Konstantopoulos, Konstantinos

William H. Schwarz Professor
Chemical And Biomolecular Engineering
http://kostaslab.johnshopkins.edu/

Croft Hall 114
(410) 516-6290
konstant@jhu.edu

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About

Education
  • Ph.D. 1995, RICE UNIVERSITY
Experience
  • 2008 - 2008:  Director, Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
  • 2008 - Present:  Chair, Department of Chemical & Biomolecular Engineering
  • 2008 - 2008:  Chair, Annual Meeting of the Biomedical Engineering Society
  • 2008 - 2008:  Chair, 13th International Congress of Biorheology & 6th International Conference on Clinical Hemorheology
  • 2008 - Present:  Department Chair, Unspecified
  • 2008 - 2008:  Director, Chemical & Biomolecular Engineering
  • 2008 - Present:  Joint, SOM Oncology Center
  • 2006 - 2006:  Chair, Faculty Search Committee
  • 2006 - 2006:  Director, Chemical & Biomolecular Engineering
  • 2006 - 2006:  Chair, Biomedical Engineering Society
  • 1998 - Present:  Joint, SOM Biomedical Engineering
Research Areas
  • Biophysical characterization of these adhesive interactions at the single-molecule level
  • CELL migration
  • Discovery of adhesion moleculues involved in tumor cell adhesion in the vasculature
  • Elucidation of novel signaling mechanisms
  • Interface of engineering and biology pertinent to cancer metastasis
  • Physically confined microenvironments
Awards
  • 2014:  AIChE Division 15d/e Plenary Award
  • 2014:  Section Editor for Biological Engineering, Current Opinion in Chemical Engineering
  • 2014:  Editorial Board, Annual Review of Biomedical Engineering
  • 2014:  Editorial Board, Technology
  • 2014:  Section Editor for Biological Engineering, Current Opinion in Chemical Engineering
  • 2013:  Bioengineering Distinguished Alumnus Award
  • 2012:  Fellow - Biomedical Engineering Society
  • 2011:  Robert B. Pond - Sr. Excellence in Teaching Award
  • 2011:  Chair - Bioengineering - Technology and Surgical Sciences Study (BTSS) Section - NIH
  • 2011:  Chair - BMES Spring Meeting
  • 2010:  Fellow - American Institute for Medical and Biological Engineering
  • 2009:  Associate Editor - Annals of Biomedical Engineering
  • 2009:  Member - Mid-Atlantic Affiliate Unified Peer Review Steering Committee - American Heart Association
  • 2008:  Member - Bioengineering - Technology and Surgical Sciences Study Section - NIH
  • 2006:  ARCS Foundation Scholarship (Christina Alves)
  • 2006:  American Heart Association Graduate Student Fellowship (Christina Alves)
  • 2005:  Masson-Agarwal Faculty Scholar - The Johns Hopkins University
  • 2003:  Robert B. Pond - Sr. Excellence in Teaching Award
  • 2001:  NSF CAREER Award - National Science Foundation
  • 2000:  DuPont Young Professor Award - DuPont
  • 1998:  Whitaker Foundation Award
  • 1994:  Whitaker Graduate Student Award in Recognition of Academic Achievement in Bioengineering - Biomedical Engineering Society
  • 1990:  Scholarship Award in Recognition of Excellence in Academic Achievement - Hellenic Professional Society of Texas
  • 1989:  Special Graduate Student Fellowship Award - Department of Chemical Engineering - Rice University
Presentations
  • "Cell sensing and motility in confinement", 2017 Physics of Cancer Gordon Research Conference.  Galveston, TX.  February 6, 2017
  • "Harnessing Engineering and Biology to Understand Cell Motility in Confined Spaces", Texas A&M.  College Station, TX.  November 30, 2016
  • "Harnessing Engineering and Biology to Understand Tumor Cell Locomotion in Confinement", Penn State Hershey Cancer Institute.  Hershey, PA.  October 27, 2016
  • "Harnessing Engineering and Biology to Understand Cell Motility in Confined Spaces", Vanderbilt University.  Nashville, TN.  October 24, 2016
  • "Harnessing Engineering and Biology to Understand Cell Motility in Confined Spaces", University of Houston.  Houston, TX.  October 14, 2016
  • "Cell sensing and motility in confinement", Symposium on Mechanical Behaviors of Cytoskeleton and Cells.  College Park, MD.  October 4, 2016
  • "Harnessing Engineering and Biology to Understand Cell Locomotion in Confinement", University of Michigan.  Ann Arbor, MI.  April 15, 2016
  • "Harnessing Engineering and Biology to Understand Cell Locomotion in Confinement", Penn State University.  State College, PA.  April 7, 2016
  • "Harnessing Engineering and Biology to Understand Cell Locomotion in Confinement", University of Notre Dame.  Notre Dame, IN.  March 22, 2016
  • "Interplay of the physical microenvironment, contact guidance and cell signaling in cell decision making", 251st ACS National Meeting & Exposition, Division of Colloid and Surface Chemistry.  San Diego, CA.  March 14, 2016
  • "A Bioengineering Perspective on Cell Locomotion", Universitat Pompeu Fabra.  Barcelona, Spain.  November 2, 2015
  • "A Bioengineering Perspective on Cell Locomotion", Florida A&M University- Florida State University.  Tallahassee, Florida.  October 23, 2015
  • "A Bioengineering Perspective on Cell Locomotion", Rice University.  Houston, Texas.  September 3, 2015
  • "Bioengineering paradigms for cell migration in confined microenvironments", Institut Curie.  Institut Curie in Paris, France.  March 25, 2015
  • "Physical cues guide tumor cell adhesion and migration", Workshop on Cell Motility.  Institut Curie in Paris, France.  March 24, 2015
  • "Water permeation regulates tumor cell migration in confined microenvironments", 2015 Directed Cell Migration Gordon Conference.  Galveston, TX.  January 1, 2015

Publications

Journal Articles
  • Jablonska A, Shea DJ, Cao S, Bulte JWM, Janowski M, Konstantopoulos K, Walczak P (2018).  Overexpression of VLA-4 in glial-restricted precursors enhances their endothelial docking and induces diapedesis in a mouse stroke model.  Journal of Cerebral Blood Flow and Metabolism.  38(5).
  • Sengupta S, Nagalingam A, Muniraj N, Bonner MY, Mistriotis P, Afthinos A, Kuppusamy P, Lanoue D, Cho S, Korangath P, Shriver M, Begum A, Merino VF, Huang CY, Arbiser JL, Matsui W, Györffy B, Konstantopoulos K, Sukumar S, Marignani PA, Saxena NK, Sharma D (2017).  Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3.  Oncogene.  36(41).
  • Gerecht S, Konstantopoulos K (2017).  Editorial overview: Biological engineering: Stem cell engineering.  Current Opinion in Chemical Engineering.  15.
  • Stroka KM, Wong BS, Shriver M, Phillip JM, Wirtz D, Kontrogianni-Konstantopoulos A, Konstantopoulos K (2017).  Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness.  Oncotarget.  8(33).
  • Curreli S, Wong BS, Latinovic O, Konstantopoulos K, Stamatos NM (2016).  Class 3 semaphorins induce F-actin reorganization in human dendritic cells: Role in cell migration..  Journal of leukocyte biology.  100(6).  1323-1334.
  • Mathieu E, Paul CD, Stahl R, Vanmeerbeeck G, Reumers V, Liu C, Konstantopoulos K, Lagae L (2016).  Time-lapse lens-free imaging of cell migration in diverse physical microenvironments..  Lab on a chip.  16(17).  3304-16.
  • Stroka KM, Wong BS, Shriver M, Phillip JM, Wirtz D, Kontrogianni-Konstantopoulos A, Konstantopoulos K (2016).  Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness..  Oncotarget.
  • Shriver M, Marimuthu S, Paul C, Geist J, Seale T, Konstantopoulos K, Kontrogianni-Konstantopoulos A (2016).  Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit..  Oncotarget.  7(29).  45414-45428.
  • Paul CD, Hung WC, Wirtz D, Konstantopoulos K (2016).  Engineered Models of Confined Cell Migration.  Annual Review of Biomedical Engineering.  18.
  • Paul CD, Hung WC, Wirtz D, Konstantopoulos K (2016).  Engineered Models of Confined Cell Migration..  Annual review of biomedical engineering.  18.  159-80.
  • Paul CD, Shea DJ, Mahoney MR, Chai A, Laney V, Hung WC, Konstantopoulos K (2016).  Interplay of the physical microenvironment, contact guidance, and intracellular signaling in cell decision making..  FASEB journal : official publication of the Federation of American Societies for Experimental Biology.  30(6).  2161-70.
  • Hung WC, Yang J, Yankaskas CL, Wong BS, Wu P, Pardo-Pastor C, Serra SA, Chiang MJ, Gu Z, Wirtz D, Valverde MA, Yang J, Zhang J, Konstantopoulos K (2016).  Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways..  Cell reports.  15(7).  1430-41.
  • Hung WC, Yang JR, Yankaskas CL, Wong BS, Wu PH, Pardo-Pastor C, Serra SA, Chiang MJ, Gu Z, Wirtz D, Valverde MA, Yang JT, Zhang J, Konstantopoulos K (2016).  Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways.  Cell Reports.  15(7).
  • Konstantopoulos K, Gerecht S (2016).  Editorial overview: Biological Engineering: Engineering Systems for cancer modeling, diagnostics and therapeutics.  Current Opinion in Chemical Engineering.  11.  iv-v.
  • Gerecht S, Konstantopoulos K (2016).  Editorial overview: Biological engineering: Engineering systems for cancer modeling, diagnostics and therapeutics.  Current Opinion in Chemical Engineering.  11.
  • He L, Chen W, Wu PH, Jimenez A, Wong BS, San A, Konstantopoulos K, Wirtz D (2016).  Local 3D matrix confinement determines division axis through cell shape.  Oncotarget.  7(6).
  • Yu X, Guan PP, Guo JW, Wang Y, Cao LL, Xu GB, Konstantopoulos K, Wang ZY, Wang P (2015).  By suppressing the expression of anterior pharynx-defective-1α and -1β and inhibiting the aggregation of β-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice..  FASEB journal : official publication of the Federation of American Societies for Experimental Biology.  29(12).  5044-58.
  • Zabransky DJ, Yankaskas CL, Cochran RL, Wong HY, Croessmann S, Chu D, Kavuri SM, Red Brewer M, Rosen DM, Dalton WB, Cimino-Mathews A, Cravero K, Button B, Kyker-Snowman K, Cidado J, Erlanger B, Parsons HA, Manto KM, Bose R, Lauring J, Arteaga CL, Konst... (2015).  HER2 missense mutations have distinct effects on oncogenic signaling and migration..  Proceedings of the National Academy of Sciences of the United States of America.  112(45).  E6205-14.
  • Zabransky DJ, Yankaskas CL, Cochran RL, Wong HY, Croessmann S, Chu D, Kavuri SM, Brewer MR, Marc Rosen D, Brian Dalton W, Cimino-Mathews A, Cravero K, Button B, Kyker-Snowman K, Cidado J, Erlanger B, Parsons HA, Manto KM, Bose R, Lauring J, Arteaga CL, Konstantopoulos K, Park BH (2015).  HER2 missense mutations have distinct effects on oncogenic signaling and migration.  Proceedings of the National Academy of Sciences of the United States of America.  112(45).
  • He L, Chen W, Wu P, Jimenez A, Wong BS, San A, Konstantopoulos K, Wirtz D (2015).  Local 3D matrix confinement determines division axis through cell shape..  Oncotarget.
  • Shea DJ, Wirtz D, Stebe KJ, Konstantopoulos K (2015).  Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear flow..  Oncotarget.  6(28).  24842-55.
  • Wang P, Chen SH, Hung WC, Paul C, Zhu F, Guan PP, Huso DL, Kontrogianni-Konstantopoulos A, Konstantopoulos K (2015).  Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways.  Oncogene.  34(35).
  • Wang P, Chen SH, Hung WC, Paul C, Zhu F, Guan PP, Huso DL, Kontrogianni-Konstantopoulos A, Konstantopoulos K (2015).  Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways..  Oncogene.  34(35).  4558-69.
  • Shriver M, Stroka KM, Vitolo MI, Martin S, Huso DL, Konstantopoulos K, Kontrogianni-Konstantopoulos A (2015).  Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis..  Oncogene.  34(32).  4248-59.
  • Shriver M, Stroka KM, Vitolo MI, Martin S, Huso DL, Konstantopoulos K, Kontrogianni-Konstantopoulos A (2015).  Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis.  Oncogene.  34(32).
  • Guan PP, Guo JW, Yu X, Wang Y, Wang T, Konstantopoulos K, Wang ZY, Wang P (2015).  The role of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage..  Scientific reports.  5.  10412.
  • Guan PP, Yu X, Guo JJ, Wang Y, Wang T, Li JY, Konstantopoulos K, Wang ZY, Wang P (2015).  By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization..  Oncotarget.  6(11).  9140-59.
  • Cheung LS, Shea DJ, Nicholes N, Date A, Ostermeier M, Konstantopoulos K (2015).  Characterization of monobody scaffold interactions with ligand via force spectroscopy and steered molecular dynamics..  Scientific reports.  5.  8247.
  • Cheung LSL, Shea DJ, Nicholes N, Date A, Ostermeier M, Konstantopoulos K (2015).  Characterization of Monobody Scaffold Interactions with Ligand via Force Spectroscopy and Steered Molecular Dynamics.  Scientific Reports.  5.
  • Konstantopoulos K, Segura T (2015).  Editorial overview: Materials engineering: Advances in smart and controlled delivery of therapeutic molecules.  Current Opinion in Chemical Engineering.  7.  v-vi.
  • Shea DJ, Wirtz D, Stebe KJ, Konstantopoulos K (2015).  Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear f low.  Oncotarget.  6(28).
  • Stroka KM, Jiang H, Chen SH, Tong Z, Wirtz D, Sun SX, Konstantopoulos K (2014).  Water permeation drives tumor cell migration in confined microenvironments.  Cell.  157(3).
  • Grabias BM, Konstantopoulos K (2014).  The physical basis of renal fibrosis: effects of altered hydrodynamic forces on kidney homeostasis.  Am J Physiol Renal Physiol.  306(5).  F473-85.
  • Stroka KM, Gu Z, Sun SX, Konstantopoulos K (2014).  Bioengineering paradigms for cell migration in confined microenvironments.  Current Opinion in Cell Biology.  30(1).
  • Wang P, Guan PP, Wang T, Yu X, Guo JJ, Konstantopoulos K, Wang ZY (2014).  Interleukin-1beta and cyclic AMP mediate the invasion of sheared chondrosarcoma cells via a matrix metalloproteinase-1-dependent mechanism.  Biochim Biophys Acta.  1843(5).  923-33.
  • Stroka KM, Konstantopoulos K (2014).  Physical biology in cancer. 4. Physical cues guide tumor cell adhesion and migration.  Am J Physiol Cell Physiol.  306(2).  C98-C109.
  • Stroka KM, Jiang H, Chen S, Tong Z, Wirtz D, Sun S, Konstantopoulos K (2014).  Water permeation drives tumor cell migration in confined microenvironments.  Cell.  157(3).  611-23.
  • Stroka KM, Gu Z, Sun S, Konstantopoulos K (2014).  Bioengineering paradigms for cell migration in confined microenvironments.  Curr Opin Cell Biol.  30.  41-50.
  • Hung WC, Chen SH, Paul CD, Stroka KM, Lo YC, Yang JT, Konstantopoulos K (2013).  Distinct signaling mechanisms regulate migration in unconfined versus confined spaces.  Journal of Cell Biology.  202(5).
  • Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen W-C, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PCW, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJT, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, Van O...Wu P-H (2013).  A physical sciences network characterization of non-tumorigenic and metastatic cells.  Scientific Reports.  3.
  • Chen WC, Wu PH, Phillip JM, Khatau SB, Choi JM, Dallas MR, Konstantopoulos K, Sun SX, Lee JSH, Hodzic D, Wirtz D (2013).  Functional interplay between the cell cycle and cell phenotypes.  Integrative Biology (United Kingdom).  5(3).
  • Konstantopoulos K, Wu PH, Wirtz D (2013).  Dimensional control of cancer cell migration.  Biophysical Journal.  104(2).
  • Chen W, Wu PH, Phillip JM, Khatau SB, Choi J, Dallas MR, Konstantopoulos K, Sun S, Lee JS, Hodzic D, Wirtz D (2013).  Functional interplay between the cell cycle and cell phenotypes.  Integr Biol (Camb).  5(3).  523-34.
  • Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C,... (2013).  A physical sciences network characterization of non-tumorigenic and metastatic cells..  Scientific reports.  3.  1449.
  • Konstantopoulos K, Wu P, Wirtz D (2013).  Dimensional control of cancer cell migration.  Biophysical Journal.  104(2).  279-280.
  • Raman PS, Paul CD, Stroka KM, Konstantopoulos K (2013).  Probing cell traction forces in confined microenvironments.  Lab Chip.  13(23).  4599-607.
  • Hung WC, Chen S, Paul CD, Stroka KM, Lo YC, Yang JT, Konstantopoulos K (2013).  Distinct signaling mechanisms regulate migration in unconfined versus confined spaces.  J Cell Biol.  202(5).  807-24.
  • Stroka KM, Jiang H, Sun SX, Konstantopoulos K (2013).  Role of water permeation in confined cell migration and polarization.  Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future.
  • Bernate JA, Liu C, Lagae L, Konstantopoulos K, Drazer G (2013).  Vector separation of particles and cells using an array of slanted open cavities.  Lab Chip.  13(6).  1086-92.
  • Grabias BM, Konstantopoulos K (2013).  Notch4-dependent antagonism of canonical TGF-beta1 signaling defines unique temporal fluctuations of SMAD3 activity in sheared proximal tubular epithelial cells.  Am J Physiol Renal Physiol.  305(1).  F123-33.
  • Chen S, Hung WC, Wang P, Paul C, Konstantopoulos K (2013).  Mesothelin binding to CA125/MUC16 promotes pancreatic cancer cell motility and invasion via MMP-7 activation.  Sci Rep.  3.  1870.
  • Wang P, Guan PP, Guo C, Zhu F, Konstantopoulos K, Wang ZY (2013).  Fluid shear stress-induced osteoarthritis: roles of cyclooxygenase-2 and its metabolic products in inducing the expression of proinflammatory cytokines and matrix metalloproteinases.  FASEB J.  27(12).  4664-77.
  • Chen SH, Hung WC, Wang P, Paul C, Konstantopoulos K (2013).  Mesothelin binding to CA125/MUC16 promotes pancreatic cancer cell motility and invasion via MMP-7 activation.  Scientific Reports.  3.
  • Streppel MM, Vincent A, Mukherjee R, Campbell NR, Chen SH, Konstantopoulos K, Goggins MG, Van Seuningen I, Maitra A, Montgomery EA (2012).  Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon.  Human Pathology.  43(10).
  • Lee KH, Galloway JF, Park J, Dvoracek CM, Dallas M, Konstantopoulos K, Maitra A, Searson PC (2012).  Quantitative molecular profiling of biomarkers for pancreatic cancer with functionalized quantum dots.  Nanomedicine: Nanotechnology, Biology, and Medicine.  8(7).
  • Dallas MR, Chen SH, Streppel MM, Sharma S, Maitra A, Konstantopoulos K (2012).  Sialofucosylated podocalyxin is a functional E- and L-selectin ligand expressed by metastatic pancreatic cancer cells.  American Journal of Physiology - Cell Physiology.  303(6).
  • Raman PS, Alves CS, Wirtz D, Konstantopoulos K (2012).  Distinct kinetic and molecular requirements govern CD44 binding to hyaluronan versus fibrin(ogen).  Biophysical Journal.  103(3).
  • Almaraz RT, Tian Y, Bhattarcharya R, Tan E, Chen SH, Dallas MR, Chen L, Zhang Z, Zhang H, Konstantopoulos K, Yarema KJ (2012).  Metabolic flux increases glycoprotein sialylation: Implications for cell adhesion and cancer metastasis.  Molecular and Cellular Proteomics.  11(7).
  • Dallas MR, Liu G, Chen WC, Thomas SN, Wirtz D, Huso DL, Konstantopoulos K (2012).  Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis.  FASEB Journal.  26(6).
  • Chen SH, Dallas MR, Balzer EM, Konstantopoulos K (2012).  Mucin 16 is a functional selectin ligand on pancreatic cancer cells.  FASEB Journal.  26(3).
  • Cheung LSL, Kanwar M, Ostermeier M, Konstantopoulos K (2012).  A hot-spot motif characterizes the interface between a designed ankyrin-repeat protein and its target ligand.  Biophysical Journal.  102(3).
  • Raman PS, Alves CS, Wirtz D, Konstantopoulos K (2012).  Distinct kinetic and molecular requirements govern CD44 binding to hyaluronan versus fibrin(ogen).  Biophys J.  103(3).  415-23.
  • Dallas MR, Chen S, Streppel MM, Sharma S, Maitra A, Konstantopoulos K (2012).  Sialofucosylated podocalyxin is a functional E- and L-selectin ligand expressed by metastatic pancreatic cancer cells.  Am J Physiol Cell Physiol.  303(6).  C616-24.
  • Cheung LS, Kanwar M, Ostermeier M, Konstantopoulos K (2012).  A hot-spot motif characterizes the interface between a designed ankyrin-repeat protein and its target ligand.  Biophys J.  102(3).  407-16.
  • Tong Z, Balzer EM, Dallas MR, Hung WC, Stebe KJ, Konstantopoulos K (2012).  Chemotaxis of cell populations through confined spaces at single-cell resolution.  PLoS One.  7(1).  e29211.
  • Streppel MM, Vincent A, Mukherjee R, Campbell N, Chen S, Konstantopoulos K, Goggins MG, Van Seuningen I, Maitra A, Montgomery EA (2012).  Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon.  Hum Pathol.  43(10).  1755-63.
  • Chen S, Dallas MR, Balzer EM, Konstantopoulos K (2012).  Mucin 16 is a functional selectin ligand on pancreatic cancer cells.  FASEB J.  26(3).  1349-59.
  • Tong Z, Cheung LS, Stebe KJ, Konstantopoulos K (2012).  Selectin-mediated adhesion in shear flow using micropatterned substrates: multiple-bond interactions govern the critical length for cell binding.  Integr Biol (Camb).  4(8).  847-56.
  • Lee KH, Galloway JF, Park J, Dvoracek CM, Dallas M, Konstantopoulos K, Maitra A, Searson P (2012).  Quantitative molecular profiling of biomarkers for pancreatic cancer with functionalized quantum dots.  Nanomedicine: Nanotechnology, Biology, and Medicine.  8(7).  1043-1051.
  • Balzer EM, Konstantopoulos K (2012).  Intercellular adhesion: mechanisms for growth and metastasis of epithelial cancers.  Wiley Interdiscip Rev Syst Biol Med.  4(2).  171-81.
  • Wang P, Zhu F, Konstantopoulos K (2012).  The antagonistic actions of endogenous interleukin-1beta and 15-deoxy-Delta12,14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes.  J Biol Chem.  287(38).  31877-93.
  • Grabias BM, Konstantopoulos K (2012).  Epithelial-mesenchymal transition and fibrosis are mutually exclusive reponses in shear-activated proximal tubular epithelial cells.  FASEB J.  26(10).  4131-41.
  • Alves CS, Konstantopoulos K (2012).  PDGF suppresses the sulfation of CD44v and potentiates CD44v-mediated binding of colon carcinoma cells to fibrin under flow.  PLoS One.  7(10).  e41472.
  • Balzer EM, Tong Z, Paul CD, Hung WC, Stroka KM, Boggs AE, Martin SS, Konstantopoulos K (2012).  Physical confinement alters tumor cell adhesion and migration phenotypes.  FASEB J.  26(10).  4045-56.
  • Dallas MR, Liu G, Chen W, Thomas SN, Wirtz D, Huso DL, Konstantopoulos K (2012).  Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis.  FASEB J.  26(6).  2648-56.
  • Almaraz RT, Tian Y, Bhattarcharya R, Tan E, Chen S, Dallas MR, Chen L, Zhang Z, Zhang H, Konstantopoulos K, Yarema KJ (2012).  Metabolic flux increases glycoprotein sialylation: implications for cell adhesion and cancer metastasis.  Mol Cell Proteomics.  11(7).  M112 017558.
  • Dallas M, Liu G, Chen W, Thomas S, Wirtz D, Huso D, Konstantopoulos K (2012).  Erratum: Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis (FASEB Journal (2012) 26 (2648-2656) DOI: 10.1096/fj.12- 203786).  FASEB Journal.  26(11).  4774.
  • Wirtz D, Konstantopoulos K, Searson PC (2011).  The physics of cancer: The role of physical interactions and mechanical forces in metastasis.  Nature Reviews Cancer.  11(7).
  • Raman PS, Alves CS, Wirtz D, Konstantopoulos K (2011).  Single-molecule binding of CD44 to fibrin versus P-selectin predicts their distinct shear-dependent interactions in cancer.  Journal of Cell Science.  124(11).
  • Cheung LSL, Raman PS, Balzer EM, Wirtz D, Konstantopoulos K (2011).  Biophysics of Selectin-Ligand interactions in inflammation and cancer.  Physical Biology.  8(1).
  • Wang P, Zhu F, Konstantopoulos K (2011).  Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Delta(12,14)-PGJ2.  PLoS One.  6(11).  e27630.
  • Cheung LS, Raman PS, Balzer EM, Wirtz D, Konstantopoulos K (2011).  Biophysics of selectin-ligand interactions in inflammation and cancer.  Phys Biol.  8(1).  015013.
  • Wirtz D, Konstantopoulos K, Searson P (2011).  The physics of cancer: The role of physical interactions and mechanical forces in metastasis.  Nature Reviews Cancer.  11(7).  512-522.
  • Konstantopoulos K, Thomas SN (2011).  Hematogenous metastasis: roles of CD44v and alternative sialofucosylated selectin ligands.  Adv Exp Med Biol.  705.  601-19.
  • Raman PS, Alves CS, Wirtz D, Konstantopoulos K (2011).  Single-molecule binding of CD44 to fibrin versus P-selectin predicts their distinct shear-dependent interactions in cancer.  J Cell Sci.  124(Pt 11).  1903-10.
  • Cheung LS, Konstantopoulos K (2011).  An analytical model for determining two-dimensional receptor-ligand kinetics.  Biophys J.  100(10).  2338-46.
  • Wang P, Zhu F, Tong Z, Konstantopoulos K (2011).  Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1.  FASEB J.  25(10).  3401-15.
  • Wirtz D, Konstantopoulos K, Searson P (2011).  The physics of cancer: The role of physical interactions and mechanical forces in metastasis.  Nature Reviews Cancer.  11(7).  512-522.
  • Wang P, Zhu F, Konstantopoulos K (2010).  Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A- and phosphatidylinositol 3-kinase-dependent NF-kappaB activation.  Am J Physiol Cell Physiol.  298(6).  C1445-56.
  • Gupta VK, Sraj IA, Konstantopoulos K, Eggleton CD (2010).  Multi-scale simulation of L-selectin-PSGL-1-dependent homotypic leukocyte binding and rupture.  Biomech Model Mechanobiol.  9(5).  613-27.
  • Zhu F, Wang P, Lee N, Goldring MB, Konstantopoulos K (2010).  Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis.  PLoS One.  5(12).  e15174.
  • Wang P, Zhu F, Lee N, Konstantopoulos K (2010).  Shear-induced interleukin-6 synthesis in chondrocytes: roles of E prostanoid (EP) 2 and EP3 in cAMP/protein kinase A- and PI3-K/Akt-dependent NF-kappaB activation.  J Biol Chem.  285(32).  24793-804.
  • Zhu F, Wang P, Kontrogianni-Konstantopoulos A, Konstantopoulos K (2010).  Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases.  Cell Death Differ.  17(8).  1325-34.
  • Thomas SN, Schnaar RL, Konstantopoulos K (2009).  Podocalyxin-like protein is an E-/L-selectin ligand on colon carcinoma cells: Comparative biochemical properties of selectin ligands in host and tumor cells.  American Journal of Physiology - Cell Physiology.  296(3).
  • Thomas SN, Schnaar RL, Konstantopoulos K (2009).  Podocalyxin-like protein is an E-/L-selectin ligand on colon carcinoma cells: comparative biochemical properties of selectin ligands in host and tumor cells.  Am J Physiol Cell Physiol.  296(3).  C505-13.
  • George NP, Ymele-Leki P, Konstantopoulos K, Ross JM (2009).  Differential binding of biofilm-derived and suspension-grown Staphylococcus aureus to immobilized platelets in shear flow.  J Infect Dis.  199(5).  633-40.
  • Konstantopoulos K, Thomas SN (2009).  Cancer cells in transit: the vascular interactions of tumor cells.  Annu Rev Biomed Eng.  11.  177-202.
  • Alves CS, Yakovlev S, Medved L, Konstantopoulos K (2009).  Biomolecular characterization of CD44-fibrin(ogen) binding: distinct molecular requirements mediate binding of standard and variant isoforms of CD44 to immobilized fibrin(ogen).  J Biol Chem.  284(2).  1177-89.
  • Thomas SN, Tong Z, Stebe KJ, Konstantopoulos K (2009).  Identification, characterization and utilization of tumor cell selectin ligands in the design of colon cancer diagnostics.  Biorheology.  46(3).  207-25.
  • Dobrowsky TM, Panorchan P, Konstantopoulos K, Wirtz D (2008).  Chapter 15 Live-Cell Single-Molecule Force Spectroscopy.  Methods in Cell Biology.  89.
  • Nimrichter L, Burdick MM, Aoki K, Laroy W, Fierro MA, Hudson SA, Von Seggern CE, Cotter RJ, Bochner BS, Tiemeyer M, Konstantopoulos K, Schnaar RL (2008).  E-selectin receptors on human leukocytes.  Blood.  112(9).
  • Dikeman DA, Rivera Rosado LA, Horn TA, Alves CS, Konstantopoulos K, Yang JT (2008).  α4β1-Integrin regulates directionally persistent cell migration in response to shear flow stimulation.  American Journal of Physiology - Cell Physiology.  295(1).
  • Thomas SN, Zhu F, Schnaar RL, Alves CS, Konstantopoulos K (2008).  Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow.  Journal of Biological Chemistry.  283(23).
  • Jaluria P, Konstantopoulos K, Betenbaugh M, Shiloach J (2008).  Egr1 and Gas6 facilitate the adaptation of HEK-293 cells to serum-free media by conferring enhanced viability and higher growth rates.  Biotechnology and Bioengineering.  99(6).
  • Ghosh M, Alves C, Tong Z, Tettey K, Konstantopoulos K, Stebe KJ (2008).  Multifunctional surfaces with discrete functionalized regions for biological applications.  Langmuir.  24(15).  8134-42.
  • Dobrowsky TM, Panorchan P, Konstantopoulos K, Wirtz D (2008).  Chapter 15: Live-cell single-molecule force spectroscopy.  Methods Cell Biol.  89.  411-32.
  • Jaluria P, Konstantopoulos K, Betenbaugh M, Shiloach J (2008).  Egr1 and Gas6 facilitate the adaptation of HEK-293 cells to serum-free media by conferring enhanced viability and higher growth rates.  Biotechnol Bioeng.  99(6).  1443-52.
  • Nimrichter L, Burdick MM, Aoki K, Laroy W, Fierro MA, Hudson SA, Von Seggern CE, Cotter RJ, Bochner BS, Tiemeyer M, Konstantopoulos K, Schnaar RL (2008).  E-selectin receptors on human leukocytes.  Blood.  112(9).  3744-52.
  • Thomas SN, Zhu F, Schnaar RL, Alves CS, Konstantopoulos K (2008).  Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow.  J Biol Chem.  283(23).  15647-55.
  • Alves CS, Burdick MM, Thomas SN, Pawar P, Konstantopoulos K (2008).  The dual role of CD44 as a functional P-selectin ligand and fibrin receptor in colon carcinoma cell adhesion.  Am J Physiol Cell Physiol.  294(4).  C907-16.
  • Healy ZR, Zhu F, Stull JD, Konstantopoulos K (2008).  Elucidation of the signaling network of COX-2 induction in sheared chondrocytes: COX-2 is induced via a Rac/MEKK1/MKK7/JNK2/c-Jun-C/EBPbeta-dependent pathway.  Am J Physiol Cell Physiol.  294(5).  C1146-57.
  • Dikeman DA, Rivera Rosado LA, Horn TA, Alves CS, Konstantopoulos K, Yang JT (2008).  alpha4 beta1-Integrin regulates directionally persistent cell migration in response to shear flow stimulation.  Am J Physiol Cell Physiol.  295(1).  C151-9.
  • Pawar P, Jadhav S, Eggleton CD, Konstantopoulos K (2008).  Roles of cell and microvillus deformation and receptor-ligand binding kinetics in cell rolling.  Am J Physiol Heart Circ Physiol.  295(4).  H1439-50.
  • Jaluria P, Betenbaugh M, Konstantopoulos K, Shiloach J (2007).  Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog.  BMC Biotechnology.  7.
  • Jaluria P, Betenbaugh M, Konstantopoulos K, Frank B, Shiloach J (2007).  Application of microarrays to identify and characterize genes involved in attachment dependence in HeLa cells.  Metabolic Engineering.  9(3).
  • Jaluria P, Konstantopoulos K, Betenbaugh M, Shiloach J (2007).  A perspective on microarrays: Current applications, pitfalls, and potential uses.  Microbial Cell Factories.  6.
  • Napier SL, Healy ZR, Schnaar RL, Konstantopoulos K (2007).  Selectin ligand expression regulates the initial vascular interactions of colon carcinoma cells: The roles of CD44V and alternative sialofucosylated selectin ligands.  Journal of Biological Chemistry.  282(6).
  • Jadhav S, Eggleton CD, Konstantopoulos K (2007).  Mathematical modeling of cell adhesion in shear flow: application to targeted drug delivery in inflammation and cancer metastasis.  Curr Pharm Des.  13(15).  1511-26.
  • Jaluria P, Betenbaugh M, Konstantopoulos K, Shiloach J (2007).  Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog.  BMC Biotechnol.  7.  71.
  • George NP, Konstantopoulos K, Ross JM (2007).  Differential kinetics and molecular recognition mechanisms involved in early versus late growth phase Staphylococcus aureus cell binding to platelet layers under physiological shear conditions.  J Infect Dis.  196(4).  639-46.
  • Jaluria P, Konstantopoulos K, Betenbaugh M, Shiloach J (2007).  A perspective on microarrays: current applications, pitfalls, and potential uses.  Microb Cell Fact.  6.  4.
  • Jaluria P, Betenbaugh M, Konstantopoulos K, Frank B, Shiloach J (2007).  Application of microarrays to identify and characterize genes involved in attachment dependence in HeLa cells.  Metab Eng.  9(3).  241-51.
  • Napier SL, Healy ZR, Schnaar RL, Konstantopoulos K (2007).  Selectin ligand expression regulates the initial vascular interactions of colon carcinoma cells: the roles of CD44v and alternative sialofucosylated selectin ligands.  J Biol Chem.  282(6).  3433-41.
  • Lim LHK, Burdick MM, Hudson SA, Mustafa FB, Konstantopoulos K, Bochner BS (2006).  Stimulation of human endothelium with IL-3 induces selective basophil accumulation in vitro.  Journal of Immunology.  176(9).
  • Grazioli A, Alves CS, Konstantopoulos K, Yang JT (2006).  Defective blood vessel development and pericyte/pvSMC distribution in α4 integrin-deficient mouse embryos.  Developmental Biology.  293(1).
  • Hanley WD, Napier SL, Burdick MM, Schnaar RL, Sackstein R, Konstantopoulos K (2006).  Variant isoforms of CD44 are P- and L-selectin ligands on colon carcinoma cells.  FASEB Journal.  20(2).
  • Panorchan P, Thompson M, Davis KJ, Tseng Y, Konstantopoulos K, Wirtz D (2006).  Single-molecule analysis of cadherin-mediated cell-cell adhesion.  J Cell Sci.  119(Pt 1).  66-74.
  • Panorchan P, Thompson MS, Davis KJ, Tseng Y, Konstantopoulos K, Wirtz D (2006).  Single-molecule analysis of cadherin-mediated cell-cell adhesion.  Journal of Cell Science.  119(1).
  • Grazioli A, Alves CS, Konstantopoulos K, Yang JT (2006).  Defective blood vessel development and pericyte/pvSMC distribution in alpha 4 integrin-deficient mouse embryos.  Dev Biol.  293(1).  165-77.
  • George NP, Wei Q, Shin PK, Konstantopoulos K, Ross JM (2006).  Staphylococcus aureus adhesion via Spa, ClfA, and SdrCDE to immobilized platelets demonstrates shear-dependent behavior.  Arterioscler Thromb Vasc Biol.  26(10).  2394-400.
  • Lim LH, Burdick MM, Hudson SA, Mustafa FB, Konstantopoulos K, Bochner BS (2006).  Stimulation of human endothelium with IL-3 induces selective basophil accumulation in vitro.  J Immunol.  176(9).  5346-53.
  • Hanley WD, Napier SL, Burdick MM, Schnaar RL, Sackstein R, Konstantopoulos K (2006).  Variant isoforms of CD44 are P- and L-selectin ligands on colon carcinoma cells.  FASEB J.  20(2).  337-9.
  • Healy ZR, Lee N, Talalay P, Kensler T, Konstantopoulos K (2005).  Elucidation of intracellular signaling pathways in shear-activated chondrocytes: A role in arthritis.  AIChE Annual Meeting, Conference Proceedings.
  • Hardesty KJ, Healy ZR, Kensler T, Konstantopoulos K (2005).  Identification of shear stress-responsive elements of the cyclooxygenase-2 gene in human chondrocytes.  AIChE Annual Meeting, Conference Proceedings.
  • Jaluria P, Betenbaugh M, Konstantopoulos K, Shiloach J (2005).  Application of microarrays to reverse engineer attachment dependence in mammalian cell lines.  AIChE Annual Meeting, Conference Proceedings.
  • Healy ZR, Lee NH, Gao X, Goldring MB, Talalay P, Kensler TW, Konstantopoulos K (2005).  Divergent responses of chondrocytes and endothelial cells to shear stress: Cross-talk among COX-2, the phase 2 response, and apoptosis.  Proceedings of the National Academy of Sciences of the United States of America.  102(39).
  • Healy ZR, Lee N, Gao X, Goldring MB, Talalay P, Kensler TW, Konstantopoulos K (2005).  Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.  Proc Natl Acad Sci U S A.  102(39).  14010-5.
  • Shin PK, Pawar P, Konstantopoulos K, Ross JM (2005).  Characteristics of new Staphylococcus aureus-RBC adhesion mechanism independent of fibrinogen and IgG under hydrodynamic shear conditions.  Am J Physiol Cell Physiol.  289(3).  C727-34.
  • Jadhav S, Eggleton CD, Konstantopoulos K (2005).  A 3-D computational model predicts that cell deformation affects selectin-mediated leukocyte rolling.  Biophys J.  88(1).  96-104.
  • Hanley WD, Burdick MM, Konstantopoulos K, Sackstein R (2005).  CD44 on LS174T colon carcinoma cells possesses E-selectin ligand activity.  Cancer Res.  65(13).  5812-7.
  • Ahn KC, Jun AJ, Pawar P, Jadhav S, Napier S, McCarty OJ, Konstantopoulos K (2005).  Preferential binding of platelets to monocytes over neutrophils under flow.  Biochem Biophys Res Commun.  329(1).  345-55.
  • Hanley WD, Wirtz D, Konstantopoulos K (2004).  Distinct kinetic and mechanical properties govern selectin-leukocyte interactions.  Journal of Cell Science.  117(12).
  • Burdick MM, Konstantopoulos K (2004).  Platelet-induced enhancement of LS174T colon carcinoma and THP-1 monocytoid cell adhesion to vascular endothelium under flow.  Am J Physiol Cell Physiol.  287(2).  C539-47.
  • Pawar P, Shin PK, Mousa S, Ross JM, Konstantopoulos K (2004).  Fluid shear regulates the kinetics and receptor specificity of Staphylococcus aureus binding to activated platelets.  J Immunol.  173(2).  1258-65.
  • McCarty OJ, Abulencia JP, Mousa S, Konstantopoulos K (2004).  Evaluation of platelet antagonists in in vitro flow models of thrombosis.  Methods Mol Med.  93.  21-34.
  • Hanley WD, Wirtz D, Konstantopoulos K (2004).  Distinct kinetic and mechanical properties govern selectin-leukocyte interactions.  J Cell Sci.  117(Pt 12).  2503-11.
  • McCarty OJT, Tien N, Bochner BS, Konstantopoulos K (2003).  Exogenous eosinophil activation converts PSGL-1-dependent binding to CD18-dependent stable adhesion to platelets in shear flow.  American Journal of Physiology - Cell Physiology.  284(5 53-5).
  • Burdick MM, Michael McCaffery J, Kim YS, Bochner BS, Konstantopoulos K (2003).  Colon carcinoma cell glycolipids, integrins, and other glycoproteins mediate adhesion to HUVECs under flow.  American Journal of Physiology - Cell Physiology.  284(4 53-4).
  • Hanley W, McCarty O, Jadhav S, Tseng Y, Wirtz D, Konstantopoulos K (2003).  Single molecule characterization of P-selectin/ligand binding.  Journal of Biological Chemistry.  278(12).
  • Hanley W, McCarty O, Jadhav S, Tseng Y, Wirtz D, Konstantopoulos K (2003).  Single molecule characterization of P-selectin/ligand binding.  J Biol Chem.  278(12).  10556-61.
  • Konstantopoulos K, Hanley W, Wirtz D (2003).  Receptor-ligand binding: 'Catch' bonds finally caught.  Current Biology.  13(15).  R611-R613.
  • McCarty OJ, Tien N, Bochner BS, Konstantopoulos K (2003).  Exogenous eosinophil activation converts PSGL-1-dependent binding to CD18-dependent stable adhesion to platelets in shear flow.  Am J Physiol Cell Physiol.  284(5).  C1223-34.
  • Abulencia JP, Gaspard R, Healy ZR, Gaarde WA, Quackenbush J, Konstantopoulos K (2003).  Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells.  J Biol Chem.  278(31).  28388-94.
  • Burdick MM, McCaffery J, Kim YS, Bochner BS, Konstantopoulos K (2003).  Colon carcinoma cell glycolipids, integrins, and other glycoproteins mediate adhesion to HUVECs under flow.  Am J Physiol Cell Physiol.  284(4).  C977-87.
  • Jadhav S, Konstantopoulos K (2002).  Fluid shear- and time-dependent modulation of molecular interactions between PMNs and colon carcinomas.  Am J Physiol Cell Physiol.  283(4).  C1133-43.
  • McCarty OJ, Jadhav S, Burdick MM, Bell WR, Konstantopoulos K (2002).  Fluid shear regulates the kinetics and molecular mechanisms of activation-dependent platelet binding to colon carcinoma cells.  Biophys J.  83(2).  836-48.
  • Jadhav S, Bochner BS, Konstantopoulos K (2001).  Hydrodynamic shear regulates the kinetics and receptor specificity of polymorphonuclear leukocyte-colon carcinoma cell adhesive interactions.  Journal of Immunology.  167(10).
  • Burdick MM, Bochner BS, Collins BE, Schnaar RL, Konstantopoulos K (2001).  Glycolipids support E-selectin-specific strong cell tethering under flow.  Biochem Biophys Res Commun.  284(1).  42-9.
  • Jadhav S, Bochner BS, Konstantopoulos K (2001).  Hydrodynamic shear regulates the kinetics and receptor specificity of polymorphonuclear leukocyte-colon carcinoma cell adhesive interactions.  J Immunol.  167(10).  5986-93.
  • Konstantopoulos K, Mousa S (2001).  Antiplatelet therapies: platelet GPIIb/IIIa antagonists and beyond.  Curr Opin Investig Drugs.  2(8).  1086-92.
  • Abulencia JP, Tien N, McCarty OJ, Plymire D, Mousa S, Konstantopoulos K (2001).  Comparative antiplatelet efficacy of a novel, nonpeptide GPIIb/IIIa antagonist (XV454) and abciximab (c7E3) in flow models of thrombosis.  Arterioscler Thromb Vasc Biol.  21(1).  149-56.
  • Burdick MM, Bochner BS, Collins BE, Schnaar RL, Konstantopoulos K (2001).  Glycolipids support E-selectin-specific strong cell tethering under flow.  Biochemical and Biophysical Research Communications.  284(1).
  • Burdick MM, McCarty OJ, Jadhav S, Konstantopoulos K (2001).  Cell-cell interactions in inflammation and cancer metastasis.  IEEE Eng Med Biol Mag.  20(3).  86-91.
  • Tachimoto H, Burdick MM, Hudson SA, Kikuchi M, Konstantopoulos K, Bochner BS (2000).  CCR3-active chemokines promote rapid detachment of eosinophils from VCAM-1 in vitro.  Journal of Immunology.  165(5).
  • McCarty OJ, Mousa S, Bray PF, Konstantopoulos K (2000).  Immobilized platelets support human colon carcinoma cell tethering, rolling, and firm adhesion under dynamic flow conditions.  Blood.  96(5).  1789-97.
  • Tachimoto H, Burdick MM, Hudson SA, Kikuchi M, Konstantopoulos K, Bochner BS (2000).  CCR3-active chemokines promote rapid detachment of eosinophils from VCAM-1 in vitro.  J Immunol.  165(5).  2748-54.
  • Konstantopoulos K, McIntire LV, Menter DG, Nicolson GL, Papadimitriou MN (1999).  Integrin alpha4beta1/VCAM-1 pathway mediates primary adhesion of RAW117 lymphoma cells to hepatic sinusoidal endothelial cells under flow.  Clin Exp Metastasis.  17(8).  669-76.
  • Konstantopoulos K, Kukreti S, McIntire LV (1998).  Biomechanics of cell interactions in shear fields.  Adv Drug Deliv Rev.  33(1-2).  141-64.
  • Berg EL, Burns AR, Hellums JD, Hentzen E, Kansas GS, Konstantopoulos K, McIntire LV, Neelamegham S, Simon SI, Smith C, Snapp KR (1998).  Venous levels of shear support neutrophil-platelet adhesion and neutrophil aggregation in blood via P-selectin and beta2-integrin.  Circulation.  98(9).  873-82.
  • Chow TW, Hellums JD, Konstantopoulos K, Moake JL, Turner NA (1997).  Shear stress-induced binding of von Willebrand factor to platelets.  Biorheology.  34(1).  57-71.
  • Konstantopoulos K, Kukreti S, McIntire LV, Smith C (1997).  Molecular mechanisms of monocyte adhesion to interleukin-1beta-stimulated endothelial cells under physiologic flow conditions.  Blood.  89(11).  4104-11.
  • Konstantopoulos K, McIntire LV (1997).  Effects of fluid dynamic forces on vascular cell adhesion.  J Clin Invest.  100(11 Suppl).  S19-23.
  • Konstantopoulos K, Kukreti S, McIntire LV, Smith C (1997).  Endothelial P-selectin and VCAM-1 each can function as primary adhesive mechanisms for T cells under conditions of flow.  J Leukoc Biol.  61(2).  179-87.
  • Konstantopoulos K, McIntire LV (1996).  Effects of fluid dynamic forces on vascular cell adhesion.  J Clin Invest.  98(12).  2661-5.
  • Banez EI, Hellums JD, Konstantopoulos K, Shattil SJ, Udden MM, Wu KK (1995).  Flow cytometric studies of platelet responses to shear stress in whole blood.  Biorheology.  32(1).  73-93.
  • Banez EI, Hellums JD, Jordan R, Kamat SG, Kleiman NS, Konstantopoulos K, Schafer AI (1995).  Shear-induced platelet aggregation is inhibited by in vivo infusion of an anti-glycoprotein IIb/IIIa antibody fragment, c7E3 Fab, in patients undergoing coronary angioplasty.  Circulation.  91(5).  1427-31.
  • Grotta JC, Hellums JD, Konstantopoulos K, Sills C, Wu KK (1995).  Shear-induced platelet aggregation in normal subjects and stroke patients.  Thromb Haemost.  74(5).  1329-34.
Books
  • Cheung LS, Raman P, Wirtz D, Konstantopoulos K (2012).  Biophysics of selectin-mediated cell adhesion.  Comprehensive Biophysics.  7.  10-32.
Book Chapters
  • Cheung LSL, Raman PS, Wirtz D, Konstantopoulos K (2012).  Biophysics of selectin-mediated cell adhesion.  Comprehensive Biophysics.  7.
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