Ratnanather, John

Assoc Research Professor
Biomedical Engineering
http://cis.jhu.edu/~tilak

Clark Hall 308B
(410) 516-3826
jratnan1@jhmi.edu

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About

Education
  • Ph.D. 1989, University of Oxford
Research Areas
  • AUDITORY training
  • Analytical methods for solving nonlinear partial differential eqs in biology
  • Analytical methods for solving nonlinear partial differential eqs in fluid mechanics
  • Auditory Cortex
  • Boundary layer seperation
  • Brain
  • Cingulate gyrus
  • Cochlear Implants
  • Cochlear fluid mechanics
  • Computational methods for solving nonlinear partial differential eqs in biology
  • Computational methods for solving nonlinear partial differential eqs in fluid mechanics
  • EPDiff
  • Hearing Aids
  • Hearing Loss
  • Hippocampus
  • IMAGE analysis
  • MATHEMATICAL models
  • Mathematical models of physiological fluidmechanics
  • Medial prefrontal cortex
  • Micromechanics of cochlear outer hair cell
  • Mobile Applications
  • Neurodeve
  • Neuropyschiatric
  • Online webcourses in applied mathematics
  • Planum temporale
  • Superior temporal gyrus
  • Web applications
Awards
  • 2015:  2012 Presidential Award for Excellence in Science, Mathematics and Engineering Mentoring
  • 2013:  2012 Farrington Daniels Award
  • 2001:  National Partnership in Advanced Computational Infrastructure Diversity in Computing Travel Award.
  • 1994:  NSF/University of California Program in Mathematics and Molecular Biology Postdoctoral Fellow
  • 1991:  Royal Society of London - Australian Academy of Sciences Postdoctoral Fellow

Publications

Journal Articles
  • Miller M, Younes E, Ratnanather J, Brown T, Trinh H, Lee D, Tward D, Mahon PB, Mori S, Albert M (2015).  Amygdalar atrophy in symptomatic Alzheimer's disease based on diffeomorphometry: the BIOCARD cohort..  Neurobiology of aging.  36 Suppl 1.  S3-S10.
  • Miller M, Younes L, Ratnanather J, Brown T, Trinh H, Lee D, Tward D, Mahon PB, Mori S, Albert M (2015).  Amygdalar atrophy in symptomatic Alzheimer's disease based on diffeomorphometry: the BIOCARD cohort..  Neurobiology of aging.  36 Suppl 1.  S3-S10.
  • Younes L, Ratnanather J, Brown T, Aylward E, Nopoulos P, Johnson H, Magnotta VA, Paulsen JS, Margolis RL, Albin RL, Miller M, Ross CA (2014).  Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis..  Human brain mapping.  35(3).  792-809.
  • Ratnanather J, Faria A, Ross C, Younes L, Miller M (2014).  Shape analysis of basal ganglia structures in Huntington's Disease.
  • Faria A, van den Noort F, Ratnanather J, Ross C, Mori S, Younes L, Miller M (2014).  Linking cortical and basal ganglia abnormalities in prodromal Huntington's Disease.
  • Kulason S, Tward DJ, Ng K, Zhang J, Krakauer J, Ratnanather J, O’Brien R, Miller M (2014).  Anatomical Biomarkers of Learning in a murine model.
  • Miller M, Younes L, Ratnanather J, Brown T, Wang M, Lu Y, Li S, Pettigrew C, Mori S, Albert M (2013).  Medial temporal lobe changes preceding symptom onset of mild cognitive impairment: The BIOCARD Cohort.  Alzheimer's & Dementia: The Journal of the Alzheimer's Association.  9(4).  P54-P54.
  • Miller M, Younes L, Ratnanather J, Brown T, Trinh H, Postell E, Lee D, Wang MC, Mori S, O'Brien R, Albert M (2013).  The diffeomorphometry of temporal lobe structures in preclinical Alzheimer's disease..  NeuroImage. Clinical.  3.  352-60.
  • Miller M, Younes L, Ratnanather J, Brown T, Reigel T, Trinh H, Tang X, Barker P, Mori S, Albert M (2012).  Amygdala Atrophy in MCI/Alzheimer's Disease in the BIOCARD cohort based on Diffeomorphic Morphometry..  Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention.  2012.  155-166.
  • Younes L, Ratnanather J, Brown T, Aylward E, Nopoulos P, Johnson H, Magnotta VA, Paulsen JS, Margolis RL, Albin RL, others (2012).  Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis.  Human brain mapping.
  • Ratnanather J, Brown T, Trinh H, Younes L, Miller M, Mori S, Albert M (2012).  Shape analysis of hippocampus and amygdala in BIOCARD.  Alzheimer's & Dementia.  8(4).  P63.
  • Ceyhan E, Hosakere M, Nishino T, Alexopoulos J, Todd RD, Botteron KN, Miller M, Ratnanather J (2011).  Statistical Analysis of Cortical Morphometrics Using Pooled Distances Based on Labeled Cortical Distance Maps.  J Math Imaging Vis.  40(1).  20-35.
  • Ceyhan E, Beg MF, Ceritoglu C, Wang L, Morris JC, Csernansky JG, Miller M, Ratnanather J (2011).  Quantization and analysis of hippocampal morphometric changes due to dementia of Alzheimer type using metric distances based on large deformation diffeomorphic metric mapping.  Comput Med Imaging Graph.  35(4).  275-93.
  • Ceyhan E, Beg MF, Ceritoglu C, Wang L, Morris JC, Csernansky JG, Miller M, Ratnanather J (2011).  Metric Distances between Hippocampal Shapes Indicate Different Rates of Change Over Time in Nondemented and Demented Subjects.  Curr Alzheimer Res.
  • Penumetcha N, Kabadi S, Jedynak B, Walcutt C, Gado MH, Wang L, Ratnanather J (2011).  Feasibility of Geometric-Intensity-Based Semi-Automated Delineation of the Tentorium Cerebelli from MRI Scans.  Journal of Neuroimaging.  21(2).  e148-e155.
  • Tward DJ, Ceritoglu C, Kolasny A, Sturgeon GM, Segars WP, Miller M, Ratnanather J (2011).  Patient Specific Dosimetry Phantoms Using Multichannel LDDMM of the Whole Body.  Int J Biomed Imaging.  2011.  481064.
  • Arrate F, Ratnanather J, Younes L (2010).  DIFFEOMORPHIC ACTIVE CONTOURS..  SIAM journal on imaging sciences.  3(2).  176-198.
  • CERITOGLU C, WANG L, SELEMON LD, CSERNANSKY JG, Miller M, Ratnanather J (2010).  Large deformation diffeomorphic metric mapping registration of reconstructed 3D histological section images and in vivo MR images.  Frontiers in Human Neuroscience.  4.  Article No.: 43.
  • Qiu A, Wang L, Younes L, Harms MP, Ratnanather J, Miller M, Csernansky JG (2009).  Neuroanatomical asymmetry patterns in individuals with schizophrenia and their non-psychotic siblings..  NeuroImage.  47(4).  1221-9.
  • Miller M, Priebe C, Qiu A, Fischl B, Kolasny A, Brown T, Park Y, Ratnanather J, Busa E, Jovicich J, Yu P, Dickerson BC, Buckner RL, BIRN M (2009).  Collaborative computational anatomy: an MRI morphometry study of the human brain via diffeomorphic metric mapping..  Human brain mapping.  30(7).  2132-2141.
  • Steinert-Threlkeld S, Ratnanather J (2009).  Open Standards, Web-Based Mathlets: Making Interactive Tutorials Using the HTML5 canvas Element.  Loci.
  • Penumetcha N, Jedynak B, Hosakere M, Ceyhan E, Botteron KN, Ratnanather J (2008).  Segmentation of arteries in MPRAGE images of the ventral medial prefrontal cortex.  Computerized Medical Imaging and Graphics.  32(1).  36-43.
  • Zhang S, Younes L, Zweck J, Ratnanather J (2008).  DIFFEOMORPHIC SURFACE FLOWS: A NOVEL METHOD OF SURFACE EVOLUTION..  SIAM journal on applied mathematics.  68(3).  806-824.
  • LEE NA, Priebe C, Miller M, Ratnanather J (2008).  Validation of alternating Kernel mixture method: Application to tissue segmentation of cortical and subcortical structures.  Journal of Biomedicine & Biotechnology.  Article No.: 346129.
  • Qiu A, Younes L, Wang L, Ratnanather J, Gillepsie SK, Kaplan G, Csernansky J, Miller M (2007).  Combining anatomical manifold information via diffeomorphic metric mappings for studying cortical thinning of the cingulate gyrus in schizophrenia..  NeuroImage.  37(3).  821-33.
  • Qiu A, Younes L, Wang L, Ratnanather J, Csernansky JG, Miller M (2007).  Cortical thinning of the cingulate gyrus in schizophrenia.  International Congress on Schizophrenia Research, Colorado Springs, CO.
  • Spector A, DEO N, GROSH K, Ratnanather J, RAPHAEL R (2006).  Electromechanical models of the outer hair cell composite membrane.  Journal of Membrane Biology.  209(2-3).  135-152.
  • Priebe C, Miller M, Ratnanather J (2006).  Segmenting magnetic resonance images via hierarchical mixture modelling.  Computational Statistics and Data Analysis.  50(2).  551-567.
  • QIU A, BITOUK D, Wang L, Ratnanather J, CSERNANSKY J, Miller M (2005).  Cingulate cortical thickness variability on the gray/white surface.  Schizophrenia Bulletin.  31(2).  404-404.
  • Beg MF, Ceritoglu C, Kolasny AE, Priebe C, Ratnanather J, Yashinski R, Younes L, Yu P, Jovicich J, Buckner RL, others (2004).  Biomedical Informatics Research Network: Multi-Site Processing Pipeline for Shape Analysis of Brain Structures.  Human Brain Mapping, 10th Annual Meeting; Budapest, Hungary.
  • Holm DD, Ratnanather J, Trouvé A, Younes L (2004).  Soliton dynamics in computational anatomy..  NeuroImage.  23 Suppl 1.  S170-8.
  • Miller M, Hosakere M, Barker, A R , Priebe C, Lee N, Ratnanather J, Wang L, Gado M, Morris JC, Csernansky JG (2003).  Labeled Cortical Mantle Distance Maps of the Cingulate Quantify Differences between Dementia of the Alzheimer Type and Healthy Aging.  Proceedings of the National Academy of Sciences of the United States of America.  100(25).  15172-15177.
Conference Proceedings
  • Segars WP, Sturgeon GM, Ward DJ, Ratnanather J, Miller M, Tsui BM  The new XCAT series of digital phantoms for multi-modality imaging.  Nuclear Science Symposium Conference Record (NSS/MIC), 2010 IEEE.  2392-2395.
  • Steinert-Threlkeld S, Ardekani S, Mejino JL, Detwiler LT, Brinkley JF, Halle M, Kikinis R, Winslow RL, Miller M, Ratnanather J  Ontological Labels for Automated Location of Left Ventricular Remodeling.  Semantic Computing (ICSC), 2011 Fifth IEEE International Conference on.  572-573.
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