Boyle, Patrick M.

Asst Research Prof.
Biomedical Engineering
BME Profile

Hackerman Hall 217B
(410) 516-3322
pmjboyle@jhu.edu

Jump to:

About

Education
  • Ph.D. 2011, University of Calgary
  • Bachelor of Science in Computer Engineering, with Distinction, Internship Program 2005, University of Calgary
Experience
  • 2017 - Present:  Fellow (FHRS), Heart Rhythm Society
  • 2014 - 2015:  Assistant Research Scientist, Johns Hopkins University, Institute for Computational Medicine
  • 2011 - 2014:  Postdoctoral Fellow, Johns Hopkins University, Institute for Computational Medicine
Awards
  • 2017:  Official Selection for "EP Concepts Ignited: Innovative Techniques and Technologies" Feature Poster Session

Publications

Journal Articles
  • Boyle PM, Hakim JB, Zahid S, Franceschi WH, Murphy MJ, Vigmond EJ, Dubois R, Haïssaguerre M, Hocini M, Jaïs P, Trayanova NA, Cochet H (2018).  Comparing reentrant drivers predicted by image-based computational modeling and mapped by electrocardiographic imaging in persistent atrial fibrillation.  Frontiers in Physiology.  9(APR).
  • Trayanova NA, Nikolov PP, Boyle PM (2018).  Personalized imaging and modeling strategies for arrhythmia prevention and therapy.  Current Opinion in Biomedical Engineering.  5.  21-28.
  • Boyle PM, TV Karathanos, NA Trayanova (2018).  Cardiac Optogenetics: 2018.  JACC: Clinical Electrophysiology.  4(2).  155-167.
  • Boyle PM, Karathanos TV, Trayanova NA (2018).  Cardiac Optogenetics 2018.  JACC: Clinical Electrophysiology.  4(2).
  • Boyle PM, Murphy MJ, Karathanos TV, Zahid S, Blake RC, Trayanova NA (2018).  Termination of re-entrant atrial tachycardia via optogenetic stimulation with optimized spatial targeting: insights from computational models.  Journal of Physiology.  596(2).
  • Boyle PM, MJ Murphy, TV Karathanos, S Zahid, RC Blake III, NA Trayanova (2018).  Termination of Re-entrant Atrial Tachycardia via Optogenetic Stimulation with Optimized Spatial Targeting: Insights from Computational Models.  J Physiol.  596(2).  181-96.
  • (2018).  Personalizing therapy for atrial fibrillation: The role of stem cell and in silico disease models.  Cardiovascular Research.  114(7).
  • Deo M, Weinberg SH, Boyle PM (2017).  Calcium Dynamics and Cardiac Arrhythmia.  Clinical Medicine Insights: Cardiology.  11.
  • Deng D, Murphy MJ, Hakim JB, Franceschi WH, Zahid S, Pashakhanloo F, Trayanova NA, Boyle PM (2017).  Sensitivity of reentrant driver localization to electrophysiological parameter variability in image-based computational models of persistent atrial fibrillation sustained by a fibrotic substrate.  Chaos.  27(9).
  • Boyle PM, Zahid S, Trayanova NA (2017).  Using personalized computer models to custom-tailor ablation procedures for atrial fibrillation patients: are we there yet?.  Expert Review of Cardiovascular Therapy.  15(5).
  • Cochet H, Dubois R, Yamashita S, Al Jefairi N, Berte B, Sellal JM, Hooks D, Frontera A, Amraoui S, Zemoura A, Denis A, Derval N, Sacher F, Corneloup O, Latrabe V, Clément-Guinaudeau S, Relan J, Zahid S, Boyle PM, Trayanova NA, Bernus O, Montaudon M, Laurent F, Hocini M, Haïssaguerre M, Jaïs P (2017).  Relationship Between Fibrosis Detected on Late Gadolinium-Enhanced CMR and Re-Entrant Activity Assessed With ECGI in Human Persistent Atrial Fibrillation.  JACC: Clinical Electrophysiology.  (1).
  • Boyle PM, Zahid S, Trayanova NA (2016).  Towards personalized computational modelling of the fibrotic substrate for atrial arrhythmia.  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.  18.
  • Karathanos TV, Bayer JD, Wang D, Boyle PM, Trayanova NA (2016).  Opsin spectral sensitivity determines the effectiveness of optogenetic termination of ventricular fibrillation in the human heart: a simulation study.  Journal of Physiology.  594(23).
  • Roney CH, Bayer JD, Zahid S, Meo M, Boyle PMJ, Trayanova NA, Haïssaguerre M, Dubois R, Cochet H, Vigmond EJ (2016).  Modelling methodology of atrial fibrosis affects rotor dynamics and electrograms.  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.  18.
  • Priest JR, Gawad C, Kahlig KM, Yuf JK, O'Hara T, Boyle PM, Rajamani S, Clark MJ, Garcia STK, Ceresnak S, Harris J, Boyle S, Dewey FE, Malloy-Walton L, Dunn K, Grove M, Perez MV, Neff NF, Chen R, Maeda K, Dubin A, Belardinelli L, West J, Antolik C, Macaya D, Quertermous T, Trayanova NA, Quake SR, Ashley EA (2016).  Early Somatic mosaicism is a rare cause of long-QT syndrome.  Proceedings of the National Academy of Sciences of the United States of America.  113(41).
  • Bruegmann T, Boyle PM, Vogt CC, Karathanos TV, Arevalo HJ, Fleischmann BK, Trayanova NA, Sasse P (2016).  Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations.  Journal of Clinical Investigation.  126(10).
  • Arevalo HJ, Boyle PM, Trayanova NA (2016).  Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia.  Progress in Biophysics and Molecular Biology.  121(2).
  • Zahid S, Cochet H, Boyle PM, Schwarz EL, Whyte KN, Vigmond EJ, Dubois R, Hocini M, Haïssaguerre M, Jaïs P, Trayanova NA (2016).  Patient-derived models link re-entrant driver localization in atrial fibrillation to fibrosis spatial pattern.  Cardiovascular Research.  110(3).
  • Karathanos TV, Boyle PM, Trayanova NA (2016).  Light-based Approaches to Cardiac Arrhythmia Research: From Basic Science to Translational Applications.  Clinical Medicine Insights: Cardiology.  10s1.
  • Zahid S, Whyte KN, Schwarz EL, Blake RC, Boyle PM, Chrispin J, Prakosa A, Ipek EG, Pashakhanloo F, Halperin HR, Calkins H, Berger RD, Nazarian S, Trayanova NA (2016).  Feasibility of using patient-specific models and the "minimum cut" algorithm to predict optimal ablation targets for left atrial flutter.  Heart Rhythm.  (8).
  • Ambrosi CM, Boyle PM, Chen K, Trayanova NA, Entcheva E (2015).  Optogenetics-enabled assessment of viral gene and cell therapy for restoration of cardiac excitability.  Scientific Reports.  5.
  • Boyle PM, Karathanos TV, Entcheva E, Trayanova NA (2015).  Computational modeling of cardiac optogenetics: Methodology overview & review of findings from simulations.  Computers in Biology and Medicine.  65.
  • Boyle PM, Karathanos TV, Trayanova NA (2015).  "Beauty is a light in the heart": The transformative potential of optogenetics for clinical applications in cardiovascular medicine.  Trends in Cardiovascular Medicine.  25(2).
  • Trayanova NA, Boyle PM (2015).  Cardiac arrhythmias: Mechanistic knowledge and innovation from computer models.  Modeling, Simulation and Applications.  14.
  • Campos FO, Shiferaw Y, Prassl AJ, Boyle PM, Vigmond EJ, Plank G (2015).  Stochastic spontaneous calcium release events trigger premature ventricular complexes by overcoming electrotonic load.  Cardiovascular Research.  107(1).
  • Karathanos TV, Boyle PM, Trayanova N (2014).  Optogenetics-enabled dynamic modulation of action potential duration in atrial tissue: feasibility of a novel therapeutic approach..  Europace.  16 Suppl 4.  iv69-iv76.
  • Karathanos TV, Boyle PM, Trayanova NA (2014).  Optogenetics-enabled dynamic modulation of action potential duration in atrial tissue: feasibility of a novel therapeutic approach.  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.  16.
  • Boyle PM, Karathanos TV, Trayanova N (2014).  "Beauty is a light in the heart": The transformative potential of optogenetics for clinical applications in cardiovascular medicine..  Trends Cardiovasc Med.
  • Trayanova NA, Boyle PM (2014).  Advances in modeling ventricular arrhythmias: From mechanisms to the clinic.  Wiley Interdisciplinary Reviews: Systems Biology and Medicine.  6(2).
  • Zamiri N, Massé S, Ramadeen A, Kusha M, Hu X, Azam MA, Liu J, Lai PFH, Vigmond EJ, Boyle PM, Behradfar E, Al-Hesayen A, Waxman MB, Backx P, Dorian P, Nanthakumar K (2014).  Dantrolene improves survival after ventricular fibrillation by mitigating impaired calcium handling in animal models.  Circulation.  129(8).
  • Boyle PM, Park CJ, Arevalo HJ, Vigmond EJ, Trayanova NA (2014).  Sodium current reduction unmasks a structure-dependent substrate for arrhythmogenesis in the normal ventricles.  PLoS ONE.  9(1).
  • Trayanova NA, Boyle PM, Arevalo HJ, Zahid S (2014).  Exploring susceptibility to atrial and ventricular arrhythmias resulting from remodeling of the passive electrical properties in the heart: A simulation approach.  Frontiers in Physiology.  5(Nov).
  • Boyle PM, Entcheva E, Trayanova NA (2014).  See the light: Can optogenetics restore healthy heartbeats? And, if it can, is it really worth the effort?.  Expert Review of Cardiovascular Therapy.  12(1).
  • Boyle PM, Entcheva E, Trayanova N (2014).  See the light: can optogenetics restore healthy heartbeats? And, if it can, is it really worth the effort?.  Expert Rev Cardiovasc Ther.  12(1).  17-20.
  • Trayanova N, Boyle PM, Arevalo HJ, Zahid S (2014).  Exploring susceptibility to atrial and ventricular arrhythmias resulting from remodeling of the passive electrical properties in the heart: a simulation approach..  Front Physiol.  5.  435.
  • Trayanova N, Boyle PM (2014).  Advances in modeling ventricular arrhythmias: from mechanisms to the clinic..  Wiley Interdiscip Rev Syst Biol Med.  6(2).  209-224.
  • Boyle PM, Park CJ, Arevalo HJ, Vigmond EJ, Trayanova N (2014).  Sodium current reduction unmasks a structure-dependent substrate for arrhythmogenesis in the normal ventricles..  PLoS One.  9(1).  e86947.
  • Boyle PM, Massé S, Nanthakumar K, Vigmond EJ (2013).  Transmural IK(ATP) heterogeneity as a determinant of activation rate gradient during early ventricular fibrillation: Mechanistic insights from rabbit ventricular models.  Heart Rhythm.  10(11).
  • Boyle PM, Williams JC, Ambrosi CM, Entcheva E, Trayanova NA (2013).  A comprehensive multiscale framework for simulating optogenetics in the heart.  Nature Communications.  4.
  • Boyle PM, Veenhuyzen GD, Vigmond EJ (2013).  Fusion during entrainment of orthodromic reciprocating tachycardia is enhanced for basal pacing sites but diminished when pacing near Purkinje system end points.  Heart Rhythm.  10(3).
  • Boyle PM, Williams JC, Ambrosi CM, Entcheva E, Trayanova N (2013).  A comprehensive multiscale framework for simulating optogenetics in the heart..  Nat Commun.  4.  2370.
  • Boyle PM, Williams JC, Entcheva E, Trayanova NA (2012).  A computational framework for simulating cardiac optogenetics.  Computing in Cardiology.  39.
  • Trayanova NA, O'Hara T, Bayer JD, Boyle PM, McDowell KS, Constantino J, Arevalo HJ, Hu Y, Vadakkumpadan F (2012).  Computational cardiology: How computer simulations could be used to develop new therapies and advance existing ones.  Europace.  14(SUPPL. 5).
  • Trayanova N, O’Hara T, Bayer JD, Boyle PM, McDowell KS, Constantino J, Arevalo HJ, Hu Y, Vadakkumpadan F (2012).  Computational cardiology: how computer simulations could be used to develop new therapies and advance existing ones..  Europace.  14 Suppl 5.  v82-v89.
  • Boyle PM, Madhavan A, Reid MP, Vigmond EJ (2012).  Propagating unstable wavelets in cardiac tissue.  Physical Review E - Statistical, Nonlinear, and Soft Matter Physics.  85(1).
  • Vigmond E, Boyle P (2011).  Safety factor in cardiac propagation.  2011 8th International Symposium on Noninvasive Functional Source Imaging of the Brain and Heart and the 2011 8th International Conference on Bioelectromagnetism, NFSI and ICBEM 2011.
  • Boyle PM, Madhaven A, Vigmond EJ (2010).  A new safety factor formulation for cardiac propagation.  AIP Conference Proceedings.  1281.
  • Bishop MJ, Boyle PM, Plank G, Welsh DG, Vigmond EJ (2010).  Modeling the role of the coronary vasculature during external field stimulation.  IEEE Transactions on Biomedical Engineering.  57(10 PART 1).
  • Deo M, Boyle PM, Kim AM, Vigmond EJ (2010).  Arrhythmogenesis by single ectopic beats originating in the Purkinje system.  American Journal of Physiology - Heart and Circulatory Physiology.  299(4).
  • Boyle PM, Vigmond EJ (2010).  An intuitive safety factor for cardiac propagation.  Biophysical Journal.  98(12).
  • Romero D, Sebastian R, Bijnens BH, Zimmerman V, Boyle PM, Vigmond EJ, Frangi AF (2010).  Effects of the purkinje system and cardiac geometry on biventricular pacing: A model study.  Annals of Biomedical Engineering.  38(4).
  • Ghaly HA, Boyle PM, Vigmond EJ, Shimoni Y, Nygren A (2010).  Simulations of reduced conduction reserve in the diabetic rat heart: Response to uncoupling and reduced excitability.  Annals of Biomedical Engineering.  38(4).
  • Boyle PM, Deo M, Plank G, Vigmond EJ (2010).  Purkinje-mediated effects in the response of quiescent ventricles to defibrillation shocks.  Annals of Biomedical Engineering.  38(2).
  • Deo M, Boyle P, Plank G, Vigmond E (2009).  Arrhythmogenic mechanisms of the Purkinje system during electric shocks: A modeling study.  Heart Rhythm.  6(12).
  • Vigmond EJ, Boyle PM, Leon LJ, Plank G (2009).  Near-real-time simulations of biolelectric activity in small mammalian hearts using graphical processing units.  Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009.
  • Romero D, Sebastian R, Bijnens BH, Zimmerman V, Boyle PM, Vigmond EJ, Frangi AF (2009).  The purkinje system and cardiac geometry: Assessing their influence on the paced heart.  Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics).  5528.
  • Vadakkumpadan F, Rantner LJ, Tice B, Boyle P, Prassl AJ, Vigmond E, Plank G, Trayanova N (2009).  Image-based models of cardiac structure with applications in arrhythmia and defibrillation studies.  Journal of Electrocardiology.  42(2).
  • Vadakkumpadan F, Rantner LJ, Tice B, Boyle PM, Prassl AJ, Vigmond E, Plank G, Trayanova N (2009).  Image-based models of cardiac structure with applications in arrhythmia and defibrillation studies..  J Electrocardiol.  42(2).  157.e1-157.10.
  • Deo M, Boyle P, Plank G, Vigmond E (2008).  Role of Purkinje system in cardiac arrhythmias.  Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology".
  • Ghaly H, Boyle P, Vigmond E, Nygren A (2008).  Reduced conduction reserve of the propagating cardiac impulse in the diabetic rat heart: A model study.  Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology".
  • Boyle PM, Deo M, Vigmond EJ (2007).  Behaviour of the Purkinje system during defibrillation-strength shocks.  Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings.
Conference Proceedings
  • Prakosa A, Cartoski MJ, Boyle PM, O'Hara RP, Pashakhanloo F, Coppini R, Pradella S, Zimmerman S, Abraham MR, Maurizi N, Olivotto I, Trayanova NA (2017).  Ventricular Arrhythmia (VA) in Hypertrophic Cardiomyopathy (HCM): Novel Arrhythmia Risk Stratification Using T1 Mapping, Late Gadolinium Enhancement MRI (LGE-MRI), and Computational Modeling.  Annual Scientific Sessions of the American Heart Association (Circulation).
  • Cartoski MJ, Nikolov PP, Boyle PM, Spevak PJ, Trayanova NA (2017).  Personalized Risk Stratification for Ventricular Arrhythmia in Pediatric Patients With Myocarditis via Image-Based Computational Simulations.  Annual Scientific Sessions of the American Heart Association (Circulation).  136.  A15442.
  • Yu JK, Franceschi WH, Boyle PM, Trayanova NA (2017).  Electrotonic Interactions Between Ventricular Myocytes and Injected Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CM) Increase Cardiac Ectopy: Insights From a 3D Human Computational Model.  Annual Scientific Sessions of the Heart Rhythm Society (Heart Rhythm).  5.  S52.
  • Yu JK, Franceschi WH, Boyle PM, Trayanova NA (2017).  Increased Clustering of Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte (hiPSC-CM) Distribution Increases the Likelihood of Cardiac Ectopy: Insights from a Realistic Human Model of Post-Myocardial Infarction Ventricular Tachycardia.  Annual Scientific Sessions of the Heart Rhythm Society (Heart Rhythm).  5.  S147.
  • Boyle PM (2017).  Reentrant Drivers of Persistent Atrial Fibrillation Identified by Personalized Computational Modeling Correlate to Rotors Observed Clinically by Intracardiac Mapping: A Pilot Study.  Annual Scientific Sessions of the Heart Rhythm Society (Heart Rhythm).  14.  S260.
  • Cartoski MJ, Reymann M, Nikolov PP, Prakosa A, Boyle PM, Spevak PJ, Trayanova NA (2017).  Risk Stratification for Ventricular Arrhythmia in Patients with Hypertrophic Cardiomyopathy via MRI-Based Computational Simulations: A Pilot Study.  SCMR Annual Scientific Sessions (J Cardiovasc Magn Reson).  19.  430.
Back to top