Iglesias, Pablo A.

Professor
Dept Of Electrical And Computer Engrg
http://www.ece.jhu.edu/cscl/

Barton Hall 226
3400 N Charles St
(410) 516-6026
pi@jhu.edu

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About

Education
  • Ph.D. 1991, Cambridge University
  • Other Bachelor's Degree (B.A.Sc.) 1987, University of Toronto
Research Areas
  • Dr. Iglesias’s research focuses on the use of control and information theory to study biological signal transduction pathways. Among his research interests are: understanding how cells interpret directional cues to guide cell motion, the regulatory mechanisms that control cell division, and the sensing and actuation that enable cells to maintain lipid homeostasis.
Awards
  • IEEE Senior Member
  • Semiplenary speaker: European Control Conference - Cambridge - UK - September 2003
  • 2017:  Fellow
  • 2012:  Edward J. Schaefer Chair in Electrical Engineering
  • 2012:  Visiting Scientist Position at Max-Planck Institute for the Physics of Complex Systems
  • 2010:  NASA Glenn Research Center Certificate of Recognition for mentorship in the NASA Motivating Undergraduates in Science and Technology (MUST) project
  • 2009:  Distinguished Lecturer: Integrative Biosystems Institute at Georgia Tech
  • 2006:  Distinguished lecturer - IEEE Control Systems Society
  • 2006:  Named a Science Spectrum Trailblazer by Science Spectrum Magazine
  • 1997:  George E. Owen Teaching Award - Johns Hopkins University
  • 1992:  George E. Ives Best Paper Award for the Journal of Imaging Technology - Society for Imaging and Technology
  • 1990:  Best Young Author Prize Finalist - IFAC World Congress - Tallinn USSR
Presentations
  • Department of Electrical & Computer Eng,.  May 14, 2016
  • Institute of Nano-Biotechnology.  Baltimore, MD.  May 3, 2016
  • Workshop on Control and Observability of Network Dynamics.  Columbus, OH.  April 11, 2016
  • "INFORMATION-THEORETIC CHARACTERIZATION OF CELL SIGNALING NETWORKS", 2015 MBMC Workshop: Communications, Inference, and Computing In Molecular and Biological Systems.  Los Angeles, CS.  December 3, 2015
  • "Excitability and other dynamic behaviors regulating motility", Workshop on Biological Systems and Networks.  Minneapolis, MN.  November 16, 2015
  • "Biased excitable networks: HOW cells direct Motion in response to gradients", Colloquium .  Laurel, MD.  October 2, 2015
  • "Biological Applications of Control", Workshop on Biological applications of Control.  Tel Aviv, Israel.  June 1, 2015
  • "Biased excitable networks and directed cell migration", Random Walks and Nonlinear Dynamics in the Life of Single Cells.  Dresden, Germany.  May 18, 2015
  • "Biased excitable networks and directed cell migration", SY-BIO Workshop.  Dallas, TX.  March 25, 2015
  • "Evolutionarily Conserved Coupling of Adaptive and Excitable Networks Mediates Eukaryotic Chemotaxis", Biophysical Society Annual Meeting.  Baltimore, MD.  2015
  • "Kinetics of Mechanoresponse in the Mammalian Actin Cytoskeleton", Biophysical Society Annual Meeting.  Baltimore, MD.  2015
  • "Nucleocytoplasmic Shuttling of a Gata-Family Transcription Factor Functions as a Development Timer", Biophysical Society Annual Meeting.  Baltimore, MD.  2015
  • "A modular view of directed cell migration", Gordon Research Conference on Gradient Sensing and Directed Cell Migration.  Galveston, TX.  January 25, 2015
  • "Uncovering the cell's guidance mechanism through computational biology", 10th Annual Engineering Science Education Conference.  Toronto, ON, Canada.  January 23, 2015
  • Signaling Across Scales.  Ann Arbor.  March 11, 2014
  • "Novel modeling approaches to cell motility", March meeting of the APS.  Denver.  March 7, 2014

Publications

Journal Articles
  • Bhattacharya., Bhattacharya, S. (2016).  The regulation of cell motility through an excitable network.  IFAC Papers online.
  • Artemenko, Y., Axiotakis, L., Borleis, J., Iglesias, P., Devreotes, P. N. (2016).  Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks.  Proceedings of the National Academy of Sciences.  113(47).  E7500–E7509.
  • Zeituni, E. M., Wilson, M. H., Zheng, X., Iglesias, P., Sepanski, M. A., Siddiqi, M. A., Anderson, J. L., Zheng, Y., Farber, S. A. (2016).  Endoplasmic reticulum lipid flux influences enterocyte nuclear morphology and lipid-dependent transcriptional responses.  Journal of Biological Chemistry.  291(45).  23804–23816.
  • Iglesias, P. (2016).  The use of rate distortion theory to evaluate biological signaling pathways.  IEEE Transactions on Molecular, Biological and Multi-Scale Communications.  2(1).  31-39.
  • Bhattacharya , S., Iglesias, P. (2016).  Modeling excitable dynamics of chemotactic networks.  Chemotaxis, Methods and Protocols.  Methods in Molecular Biology.  1407.  397–415 .
  • Schiffhauer, E. S., Luo, T., Mohan, K., Srivastava, V., Qian, X., Griffis, E. R., Iglesias, P., Robinson, D. N. (2016).  Mechanoaccumulative elements of the mammalian actin cytoskeleton.  Current Biology.  26(11).  1473–1479.
  • Srivastava, V., Iglesias, P., Robinson, D. N. (2016).  Cytokinesis: Robust cell shape regulation.  Seminars in Cell & Developmental Biology.  53.  39-44.
  • Mohan, K., Luo, T., Robinson, D. N., Iglesias, P. (2015).  Cell shape regulation through mechanosensory feedback control.  Journal of The Royal Society Interface.  12(109).  20150512.
  • Swaney, K. F., Borleis, J., Iglesias, P., Devreotes, P. N. (2015).  Novel protein Callipygian defines the back of migrating cells.  Proceedings of the National Academy of Sciences.  112(29).  E3845–E3854.
  • Iglesias, P., Shi, C. (2014).  Comparison of adaptation motifs: temporal, stochastic and spatial responses.  IET Systems Biology.  8(6).  268-281.
  • Mohan, K., Luo, T., Robinson, D. N., Iglesias, P. (2014).  Computational Model for Cell Shape Regulation through Mechanosensing and Mechanical Feedback.  Biophysical Journal.  106(2).  378a.
  • Robinson, D. N., Luo, T., Mohan, K., Srivastava, V., Ren, Y., Iglesias, P. (2014).  Molecular Mechanisms of Contractility-Based Cellular Mechanosensing.  Biophysical Journal.  106(2).  357a.
  • Huang, C., Iglesias, P. (2014).  Cell memory and adaptation in chemotaxis.  Proceedings of the National Academy of Sciences.  111(43).  15287–15288.
  • Tang, M., Wang, M., Shi, C., Iglesias, P., Devreotes, P. N., Huang, C. (2014).  Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis.  Nature Communications.  5.  Article: 5175.
  • Wang, M., Artemenko, Y., Cai, W., Iglesias, P., Devreotes, P. N. (2014).  The Directional Response of Chemotactic Cells Depends on a Balance between Cytoskeletal Architecture and the External Gradient.  Cell Reports.  9(3).  1110-1121.
  • Shi, C., Channels, W. E., Zheng, Y., Iglesias, P. (2014).  A computational model for the formation of lamin-B mitotic spindle envelope and matrix.  Interface Focus.  4(3).  20130063.
  • Cai, H., Katoh-Kurasawa, M., Muramoto, T., Santhanam, B., Long, Y., Li, L., Ueda, M., Iglesias, P., Shaulsky, G., Devreotes, P. N. (2014).  Nucleocytoplasmic Shuttling of a GATA Transcription Factor Functions as a Development Timer.  Science.  343(6177).  1249531.
  • Huang, C., Tang, M., Shi, C., Iglesias, P., Devreotes, P. N. (2013).  An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration.  Nature cell biology.
  • Shi, C., Iglesias, P. (2013).  Excitable behavior in amoeboid chemotaxis.  Wiley Interdisciplinary Reviews: Systems Biology and Medicine.  5(5).  631–642.
  • Shi, C., Huang, C., Devreotes, P. N., Iglesias, P. (2013).  Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells.  PLoS computational biology.  9(7).  e1003122.
  • Zheng, Y., Iglesias, P. (2013).  Nucleating New Branches from Old.  Cell.  152(4).  669–670.
  • Iglesias, P. (2013).  Systems Biology: The Role of Engineering in the Reverse Engineering of Biological Signaling.  Cells.  2(2).  393–413.
  • Luo, T., Mohan, K., Iglesias, P., Robinson, D. N. (2013).  The Molecular Landscape of Mechanosensing by the Cell Cortex.  Biophysical Journal.  104.  476.
  • Porter, J. R., Andrews, B. W., Iglesias, P. (2012).  A framework for designing and analyzing binary decision-making strategies in cellular systems.  Integrative Biology.  4(3).  310–317.
  • Kee, Y., Ren, Y., Dorfman, D., Iijima, M., Firtel, R., Iglesias, P., Robinson, D. N. (2012).  A mechanosensory system governs myosin II accumulation in dividing cells.  Molecular biology of the cell.  23(8).  1510–1523.
  • Seir Kee, Y., Ren, Y., Dorfman, D., Iijima, M., Firtel, R., Iglesias, P., Robinson, D. (2012).  A Mechanosensory System Governs Myosin II Cleavage Furrow Accumulation.  Biophysical Journal.  102(3).  349a.
  • Iglesias, P., Devreotes, P. N. (2012).  Biased excitable networks: how cells direct motion in response to gradients.  Current Opinion in Cell Biology.  24(2).  245–253.
  • Robinson, D. N., Iglesias, P. (2012).  Bringing the physical sciences into your cell biology research.  Molecular biology of the cell.  23(21).  4167–4170.
  • Iglesias, P. (2012).  Chemoattractant signaling in dictyostelium: adaptation and amplification.  Science signaling.  5(213).  pe8.
  • Poirier, C. C., Ng, W. P., Robinson, D. N., Iglesias, P. (2012).  Deconvolution of the cellular force-generating subsystems that govern cytokinesis furrow ingression.  PLoS computational biology.  8(4).  e1002467.
  • Porter, J. R., Burg, J. S., Espenshade, P. J., Iglesias, P. (2012).  Identifying a static nonlinear structure in a biological system using noisy, sparse data.  Journal of theoretical biology.  300.  232–241.
  • Porter, J. R., Lee, C. S., Espenshade, P. J., Iglesias, P. (2012).  Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA bindingand degradation.  Molecular biology of the cell.  23(18).  3764–3774.
  • Mohan, K., Iglesias, P., Robinson, D. N. (2012).  Separation anxiety: Stress, tension and cytokinesis.  Experimental Cell Research.  318(12).  1428–1434.
  • Luo, T., Mohan, K., Srivastava, V., Ren, Y., Iglesias, P., Robinson, D. N. (2012).  Understanding the cooperative interaction between myosin II and actin cross-linkers mediated by actin filaments during mechanosensation.  Biophysical journal.  102(2).  238–247.
  • Poirier, C. C., Ng, W., Robinson, D. N., Iglesias, P. (2011).  A Dynamic Model of Furrow Ingression during Cytokinesis.  Biophysical Journal.  100(3).  610a.
  • Xiong, Y., Huang, C., Iglesias, P., Devreotes, P. N. (2011).  A LEGI-Biased Excitable Network Controls Temporal and Spatial Responses to Chemoattractants.  Biophysical Journal.  100(3 Supplement 1).
  • De Keijzer, S., Galloway, J., Harms, G., Devreotes, P., Iglesias, P. (2011).  Disrupting microtubule network immobilizes amoeboid chemotactic receptor in the plasma membrane.  Biochimica et Biophysica Acta (BBA)-Biomembranes.  1808(6).  1701–1708.
  • Poirier, C. C., Zheng, Y., Iglesias, P. (2011).  Enclosing, Deformable Membrane Aids in Focusing and Stabilizing the Mitotic Spindle.  Biophysical Journal.  100(3).  450a.
  • McDole, K., Xiong, Y., Iglesias, P., Zheng, Y. (2011).  Lineage mapping the pre-implantation mouse embryo by two-photon microscopy, new insights into the segregation of cell fates.  Developmental biology.  355(2).  239–249.
  • Kee, Y. S., Firtel, R., Iglesias, P., Robinson, D. (2011).  Mechanosensing Directs Mitotic Signaling Proteins to Sites of High Mechanical Stress to Regulate Cytokinesis Through a Feedback Control System.  Biophysical Journal.  100(3).  444a–445a.
  • Zhou, Q., Kee, Y., Poirier, C. C., Jelinek, C., Osborne, J., Divi, S., Surcel, A., Will, M. E., Eggert, U. S., Müller-Taubenberger, A., others. (2010).  14-3-3 coordinates microtubules, Rac, and myosin II to control cell mechanics and cytokinesis.  Current Biology.  20(21).  1881–1889.
  • Ingalls, B. P., Iglesias, P. (2010).  A Primer on Control Engineering.  Control Theory and Systems Biology.  1–28.
  • Xiong, Y., Kabacoff, C., Franca-Koh, J., Devreotes, P. N., Robinson, D. N., Iglesias, P. (2010).  Automated characterization of cell shape changes during amoeboid motility by skeletonization.  BMC systems biology.  4(1).  33.
  • Xiong, Y., Huang, C., Iglesias, P., Devreotes, P. N. (2010).  Cells navigate with a local-excitation, global-inhibition-biased excitable network.  Proceedings of the National Academy of Sciences.  107(40).  17079–17086.
  • Porter, J. R., Burg, J. S., Espenshade, P. J., Iglesias, P. (2010).  Ergosterol regulates sterol regulatory element binding protein (SREBP) cleavage in fission yeast.  Journal of Biological Chemistry.  285(52).  41051–41061.
  • Goodman, B., Channels, W., Qiu, M., Iglesias, P., Yang, G., Zheng, Y. (2010).  Lamin B counteracts the kinesin Eg5 to restrain spindle pole separation during spindle assembly.  Journal of Biological Chemistry.  285(45).  35238–35244.
  • Poirier, C. C., Zheng, Y., Iglesias, P. (2010).  Mitotic membrane helps to focus and stabilize the mitotic spindle.  Biophysical journal.  99(10).  3182–3190.
  • Kee, Y. S., Firtel, R., Iglesias, P., Robinson, D. (2010).  Myosin II is an Active Stress Sensor at the Core of a Cell Division Control System.  Biophysical Journal.  98(3).  161a–162a.
  • Channels, W. E., Iglesias, P. (2010).  Simulating Filament Dynamics in Cellular Systems.  Elements of Computational Systems Biology.  141–162.
  • Iglesias, A. (2010).  Spatial modeling.  Control Theory and Systems Biology.  45–68.
  • Xiong, Y., Iglesias, P. (2010).  Tools for analyzing cell shape changes during chemotaxis.  Integrative Biology.  2(11-12).  561–567.
  • Ghaemi, R., Sun, J., Iglesias, P., Del Vecchio, D. (2009).  A method for determining the robustness of bio-molecular oscillator models.  BMC systems biology.  3(1).  95.
  • Ren, Y., Effler, J. C., Norstrom, M., Luo, T., Firtel, R. A., Iglesias, P., Rock, R. S., Robinson, D. N. (2009).  Mechanosensing through cooperative interactions between myosin II and the actin crosslinker cortexillin I.  Current Biology.  19(17).  1421–1428.
  • Iglesias, P. (2009).  Spatial regulation of PI3K signaling during chemotaxis.  Wiley Interdisciplinary Reviews: Systems Biology and Medicine.  1(2).  247–253.
  • Andrews, B., Sontag, E. D., Iglesias, P. (2008).  An approximate internal model principle: Applications to nonlinear models of biological systems.  Proceedings of the 17th IFAC World Congress.  6–11.
  • Arkowitz, R. A., Iglesias, P. (2008).  Basic principles of polarity establishment and maintenance.  EMBO reports.  9(9).  847–852.
  • Reichl, E. M., Ren, Y., Morphew, M. K., Delannoy, M., Effler, J. C., Girard, K. D., Divi, S., Iglesias, P., Kuo, S. C., Robinson, D. N. (2008).  Interactions between myosin and actin crosslinkers control cytokinesis contractility dynamics and mechanics.  Current Biology.  18(7).  471–480.
  • Yang, L., Effler, J. C., Kutscher, B. L., Sullivan, S. E., Robinson, D. N., Iglesias, P. (2008).  Modeling cellular deformations using the level set formalism.  BMC systems biology.  2(1).  68.
  • Iglesias, P., Devreotes, P. N. (2008).  Navigating through models of chemotaxis.  Current opinion in cell biology.  20(1).  35–40.
  • Kamimura, Y., Xiong, Y., Iglesias, P., Hoeller, O., Bolourani, P., Devreotes, P. N. (2008).  PIP< sub> 3-Independent Activation of TorC2 and PKB at the Cell’s Leading Edge Mediates Chemotaxis.  Current Biology.  18(14).  1034–1043.
  • Channels, W. E., Nédélec, F. J., Zheng, Y., Iglesias, P. (2008).  Spatial regulation improves antiparallel microtubule overlap during mitotic spindle assembly.  Biophysical journal.  94(7).  2598–2609.
  • Krishnan, J., Iglesias, P. (2008).  Systems analysis of regulatory processes underlying eukaryotic gradient perception.  Automatic Control, IEEE Transactions on.  53(Special Issue).  126–138.
  • Tang, L., Franca-Koh, J., Xiong, Y., Chen, M., Long, Y., Bickford, R. M., Knecht, D. A., Iglesias, P., Devreotes, P. N. (2008).  tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis.  Genes & development.  22(16).  2278–2290.
  • Effler, J. C., Iglesias, P., Robinson, D. N. (2007).  A mechanosensory system controls cell shape changes during mitosis.  CELL CYCLE-LANDES BIOSCIENCE-.  6(1).  30.
  • Andrews, B. W., Iglesias, P. (2007).  An information-theoretic characterization of the optimal gradient sensing response of cells.  PLoS computational biology.  3(8).  e153.
  • Poirier, C. C., Iglesias, P. (2007).  An integrative approach to understanding mechanosensation.  Briefings in bioinformatics.  8(4).  258–265.
  • Yi, T., Andrews, B. W., Iglesias, P. (2007).  Control analysis of bacterial chemotaxis signaling.  Methods in enzymology.  422.  123–140.
  • Li, H. Y., Ng, W. P., Wong, C. H., Iglesias, P., Zheng, Y. (2007).  Coordination of chromosome alignment and mitotic progression chromosome-based Ran signal.  CELL CYCLE-LANDES BIOSCIENCE-.  6(15).  1886.
  • Kabacoff, C., Xiong, Y., Musib, R., Reichl, E. M., Kim, J., Iglesias, P., Robinson, D. N. (2007).  Dynacortin facilitates polarization of chemotaxing cells.  BMC biology.  5(1).  53.
  • Paliwal, S., Iglesias, P., Campbell, K., Hilioti, Z., Groisman, A., Levchenko, A. (2007).  MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast.  Nature.  446(7131).  46–51.
  • Chen, L., Iijima, M., Tang, M., Landree, M. A., Huang, Y. E., Xiong, Y., Iglesias, P., Devreotes, P. N. (2007).  PLA< sub> 2 and PI3K/PTEN Pathways Act in Parallel to Mediate Chemotaxis.  Developmental cell.  12(4).  603–614.
  • Krishnan, J., Iglesias, P. (2007).  Receptor-mediated and intrinsic polarization and their interaction in chemotaxing cells.  Biophysical journal.  92(3).  816–830.
  • Effler, J. C., Kee, Y., Berk, J. M., Tran, M. N., Iglesias, P., Robinson, D. N. (2006).  Mitosis-specific mechanosensing and contractile-protein redistribution control cell shape.  Current biology.  16(19).  1962–1967.
  • Andrews, B. W., Yi, T., Iglesias, P. (2006).  Optimal noise filtering in the chemotactic response of Escherichia coli.  PLoS computational biology.  2(11).  e154.
  • Yang, L., Iglesias, P. (2006).  Positive feedback may cause the biphasic response observed in the chemoattractant-induced response of< i> Dictyostelium cells.  Systems & control letters.  55(4).  329–337.
  • Kim, J., Bates, D. G., Postlethwaite, I., Ma, L., Iglesias, P. (2006).  Robustness analysis of biochemical network models.  IEE Proceedings-Systems Biology.  153(3).  96–104.
  • Ingalls, B., Yi, T., Iglesias, P. (2006).  Using control theory to study biology.  System Modeling in Cellular Biology.  243–267.
  • Krishnan, J., Iglesias, P. (2005).  A modelling framework describing the enzyme regulation of membrane lipids underlying gradient perception in< i> Dictyostelium cells II: Input–output analysis.  Journal of theoretical biology.  235(4).  504–520.
  • Vong, Q. P., Cao, K., Li, H. Y., Iglesias, P., Zheng, Y. (2005).  Chromosome alignment and segregation regulated by ubiquitination of survivin.  Science.  310(5753).  1499–1504.
  • Iglesias, P. (2005).  Directional migration: a prototypical cellular control system.  IEEE CONFERENCE ON DECISION AND CONTROL.  44(3).  2326.
  • Prill, R. J., Iglesias, P., Levchenko, A. (2005).  Dynamic properties of network motifs contribute to biological network organization.  PLoS biology.  3(11).  e343.
  • Krishnan, J., Iglesias, P. (2004).  A modeling framework describing the enzyme regulation of membrane lipids underlying gradient perception in< i> Dictyostelium cells.  Journal of theoretical biology.  229(1).  85–99.
  • Manahan, C. L., Iglesias, P., Long, Y., Devreotes, P. N. (2004).  Chemoattractant signaling in Dictyostelium discoideum.  Annu. Rev. Cell Dev. Biol..  20.  223–253.
  • Janetopoulos, C., Ma, L., Devreotes, P. N., Iglesias, P. (2004).  Chemoattractant-induced phosphatidylinositol 3, 4, 5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton.  Proceedings of the National Academy of Sciences of the United States of America.  101(24).  8951–8956.
  • Kutscher, B., Devreotes, P., Iglesias, P. (2004).  Local excitation, global inhibition mechanism for gradient sensing: an interactive applet.  Science Signaling.  2004(219).  pl3.
  • Paliwal, S., Ma, L., Krishnan, J., Levchenko, A., Iglesias, P. (2004).  Responding to directional cues: a tale of two cells [biochemical signaling pathways].  Control Systems, IEEE.  24(4).  77–90.
  • Ma, L., Janetopoulos, C., Yang, L., Devreotes, P. N., Iglesias, P. (2004).  Two Complementary, Local Excitation, Global Inhibition Mechanisms Acting in Parallel Can Explain the Chemoattractant-Induced Regulation of PI (3, 4, 5) P< sub> 3 Response in< i> Dictyostelium Cells.  Biophysical journal.  87(6).  3764–3774.
  • Krishnan, J., Iglesias, P. (2004).  Uncovering directional sensing: where are we headed?.  Systems biology.  1(1).  54–61.
  • Krishnan, J., Iglesias, P. (2003).  Analysis of the signal transduction properties of a module of spatial sensing in eukaryotic chemotaxis.  Bulletin of mathematical biology.  65(1).  95–128.
  • Zang, G., Iglesias, P. (2003).  Fading memory and stability.  Journal of the Franklin Institute.  340(6).  489–502.
  • Iglesias, P. (2003).  Feedback Control in Intracellular Signaling Pathways: Regulating Chemotaxis in< i> Dictyostelium Discoideum.  European journal of control.  9(2).  227–236.
  • Zang, G., Iglesias, P. (2003).  Nonlinear extension of Bode’s integral based on an information-theoretic interpretation.  Systems & control letters.  50(1).  11–19.
  • Iglesias, P. (2002).  Logarithmic integrals and system dynamics: an analogue of Bode’s sensitivity integral for continuous-time, time-varying systems.  Linear algebra and its applications.  343.  451–471.
  • Iglesias, P., Levchenko, A. (2002).  Modeling the cell’s guidance system.  Science Signaling.  2002(148).  re12.
  • Levchenko, A., Iglesias, P. (2002).  Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils.  Biophysical journal.  82(1).  50–63.
  • Ma, L., Iglesias, P. (2002).  Quantifying robustness of biochemical network models.  BMC bioinformatics.  3(1).  38.
  • Ma, L., Iglesias, P. (2002).  Robustness analysis of a self-oscillating molecular network in dictyostelium discoideum.  IEEE CONFERENCE ON DECISION AND CONTROL.  3.  2538–2543.
  • Iglesias, P. (2001).  A time-varying analogue of Jensen’s formula.  Integral Equations and Operator Theory.  40(1).  34–51.
  • O’Brien, R., Iglesias, P. (2001).  On the poles and zeros of linear, time-varying systems.  Circuits and Systems I: Fundamental Theory and Applications, IEEE Transactions on.  48(5).  565–577.
  • Krishnan, J., Iglesias, P., Ma, L. (2001).  Spatial sensing of chemotactic gradients: A reaction-diffusion model.  Proc. 2nd Internat. Conf. System Biology, Pasadena, CA.  148–157.
  • Iglesias, P., Zang, G. (2001).  Szego’s First Limit Theorem in Terms of a Realization of a Continuous-Time Time-Varying System.  International Journal of Applied Mathematics and Computer Science.  11.  1261–1276.
  • Iglesias, P. (2001).  Tradeoffs in linear time-varying systems: an analogue of Bode’s sensitivity integral.  Automatica.  37(10).  1541–1550.
  • Iglesias, P., Peters, M. A. (2000).  An entropy formula for nonlinear systems.  Journal of the Franklin Institute.  337(7).  859–874.
  • Iglesias, P., Urban, T. J. (2000).  Loop shaping design for missile autopilots: controller configurations and weighting filter selection.  Journal of Guidance, Control, and Dynamics.  23(3).  516–525.
  • Iglesias, P., Levchenko, A. (2000).  Spatial sensing in Dictyostelium: Amplification through saturating nonlinearities.  First Intern Conf Systems Biology, Tokyo, Japan.  154–159.
  • Iglesias, P. (2000).  The strictly proper discrete-time controller for the normalized left-coprime factorization robust stabilization problem.  Automatic Control, IEEE Transactions on.  45(3).  516–520.
  • Peters, M., Iglesias, P. (1999).  A spectral test for observability and reachability of time-varying systems.  SIAM journal on control and optimization.  37(5).  1330–1345.
  • Iglesias, P. (1999).  On the Riccati difference equation of optimal control.  Linear and Multilinear Algebra.  46(4).  313–326.
  • O’Brien, Jr, R., Iglesias, P. (1999).  Robust controller design for linear, time-varying systems.  European journal of control.  5(2).  222–241.
  • Peters, M., Iglesias, P. (1999).  The relationship between minimum entropy control and risk-sensitive control for time-varying systems.  IEEE transactions on automatic control.  44(5).  1065–1069.
  • Iglesias, P. (1999).  Use of frozen-time ℋ∞ controllers in time-varying applications.  IEE Proceedings-Control Theory and Applications.  146(1).  31–36.
  • O’Brien, Jr, R. T., Iglesias, P. (1998).  Closed loop cancellations in H infinity control of time-varying systems.  International Journal of Control.  71(1).  163–189.
  • O’Brien, Jr, R. T., Iglesias, P. (1998).  Pole/zero cancellations in time-varying systems.  International Journal of Control.  71(1).  103–130.
  • Peters, M. A., Iglesias, P. (1997).  Continuous-time time-varying entropy.  Mathematics of Control, Signals and Systems.  10(1).  76–96.
  • Iglesias, P., Peters, M. A. (1997).  On the induced norms of discrete-time and hybrid time-varying systems.  International Journal of Robust and Nonlinear Control.  7(9).  811–833.
  • Iglesias, P. (1996).  An entropy formula for time-varying discrete-time control systems.  SIAM journal on control and optimization.  34(5).  1691–1706.
  • Peters, M. A., Iglesias, P. (1996).  Connections between minimum entropy control and linear exponential quadratic Gaussian control: The time-varying case.  Proceedings of the Conference on Information Sciences and Systems.  2.  674.
  • O’brien, R., Iglesias, P., Urban, T. (1996).  Vehicle lateral control for automated highway systems.  Control Systems Technology, IEEE Transactions on.  4(3).  266–273.
  • Peters, M. A., Iglesias, P. (1995).  Connections between minimum entropy control and mixed H< sub> 2/H< sub>∞ control for time-varying systems.  Systems & control letters.  26(5).  341–347.
  • Iglesias, P. (1995).  Input-output stability of sampled-data linear time-varying systems.  IEEE transactions on automatic control.  40(9).  1646–1650.
  • O’Brien, R., Urban, T., Iglesias, P. (1995).  Lane change maneuver via modern steering control methods.  Proc. ITS America Conference 1995.  1–9.
  • Peters, M. A., Iglesias, P. (1995).  Minimum entropy control for discrete-time time-varying systems: The disturbance feedforward problem.  Proc. 1995 Conf. Inf. Sci. Sys., Baltimore, MD.  130–135.
  • Iglesias, P., Mustafa, D. (1993).  State-space solution of the discrete-time minimum entropy control problem via separation.  IEEE transactions on automatic control.  38(10).  1525–1530.
  • Popovic, Z., Iglesias, P., Parco, D., Robinette, S. (1991).  Characterization of microscopic electrical defects in xerographic photoreceptors.  Journal of imaging technology.  17(2).  71–75.
  • Iglesias, P., Glover, K. (1991).  State-space approach to discrete-time, ℋ∞ control.  International Journal of Control.  54(5).  1031–1073.
  • Iglesias, P., Mustafa, D., Glover, K. (1990).  Discrete time H< sub>∞ controllers satisfying a minimum entropy criterion.  Systems & Control Letters.  14(4).  275–286.
  • Glover, K., Iglesias, P. (1990).  State space approach to discrete time H (infinity) control.  Cambridge University Department of Engineering.
  • Iglesias, P., Glover, K. (1990).  State space solutions to H-infinity control problems at optimality: full information problem.  Proceedings of the 29th IEEE Conference on Decision and Control.  2.  1032–1033.
  • Popovic, Z., Iglesias, P. (1989).  Characterization of Microscopie Elelectrical Non-Uniformities in Xerographic Photoreceptors.  Fifth International Congress on Advances and Non-Impact printing Technologies.  11–14.
Books
  • Iglesias, P., Ingalls, B. P. (2010).  Control theory and systems biology.  MIT Press.
  • Peters, M. A., Iglesias, P. (1997).  Minimum entropy control for time-varying systems.  Springer.
Book Chapters
  • Iglesias, P. (2016).  A Modular View of the Signaling System Regulating Chemotaxis.  Physical Models of Cell Motility.  Springer International Publishing.  95–134.
  • Iglesias, P. (2016).  Dynamics of Gradient Sensing and Chemotaxis .  Encyclopedia of Cell Biology .  Academic Press.  4 - 9.
  • Iglesias, P. (2014).  Spatial Description of Biochemical Networks.  Encyclopedia of Systems and Control.  Springer London.  1-9.
  • Iglesias, P. (2012).  A systems biology view of adaptation in sensory mechanisms.  Advances in Systems Biology.  Springer New York.  499–516.
  • Yang, L., Iglesias, P. (2009).  Modeling spatial and temporal dynamics of chemotactic networks.  Chemotaxis.  Humana Press.  489–505.
  • Andrews, B. W., Iglesias, P. (2007).  Control engineering and systems biology.  Mathematical Methods for Robust and Nonlinear Control.  Springer London.  267–288.
  • Effler, J. C., Iglesias, P., Robinson, D. N. (2006).  Regulating cell shape during cytokinesis.  Control of Uncertain Systems: Modelling, Approximation, and Design.  Springer Berlin Heidelberg.  203–224.
  • Peters, M. A., Iglesias, P. (1997).  Connections With Related Optimal Control Problems.  Minimum Entropy Control for Time-Varying Systems.  Birkhäuser Boston.  69–93.
  • Peters, M. A., Iglesias, P. (1997).  Discrete-Time Entropy.  Minimum Entropy Control for Time-Varying Systems.  Birkhäuser Boston.  46–68.
  • Peters, M. A., Iglesias, P. (1997).  Induced Operator Norms.  Minimum Entropy Control for Time-Varying Systems.  Birkhäuser Boston.  26–45.
Other Publications
  • Huang, C., Tang, M., Wang, M., Shi, C., Iglesias, P., Devreotes, P. N. (2015).  Evolutionarily Conserved Coupling of Adaptive and Excitable Networks Mediates Eukaryotic Chemotaxis.  Biophysical Journal.  108(2).  456a.
  • Schiffhauer, E., Luo, T., Qian, X., Mohan, K., Iglesias, P., Robinson, D. (2015).  Kinetics of Mechanoresponse in the Mammalian Actin Cytoskeleton.  Biophysical Journal.  108(2).  180a.
  • Cai, H., Katoh-Kurasawa, M., Muramoto, T., Santhanam, B., Long, Y., Li, L., Ueda, M., Iglesias, P., Shaulsky, G., Devreotes, P. N. (2015).  Nucleocytoplasmic Shuttling of a Gata-Family Transcription Factor Functions as a Development Timer.  Biophysical Journal.  108(2).  463a.
  • Iglesias, P. (2001).  Algorithms for linear quadratic optimization: Vasile Sima; Marcel Dekker, New York, 1996, ISBN: 0-8247-9612-8.  Pergamon.
  • Iglesias, P. (1994).  On the stabilization of discrete-time linear time-varying systems.  Technical Report TR 94/08, Dept. Elec. & Comp. Eng., Johns Hopkins Univ., Baltimore, MD.
  • Iglesias, P. (1993).  Implementation issues arising in the use of optimal control methods for a linear time-varying guidance filter.  Technical Report TR 93/11, Department of Electrical & Computer Engineering, The Johns Hopkins University, Baltimore, MD.
  • Iglesias, P. (1991).  Robust and adaptive control for discrete-time systems..  University of Cambridge.
Conference Proceedings
  • Iglesias, P. (2013).  Excitable Systems in Cell Motility.  52nd IEEE Conf. on Decision and Control.  757-762.
  • Shi, C., Channels, W. E., Zheng, Y., Iglesias, P. (2011).  A continuum computational model of mitotic matrix formation.  Information Sciences and Systems (CISS), 2011 45th Annual Conference on.  1–5.
  • Porter, J. R., Iglesias, P., Burg, J. S., Espenshade, P. J. (2011).  Overcoming data limitations to identify a static nonlinearity in a biological signaling cascade.  Information Sciences and Systems (CISS), 2011 45th Annual Conference on.  1–6.
  • Xiong, Y., Iglesias, P. (2009).  Automated characterization of amoeboid motility.  Information Sciences and Systems, 2009. CISS 2009. 43rd Annual Conference on.  369–370.
  • Andrews, B. W., Iglesias, P., Yi, T. (2007).  Coping with Noise in E. coli Chemotaxis.  Information Sciences and Systems, 2007. CISS’07. 41st Annual Conference on.  442–443.
  • Effler, J. C., Kee, Y., Berk, J. M., Ren, Y., Tran, M. N., Iglesias, P., Robinson, D. N. (2007).  Mechanosensing and contractile protein redistribution control cell shape during cytokinesis.  BIOPHYSICAL JOURNAL.  304A–304A.
  • Andrews, B. W., Iglesias, P. (2007).  Rate distortion theory in cellular signaling.  Information Sciences and Systems, 2007. CISS’07. 41st Annual Conference on.  172–173.
  • Iglesias, P., Khammash, M., Munsky, B., Sontag, E. D., Del Vecchio, D. (2007).  Systems biology and control—A tutorial.  Decision and Control, 2007 46th IEEE Conference on.  1–12.
  • Andrews, B. W., Iglesias, P., Sontag, E. D. (2006).  Signal detection and approximate adaptation implies an approximate internal model.  Decision and Control, 2006 45th IEEE Conference on.  2364–2369.
  • Yang, L., Iglesias, P. (2005).  Feedback induced biphasic response in the chemotaxis pathway of Dictyostelium.  American Control Conference, 2005. Proceedings of the 2005.  4393–4398.
  • Kim, J., Bates, D. G., Postlethwaite, I., Ma, L., Iglesias, P. (2005).  Robustness Analysis of Biochemical Networks Using $μ$-Analysis and Hybrid Optimisation.  Decision and Control, 2005 and 2005 European Control Conference. CDC-ECC’05. 44th IEEE Conference on.  6234–6239.
  • Yi, T., Iglesias, P., Ingalls, B. (2003).  Control theory in biology: From mca to chemotaxis.  In Tutorial at ICSB.
  • Iglesias, P., Levchenko, A. (2001).  A general framework for achieving integral control in chemotactic biological signaling mechanisms.  Decision and Control, 2001. Proceedings of the 40th IEEE Conference on.  1.  843–848.
  • Iglesias, P. (2001).  An analogue of Bode’s integral for stable nonlinear systems: Relations to entropy.  Decision and Control, 2001. Proceedings of the 40th IEEE Conference on.  4.  3419–3420.
  • Iglesias, P. (1999).  Analytic constraints in feedback control of linear time-varying systems: Bode’s sensitivity integral.  American Control Conference, 1999. Proceedings of the 1999.  6.  3790–3794.
  • Urban, T. J., Iwaskiw, P., Iglesias, P. (1999).  Understanding missile autopilot design using the H∞ loop shaping design procedure.  Control Applications, 1999. Proceedings of the 1999 IEEE International Conference on.  1.  236–242.
  • O’Brien, Jr, R. T., Iglesias, P. (1998).  Robust controller design for time-varying systems.  Decision and Control, 1998. Proceedings of the 37th IEEE Conference on.  4.  3813–3818.
  • O’Brien, Jr, R., Iglesias, P. (1998).  Time-varying steering control for an autonomous highway vehicle.  American Control Conference, 1998. Proceedings of the 1998.  1.  26–30.
  • Peters, M., Iglesias, P. (1997).  A spectral test for observability and detectability of discrete-time linear time-varying systems.  Decision and Control, 1997., Proceedings of the 36th IEEE Conference on.  4.  3920–3925.
  • O’Brien, Jr, R. T., Iglesias, P. (1997).  Poles and zeros for time-varying systems.  American Control Conference, 1997. Proceedings of the 1997.  5.  2672–2676.
  • O’Brien, R., Iglesias, P., Urban, T. (1995).  H [INFINITY] STEERING CONTROL FOR AUTOMATED HIGHWAY VEHICLES.  Conference on Information Sciences and systems (29th: 1995: Baltimore, Md.). Proceedings.
  • Peters, M. A., Iglesias, P. (1994).  Minimum entropy control for discrete-time time-varying systems: The full information problem.  Dept. Elec. & Comp. Eng., Johns Hopkins Univ.
  • Iglesias, P. (1994).  On the stability of sampled-data linear time-varying feedback systems.  Decision and Control, 1994., Proceedings of the 33rd IEEE Conference on.  1.  219–224.
  • Popovic, Z. D., Parco, D., Iglesias, P. (1990).  Nature of microscopic electrical defects in organic photoreceptors.  SC-DL tentative.  175–182.
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