacial cracks.  Engineering Fracture Mechanics.  53(3).
  • Spector AA, Batra RC (1996).  Rolling/sliding of a vibrating elastic body on an elastic substrate.  Journal of Tribology.  118(1).
  • Spector AA, Batra RC (1995).  Rolling/sliding of a vibrating elastic body on an elastic substrate.  American Society of Mechanical Engineers (Paper).
  • Spector AA, Brownell WE, Popel AS (1995).  Mechanical model of the outer hair cell wall.  American Society of Mechanical Engineers, Bioengineering Division (Publication) BED.  31.
  • Spector A, Batra RC (1995).  On contact interaction between a moving massive body and a linear elastic half space.  Continuum Mechanics and Thermodynamics.  7(2).
  • Spector A, Batra RC (1995).  On the motion of an elastic body rolling/sliding on an elastic substrate.  Journal of Tribology.  117(2).
  • Spector A, Batra RC (1994).  On the motion of an elastic body rolling/sliding on an elastic substrate.  American Society of Mechanical Engineers (Paper).
  • Spector A, Batra RC (1994).  Rolling/sliding of a linear elastic body on a deformable layered substrate.  International Journal of Non-Linear Mechanics.  29(3).
Books
  • Sun S, Farrell B, Chana M, Feng S, Oster G, Brownell W, Spector A, Cooper N, Kemp D (2009).  VOLTAGE AND FREQUENCY DEPENDENCE OF CHARGE TRANSFER BY PRESTIN: AN ELECTRO-DIFFUSION MODEL.  385-390.
Book Chapters
  • Spector AA, Tran-Son-Tay R (2014).  Modeling in cellular biomechanics.  Biomechanics: Principles and Practices.
  • Spector AA (2003).  Modeling a piezoelectric biological membrane.  Computational Fluid and Solid Mechanics 2003.
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