Chen, Shiyi

J/s Faculty Appointment
Unassigned

Latrobe Hall 124
schen5@jhu.edu

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About

Education
  • Ph.D. 1984, Peking University
Experience
  • 2011 - 2017:  J/S FACULTY APPOINTMENT, A&S Physics & Astronomy

Publications

Journal Articles
  • Wang P, Chen SH, Hung WC, Paul C, Zhu F, Guan PP, Huso DL, Kontrogianni-Konstantopoulos A, Konstantopoulos K (2014).  Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways.  Oncogene.  34(35).
  • Kumar V, Chang CK, Tan KP, Jung YS, Chen SH, Cheng YSE, Liang PH (2014).  Identification, synthesis, and evaluation of new neuraminidase inhibitors.  Organic Letters.  16(19).
  • Stroka KM, Jiang H, Chen SH, Tong Z, Wirtz D, Sun SX, Konstantopoulos K (2014).  Water permeation drives tumor cell migration in confined microenvironments.  Cell.  157(3).
  • Wang P, Chen S, Hung WC, Paul C, Zhu F, Guan PP, Huso DL, Kontrogianni-Konstantopoulos A, Konstantopoulos K (2014).  Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways.  Oncogene.
  • Stroka KM, Jiang H, Chen S, Tong Z, Wirtz D, Sun S, Konstantopoulos K (2014).  Water permeation drives tumor cell migration in confined microenvironments.  Cell.  157(3).  611-23.
  • Al-Mudaris ZA, Majid ASA, Ji D, Al-Mudarris BA, Chen SH, Liang PH, Osman H, Jamal Din SKK, Abdul Majid AMS (2013).  Conjugation of benzylvanillin and benzimidazole structure improves DNA binding with enhanced antileukemic properties.  PLoS ONE.  8(11).
  • Chen SH, Lin SW, Lin SR, Liang PH, Yang JM (2013).  Moiety-linkage map reveals selective nonbisphosphonate inhibitors of human geranylgeranyl diphosphate synthase.  Journal of Chemical Information and Modeling.  53(9).
  • Hung WC, Chen SH, Paul CD, Stroka KM, Lo YC, Yang JT, Konstantopoulos K (2013).  Distinct signaling mechanisms regulate migration in unconfined versus confined spaces.  Journal of Cell Biology.  202(5).
  • Lin YF, Lai TC, Chang CK, Chen CL, Huang MS, Yang CJ, Liu HG, Dong JJ, Chou YA, Teng KH, Chen SH, Tian WT, Jan YH, Hsiao M, Liang PH (2013).  Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies.  Journal of Clinical Investigation.  123(9).
  • Lin YC, Tsai PH, Lin CY, Cheng CH, Lin TH, Lee KPH, Huang KY, Chen SH, Hwang JJ, Kandaswami CC, Lee MT (2013).  Impact of Flavonoids on Matrix Metalloproteinase Secretion and Invadopodia Formation in Highly Invasive A431-III Cancer Cells.  PLoS ONE.  8(8).
  • Hung WC, Chen S, Paul CD, Stroka KM, Lo YC, Yang JT, Konstantopoulos K (2013).  Distinct signaling mechanisms regulate migration in unconfined versus confined spaces.  J Cell Biol.  202(5).  807-24.
  • Chen SH, Hung WC, Wang P, Paul C, Konstantopoulos K (2013).  Mesothelin binding to CA125/MUC16 promotes pancreatic cancer cell motility and invasion via MMP-7 activation.  Scientific Reports.  3.
  • Chen S, Hung WC, Wang P, Paul C, Konstantopoulos K (2013).  Mesothelin binding to CA125/MUC16 promotes pancreatic cancer cell motility and invasion via MMP-7 activation.  Sci Rep.  3.  1870.
  • Streppel MM, Vincent A, Mukherjee R, Campbell NR, Chen SH, Konstantopoulos K, Goggins MG, Van Seuningen I, Maitra A, Montgomery EA (2012).  Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon.  Human Pathology.  43(10).
  • Dallas MR, Chen SH, Streppel MM, Sharma S, Maitra A, Konstantopoulos K (2012).  Sialofucosylated podocalyxin is a functional E- and L-selectin ligand expressed by metastatic pancreatic cancer cells.  American Journal of Physiology - Cell Physiology.  303(6).
  • Almaraz RT, Tian Y, Bhattarcharya R, Tan E, Chen SH, Dallas MR, Chen L, Zhang Z, Zhang H, Konstantopoulos K, Yarema KJ (2012).  Metabolic flux increases glycoprotein sialylation: Implications for cell adhesion and cancer metastasis.  Molecular and Cellular Proteomics.  11(7).
  • Chang KM, Chen SH, Kuo CJ, Chang CK, Guo RT, Yang JM, Liang PH (2012).  Roles of amino acids in the Escherichia coli octaprenyl diphosphate synthase active site probed by structure-guided site-directed mutagenesis.  Biochemistry.  51(16).
  • Chen SH, Dallas MR, Balzer EM, Konstantopoulos K (2012).  Mucin 16 is a functional selectin ligand on pancreatic cancer cells.  FASEB Journal.  26(3).
  • Chen S, Dallas MR, Balzer EM, Konstantopoulos K (2012).  Mucin 16 is a functional selectin ligand on pancreatic cancer cells.  FASEB J.  26(3).  1349-59.
  • Streppel MM, Vincent A, Mukherjee R, Campbell N, Chen S, Konstantopoulos K, Goggins MG, Van Seuningen I, Maitra A, Montgomery EA (2012).  Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon.  Hum Pathol.  43(10).  1755-63.
  • Almaraz RT, Tian Y, Bhattarcharya R, Tan E, Chen S, Dallas MR, Chen L, Zhang Z, Zhang H, Konstantopoulos K, Yarema KJ (2012).  Metabolic flux increases glycoprotein sialylation: implications for cell adhesion and cancer metastasis.  Mol Cell Proteomics.  11(7).  M112 017558.
  • Dallas MR, Chen S, Streppel MM, Sharma S, Maitra A, Konstantopoulos K (2012).  Sialofucosylated podocalyxin is a functional E- and L-selectin ligand expressed by metastatic pancreatic cancer cells.  Am J Physiol Cell Physiol.  303(6).  C616-24.
  • Chen SH, Lin CY, Lee LT, Chang GD, Lee PP, Hung CC, Kao WT, Tsai PH, Schally AV, Hwang JJ, Lee MT (2010).  Up-regulation of fibronectin and tissue transglutaminase promotes cell invasion involving increased association with integrin and MMP expression in A431 cells.  Anticancer Research.  30(10).
  • Wan M, Xiao Z, Meneveau C, Eyink G, Chen S (2010).  Dissipation-energy flux correlations as evidence for the Lagrangian energy cascade in turbulence.  Physics of Fluids (1994-present).  22(6).  061702.
  • Lo CH, Chang YH, Wright JD, Chen SH, Kan D, Lim C, Liang PH (2009).  Combined experimental and theoretical study of long-range interactions modulating dimerization and activity of yeast geranylgeranyl diphosphate synthase.  Journal of the American Chemical Society.  131(11).
  • Kao WT, Lin CY, Lee LT, Lee PPH, Hung CC, Lin YS, Chen SH, Ke FC, Hwang JJ, Lee MT (2008).  Investigation of MMP-2 and -9 in a highly invasive A431 tumor cell sub-line selected from a boyden chamber assay.  Anticancer Research.  28(4 B).
  • Li Y, Perlman E, Wan M, Yang Y, Meneveau C, Burns R, Chen S, Szalay A, Eyink G (2008).  A public turbulence database cluster and applications to study Lagrangian evolution of velocity increments in turbulence.  Journal of Turbulence.  (9).
  • Meneveau C, Li Y, Perlman E, Wan M, Yang Y, Burns R, Chen S, Eyink G, Szalay A (2007).  Analysis of Turbulence Datasets using a Database Cluster: Requirements, Design, and Sample Applications.  Bulletin of the American Physical Society.  52.
  • Li Y, Meneveau C, Chen S, Eyink G (2006).  Subgrid-scale modeling of helicity and energy dissipation in helical turbulence.  Physical Review E.  74(2).  026310.
Conference Proceedings
  • Meneveau C, Yang Y, Perlman E, Wan M, Burns R, Szalay A, Chen S, Eyink G (2008).  Analysis of isotropic turbulence using a public database and the Web service model, and applications to study subgrid models.  APS Division of Fluid Dynamics Meeting Abstracts.  1.
  • Li Y, Meneveau C, Eyink G, Chen S (2003).  Joint energy and helicity dissipation in LES of isotropic turbulence.  APS Division of Fluid Dynamics Meeting Abstracts.  1.
  • Nelkin M, Chen S, Eyink G, Meneveau C (2001).  Shell Models, Hypoviscosity and Intermittency.  APS Division of Fluid Dynamics Meeting Abstracts.  1.
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