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Konstantopoulos, Konstantinos

William H. Schwarz Professor
Chemical And Biomolecular Engineering
http://kostaslab.johnshopkins.edu/

Croft Hall 114
(410) 516-6290
konstant@jhu.edu

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About

Education
  • Ph.D. 1995, RICE UNIVERSITY
  • Other 1989, National Technical University of Athens, Athens, Greece
Experience
  • 2008 - 2008:  Director, Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
  • 2008 - Present:  Chair, Department of Chemical & Biomolecular Engineering
  • 2008 - 2008:  Chair, Annual Meeting of the Biomedical Engineering Society
  • 2008 - 2008:  Chair, 13th International Congress of Biorheology & 6th International Conference on Clinical Hemorheology
  • 2008 - Present:  Department Chair, Unspecified
  • 2008 - 2008:  Director, Chemical & Biomolecular Engineering
  • 2008 - Present:  Joint, SOM Oncology Center
  • 2006 - 2006:  Chair, Faculty Search Committee
  • 2006 - 2006:  Director, Chemical & Biomolecular Engineering
  • 2006 - 2006:  Chair, Biomedical Engineering Society
  • 2006 - 2006:  Faculty Advisor, Unspecified
  • 2003 - 2003:  Faculty Advisor, Department of Chemical & Biomolecular Engineering
  • 2001 - 2001:  Faculty Advisor, Unspecified
  • 2001 - 2001:  Advisor, AICHE
  • 1998 - Present:  Joint, SOM Biomedical Engineering
Research Areas
  • Biophysical characterization of these adhesive interactions at the single-molecule level
  • CELL migration
  • Discovery of adhesion moleculues involved in tumor cell adhesion in the vasculature
  • Elucidation of novel signaling mechanisms
  • Interface of engineering and biology pertinent to cancer metastasis
  • Physically confined microenvironments
Awards
  • 2014:  AIChE Division 15d/e Plenary Award
  • 2014:  Section Editor for Biological Engineering, Current Opinion in Chemical Engineering
  • 2014:  Editorial Board, Annual Review of Biomedical Engineering
  • 2014:  Editorial Board, Technology
  • 2014:  Section Editor for Biological Engineering, Current Opinion in Chemical Engineering
  • 2013:  Bioengineering Distinguished Alumnus Award
  • 2012:  Fellow - Biomedical Engineering Society
  • 2011:  Robert B. Pond - Sr. Excellence in Teaching Award
  • 2011:  Chair - Bioengineering - Technology and Surgical Sciences Study (BTSS) Section - NIH
  • 2011:  Chair - BMES Spring Meeting
  • 2010:  Fellow - American Institute for Medical and Biological Engineering
  • 2009:  Associate Editor - Annals of Biomedical Engineering
  • 2009:  Member - Mid-Atlantic Affiliate Unified Peer Review Steering Committee - American Heart Association
  • 2008:  Member - Bioengineering - Technology and Surgical Sciences Study Section - NIH
  • 2006:  ARCS Foundation Scholarship (Christina Alves)
  • 2006:  American Heart Association Graduate Student Fellowship (Christina Alves)
  • 2005:  Masson-Agarwal Faculty Scholar - The Johns Hopkins University
  • 2003:  Robert B. Pond - Sr. Excellence in Teaching Award
  • 2001:  NSF CAREER Award - National Science Foundation
  • 2000:  DuPont Young Professor Award - DuPont
  • 1998:  Whitaker Foundation Award
  • 1994:  Whitaker Graduate Student Award in Recognition of Academic Achievement in Bioengineering - Biomedical Engineering Society
  • 1990:  Scholarship Award in Recognition of Excellence in Academic Achievement - Hellenic Professional Society of Texas
  • 1989:  Special Graduate Student Fellowship Award - Department of Chemical Engineering - Rice University
Presentations
  • "Cell sensing and motility in confinement", 2017 Physics of Cancer Gordon Research Conference.  Galveston, TX.  February 6, 2017
  • "Harnessing Engineering and Biology to Understand Cell Motility in Confined Spaces", Texas A&M.  College Station, TX.  November 30, 2016
  • "Harnessing Engineering and Biology to Understand Tumor Cell Locomotion in Confinement", Penn State Hershey Cancer Institute.  Hershey, PA.  October 27, 2016
  • "Harnessing Engineering and Biology to Understand Cell Motility in Confined Spaces", Vanderbilt University.  Nashville, TN.  October 24, 2016
  • "Harnessing Engineering and Biology to Understand Cell Motility in Confined Spaces", University of Houston.  Houston, TX.  October 14, 2016
  • "Cell sensing and motility in confinement", Symposium on Mechanical Behaviors of Cytoskeleton and Cells.  College Park, MD.  October 4, 2016
  • "Harnessing Engineering and Biology to Understand Cell Locomotion in Confinement", University of Michigan.  Ann Arbor, MI.  April 15, 2016
  • "Harnessing Engineering and Biology to Understand Cell Locomotion in Confinement", Penn State University.  State College, PA.  April 7, 2016
  • "Harnessing Engineering and Biology to Understand Cell Locomotion in Confinement", University of Notre Dame.  Notre Dame, IN.  March 22, 2016
  • "Interplay of the physical microenvironment, contact guidance and cell signaling in cell decision making", 251st ACS National Meeting & Exposition, Division of Colloid and Surface Chemistry.  San Diego, CA.  March 14, 2016
  • "A Bioengineering Perspective on Cell Locomotion", Universitat Pompeu Fabra.  Barcelona, Spain.  November 2, 2015
  • "A Bioengineering Perspective on Cell Locomotion", Florida A&M University- Florida State University.  Tallahassee, Florida.  October 23, 2015
  • "A Bioengineering Perspective on Cell Locomotion", Rice University.  Houston, Texas.  September 3, 2015
  • "Bioengineering paradigms for cell migration in confined microenvironments", Institut Curie.  Institut Curie in Paris, France.  March 25, 2015
  • "Physical cues guide tumor cell adhesion and migration", Workshop on Cell Motility.  Institut Curie in Paris, France.  March 24, 2015
  • "Water permeation regulates tumor cell migration in confined microenvironments", 2015 Directed Cell Migration Gordon Conference.  Galveston, TX.  January 1, 2015

Publications

Journal Articles
  • Kyker-Snowman K, Hughes RM, Yankaskas CL, Cravero K, Karthikeyan S, Button B, Waters I, Rosen DM, Dennison L, Hunter N, Donaldson J, Christenson ES, Konstantopoulos K, Hurley PJ, Croessmann S, Park BH (2020).  TrkA overexpression in non-tumorigenic human breast cell lines confers oncogenic and metastatic properties.  Breast Cancer Research and Treatment.  179(3).  631-642.
  • Mistriotis P, Wisniewski EO, Bera K, Keys J, Li Y, Tuntithavornwat S, Law RA, Perez-Gonzalez NA, Erdogmus E, Zhang Y, Zhao R, Sun SX, Kalab P, Lammerding J, Konstantopoulos K (2019).  Confinement hinders motility by inducing RhoA-mediated nuclear influx, volume expansion, and blebbing.  The Journal of cell biology.  218(12).  4093-4111.
  • Zhao R, Afthinos A, Zhu T, Mistriotis P, Li Y, Serra SA, Zhang Y, Yankaskas CL, He S, Valverde MA, Sun SX, Konstantopoulos K (2019).  Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area.  Science Advances.  5(7).
  • Yankaskas CL, Thompson KN, Paul CD, Vitolo MI, Mistriotis P, Mahendra A, Bajpai VK, Shea DJ, Manto KM, Chai AC, Varadarajan N, Kontrogianni-Konstantopoulos A, Martin SS, Konstantopoulos K (2019).  A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens.  Nature Biomedical Engineering.  3(6).  452-465.
  • Wong BS, Shea DJ, Mistriotis P, Tuntithavornwat S, Law RA, Bieber JM, Zheng L, Konstantopoulos K (2019).  A direct podocalyxin–dynamin-2 interaction regulates cytoskeletal dynamics to promote migration and metastasis in pancreatic cancer cells.  Cancer Research.  79(11).  2878-2891.
  • Jablonska A, Shea DJ, Cao S, Bulte JWM, Janowski M, Konstantopoulos K, Walczak P (2018).  Overexpression of VLA-4 in glial-restricted precursors enhances their endothelial docking and induces diapedesis in a mouse stroke model.  Journal of Cerebral Blood Flow and Metabolism.  38(5).  835-846.
  • Pardo-Pastor C, Rubio-Moscardo F, Vogel-González M, Serra SA, Afthinos A, Mrkonjic S, Destaing O, Abenza JF, Fernández-Fernández JM, Trepat X, Albiges-Rizo C, Konstantopoulos K, Valverde MA (2018).  Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses.  Proceedings of the National Academy of Sciences of the United States of America.  115(8).  1925-1930.
  • Dong C, Zahir N, Konstantopoulos K (2018).  Preface.  Advances in Experimental Medicine and Biology.  1092.  v-vi.
  • Lyons JS, Joca HC, Law RA, Williams KM, Kerr JP, Shi G, Khairallah RJ, Martin SS, Konstantopoulos K, Ward CW, Stains JP (2017).  Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes.  Science Signaling.  10(506).
  • Shea DJ, Li YW, Stebe KJ, Konstantopoulos K (2017).  E-selectin-mediated rolling facilitates pancreatic cancer cell adhesion to hyaluronic acid.  FASEB Journal.  31(11).  5078-5086.
  • Sengupta S, Nagalingam A, Muniraj N, Bonner MY, Mistriotis P, Afthinos A, Kuppusamy P, Lanoue D, Cho S, Korangath P, Shriver M, Begum A, Merino VF, Huang CY, Arbiser JL, Matsui W, Györffy B, Konstantopoulos K, Sukumar S, Marignani PA, Saxena NK, Sharma D (2017).  Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3.  Oncogene.  36(41).  5709-5721.
  • Gerecht S, Konstantopoulos K (2017).  Editorial overview: Biological engineering: Stem cell engineering.  Current Opinion in Chemical Engineering.  15.  i-ii.
  • Paul CD, Mistriotis P, Konstantopoulos K (2017).  Cancer cell motility: Lessons from migration in confined spaces.  Nature Reviews Cancer.  17(2).  131-140.
  • Stroka KM, Wong BS, Shriver M, Phillip JM, Wirtz D, Kontrogianni-Konstantopoulos A, Konstantopoulos K (2017).  Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness.  Oncotarget.  8(33).  54004-54020.
  • Curreli S, Wong BS, Latinovic O, Konstantopoulos K, Stamatos NM (2016).  Class 3 semaphorins induce F-actin reorganization in human dendritic cells: Role in cell migration..  Journal of leukocyte biology.  100(6).  1323-1334.
  • Curreli S, Wong BS, Latinovic O, Konstantopoulo K, Stamatos NM (2016).  Class 3 semaphorins induce F-actin reorganization in human dendritic cells: Role in cell migration.  Journal of Leukocyte Biology.  100(6).  1323-1334.
  • Mathieu E, Paul CD, Stahl R, Vanmeerbeeck G, Reumers V, Liu C, Konstantopoulos K, Lagae L (2016).  Time-lapse lens-free imaging of cell migration in diverse physical microenvironments..  Lab on a chip.  16(17).  3304-16.
  • Stroka KM, Wong BS, Shriver M, Phillip JM, Wirtz D, Kontrogianni-Konstantopoulos A, Konstantopoulos K (2016).  Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness..  Oncotarget.
  • Shriver M, Marimuthu S, Paul C, Geist J, Seale T, Konstantopoulos K, Kontrogianni-Konstantopoulos A (2016).  Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit..  Oncotarget.  7(29).  45414-45428.
  • Paul CD, Hung WC, Wirtz D, Konstantopoulos K (2016).  Engineered Models of Confined Cell Migration.  Annual Review of Biomedical Engineering.  18.  159-180.
  • Paul CD, Hung WC, Wirtz D, Konstantopoulos K (2016).  Engineered Models of Confined Cell Migration..  Annual review of biomedical engineering.  18.  159-80.
  • Paul CD, Shea DJ, Mahoney MR, Chai A, Laney V, Hung WC, Konstantopoulos K (2016).  Interplay of the physical microenvironment, contact guidance, and intracellular signaling in cell decision making.  FASEB Journal.  30(6).  2161-2170.
  • Paul CD, Shea DJ, Mahoney MR, Chai A, Laney V, Hung WC, Konstantopoulos K (2016).  Interplay of the physical microenvironment, contact guidance, and intracellular signaling in cell decision making..  FASEB journal : official publication of the Federation of American Societies for Experimental Biology.  30(6).  2161-70.
  • Hung WC, Yang JR, Yankaskas CL, Wong BS, Wu PH, Pardo-Pastor C, Serra SA, Chiang MJ, Gu Z, Wirtz D, Valverde MA, Yang JT, Zhang J, Konstantopoulos K (2016).  Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways.  Cell Reports.  15(7).  1430-1441.
  • Hung WC, Yang J, Yankaskas CL, Wong BS, Wu P, Pardo-Pastor C, Serra SA, Chiang MJ, Gu Z, Wirtz D, Valverde MA, Yang J, Zhang J, Konstantopoulos K (2016).  Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways..  Cell reports.  15(7).  1430-41.
  • Konstantopoulos K, Gerecht S (2016).  Editorial overview: Biological Engineering: Engineering Systems for cancer modeling, diagnostics and therapeutics.  Current Opinion in Chemical Engineering.  11.  iv-v.
  • Gerecht S, Konstantopoulos K (2016).  Editorial overview: Biological engineering: Engineering systems for cancer modeling, diagnostics and therapeutics.  Current Opinion in Chemical Engineering.  11.  iv-v.
  • He L, Chen W, Wu PH, Jimenez A, Wong BS, San A, Konstantopoulos K, Wirtz D (2016).  Local 3D matrix confinement determines division axis through cell shape.  Oncotarget.  7(6).  6994-7011.
  • Mathieu E, Paul CD, Stahl R, Vanmeerbeeck G, Reumers V, Liu C, Konstantopoulos K, Lagae L (2016).  Time-lapse lens-free imaging of cell migration in diverse physical microenvironments.  Lab on a Chip.  16(17).  3304-3316.
  • Shriver M, Marimuthu S, Paul C, Geist J, Seale T, Konstantopoulos K, Kontrogianni-Konstantopoulos A (2016).  Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit.  Oncotarget.  7(29).  45414-45428.
  • Yu X, Guan PP, Guo JW, Wang Y, Cao LL, Xu GB, Konstantopoulos K, Wang ZY, Wang P (2015).  By suppressing the expression of anterior pharynx-defective-1α and -1β and inhibiting the aggregation of β-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice.  FASEB Journal.  29(12).  5044-5058.
  • Yu X, Guan PP, Guo JW, Wang Y, Cao LL, Xu GB, Konstantopoulos K, Wang ZY, Wang P (2015).  By suppressing the expression of anterior pharynx-defective-1α and -1β and inhibiting the aggregation of β-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice..  FASEB journal : official publication of the Federation of American Societies for Experimental Biology.  29(12).  5044-58.
  • Zabransky DJ, Yankaskas CL, Cochran RL, Wong HY, Croessmann S, Chu D, Kavuri SM, Brewer MR, Marc Rosen D, Brian Dalton W, Cimino-Mathews A, Cravero K, Button B, Kyker-Snowman K, Cidado J, Erlanger B, Parsons HA, Manto KM, Bose R, Lauring J, Arteaga CL, Konstantopoulos K, Park BH (2015).  HER2 missense mutations have distinct effects on oncogenic signaling and migration.  Proceedings of the National Academy of Sciences of the United States of America.  112(45).  E6205-E6214.
  • Zabransky DJ, Yankaskas CL, Cochran RL, Wong HY, Croessmann S, Chu D, Kavuri SM, Red Brewer M, Rosen DM, Dalton WB, Cimino-Mathews A, Cravero K, Button B, Kyker-Snowman K, Cidado J, Erlanger B, Parsons HA, Manto KM, Bose R, Lauring J, Arteaga CL, Konst... (2015).  HER2 missense mutations have distinct effects on oncogenic signaling and migration..  Proceedings of the National Academy of Sciences of the United States of America.  112(45).  E6205-14.
  • He L, Chen W, Wu P, Jimenez A, Wong BS, San A, Konstantopoulos K, Wirtz D (2015).  Local 3D matrix confinement determines division axis through cell shape..  Oncotarget.
  • Shea DJ, Wirtz D, Stebe KJ, Konstantopoulos K (2015).  Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear flow..  Oncotarget.  6(28).  24842-55.
  • Wang P, Chen SH, Hung WC, Paul C, Zhu F, Guan PP, Huso DL, Kontrogianni-Konstantopoulos A, Konstantopoulos K (2015).  Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways.  Oncogene.  34(35).  4558-4569.
  • Wang P, Chen SH, Hung WC, Paul C, Zhu F, Guan PP, Huso DL, Kontrogianni-Konstantopoulos A, Konstantopoulos K (2015).  Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways..  Oncogene.  34(35).  4558-69.
  • Shriver M, Stroka KM, Vitolo MI, Martin S, Huso DL, Konstantopoulos K, Kontrogianni-Konstantopoulos A (2015).  Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis..  Oncogene.  34(32).  4248-59.
  • Shriver M, Stroka KM, Vitolo MI, Martin S, Huso DL, Konstantopoulos K, Kontrogianni-Konstantopoulos A (2015).  Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis.  Oncogene.  34(32).  4248-4259.
  • Guan PP, Guo JW, Yu X, Wang Y, Wang T, Konstantopoulos K, Wang ZY, Wang P (2015).  The role of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage..  Scientific reports.  5.  10412.
  • Guan PP, Guo JW, Yu X, Wang Y, Wang T, Konstantopoulos K, Wang ZY, Wang P (2015).  The role of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage.  Scientific Reports.  5.
  • Guan PP, Yu X, Guo JJ, Wang Y, Wang T, Li JY, Konstantopoulos K, Wang ZY, Wang P (2015).  By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization..  Oncotarget.  6(11).  9140-59.
  • Cheung LSL, Shea DJ, Nicholes N, Date A, Ostermeier M, Konstantopoulos K (2015).  Characterization of Monobody Scaffold Interactions with Ligand via Force Spectroscopy and Steered Molecular Dynamics.  Scientific Reports.  5.
  • Cheung LS, Shea DJ, Nicholes N, Date A, Ostermeier M, Konstantopoulos K (2015).  Characterization of monobody scaffold interactions with ligand via force spectroscopy and steered molecular dynamics..  Scientific reports.  5.  8247.
  • Konstantopoulos K, Segura T (2015).  Editorial overview: Materials engineering: Advances in smart and controlled delivery of therapeutic molecules.  Current Opinion in Chemical Engineering.  7.  v-vi.
  • Konstantopoulos K, Segura T (2015).  Editorial overview: Biological engineering: Advances in smart and controlled delivery of therapeutic molecules.  Current Opinion in Chemical Engineering.  7.  v-vi.
  • Shea DJ, Wirtz D, Stebe KJ, Konstantopoulos K (2015).  Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear f low.  Oncotarget.  6(28).  24842-24855.
  • Guan PP, Yu X, Guo JJ, Wang Y, Wang T, Li JY, Konstantopoulos K, Wang ZY, Wang P (2015).  By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization.  Oncotarget.  6(11).  9140-9159.
  • Wang P, Guan PP, Wang T, Yu X, Guo JJ, Konstantopoulos K, Wang ZY (2014).  Interleukin-1β and cyclic AMP mediate the invasion of sheared chondrosarcoma cells via a matrix metalloproteinase-1-dependent mechanism.  Biochimica et Biophysica Acta - Molecular Cell Research.  1843(5).  923-933.
  • Stroka KM, Jiang H, Chen SH, Tong Z, Wirtz D, Sun SX, Konstantopoulos K (2014).  Water permeation drives tumor cell migration in confined microenvironments.  Cell.  157(3).  611-623.
  • Grabias BM, Konstantopoulos K (2014).  The physical basis of renal fibrosis: Effects of altered hydrodynamic forces on kidney homeostasis.  American Journal of Physiology - Renal Physiology.  306(5).
  • Stroka KM, Konstantopoulos K (2014).  Physical biology in cancer. 4. Physical cues guide tumor cell adhesion and migration.  American Journal of Physiology - Cell Physiology.  306(2).
  • Stroka KM, Gu Z, Sun SX, Konstantopoulos K (2014).  Bioengineering paradigms for cell migration in confined microenvironments.  Current Opinion in Cell Biology.  30(1).  41-50.
  • Stroka KM, Gu Z, Sun S, Konstantopoulos K (2014).  Bioengineering paradigms for cell migration in confined microenvironments.  Curr Opin Cell Biol.  30.  41-50.
  • Stroka KM, Konstantopoulos K (2014).  Physical biology in cancer. 4. Physical cues guide tumor cell adhesion and migration.  Am J Physiol Cell Physiol.  306(2).  C98-C109.
  • Grabias BM, Konstantopoulos K (2014).  The physical basis of renal fibrosis: effects of altered hydrodynamic forces on kidney homeostasis.  Am J Physiol Renal Physiol.  306(5).  F473-85.
  • Wang P, Guan PP, Wang T, Yu X, Guo JJ, Konstantopoulos K, Wang ZY (2014).  Interleukin-1beta and cyclic AMP mediate the invasion of sheared chondrosarcoma cells via a matrix metalloproteinase-1-dependent mechanism.  Biochim Biophys Acta.  1843(5).  923-33.
  • Stroka KM, Jiang H, Chen S, Tong Z, Wirtz D, Sun S, Konstantopoulos K (2014).  Water permeation drives tumor cell migration in confined microenvironments.  Cell.  157(3).  611-23.
  • Raman PS, Paul CD, Stroka KM, Konstantopoulos K (2013).  Probing cell traction forces in confined microenvironments.  Lab on a Chip.  13(23).  4599-4607.
  • Wang P, Guan PP, Guo C, Zhu F, Konstantopoulos K, Wang ZY (2013).  Fluid shear stress-induced osteoarthritis: Roles of cyclooxygenase-2 and its metabolic products in inducing the expression of proinflammatory cytokines and matrix metalloproteinases.  FASEB Journal.  27(12).  4664-4677.
  • Hung WC, Chen SH, Paul CD, Stroka KM, Lo YC, Yang JT, Konstantopoulos K (2013).  Distinct signaling mechanisms regulate migration in unconfined versus confined spaces.  Journal of Cell Biology.  202(5).  807-824.
  • Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen W-C, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PCW, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJT, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, Van O...Wu P-H (2013).  A physical sciences network characterization of non-tumorigenic and metastatic cells.  Scientific Reports.  3.
  • Grabias BM, Konstantopoulos K (2013).  Notch4-dependent antagonism of canonical TGF-β1 signaling defines unique temporal fluctuations of SMAD3 activity in sheared proximal tubular epithelial cells.  American Journal of Physiology - Renal Physiology.  305(1).
  • Bernate JA, Liu C, Lagae L, Konstantopoulos K, Drazer G (2013).  Vector separation of particles and cells using an array of slanted open cavities.  Lab on a Chip.  13(6).  1086-1092.
  • Chen WC, Wu PH, Phillip JM, Khatau SB, Choi JM, Dallas MR, Konstantopoulos K, Sun SX, Lee JSH, Hodzic D, Wirtz D (2013).  Functional interplay between the cell cycle and cell phenotypes.  Integrative Biology (United Kingdom).  5(3).  523-534.
  • Hung WC, Chen S, Paul CD, Stroka KM, Lo YC, Yang JT, Konstantopoulos K (2013).  Distinct signaling mechanisms regulate migration in unconfined versus confined spaces.  J Cell Biol.  202(5).  807-24.
  • Stroka KM, Jiang H, Sun SX, Konstantopoulos K (2013).  Role of water permeation in confined cell migration and polarization.  Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future.  600-601.
  • Paul CD, Raman PS, Stroka KM, Konstantopoulos K (2013).  A microfluidic device to measure traction forces during confined chemotactic migration.  Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future.  850.
  • Chen W, Wu PH, Phillip JM, Khatau SB, Choi J, Dallas MR, Konstantopoulos K, Sun S, Lee JS, Hodzic D, Wirtz D (2013).  Functional interplay between the cell cycle and cell phenotypes.  Integr Biol (Camb).  5(3).  523-34.
  • Stroka KM, Shriver M, Konstantopoulos K, Kontrogianni-Konstantopoulos A (2013).  Loss of giant obscurins promotes a metastatic phenotype in breast epithelium.  Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future.  805.
  • Chen SH, Hung WC, Wang P, Paul C, Konstantopoulos K (2013).  Mesothelin binding to CA125/MUC16 promotes pancreatic cancer cell motility and invasion via MMP-7 activation.  Scientific Reports.  3.
  • Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C,... (2013).  A physical sciences network characterization of non-tumorigenic and metastatic cells..  Scientific reports.  3.  1449.
  • Konstantopoulos K, Wu P, Wirtz D (2013).  Dimensional control of cancer cell migration.  Biophysical Journal.  104(2).  279-280.
  • Wang P, Guan PP, Guo C, Zhu F, Konstantopoulos K, Wang ZY (2013).  Fluid shear stress-induced osteoarthritis: roles of cyclooxygenase-2 and its metabolic products in inducing the expression of proinflammatory cytokines and matrix metalloproteinases.  FASEB J.  27(12).  4664-77.
  • Chen S, Hung WC, Wang P, Paul C, Konstantopoulos K (2013).  Mesothelin binding to CA125/MUC16 promotes pancreatic cancer cell motility and invasion via MMP-7 activation.  Sci Rep.  3.  1870.
  • Bernate JA, Liu C, Lagae L, Konstantopoulos K, Drazer G (2013).  Vector separation of particles and cells using an array of slanted open cavities.  Lab Chip.  13(6).  1086-92.
  • Grabias BM, Konstantopoulos K (2013).  Notch4-dependent antagonism of canonical TGF-beta1 signaling defines unique temporal fluctuations of SMAD3 activity in sheared proximal tubular epithelial cells.  Am J Physiol Renal Physiol.  305(1).  F123-33.
  • Raman PS, Paul CD, Stroka KM, Konstantopoulos K (2013).  Probing cell traction forces in confined microenvironments.  Lab Chip.  13(23).  4599-607.
  • Alves CS, Konstantopoulos K (2012).  PDGF Suppresses the Sulfation of CD44v and Potentiates CD44v-Mediated Binding of Colon Carcinoma Cells to Fibrin under Flow.  PLoS ONE.  7(10).
  • Grabias BM, Konstantopoulos K (2012).  Epithelial-mesenchymal transition and fibrosis are mutually exclusive reponses in shear-activated proximal tubular epithelial cells.  FASEB Journal.  26(10).  4131-4141.
  • Balzer EM, Tong Z, Paul CD, Hung WC, Stroka KM, Boggs AE, Martin SS, Konstantopoulos K (2012).  Physical confinement alters tumor cell adhesion and migration phenotypes.  FASEB Journal.  26(10).  4045-4056.
  • Lee KH, Galloway JF, Park J, Dvoracek CM, Dallas M, Konstantopoulos K, Maitra A, Searson PC (2012).  Quantitative molecular profiling of biomarkers for pancreatic cancer with functionalized quantum dots.  Nanomedicine: Nanotechnology, Biology, and Medicine.  8(7).  1043-1051.
  • Streppel MM, Vincent A, Mukherjee R, Campbell NR, Chen SH, Konstantopoulos K, Goggins MG, Van Seuningen I, Maitra A, Montgomery EA (2012).  Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon.  Human Pathology.  43(10).  1755-1763.
  • Dallas MR, Chen SH, Streppel MM, Sharma S, Maitra A, Konstantopoulos K (2012).  Sialofucosylated podocalyxin is a functional E- and L-selectin ligand expressed by metastatic pancreatic cancer cells.  American Journal of Physiology - Cell Physiology.  303(6).
  • Wang P, Zhu F, Konstantopoulos K (2012).  The antagonistic actions of endogenous interleukin-1β and 15-deoxy-Δ12,14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes.  Journal of Biological Chemistry.  287(38).  31877-31893.
  • Raman PS, Alves CS, Wirtz D, Konstantopoulos K (2012).  Distinct kinetic and molecular requirements govern CD44 binding to hyaluronan versus fibrin(ogen).  Biophysical Journal.  103(3).  415-423.
  • Tong Z, Cheung LSL, Stebe KJ, Konstantopoulos K (2012).  Selectin-mediated adhesion in shear flow using micropatterned substrates: Multiple-bond interactions govern the critical length for cell binding.  Integrative Biology (United Kingdom).  4(8).  847-856.
  • Almaraz RT, Tian Y, Bhattarcharya R, Tan E, Chen SH, Dallas MR, Chen L, Zhang Z, Zhang H, Konstantopoulos K, Yarema KJ (2012).  Metabolic flux increases glycoprotein sialylation: Implications for cell adhesion and cancer metastasis.  Molecular and Cellular Proteomics.  11(7).
  • Dallas MR, Liu G, Chen WC, Thomas SN, Wirtz D, Huso DL, Konstantopoulos K (2012).  Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis.  FASEB Journal.  26(6).  2648-2656.
  • Silva Z, Konstantopoulos K, Videira PA (2012).  The role of sugars in dendritic cell trafficking.  Annals of Biomedical Engineering.  40(4).  777-789.
  • Chen SH, Dallas MR, Balzer EM, Konstantopoulos K (2012).  Mucin 16 is a functional selectin ligand on pancreatic cancer cells.  FASEB Journal.  26(3).  1349-1359.
  • Balzer EM, Konstantopoulos K (2012).  Intercellular adhesion: Mechanisms for growth and metastasis of epithelial cancers.  Wiley Interdisciplinary Reviews: Systems Biology and Medicine.  4(2).  171-181.
  • Cheung LSL, Kanwar M, Ostermeier M, Konstantopoulos K (2012).  A hot-spot motif characterizes the interface between a designed ankyrin-repeat protein and its target ligand.  Biophysical Journal.  102(3).  407-416.
  • Tong ZQ, Balzer EM, Dallas MR, Hung WC, Stebe KJ, Konstantopoulos K (2012).  Chemotaxis of cell populations through confined spaces at Single-Cell resolution.  PLoS ONE.  7(1).
  • Balzer EM, Konstantopoulos K (2012).  Intercellular adhesion: mechanisms for growth and metastasis of epithelial cancers.  Wiley Interdiscip Rev Syst Biol Med.  4(2).  171-81.
  • Alves CS, Konstantopoulos K (2012).  PDGF suppresses the sulfation of CD44v and potentiates CD44v-mediated binding of colon carcinoma cells to fibrin under flow.  PLoS One.  7(10).  e41472.
  • Chen S, Dallas MR, Balzer EM, Konstantopoulos K (2012).  Mucin 16 is a functional selectin ligand on pancreatic cancer cells.  FASEB J.  26(3).  1349-59.
  • Balzer EM, Tong Z, Paul CD, Hung WC, Stroka KM, Boggs AE, Martin SS, Konstantopoulos K (2012).  Physical confinement alters tumor cell adhesion and migration phenotypes.  FASEB J.  26(10).  4045-56.
  • Dallas MR, Liu G, Chen W, Thomas SN, Wirtz D, Huso DL, Konstantopoulos K (2012).  Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis.  FASEB J.  26(6).  2648-56.
  • Dallas M, Liu G, Chen W, Thomas S, Wirtz D, Huso D, Konstantopoulos K (2012).  Erratum: Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis (FASEB Journal (2012) 26 (2648-2656) DOI: 10.1096/fj.12- 203786).  FASEB Journal.  26(11).  4774.
  • Almaraz RT, Tian Y, Bhattarcharya R, Tan E, Chen S, Dallas MR, Chen L, Zhang Z, Zhang H, Konstantopoulos K, Yarema KJ (2012).  Metabolic flux increases glycoprotein sialylation: implications for cell adhesion and cancer metastasis.  Mol Cell Proteomics.  11(7).  M112 017558.
  • Raman PS, Alves CS, Wirtz D, Konstantopoulos K (2012).  Distinct kinetic and molecular requirements govern CD44 binding to hyaluronan versus fibrin(ogen).  Biophys J.  103(3).  415-23.
  • Cheung LS, Kanwar M, Ostermeier M, Konstantopoulos K (2012).  A hot-spot motif characterizes the interface between a designed ankyrin-repeat protein and its target ligand.  Biophys J.  102(3).  407-16.
  • Tong Z, Cheung LS, Stebe KJ, Konstantopoulos K (2012).  Selectin-mediated adhesion in shear flow using micropatterned substrates: multiple-bond interactions govern the critical length for cell binding.  Integr Biol (Camb).  4(8).  847-56.
  • Streppel MM, Vincent A, Mukherjee R, Campbell N, Chen S, Konstantopoulos K, Goggins MG, Van Seuningen I, Maitra A, Montgomery EA (2012).  Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon.  Hum Pathol.  43(10).  1755-63.
  • Tong Z, Balzer EM, Dallas MR, Hung WC, Stebe KJ, Konstantopoulos K (2012).  Chemotaxis of cell populations through confined spaces at single-cell resolution.  PLoS One.  7(1).  e29211.
  • Dallas MR, Chen S, Streppel MM, Sharma S, Maitra A, Konstantopoulos K (2012).  Sialofucosylated podocalyxin is a functional E- and L-selectin ligand expressed by metastatic pancreatic cancer cells.  Am J Physiol Cell Physiol.  303(6).  C616-24.
  • Lee KH, Galloway JF, Park J, Dvoracek CM, Dallas M, Konstantopoulos K, Maitra A, Searson P (2012).  Quantitative molecular profiling of biomarkers for pancreatic cancer with functionalized quantum dots.  Nanomedicine: Nanotechnology, Biology, and Medicine.  8(7).  1043-1051.
  • Grabias BM, Konstantopoulos K (2012).  Epithelial-mesenchymal transition and fibrosis are mutually exclusive reponses in shear-activated proximal tubular epithelial cells.  FASEB J.  26(10).  4131-41.
  • Wang P, Zhu F, Konstantopoulos K (2012).  The antagonistic actions of endogenous interleukin-1beta and 15-deoxy-Delta12,14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes.  J Biol Chem.  287(38).  31877-93.
  • Konstantopoulos K, Thomas SN (2011).  Hematogenous metastasis: Roles of CD44v and alternative sialofucosylated selectin ligands.  Advances in Experimental Medicine and Biology.  705.  601-619.
  • Wang P, Zhu F, Konstantopoulos K (2011).  Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E 2 and 15-deoxy-δ 12,14-PGJ 2.  PLoS ONE.  6(11).
  • Wang P, Zhu F, Tong ZQ, Konstantopoulos K (2011).  Response of chondrocytes to shear stress: Antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1.  FASEB Journal.  25(10).  3401-3415.
  • Wirtz D, Konstantopoulos K, Searson PC (2011).  The physics of cancer: The role of physical interactions and mechanical forces in metastasis.  Nature Reviews Cancer.  11(7).  512-522.
  • Silva Z, Tong ZQ, Guadalupe Cabral M, Martins C, Castro R, Reis C, Trindade H, Konstantopoulos K, Videira PA (2011).  Sialyl Lewisx-dependent binding of human monocyte-derived dendritic cells to selectins.  Biochemical and Biophysical Research Communications.  409(3).  459-464.
  • Raman PS, Alves CS, Wirtz D, Konstantopoulos K (2011).  Single-molecule binding of CD44 to fibrin versus P-selectin predicts their distinct shear-dependent interactions in cancer.  Journal of Cell Science.  124(11).  1903-1910.
  • Kastritis E, Kyrtsonis MC, Hatjiharissi E, Symeonidis A, Michalis E, Repoussis P, Tsatalas K, Michael M, Sioni A, Kartasis Z, Stefanoudaki E, Voulgarelis M, Delimpasi S, Gavriatopoulou M, Koulieris E, Gika D, Vervesou E, Konstantopoulos K, Kokkini G, Zomas A, Roussou P, Anagnostopoulos N, Economopoulos T, Terpos E, Zervas K, Dimopoulos MA (2011).  No significant improvement in the outcome of patients with Waldenström's macroglobulinemia treated over the last 25 years.  American Journal of Hematology.  86(6).  479-483.
  • Cheung LSL, Konstantopoulos K (2011).  An analytical model for determining two-dimensional receptor-ligand kinetics.  Biophysical Journal.  100(10).  2338-2346.
  • Sundd P, Pospieszalska MK, Cheung LSL, Konstantopoulos K, Ley K (2011).  Biomechanics of leukocyte rolling.  Biorheology.  48(1).  1-35.
  • Sraj I, Chan KY, Konstantopoulos K, Eggleton CD (2011).  A numerical study of the influence of cellular adhesion on prestress in Atomic Force Microscopy measurements.  Journal of Advanced Microscopy Research.  6(2).  89-96.
  • Wang P, Zhu F, Konstantopoulos K (2011).  Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Delta(12,14)-PGJ2.  PLoS One.  6(11).  e27630.
  • Cheung LSL, Raman PS, Balzer EM, Wirtz D, Konstantopoulos K (2011).  Biophysics of Selectin-Ligand interactions in inflammation and cancer.  Physical Biology.  8(1).
  • Cheung LS, Raman PS, Balzer EM, Wirtz D, Konstantopoulos K (2011).  Biophysics of selectin-ligand interactions in inflammation and cancer.  Phys Biol.  8(1).  015013.
  • Raman PS, Alves CS, Wirtz D, Konstantopoulos K (2011).  Single-molecule binding of CD44 to fibrin versus P-selectin predicts their distinct shear-dependent interactions in cancer.  J Cell Sci.  124(Pt 11).  1903-10.
  • Wang P, Zhu F, Tong Z, Konstantopoulos K (2011).  Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1.  FASEB J.  25(10).  3401-15.
  • Wirtz D, Konstantopoulos K, Searson P (2011).  The physics of cancer: The role of physical interactions and mechanical forces in metastasis.  Nature Reviews Cancer.  11(7).  512-522.
  • Wirtz D, Konstantopoulos K, Searson P (2011).  The physics of cancer: The role of physical interactions and mechanical forces in metastasis.  Nature Reviews Cancer.  11(7).  512-522.
  • Konstantopoulos K, Thomas SN (2011).  Hematogenous metastasis: roles of CD44v and alternative sialofucosylated selectin ligands.  Adv Exp Med Biol.  705.  601-19.
  • Cheung LS, Konstantopoulos K (2011).  An analytical model for determining two-dimensional receptor-ligand kinetics.  Biophys J.  100(10).  2338-46.
  • Zhu F, Wang P, Lee NH, Goldring MB, Konstantopoulos K (2010).  Prolonged Application of High Fluid Shear to Chondrocytes Recapitulates Gene Expression Profiles Associated with Osteoarthritis.  PLoS ONE.  5(12).
  • Gupta VK, Sraj IA, Konstantopoulos K, Eggleton CD (2010).  Multi-scale simulation of L-selectin-PSGL-1-dependent homotypic leukocyte binding and rupture.  Biomechanics and Modeling in Mechanobiology.  9(5).  613-627.
  • Wang P, Zhu F, Lee NH, Konstantopoulos K (2010).  Shear-induced interleukin-6 synthesis in chondrocytes: Roles of E prostanoid (EP) 2 and EP3 in cAMP/protein kinase A- and PI3-K/Akt-dependent NF-κB activation.  Journal of Biological Chemistry.  285(32).  24793-24804.
  • Zhu F, Wang P, Kontrogianni-Konstantopoulos A, Konstantopoulos K (2010).  Prostaglandin (PG)D"2 and 15-deoxy-Δ12,14-PGJ"2, but not PGE"2, mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases.  Cell Death and Differentiation.  17(8).  1325-1334.
  • Wang P, Zhu F, Konstantopoulos K (2010).  Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A- and phosphatidylinositol 3-kinase-dependent NF-κB activation.  American Journal of Physiology - Cell Physiology.  298(6).
  • Wang P, Zhu F, Konstantopoulos K (2010).  Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A- and phosphatidylinositol 3-kinase-dependent NF-kappaB activation.  Am J Physiol Cell Physiol.  298(6).  C1445-56.
  • Zhu F, Wang P, Kontrogianni-Konstantopoulos A, Konstantopoulos K (2010).  Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases.  Cell Death Differ.  17(8).  1325-34.
  • Wang P, Zhu F, Lee N, Konstantopoulos K (2010).  Shear-induced interleukin-6 synthesis in chondrocytes: roles of E prostanoid (EP) 2 and EP3 in cAMP/protein kinase A- and PI3-K/Akt-dependent NF-kappaB activation.  J Biol Chem.  285(32).  24793-804.
  • Zhu F, Wang P, Lee N, Goldring MB, Konstantopoulos K (2010).  Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis.  PLoS One.  5(12).  e15174.
  • Gupta VK, Sraj IA, Konstantopoulos K, Eggleton CD (2010).  Multi-scale simulation of L-selectin-PSGL-1-dependent homotypic leukocyte binding and rupture.  Biomech Model Mechanobiol.  9(5).  613-27.
  • Thomas SN, Tong Z, Stebe KJ, Konstantopoulos K (2009).  Identification, characterization and utilization of tumor cell selectin ligands in the design of colon cancer diagnostics.  Biorheology.  46(3).  207-225.
  • Konstantopoulos K, Thomas SN (2009).  Cancer cells in transit: The vascular interactions of tumor cells.  Annual Review of Biomedical Engineering.  11.  177-202.
  • Thomas SN, Schnaar RL, Konstantopoulos K (2009).  Podocalyxin-like protein is an E-/L-selectin ligand on colon carcinoma cells: Comparative biochemical properties of selectin ligands in host and tumor cells.  American Journal of Physiology - Cell Physiology.  296(3).
  • George NPE, Ymele-Leki P, Konstantopoulos K, Ross JM (2009).  Differential binding of biofilm-derived and suspension-grown Staphylococcus aureus to immobilized platelets in shear flow.  Journal of Infectious Diseases.  199(5).  633-640.
  • Alves CS, Yakovlev S, Medved L, Konstantopoulos K (2009).  Biomolecular characterization of CD44-fibrin(ogen) binding distinct molecular requirements mediate binding of standard and variant isoforms of CD44 to immobilized fibrin(ogen).  Journal of Biological Chemistry.  284(2).  1177-1189.
  • Alves CS, Yakovlev S, Medved L, Konstantopoulos K (2009).  Biomolecular characterization of CD44-fibrin(ogen) binding: distinct molecular requirements mediate binding of standard and variant isoforms of CD44 to immobilized fibrin(ogen).  J Biol Chem.  284(2).  1177-89.
  • Thomas SN, Tong Z, Stebe KJ, Konstantopoulos K (2009).  Identification, characterization and utilization of tumor cell selectin ligands in the design of colon cancer diagnostics.  Biorheology.  46(3).  207-25.
  • Thomas SN, Schnaar RL, Konstantopoulos K (2009).  Podocalyxin-like protein is an E-/L-selectin ligand on colon carcinoma cells: comparative biochemical properties of selectin ligands in host and tumor cells.  Am J Physiol Cell Physiol.  296(3).  C505-13.
  • Konstantopoulos K, Thomas SN (2009).  Cancer cells in transit: the vascular interactions of tumor cells.  Annu Rev Biomed Eng.  11.  177-202.
  • George NP, Ymele-Leki P, Konstantopoulos K, Ross JM (2009).  Differential binding of biofilm-derived and suspension-grown Staphylococcus aureus to immobilized platelets in shear flow.  J Infect Dis.  199(5).  633-40.
  • Dobrowsky TM, Panorchan P, Konstantopoulos K, Wirtz D (2008).  Chapter 15 Live-Cell Single-Molecule Force Spectroscopy.  Methods in Cell Biology.  89.  411-432.
  • Alves CS, Yakovlev S, Medved L, Konstantopoulos K (2008).  Fibrin(ogen) is a functional CD44 ligand.  AIChE Annual Meeting, Conference Proceedings.
  • Nimrichter L, Burdick MM, Aoki K, Laroy W, Fierro MA, Hudson SA, Von Seggern CE, Cotter RJ, Bochner BS, Tiemeyer M, Konstantopoulos K, Schnaar RL (2008).  E-selectin receptors on human leukocytes.  Blood.  112(9).  3744-3752.
  • Pawar P, Jadhav S, Eggleton CD, Konstantopoulos K (2008).  Roles of cell and microvillus deformation and receptor-ligand binding kinetics in cell rolling.  American Journal of Physiology - Heart and Circulatory Physiology.  295(4).
  • Ghosh M, Alves C, Tong Z, Tettey K, Konstantopoulos K, Stebe KJ (2008).  Multifunctional surfaces with discrete functionalized regions for biological applications.  Langmuir.  24(15).  8134-8142.
  • Dikeman DA, Rivera Rosado LA, Horn TA, Alves CS, Konstantopoulos K, Yang JT (2008).  α4β1-Integrin regulates directionally persistent cell migration in response to shear flow stimulation.  American Journal of Physiology - Cell Physiology.  295(1).
  • Thomas SN, Zhu F, Schnaar RL, Alves CS, Konstantopoulos K (2008).  Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow.  Journal of Biological Chemistry.  283(23).  15647-15655.
  • Healy ZR, Zhu F, Stull JD, Konstantopoulos K (2008).  Elucidation of the signaling network of COX-2 induction in sheared chondrocytes: COX-2 is induced via a Rac/MEKK1/MKK7/JNK2/c-Jun-C/EBPβ- dependent pathway.  American Journal of Physiology - Cell Physiology.  294(5).
  • Jaluria P, Konstantopoulos K, Betenbaugh M, Shiloach J (2008).  Egr1 and Gas6 facilitate the adaptation of HEK-293 cells to serum-free media by conferring enhanced viability and higher growth rates.  Biotechnology and Bioengineering.  99(6).  1443-1452.
  • Alves CS, Burdick MM, Thomas SN, Pawar P, Konstantopoulos K (2008).  The dual role of CD44 as a functional P-selectin ligand and fibrin receptor in colon carcinoma cell adhesion.  American Journal of Physiology - Cell Physiology.  294(4).
  • Nimrichter L, Burdick MM, Aoki K, Laroy W, Fierro MA, Hudson SA, Von Seggern CE, Cotter RJ, Bochner BS, Tiemeyer M, Konstantopoulos K, Schnaar RL (2008).  E-selectin receptors on human leukocytes.  Blood.  112(9).  3744-52.
  • Ghosh M, Alves C, Tong Z, Tettey K, Konstantopoulos K, Stebe KJ (2008).  Multifunctional surfaces with discrete functionalized regions for biological applications.  Langmuir.  24(15).  8134-42.
  • Healy ZR, Zhu F, Stull JD, Konstantopoulos K (2008).  Elucidation of the signaling network of COX-2 induction in sheared chondrocytes: COX-2 is induced via a Rac/MEKK1/MKK7/JNK2/c-Jun-C/EBPbeta-dependent pathway.  Am J Physiol Cell Physiol.  294(5).  C1146-57.
  • Pawar P, Jadhav S, Eggleton CD, Konstantopoulos K (2008).  Roles of cell and microvillus deformation and receptor-ligand binding kinetics in cell rolling.  Am J Physiol Heart Circ Physiol.  295(4).  H1439-50.
  • Dikeman DA, Rivera Rosado LA, Horn TA, Alves CS, Konstantopoulos K, Yang JT (2008).  alpha4 beta1-Integrin regulates directionally persistent cell migration in response to shear flow stimulation.  Am J Physiol Cell Physiol.  295(1).  C151-9.
  • Thomas SN, Zhu F, Schnaar RL, Alves CS, Konstantopoulos K (2008).  Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow.  J Biol Chem.  283(23).  15647-55.
  • Jaluria P, Konstantopoulos K, Betenbaugh M, Shiloach J (2008).  Egr1 and Gas6 facilitate the adaptation of HEK-293 cells to serum-free media by conferring enhanced viability and higher growth rates.  Biotechnol Bioeng.  99(6).  1443-52.
  • Alves CS, Burdick MM, Thomas SN, Pawar P, Konstantopoulos K (2008).  The dual role of CD44 as a functional P-selectin ligand and fibrin receptor in colon carcinoma cell adhesion.  Am J Physiol Cell Physiol.  294(4).  C907-16.
  • Dobrowsky TM, Panorchan P, Konstantopoulos K, Wirtz D (2008).  Chapter 15: Live-cell single-molecule force spectroscopy.  Methods Cell Biol.  89.  411-32.
  • Jaluria P, Betenbaugh M, Konstantopoulos K, Shiloach J (2007).  Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog.  BMC Biotechnology.  7.
  • Jadhav S, Chan KY, Konstantopoulos K, Eggleton CD (2007).  Shear modulation of intercellular contact area between two deformable cells colliding under flow.  Journal of Biomechanics.  40(13).  2891-2897.
  • George NPE, Konstantopoulos K, Ross JM (2007).  Differential kinetics and molecular recognition mechanisms involved in early versus late growth phase Staphylococcus aureus cell binding to platelet layers under physiological shear conditions.  Journal of Infectious Diseases.  196(4).  639-646.
  • Jaluria P, Betenbaugh M, Konstantopoulos K, Frank B, Shiloach J (2007).  Application of microarrays to identify and characterize genes involved in attachment dependence in HeLa cells.  Metabolic Engineering.  9(3).  241-251.
  • Jadhav S, Eggleton CD, Konstantopoulos K (2007).  Mathematical modeling of cell adhesion in shear flow: Application to targeted drug delivery in inflammation and cancer metastasis.  Current Pharmaceutical Design.  13(15).  1511-1526.
  • Jaluria P, Konstantopoulos K, Betenbaugh M, Shiloach J (2007).  A perspective on microarrays: Current applications, pitfalls, and potential uses.  Microbial Cell Factories.  6.
  • Napier SL, Healy ZR, Schnaar RL, Konstantopoulos K (2007).  Selectin ligand expression regulates the initial vascular interactions of colon carcinoma cells: The roles of CD44V and alternative sialofucosylated selectin ligands.  Journal of Biological Chemistry.  282(6).  3433-3441.
  • Napier SL, Healy ZR, Schnaar RL, Konstantopoulos K (2007).  Selectin ligand expression regulates the initial vascular interactions of colon carcinoma cells: the roles of CD44v and alternative sialofucosylated selectin ligands.  J Biol Chem.  282(6).  3433-41.
  • Jadhav S, Eggleton CD, Konstantopoulos K (2007).  Mathematical modeling of cell adhesion in shear flow: application to targeted drug delivery in inflammation and cancer metastasis.  Curr Pharm Des.  13(15).  1511-26.
  • Jaluria P, Konstantopoulos K, Betenbaugh M, Shiloach J (2007).  A perspective on microarrays: current applications, pitfalls, and potential uses.  Microb Cell Fact.  6.  4.
  • George NP, Konstantopoulos K, Ross JM (2007).  Differential kinetics and molecular recognition mechanisms involved in early versus late growth phase Staphylococcus aureus cell binding to platelet layers under physiological shear conditions.  J Infect Dis.  196(4).  639-46.
  • Jaluria P, Betenbaugh M, Konstantopoulos K, Shiloach J (2007).  Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog.  BMC Biotechnol.  7.  71.
  • Jaluria P, Betenbaugh M, Konstantopoulos K, Frank B, Shiloach J (2007).  Application of microarrays to identify and characterize genes involved in attachment dependence in HeLa cells.  Metab Eng.  9(3).  241-51.
  • George NPE, Wei Q, Shin PK, Konstantopoulos K, Ross JM (2006).  Staphylococcus aureus adhesion via Spa, ClfA, and SdrCDE to immobilized platelets demonstrates shear-dependent behavior.  Arteriosclerosis, Thrombosis, and Vascular Biology.  26(10).  2394-2400.
  • Grazioli A, Alves CS, Konstantopoulos K, Yang JT (2006).  Defective blood vessel development and pericyte/pvSMC distribution in α4 integrin-deficient mouse embryos.  Developmental Biology.  293(1).  165-177.
  • Lim LHK, Burdick MM, Hudson SA, Mustafa FB, Konstantopoulos K, Bochner BS (2006).  Stimulation of human endothelium with IL-3 induces selective basophil accumulation in vitro.  Journal of Immunology.  176(9).  5346-5353.
  • Hanley WD, Napier SL, Burdick MM, Schnaar RL, Sackstein R, Konstantopoulos K (2006).  Variant isoforms of CD44 are P- and L-selectin ligands on colon carcinoma cells.  FASEB Journal.  20(2).  337-339.
  • Lim LH, Burdick MM, Hudson SA, Mustafa FB, Konstantopoulos K, Bochner BS (2006).  Stimulation of human endothelium with IL-3 induces selective basophil accumulation in vitro.  J Immunol.  176(9).  5346-53.
  • Panorchan P, Thompson M, Davis KJ, Tseng Y, Konstantopoulos K, Wirtz D (2006).  Single-molecule analysis of cadherin-mediated cell-cell adhesion.  J Cell Sci.  119(Pt 1).  66-74.
  • Hanley WD, Napier SL, Burdick MM, Schnaar RL, Sackstein R, Konstantopoulos K (2006).  Variant isoforms of CD44 are P- and L-selectin ligands on colon carcinoma cells.  FASEB J.  20(2).  337-9.
  • Panorchan P, Thompson MS, Davis KJ, Tseng Y, Konstantopoulos K, Wirtz D (2006).  Single-molecule analysis of cadherin-mediated cell-cell adhesion.  Journal of Cell Science.  119(1).  66-74.
  • Grazioli A, Alves CS, Konstantopoulos K, Yang JT (2006).  Defective blood vessel development and pericyte/pvSMC distribution in alpha 4 integrin-deficient mouse embryos.  Dev Biol.  293(1).  165-77.
  • George NP, Wei Q, Shin PK, Konstantopoulos K, Ross JM (2006).  Staphylococcus aureus adhesion via Spa, ClfA, and SdrCDE to immobilized platelets demonstrates shear-dependent behavior.  Arterioscler Thromb Vasc Biol.  26(10).  2394-400.
  • Pawar P, Jadhav S, Eggleton C, Konstantopoulos K (2005).  Multiscale modeling of neutrophil rolling over a selectin-coated surface.  AIChE Annual Meeting, Conference Proceedings.  8786.
  • Hardesty KJ, Healy ZR, Kensler T, Konstantopoulos K (2005).  Identification of shear stress-responsive elements of the cyclooxygenase-2 gene in human chondrocytes.  AIChE Annual Meeting, Conference Proceedings.  8760.
  • Healy ZR, Lee N, Talalay P, Kensler T, Konstantopoulos K (2005).  Elucidation of intracellular signaling pathways in shear-activated chondrocytes: A role in arthritis.  AIChE Annual Meeting, Conference Proceedings.  8072.
  • Jaluria P, Betenbaugh M, Konstantopoulos K, Shiloach J (2005).  Application of microarrays to reverse engineer attachment dependence in mammalian cell lines.  AIChE Annual Meeting, Conference Proceedings.  8052.
  • Napier SL, Hanley WD, Konstantopoulos K (2005).  Biophysical and biochemical characterization of selectin-ligand interactions pertinent to metastasis.  AIChE Annual Meeting, Conference Proceedings.  9125.
  • George NPE, Konstantopoulos K, Ross JM (2005).  Early versus late growth S. aureus adhesion to immobilized platelets under physiological shear regimes.  AIChE Annual Meeting, Conference Proceedings.  9262.
  • Healy ZR, Lee NH, Gao X, Goldring MB, Talalay P, Kensler TW, Konstantopoulos K (2005).  Divergent responses of chondrocytes and endothelial cells to shear stress: Cross-talk among COX-2, the phase 2 response, and apoptosis.  Proceedings of the National Academy of Sciences of the United States of America.  102(39).  14010-14015.
  • Shin PK, Pawar P, Konstantopoulos K, Ross JM (2005).  Characteristics of new Staphylococcus aureus-RBC adhesion mechanism independent of fibrinogen and IgG under hydrodynamic shear conditions.  American Journal of Physiology - Cell Physiology.  289(3 58-3).
  • Hanley WD, Burdick MM, Konstantopoulos K, Sackstein R (2005).  CD44 on LS174T colon carcinoma cells possesses E-selectin ligand activity.  Cancer Research.  65(13).  5812-5817.
  • Ahn KC, Jun AJ, Pawar P, Jadhav S, Napier S, McCarty OJT, Konstantopoulos K (2005).  Preferential binding of platelets to monocytes over neutrophils under flow.  Biochemical and Biophysical Research Communications.  329(1).  345-355.
  • Jadhav S, Eggleton CD, Konstantopoulos K (2005).  A 3-D computational model predicts that cell deformation affects selectin-mediated leukocyte rolling.  Biophysical Journal.  88(1).  96-104.
  • Ahn KC, Jun AJ, Pawar P, Jadhav S, Napier S, McCarty OJ, Konstantopoulos K (2005).  Preferential binding of platelets to monocytes over neutrophils under flow.  Biochem Biophys Res Commun.  329(1).  345-55.
  • Healy ZR, Lee N, Gao X, Goldring MB, Talalay P, Kensler TW, Konstantopoulos K (2005).  Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.  Proc Natl Acad Sci U S A.  102(39).  14010-5.
  • Shin PK, Pawar P, Konstantopoulos K, Ross JM (2005).  Characteristics of new Staphylococcus aureus-RBC adhesion mechanism independent of fibrinogen and IgG under hydrodynamic shear conditions.  Am J Physiol Cell Physiol.  289(3).  C727-34.
  • Hanley WD, Burdick MM, Konstantopoulos K, Sackstein R (2005).  CD44 on LS174T colon carcinoma cells possesses E-selectin ligand activity.  Cancer Res.  65(13).  5812-7.
  • Jadhav S, Eggleton CD, Konstantopoulos K (2005).  A 3-D computational model predicts that cell deformation affects selectin-mediated leukocyte rolling.  Biophys J.  88(1).  96-104.
  • Burdick MM, Konstantopoulos K (2004).  Platelet-induced enhancement of LS174T colon carcinoma and THP-1 monocytoid cell adhesion to vascular endothelium under flow.  American Journal of Physiology - Cell Physiology.  287(2 56-2).
  • Pawar P, Shin PK, Mousa SA, Ross JM, Konstantopoulos K (2004).  Fluid shear regulates the kinetics and receptor specificity of Staphylococcus aureus binding to activated platelets.  Journal of Immunology.  173(2).  1258-1265.
  • Hanley WD, Wirtz D, Konstantopoulos K (2004).  Distinct kinetic and mechanical properties govern selectin-leukocyte interactions.  Journal of Cell Science.  117(12).  2503-2511.
  • McCarty OJT, Abulencia JP, Mousa SA, Konstantopoulos K (2004).  Evaluation of platelet antagonists in in vitro flow models of thrombosis..  Methods in molecular medicine.  93.  21-34.
  • Pawar P, Shin PK, Mousa S, Ross JM, Konstantopoulos K (2004).  Fluid shear regulates the kinetics and receptor specificity of Staphylococcus aureus binding to activated platelets.  J Immunol.  173(2).  1258-65.
  • McCarty OJ, Abulencia JP, Mousa S, Konstantopoulos K (2004).  Evaluation of platelet antagonists in in vitro flow models of thrombosis.  Methods Mol Med.  93.  21-34.
  • Burdick MM, Konstantopoulos K (2004).  Platelet-induced enhancement of LS174T colon carcinoma and THP-1 monocytoid cell adhesion to vascular endothelium under flow.  Am J Physiol Cell Physiol.  287(2).  C539-47.
  • Hanley WD, Wirtz D, Konstantopoulos K (2004).  Distinct kinetic and mechanical properties govern selectin-leukocyte interactions.  J Cell Sci.  117(Pt 12).  2503-11.
  • Konstantopoulos K, Hanley WD, Wirtz D (2003).  Receptor-ligand binding: 'Catch' bonds finally caught.  Current Biology.  13(15).
  • Abulencia JP, Gaspard R, Healy ZR, Gaarde WA, Quackenbush J, Konstantopoulos K (2003).  Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells.  Journal of Biological Chemistry.  278(31).  28388-28394.
  • McCarty OJT, Tien N, Bochner BS, Konstantopoulos K (2003).  Exogenous eosinophil activation converts PSGL-1-dependent binding to CD18-dependent stable adhesion to platelets in shear flow.  American Journal of Physiology - Cell Physiology.  284(5 53-5).
  • Burdick MM, Michael McCaffery J, Kim YS, Bochner BS, Konstantopoulos K (2003).  Colon carcinoma cell glycolipids, integrins, and other glycoproteins mediate adhesion to HUVECs under flow.  American Journal of Physiology - Cell Physiology.  284(4 53-4).
  • Hanley W, McCarty O, Jadhav S, Tseng Y, Wirtz D, Konstantopoulos K (2003).  Single molecule characterization of P-selectin/ligand binding.  Journal of Biological Chemistry.  278(12).  10556-10561.
  • McCarty OJ, Tien N, Bochner BS, Konstantopoulos K (2003).  Exogenous eosinophil activation converts PSGL-1-dependent binding to CD18-dependent stable adhesion to platelets in shear flow.  Am J Physiol Cell Physiol.  284(5).  C1223-34.
  • Burdick MM, McCaffery J, Kim YS, Bochner BS, Konstantopoulos K (2003).  Colon carcinoma cell glycolipids, integrins, and other glycoproteins mediate adhesion to HUVECs under flow.  Am J Physiol Cell Physiol.  284(4).  C977-87.
  • Hanley W, McCarty O, Jadhav S, Tseng Y, Wirtz D, Konstantopoulos K (2003).  Single molecule characterization of P-selectin/ligand binding.  J Biol Chem.  278(12).  10556-61.
  • Abulencia JP, Gaspard R, Healy ZR, Gaarde WA, Quackenbush J, Konstantopoulos K (2003).  Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells.  J Biol Chem.  278(31).  28388-94.
  • Konstantopoulos K, Hanley W, Wirtz D (2003).  Receptor-ligand binding: 'Catch' bonds finally caught.  Current Biology.  13(15).  R611-R613.
  • Jadhav S, Konstantopoulos K (2002).  Fluid shear modulates the molecular interactions between polymorphonuclear leukocytes and colon carcinomas.  Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings.  1.  734-735.
  • Abulencia JP, Gaspard R, Quackenbush J, Konstantopoulos K (2002).  Microarray analysis of the chondrocytic cell line T/C-28a2 under dynamic fluid shear.  Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings.  1.  654-655.
  • Jadhav S, Konstantopoulos K (2002).  Fluid shear- and time-dependent modulation of molecular interactions between PMNs and colon carcinomas.  American Journal of Physiology - Cell Physiology.  283(4 52-4).
  • Mousa SA, Abulencia JP, McCarty OJT, Turner NA, Konstantopoulos K (2002).  Comparative efficacy between the glycoprotein IIb/IIIa antagonists roxifiban and orbofiban in inhibiting platelet responses in flow models of thrombosis.  Journal of Cardiovascular Pharmacology.  39(4).  552-560.
  • McCarty OJ, Jadhav S, Burdick MM, Bell WR, Konstantopoulos K (2002).  Fluid shear regulates the kinetics and molecular mechanisms of activation-dependent platelet binding to colon carcinoma cells.  Biophys J.  83(2).  836-48.
  • McCarty OJT, Jadhav S, Burdick MM, Bell WR, Konstantopoulos K (2002).  Fluid shear regulates the kinetics and molecular mechanisms of activation-dependent platelet binding to colon carcinoma cells.  Biophysical Journal.  83(2).  836-848.
  • Jadhav S, Konstantopoulos K (2002).  Fluid shear- and time-dependent modulation of molecular interactions between PMNs and colon carcinomas.  Am J Physiol Cell Physiol.  283(4).  C1133-43.
  • Jadhav S, Bochner BS, Konstantopoulos K (2001).  Hydrodynamic shear regulates the kinetics and receptor specificity of polymorphonuclear leukocyte-colon carcinoma cell adhesive interactions.  Journal of Immunology.  167(10).  5986-5993.
  • Konstantopoulos K, Mousa SA (2001).  Antiplatelet therapies: Platelet GPIIb/IIIa antagonists and beyond.  Current Opinion in Investigational Drugs.  2(8).  1086-1092.
  • Burdick MM, McCarty OJT, Jadhav S, Konstantopoulos K (2001).  Cellular/tissue engineering.  IEEE Engineering in Medicine and Biology Magazine.  20(3).  86-91.
  • Konstantopoulos K, Mousa S (2001).  Antiplatelet therapies: platelet GPIIb/IIIa antagonists and beyond.  Curr Opin Investig Drugs.  2(8).  1086-92.
  • Jadhav S, Bochner BS, Konstantopoulos K (2001).  Hydrodynamic shear regulates the kinetics and receptor specificity of polymorphonuclear leukocyte-colon carcinoma cell adhesive interactions.  J Immunol.  167(10).  5986-93.
  • Abulencia JP, Tien N, McCarty OJ, Plymire D, Mousa S, Konstantopoulos K (2001).  Comparative antiplatelet efficacy of a novel, nonpeptide GPIIb/IIIa antagonist (XV454) and abciximab (c7E3) in flow models of thrombosis.  Arterioscler Thromb Vasc Biol.  21(1).  149-56.
  • Burdick MM, Bochner BS, Collins BE, Schnaar RL, Konstantopoulos K (2001).  Glycolipids support E-selectin-specific strong cell tethering under flow.  Biochemical and Biophysical Research Communications.  284(1).  42-49.
  • Abulencia JP, Tien N, McCarty OJT, Plymire D, Mousa SA, Konstantopoulos K (2001).  Comparative antiplatelet efficacy of a novel, nonpeptide GPIIb/IIIa antagonist (XV454) and abciximab (c7E3) in flow models of thrombosis.  Arteriosclerosis, Thrombosis, and Vascular Biology.  21(1).  149-156.
  • Burdick MM, McCarty OJ, Jadhav S, Konstantopoulos K (2001).  Cell-cell interactions in inflammation and cancer metastasis.  IEEE Eng Med Biol Mag.  20(3).  86-91.
  • Burdick MM, Bochner BS, Collins BE, Schnaar RL, Konstantopoulos K (2001).  Glycolipids support E-selectin-specific strong cell tethering under flow.  Biochem Biophys Res Commun.  284(1).  42-9.
  • Ross J, Konstantopoulos K, McCarty O, Mohamed N (2000).  Shear stress modulates platelet-staphylococcal interactions.  Annals of Biomedical Engineering.  28(SUPPL. 1).
  • Burdick M, Konstantopoulos K (2000).  Analysis of selectin binding to immobilized glycosphingolipids under flow conditions.  Annals of Biomedical Engineering.  28(SUPPL. 1).
  • McCarty O, Konstantopoulos K (2000).  Immobilized platelets support human colon carcinoma cell tethering, rolling and firm adhesion under dynamic flow conditions.  Annals of Biomedical Engineering.  28(SUPPL. 1).
  • McCarty OJT, Mousa SA, Bray PF, Konstantopoulos K (2000).  Immobilized platelets support human colon carcinoma cell tethering, rolling, and firm adhesion under dynamic flow conditions.  Blood.  96(5).  1789-1797.
  • Tachimoto H, Burdick MM, Hudson SA, Kikuchi M, Konstantopoulos K, Bochner BS (2000).  CCR3-active chemokines promote rapid detachment of eosinophils from VCAM-1 in vitro.  Journal of Immunology.  165(5).  2748-2754.
  • Tachimoto H, Burdick MM, Hudson SA, Kikuchi M, Konstantopoulos K, Bochner BS (2000).  CCR3-active chemokines promote rapid detachment of eosinophils from VCAM-1 in vitro.  J Immunol.  165(5).  2748-54.
  • McCarty OJ, Mousa S, Bray PF, Konstantopoulos K (2000).  Immobilized platelets support human colon carcinoma cell tethering, rolling, and firm adhesion under dynamic flow conditions.  Blood.  96(5).  1789-97.
  • McCarty O, Konstantopoulos K (1999).  Molecular mechanisms of platelet-tumor cell adhesion under flow.  Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings.  1.  61.
  • Papadimitriou MNB, Menter DG, Konstantopoulos K, Nicolson GL, McIntire LV (1999).  Integrin α4β1/VCAM-1 pathway mediates primary adhesion of RAW117 lymphoma cells to hepatic sinusoidal endothelial cells under flow.  Clinical and Experimental Metastasis.  17(8).  669-676.
  • Konstantopoulos K, McIntire LV, Menter DG, Nicolson GL, Papadimitriou MN (1999).  Integrin alpha4beta1/VCAM-1 pathway mediates primary adhesion of RAW117 lymphoma cells to hepatic sinusoidal endothelial cells under flow.  Clin Exp Metastasis.  17(8).  669-76.
  • Konstantopoulos K, Neelamegham S, Burns AR, Hentzen E, Kansas GS, Snapp KR, Berg EL, Hellums JD, Smith CW, McIntire LV, Simon SI (1998).  Venous levels of shear support neutrophil-platelet adhesion and neutrophil aggregation in blood via P-selectin and β2-integrin.  Circulation.  98(9).  873-882.
  • Konstantopoulos K, Kukreti S, McIntire LV (1998).  Biomechanics of cell interactions in shear fields.  Advanced Drug Delivery Reviews.  33(1-2).  141-164.
  • Konstantopoulos K, Kukreti S, McIntire LV (1998).  Biomechanics of cell interactions in shear fields.  Adv Drug Deliv Rev.  33(1-2).  141-64.
  • Berg EL, Burns AR, Hellums JD, Hentzen E, Kansas GS, Konstantopoulos K, McIntire LV, Neelamegham S, Simon SI, Smith C, Snapp KR (1998).  Venous levels of shear support neutrophil-platelet adhesion and neutrophil aggregation in blood via P-selectin and beta2-integrin.  Circulation.  98(9).  873-82.
  • Konstantopoulos K, McIntire LV (1997).  Effects of fluid dynamic forces on vascular cell adhesion.  Journal of Clinical Investigation.  100(11 SUPPL.).
  • Konstantopoulos K, Chow TW, Turner NA, Hellums JD, Moake JL (1997).  Shear stress-induced binding of von Willebrand factor to platelets.  Biorheology.  34(1).  57-71.
  • Kukreti S, Konstantopoulos K, Smith CW, McIntire LV (1997).  Molecular mechanisms of monocyte adhesion to interleukin-1β-stimulated endothelial cells under physiologic flow conditions.  Blood.  89(11).  4104-4111.
  • Kamat SG, Turner NA, Konstantopoulos K, Hellums JD, McIntire LV, Kleiman NS, Moake JL (1997).  Effects of integrelin on platelet function in flow models of arterial thrombosis.  Journal of Cardiovascular Pharmacology.  29(2).  156-163.
  • Konstantopoulos K, Kukreti S, McIntire LV, Smith C (1997).  Endothelial P-selectin and VCAM-1 each can function as primary adhesive mechanisms for T cells under conditions of flow.  J Leukoc Biol.  61(2).  179-87.
  • Konstantopoulos K, Kukreti S, McIntire LV, Smith C (1997).  Molecular mechanisms of monocyte adhesion to interleukin-1beta-stimulated endothelial cells under physiologic flow conditions.  Blood.  89(11).  4104-11.
  • Konstantopoulos K, Kukreti S, Smith CW, McIntire LV (1997).  Endothelial P-selectin and VCAM-1 each can function as primary adhesive mechanisms for T cells under conditions of flow.  Journal of Leukocyte Biology.  61(2).  179-187.
  • Konstantopoulos K, McIntire LV (1997).  Effects of fluid dynamic forces on vascular cell adhesion.  J Clin Invest.  100(11 Suppl).  S19-23.
  • Chow TW, Hellums JD, Konstantopoulos K, Moake JL, Turner NA (1997).  Shear stress-induced binding of von Willebrand factor to platelets.  Biorheology.  34(1).  57-71.
  • Konstantopoulos K, McIntire LV (1996).  Effects of fluid dynamic forces on vascular cell adhesion.  Journal of Clinical Investigation.  98(12).  2661-2665.
  • Konstantopoulos K, McIntire LV (1996).  Effects of fluid dynamic forces on vascular cell adhesion.  J Clin Invest.  98(12).  2661-5.
  • Konstantopoulos K, Kamat SG, Schafer AI, Bañez EI, Jordan R, Kleiman NS, Hellums JD (1995).  Shear-induced platelet aggregation is inhibited by in vivo infusion of an anti-glycoprotein IIb/IIIa antibody fragment, c7E3 Fab, in patients undergoing coronary angioplasty.  Circulation.  91(5).  1427-1431.
  • Banez EI, Hellums JD, Konstantopoulos K, Shattil SJ, Udden MM, Wu KK (1995).  Flow cytometric studies of platelet responses to shear stress in whole blood.  Biorheology.  32(1).  73-93.
  • Banez EI, Hellums JD, Jordan R, Kamat SG, Kleiman NS, Konstantopoulos K, Schafer AI (1995).  Shear-induced platelet aggregation is inhibited by in vivo infusion of an anti-glycoprotein IIb/IIIa antibody fragment, c7E3 Fab, in patients undergoing coronary angioplasty.  Circulation.  91(5).  1427-31.
  • Konstantopoulos K, Wu KK, Udden MM, Bañez EI, Shattil SJ, Hellums JD (1995).  Flow cytometric studies of platelet responses to shear stress in whole blood.  Biorheology.  32(1).  73-93.
  • Konstantopoulos K, Grotta JC, Sills C, Wu KK, Hellums JD (1995).  Shear-induced platelet aggregation in normal subjects and stroke patients.  Thrombosis and Haemostasis.  74(5).  1329-1334.
  • Grotta JC, Hellums JD, Konstantopoulos K, Sills C, Wu KK (1995).  Shear-induced platelet aggregation in normal subjects and stroke patients.  Thromb Haemost.  74(5).  1329-34.
Books
  • Cheung LS, Raman P, Wirtz D, Konstantopoulos K (2012).  Biophysics of selectin-mediated cell adhesion.  Comprehensive Biophysics.  7.  10-32.
Book Chapters
  • Wong BS, Mistriotis P, Konstantopoulos K (2018).  Exposing cell-itary confinement: Understanding the mechanisms of confined single cell migration.  Advances in Experimental Medicine and Biology.  1092.  139-157.
  • Cheung LSL, Raman PS, Wirtz D, Konstantopoulos K (2012).  Biophysics of selectin-mediated cell adhesion.  Comprehensive Biophysics.  7.  10-32.
Patents
  • "Microfluidic chip for analysis of cell motility and methods for using same", 2018.
  • "Selectin ligands useful in the diagnosis and treatment of cancer", 2018.
  • "Giant obscurins and uses thereof in cancer prognosis and therapy", 2017.
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