Betenbaugh, Michael J.

Professor
Chemical And Biomolecular Engineering

Maryland Hall 222
(410) 516-5461
beten@jhu.edu

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Betenbaugh wins ACS BIOT Division’s Marvin J. Johnson Award

February 19, 2015

Michael J. Betenbaugh, professor in the Department of Chemical and Biomolecular Engineering and chair of the Engineering for Professionals program, has been selected by the American Chemical Society’s Division of Biochemical Technology to receive the Marvin J. Johnson Award in Microbial and Biochemical Technology. This honor recognizes outstanding research contributions toward the advancement of microbial […]

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About

Education
  • Ph.D. 1988, Univ of Delaware
Experience
  • 2011 - Present:  Chair, Chemical Engineering Professionals Program
  • 2008 - Present:  Director, Chemical and Biomolecular Engineering Graduate Admissions Committee
  • 2006 - 2007:  Chair, Biotechnology & Bioengineering
  • 2004 - 2004:  Past Chair, American Chemical Society
  • 2003 - 2003:  Division Chair, American Chemical Society, Division of Biochemical Technology
  • 2002 - 2002:  Chair, Unspecified
  • 2002 - 2002:  Program Chair, Cell Culture Engineering
Research Areas
  • Biofuels Production
  • Cell Line Optimization
  • Mammalian Cell Engineering
  • Metabolic Engineering
  • Microalgae Genetic Engineering
Awards
  • 2017:  Daniel I.C. Wang Award for Excellence in Biochemical Engineering
  • 2015:  Marvin Johnson Award
  • 2010:  Merck Cell Culture Engineering Award
  • 2004:  American Institute of Chemical Engineers - Food - Pharmaceutical - and Bioengineering Division Plenary Session Biochemical Engineering (Area 15c) Award
  • 2004:  Bayer Lectureship in Biochemical Engineering - University of California at Berkeley
  • 2002:  2002 James Van Lanen Award for Distinguished Service - American Chemical Society Division of Biochemical Technology
  • 2001:  Fellow - American Institute of Medical and Biological Engineers
  • 1993:  National Science Foundation Young Investigator
  • 1988:  Member - Sigma Xi
  • 1985:  William H. Peterson Award - Microbial and Biological Technology Division - Annual American Chemical Society Meeting
  • 1984:  Amoco Research Fellowship
  • 1981:  Outstanding Senior Award - University of Virginia
  • 1980:  Member - Tau Beta Pi
Presentations
  • "Assessment of short carboxylic acids as cheap organic carbon substrate for mixotrophic or heterotrophic microalgal growth", 9th Annual Algae Biomass Summit.  Washington, D.C..  September 29, 2015
  • "Integration of microalgal biofuel production with phytoremediation using Algal Turf Scrubber", 9th Annual Algae Biomass Summit.  Washington, D.C..  September 29, 2015
  • "Nutrient Requirements for Algal Biofuels: Accessing the Sustainability of Scaling-Up", 5th International Conference on Algal Biomass: Biofuels and Bioproducts.  San Diego, CA.  June 7, 2015
  • "Assessment of Integrated Technology for Biofuel Production with Phytoremediation using Algal Turf Scrubber", 5th International Conference on Algal Biomass: Biofuels and Bioproducts.  San Diego, CA.  June 7, 2015
  • "Anaerobic Digestion of Post-Extracted Algal Residues: a Possibility to Double Energy Yield and Recycle Nutrients for Algae Cultivation Stage", 7th Annual Algae Biomass Summit.  Orlando, FL.  September 30, 2013
  • "Mixotrophic/Heterotrophic Algae Growth on a Low-Cost Substrate: Linking Organic Waste Processing and Microalgae Cultivation", 7th Annual Algae Biomass Summit.  Orlando, FL.  September 30, 2013
  • "Enzymatic Hydrolysis of Algal Biomass and Delipidated Residues to Enhance Energy Production and Nutrient Recycling", 3rd International Conference on Algal Biomass, Biofuels, and Bioproducts.  Toronto, Canada.  June 16, 2013
  • "Integrated Biofuel Feedstock Production and Wastewater Remediation: Algal Strains Screening and Process Optimization", 3rd International Conference on Algal Biomass, Biofuels, and Bioproducts.  Toronto, Canada.  June 16, 2013

Publications

Journal Articles
  • Bohutskyi P, Phan D, Spierling RE, Kopachevsky AM, Bouwer EJ, Lundquist TJ, Betenbaugh MJ (2019).  Production of lipid-containing algal-bacterial polyculture in wastewater and biomethanation of lipid extracted residues: Enhancing methane yield through hydrothermal pretreatment and relieving solvent toxicity through co-digestion.  Science of the Total Environment.  653.
  • Naik HM, Majewska NI, Betenbaugh MJ (2018).  Impact of nucleotide sugar metabolism on protein N-glycosylation in Chinese Hamster Ovary (CHO) cell culture.  Current Opinion in Chemical Engineering.  22.
  • Bohutskyi P, Phan D, Kopachevsky AM, Chow S, Bouwer EJ, Betenbaugh MJ (2018).  Synergistic co-digestion of wastewater grown algae-bacteria polyculture biomass and cellulose to optimize carbon-to-nitrogen ratio and application of kinetic models to predict anaerobic digestion energy balance.  Bioresource Technology.  269.
  • Jenkins J, Park J, Petersen K, Shajihan K, Kruthiventi S, Betenbaugh M (2018).  Adoptive T cell therapy: engineering and biomanufacturing chimeric antigen receptor-T cell.  Current Opinion in Chemical Engineering.  22.
  • Park J, Inwood S, Kruthiventi S, Jenkins J, Shiloach J, Betenbaugh M (2018).  Progressing from transient to stable packaging cell lines for continuous production of lentiviral and gammaretroviral vectors.  Current Opinion in Chemical Engineering.  22.
  • Bohutskyi P, Spierling RE, Phan D, Kopachevsky AM, Tang Y, Betenbaugh MJ, Bouwer EJ, Lundquist TJ (2018).  Bioenergy from wastewater resources: Nutrient removal, productivity and settleability of indigenous algal-bacteria polyculture, and effect of biomass composition variability on methane production kinetics and anaerobic digestion energy balance.  Algal Research.  36.
  • Khalid M, Johnson E, Vij A, Bouwer EJ, Janjua HA, Betenbaugh MJ (2018).  Anaerobic digestion restricted to phase I for nutrient release and energy production using waste-water grown Chlorella vulgaris.  Chemical Engineering Journal.  352.
  • Rupp O, MacDonald ML, Li S, Dhiman H, Polson S, Griep S, Heffner K, Hernandez I, Brinkrolf K, Jadhav V, Samoudi M, Hao H, Kingham B, Goesmann A, Betenbaugh MJ, Lewis NE, Borth N, Lee KH (2018).  A reference genome of the Chinese hamster based on a hybrid assembly strategy.  Biotechnology and Bioengineering.  115(8).
  • Yin B, Wang Q, Chung CY, Ren X, Bhattacharya R, Yarema KJ, Betenbaugh MJ (2018).  Butyrated ManNAc analog improves protein expression in Chinese hamster ovary cells.  Biotechnology and Bioengineering.  115(6).
  • Wang Q, Chung CY, Chough S, Betenbaugh MJ (2018).  Antibody glycoengineering strategies in mammalian cells.  Biotechnology and Bioengineering.  115(6).
  • Inwood S, Xu H, Black MA, Betenbaugh MJ, Feldman S, Shiloach J (2018).  Continuous production process of retroviral vector for adoptive T- cell therapy.  Biochemical Engineering Journal.  132.
  • Guarnieri MT, Levering J, Henard CA, Boore JL, Betenbaugh MJ, Zengler K, Knoshaug EP (2018).  Genome sequence of the oleaginous green alga, Chlorella vulgaris UTEX 395.  Frontiers in Bioengineering and Biotechnology.  6(APR).
  • Wang Q, Chen CH, Chung CY, Priola J, Chu JH, Tang J, Ulmschneider MB, Betenbaugh MJ (2018).  Proline-Rich Chaperones Are Compared Computationally and Experimentally for Their Abilities to Facilitate Recombinant Butyrylcholinesterase Tetramerization in CHO Cells.  Biotechnology Journal.  13(3).
  • Betenbaugh MJ, Wang Q, Chung CY, Chough S (2018).  Antibody Glycoengineering Strategies in Mammalian Cells.  Biotechnology & Bioengineering.
  • Betenbaugh MJ, Yin B, Wang Q, Chung CY, Ren X, Bhattacharya R, Yarema KJ (2018).  Butyrated ManNAc analog improves protein expression in Chinese hamster ovary cells.  Biotechnology & Bioengineering.
  • Inwood S, Buehler E, Betenbaugh M, Lal M, Shiloach J (2018).  Identifying HIPK1 as Target of miR-22-3p Enhancing Recombinant Protein Production From HEK 293 Cell by Using Microarray and HTP siRNA Screen.  Biotechnology Journal.  13(2).
  • Vcelar S, Jadhav V, Melcher M, Auer N, Hrdina A, Sagmeister R, Heffner K, Puklowski A, Betenbaugh M, Wenger T, Leisch F, Baumann M, Borth N (2018).  Karyotype variation of CHO host cell lines over time in culture characterized by chromosome counting and chromosome painting.  Biotechnology and Bioengineering.  115(1).
  • Zuñiga C, Levering J, Antoniewicz MR, Guarnieri MT, Betenbaugh MJ, Zengler K (2018).  Predicting dynamic metabolic demands in the photosynthetic Eukaryote Chlorella vulgaris.  Plant Physiology.  176(1).
  • Dhara VG, Naik HM, Majewska NI, Betenbaugh MJ (2018).  Recombinant Antibody Production in CHO and NS0 Cells: Differences and Similarities.  BioDrugs.
  • Betenbaugh MJ, Inwood S, Shiloach J (2018).  Methods for Using Small Non-Coding RNAs to Improve Recombinant Protein Expression in Mammalian Cells.  Genes.
  • Wang Q, Chung CY, Yang W, Yang G, Chough S, Chen Y, Yin B, Bhattacharya R, Hu Y, Saeui CT, Yarema KJ, Betenbaugh MJ, Zhang H (2018).  Combining Butyrated ManNAc with Glycoengineered CHO Cells Improves EPO Glycan Quality and Production.  Biotechnology Journal.
  • Wang X, Kan G, Ren X, Yu G, Shi C, Xie Q, Wen H, Betenbaugh M (2018).  Molecular cloning and characterization of a novel -Amylase from antarctic sea ice bacterium pseudoalteromonas sp. M175 and its primary application in detergent.  BioMed Research International.  2018.
  • Inwood S, Betenbaugh MJ, Shiloach J (2018).  Methods for using small non-coding rnas to improve recombinant protein expression in mammalian cells.  Genes.  9(1).
  • Betenbaugh MJ, Chung CY, Wang Q, Yang S, Ponce SA, Kirsch BJ, Zhang H (2017).  Combinatorial genome and protein engineering yields monoclonal antibodies with hypergalactosylation from CHO cells.  Biotechnology & Bioengineering.
  • Chung CY, Wang Q, Yang S, Ponce SA, Kirsch BJ, Zhang H, Betenbaugh MJ (2017).  Combinatorial genome and protein engineering yields monoclonal antibodies with hypergalactosylation from CHO cells.  Biotechnology and Bioengineering.  114(12).
  • Betenbaugh MJ, Wang Q, Chen CH, Chung C-y, Priola J, Chu JH, Tang J, Ulmschneider MB (2017).  Proline-Rich Chaperones Are Compared Computationally and Experimentally for Their Abilities to Facilitate Recombinant Butyrylcholinesterase Tetramerization in CHO Cells.  Biotechnology Journal.
  • Heffner KM, Hizal DB, Yerganian GS, Kumar A, Can Ö, O'meally R, Cole R, Chaerkady R, Wu H, Bowen MA, Betenbaugh MJ (2017).  Lessons from the hamster: Cricetulus griseus tissue and CHO cell line proteome comparison.  Journal of Proteome Research.  16(10).
  • Betenbaugh MJ, Heffner KM, Hizal DB, Yerganian GS, Kumar A, Can O, O'Meally R, Cole R, Chaerkady R, Wu H, Bowen MA (2017).  Lessons from the Hamster: Cricetulus griseus Tissue and CHO Cell Line Proteome Comparison.  Journal of Proteome Research.
  • Templeton N, Smith KD, McAtee-Pereira AG, Dorai H, Betenbaugh MJ, Lang SE, Young JD (2017).  Application of 13C flux analysis to identify high-productivity CHO metabolic phenotypes.  Metabolic Engineering.  43.
  • Yin B, Wang Q, Chung CY, Bhattacharya R, Ren X, Tang J, Yarema KJ, Betenbaugh MJ (2017).  A novel sugar analog enhances sialic acid production and biotherapeutic sialylation in CHO cells.  Biotechnology and Bioengineering.  114(8).
  • Betenbaugh MJ, Yin B, Wang Q, Chung CY, Bhattacharya R, Ren X, Tang J, Yarema KJ (2017).  A novel sugar analog enhances sialic acid production and biotherapeutic sialylation in CHO cells.  Biotechnology & Bioegineering.
  • Kelly PS, Clarke C, Costello A, Monger C, Meiller J, Dhiman H, Borth N, Betenbaugh MJ, Clynes M, Barron N (2017).  Ultra-deep next generation mitochondrial genome sequencing reveals widespread heteroplasmy in Chinese hamster ovary cells.  Metabolic Engineering.  41.
  • Krambeck FJ, Bennun SV, Andersen MR, Betenbaugh MJ (2017).  Model-based analysis of N-glycosylation in Chinese hamster ovary cells.  PLoS ONE.  12(5).
  • Li T, Li CT, Butler K, Hays SG, Guarnieri MT, Oyler GA, Betenbaugh MJ (2017).  Mimicking lichens: Incorporation of yeast strains together with sucrose-secreting cyanobacteria improves survival, growth, ROS removal, and lipid production in a stable mutualistic co-culture production platform.  Biotechnology for Biofuels.  10(1).
  • Zhang Y, Baycin-Hizal D, Kumar A, Priola J, Bahri M, Heffner KM, Wang M, Han X, Bowen MA, Betenbaugh MJ (2017).  High-Throughput Lipidomic and Transcriptomic Analysis to Compare SP2/0, CHO, and HEK-293 Mammalian Cell Lines.  Analytical Chemistry.  89(3).
  • Chung CY, Wang Q, Yang S, Yin B, Zhang H, Betenbaugh M (2017).  Integrated Genome and Protein Editing Swaps α-2,6 Sialylation for α-2,3 Sialic Acid on Recombinant Antibodies from CHO.  Biotechnology Journal.  12(2).
  • Betenbaugh MJ, Templeton N, Smith KD, McAtee-Pereira AG, Dorai H, Lang SE, Young JD (2017).  Application of 13C flux analysis to identify high-productivity CHO metabolic phenotypes.  Metabolic Engineering.
  • Bohutskyi P, Chow S, Ketter B, Fung Shek C, Yacar D, Tang Y, Zivojnovich M, Betenbaugh MJ, Bouwer EJ (2016).  Phytoremediation of agriculture runoff by filamentous algae poly-culture for biomethane production, and nutrient recovery for secondary cultivation of lipid generating microalgae.  Bioresource Technology.  222.
  • Hefzi H, Ang KS, Hanscho M, Bordbar A, Ruckerbauer D, Lakshmanan M, Orellana CA, Baycin-Hizal D, Huang Y, Ley D, Martinez VS, Kyriakopoulos S, Jiménez NE, Zielinski DC, Quek LE, Wulff T, Arnsdorf J, Li S, Lee JS, Paglia G, Loira N, Spahn PN, Pedersen LE, Gutierrez JM, King ZA, Lund AM, Nagarajan H, Thomas A, Abdel-Haleem AM, Zanghellini J, Kildegaard HF, Voldborg BG, Gerdtzen ZP, Betenbaugh MJ, Palsson BO, Andersen MR, Nielsen LK, Borth N, Lee DY, Lewis NE (2016).  A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism.  Cell Systems.  3(5).
  • Tang Y, Rosenberg JN, Betenbaugh MJ, Wang F (2016).  Optimization of one-step in situ transesterification method for accurate quantification of epa in nannochloropsis gaditana.  Applied Sciences (Switzerland).  6(11).
  • Xiao S, Chen YC, Buehler E, Mandal S, Mandal A, Betenbaugh M, Park MH, Martin S, Shiloach J (2016).  Genome-scale RNA interference screen identifies antizyme 1 (OAZ1) as a target for improvement of recombinant protein production in mammalian cells.  Biotechnology and Bioengineering.  113(11).
  • Bohutskyi P, Kligerman DC, Byers N, Nasr LK, Cua C, Chow S, Su C, Tang Y, Betenbaugh MJ, Bouwer EJ (2016).  Effects of inoculum size, light intensity, and dose of anaerobic digestion centrate on growth and productivity of Chlorella and Scenedesmus microalgae and their poly-culture in primary and secondary wastewater.  Algal Research.  19.
  • Zuñiga C, Li CT, Huelsman T, Levering J, Zielinski DC, McConnell BO, Long CP, Knoshaug EP, Guarnieri MT, Antoniewicz MR, Betenbaugh MJ, Zengler K (2016).  Genome-scale metabolic model for the green alga chlorella vulgaris UTEX 395 accurately predicts phenotypes under autotrophic, heterotrophic, and mixotrophic growth conditions.  Plant Physiology.  172(1).
  • Baker JJ, Crivellari F, Gagnon Z, Betenbaugh MJ (2016).  Microfluidic bubbler facilitates near complete mass transfer for sustainable multiphase and microbial processing.  Biotechnology and Bioengineering.  113(9).
  • Bennun SV, Hizal DB, Heffner K, Can O, Zhang H, Betenbaugh MJ (2016).  Systems Glycobiology: Integrating Glycogenomics, Glycoproteomics, Glycomics, and Other ‘Omics Data Sets to Characterize Cellular Glycosylation Processes.  Journal of Molecular Biology.  428(16).
  • Priola JJ, Calzadilla N, Baumann M, Borth N, Tate CG, Betenbaugh MJ (2016).  High-throughput screening and selection of mammalian cells for enhanced protein production.  Biotechnology Journal.  11(7).
  • Williams A, Hayashi T, Wolozny D, Yin B, Su TC, Betenbaugh MJ, Su TP (2016).  The non-apoptotic action of Bcl-xL: regulating Ca2+signaling and bioenergetics at the ER-mitochondrion interface.  Journal of Bioenergetics and Biomembranes.  48(3).
  • Gramlich PA, Westbroek W, Feldman RA, Awad O, Mello N, Remington MP, Sun Y, Zhang W, Sidransky E, Betenbaugh MJ, Fishman PS (2016).  A peptide-linked recombinant glucocerebrosidase for targeted neuronal delivery: Design, production, and assessment.  Journal of Biotechnology.  221.
  • Chu C, Bottaro DP, Betenbaugh MJ, Shiloach J (2016).  Stable ectopic expression of ST6GALNAC5 induces autocrine MET activation and anchorage-independence in MDCK Cells.  PLoS ONE.  11(2).
  • Betenbaugh MJ (2016).  Sugar and spice in mammalian cell cultures.  Metabolic Engineering 11.
  • Zuniga PC, Li CT, Huelsman T, Levering J, Zielinski DC, McConnell BP, Long CP, Antoniewicz M, Betenbaugh MJ, Zengler K (2016).  The genome-scale metabolic model for chlorella vulgaris utex 395 reveals quantitative flux distributions for compartmental-pathway activity under polytrophic growth.  Metabolic Engineering 11.
  • Tang Y, Zhang Y, Rosenberg JN, Sharif N, Betenbaugh MJ, Wang F (2016).  Efficient lipid extraction and quantification of fatty acids from algal biomass using accelerated solvent extraction (ASE).  RSC Advances.  6(35).
  • Tang Y, Rosenberg JN, Bohutskyi P, Yu G, Betenbaugh MJ, Wang F (2016).  Microalgae as a feedstock for biofuel precursors and value-added products: Green fuels and golden opportunities.  BioResources.  11(1).
  • Kaas CS, Kristensen C, Betenbaugh MJ, Andersen MR (2015).  Sequencing the CHO DXB11 genome reveals regional variations in genomic stability and haploidy.  BMC Genomics.  16(1).
  • Kobayashi N, Barnes A, Jensen T, Noel E, Andlay G, Rosenberg JN, Betenbaugh MJ, Guarnieri MT, Oyler GA (2015).  Comparison of biomass and lipid production under ambient carbon dioxide vigorous aeration and 3% carbon dioxide condition among the lead candidate Chlorella strains screened by various photobioreactor scales.  Bioresource Technology.  198.
  • Betenbaugh MJ, Bentley WE (2015).  Editorial Overview: Synthetic biology hybrids – a golden age of pathway engineering.  Current Opinion in Biotechnology.  36.
  • Yu G, Rosenberg JN, Betenbaugh MJ, Oyler GA (2015).  Pac-Man for biotechnology: Co-opting degrons for targeted protein degradation to control and alter cell function.  Current Opinion in Biotechnology.  36.
  • Gopalakrishnan S, Baker J, Kristoffersen L, Betenbaugh MJ (2015).  Redistribution of metabolic fluxes in Chlorella protothecoides by variation of media nitrogen concentration.  Metabolic Engineering Communications.  2.
  • Kumar A, Baycin-Hizal D, Zhang Y, Bowen MA, Betenbaugh MJ (2015).  Cellular traffic cops: The interplay between lipids and proteins regulates vesicular formation, trafficking, and signaling in mammalian cells.  Current Opinion in Biotechnology.  36.
  • Yang S, Wang M, Chen L, Yin B, Song G, Turko IV, Phinney KW, Betenbaugh MJ, Zhang H, Li S (2015).  QUANTITY: An isobaric tag for quantitative glycomics.  Scientific Reports.  5.
  • Kumar A, Baycin-Hizal D, Wolozny D, Pedersen LE, Lewis NE, Heffner K, Chaerkady R, Cole RN, Shiloach J, Zhang H, Bowen MA, Betenbaugh MJ (2015).  Elucidation of the CHO super-ome (CHO-SO) by proteoinformatics.  Journal of Proteome Research.  14(11).
  • Yin B, Gao Y, Chung Cy, Yang S, Blake E, Stuczynski MC, Tang J, Kildegaard HF, Andersen MR, Zhang H, Betenbaugh MJ (2015).  Glycoengineering of Chinese hamster ovary cells for enhanced erythropoietin N-glycan branching and sialylation.  Biotechnology and Bioengineering.  112(11).
  • Fan Y, Jimenez Del Val I, Müller C, Lund AM, Sen JW, Rasmussen SK, Kontoravdi C, Baycin-Hizal D, Betenbaugh MJ, Weilguny D, Andersen MR (2015).  A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture.  Biotechnology and Bioengineering.  112(10).
  • Bohutskyi P, Chow S, Ketter B, Betenbaugh MJ, Bouwer EJ (2015).  Prospects for methane production and nutrient recycling from lipid extracted residues and whole Nannochloropsis salina using anaerobic digestion.  Applied Energy.  154.
  • Xiao S, Chen YC, Betenbaugh MJ, Martin SE, Shiloach J (2015).  MiRNA mimic screen for improved expression of functional neurotensin receptor from HEK 293 cells.  Biotechnology and Bioengineering.  112(8).
  • Bohutskyi P, Liu K, Nasr LK, Byers N, Rosenberg JN, Oyler GA, Betenbaugh MJ, Bouwer EJ (2015).  Bioprospecting of microalgae for integrated biomass production and phytoremediation of unsterilized wastewater and anaerobic digestion centrate.  Applied Microbiology and Biotechnology.  99(14).
  • Chung CY, Yin B, Wang Q, Chuang KY, Chu JH, Betenbaugh MJ (2015).  Assessment of the coordinated role of ST3GAL3, ST3GAL4 and ST3GAL6 on the α2,3 sialylation linkage of mammalian glycoproteins.  Biochemical and Biophysical Research Communications.  463(3).
  • Apostolidis PA, Tseng A, Koziol ME, Betenbaugh MJ, Chiang B (2015).  Investigation of low viability in sparged bioreactor CHO cell cultures points to variability in the Pluronic F-68 shear protecting component of cell culture media.  Biochemical Engineering Journal.  98.
  • Bohutskyi P, Ketter B, Chow S, Adams KJ, Betenbaugh MJ, Allnutt FCT, Bouwer EJ (2015).  Anaerobic digestion of lipid-extracted Auxenochlorella protothecoides biomass for methane generation and nutrient recovery.  Bioresource Technology.  183.
  • Kumar A, Shiloach J, Betenbaugh MJ, Gallagher EJ (2015).  The beta-3 adrenergic agonist (CL-316,243) restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice.  Nutrition and Metabolism.  12(1).
  • Viswanathan K, Narang S, Betenbaugh MJ (2015).  Engineering sialic acid synthesis ability in insect cells.  Methods in Molecular Biology.  1321.
  • Wang Q, Stuczynski M, Gao Y, Betenbaugh MJ (2015).  Strategies for engineering protein N-glycosylation pathways in mammalian cells.  Methods in Molecular Biology.  1321.
  • Kumar A, Baycin-Hizal D, Shiloach J, Bowen MA, Betenbaugh MJ (2015).  Coupling enrichment methods with proteomics for understanding and treating disease.  Proteomics - Clinical Applications.  9(1-2).
  • Wan M, Jin X, Xia J, Rosenberg JN, Yu G, Nie Z, Oyler GA, Betenbaugh MJ (2014).  The effect of iron on growth, lipid accumulation, and gene expression profile of the freshwater microalga Chlorella sorokiniana.  Applied Microbiology and Biotechnology.  98(22).
  • Baycin-Hizal D, Gottschalk A, Jacobson E, Mai S, Wolozny D, Zhang H, Krag SS, Betenbaugh MJ (2014).  Physiologic and pathophysiologic consequences of altered sialylation and glycosylation on ion channel function.  Biochemical and Biophysical Research Communications.  453(2).
  • Kumar A, Harrelson T, Lewis NE, Gallagher EJ, LeRoith D, Shiloach J, Betenbaugh MJ (2014).  Multi-tissue computational modeling analyzes pathophysiology of type 2 diabetes in MKR mice.  PLoS ONE.  9(7).
  • Rosenberg JN, Kobayashi N, Barnes A, Noel EA, Betenbaugh MJ, Oyler GA (2014).  Comparative analyses of three Chlorella species in response to light and sugar reveal distinctive lipid accumulation patterns in the microalga C. sorokiniana.  PLoS ONE.  9(4).
  • Lewis A, Hayashi T, Su TP, Betenbaugh MJ (2014).  Bcl-2 family in inter-organelle modulation of calcium signaling; Roles in bioenergetics and cell survival.  Journal of Bioenergetics and Biomembranes.  46(1).
  • Bohutskyi P, Betenbaugh MJ, Bouwer EJ (2014).  The effects of alternative pretreatment strategies on anaerobic digestion and methane production from different algal strains.  Bioresource Technology.  155.
  • Hizal DB, Wolozny D, Colao J, Jacobson E, Tian Y, Krag SS, Betenbaugh MJ, Zhang H (2014).  Glycoproteomic and glycomic databases.  Clinical Proteomics.  11(1).
  • Bohutskyi P, Betenbaugh M, Bouwer E (2014).  The effects of alternative pretreatment strategies on anaerobic digestion and methane production from different algal strains.  Bioresource Technology.  155.  366-372.
  • Rogers JN, Rosenberg JN, Guzman BJ, Oh VH, Mimbela LE, Ghassemi A, Betenbaugh M, Oyler G, Donohue M (2014).  A critical analysis of paddlewheel-driven raceway ponds for algal biofuel production at commercial scales.  Algal Research.  4.  76-88.
  • Bohutskyi P, Liu K, Kessler BA, Kula T, Hong Y, Bouwer E, Betenbaugh M, Allnutt FC (2014).  Mineral and non-carbon nutrient utilization and recovery during sequential phototrophic-heterotrophic growth of lipid-rich algae.  Applied Microbiology and Biotechnology.  98(11).  5261-5273.
  • Heffner KM, Hizal DB, Kumar A, Shiloach J, Zhu J, Bowen MA, Betenbaugh MJ (2014).  Exploiting the proteomics revolution in biotechnology: From disease and antibody targets to optimizing bioprocess development.  Current Opinion in Biotechnology.  30.
  • Bohutskyi P, Liu K, Kessler BA, Kula T, Hong Y, Bouwer EJ, Betenbaugh MJ, Allnutt FCT (2014).  Mineral and non-carbon nutrient utilization and recovery during sequential phototrophic-heterotrophic growth of lipid-rich algae.  Applied Microbiology and Biotechnology.  98(11).
  • Ronda C, Pedersen LE, Hansen HG, Kallehauge TB, Betenbaugh MJ, Nielsen AT, Kildegaard HF (2014).  Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool.  Biotechnology and Bioengineering.  111(8).
  • Zustiak MP, Jose L, Xie Y, Zhu J, Betenbaugh MJ (2014).  Enhanced transient recombinant protein production in CHO cells through the co-transfection of the product gene with Bcl-xL.  Biotechnology Journal.  9(9).
  • Bohutskyi P, Kula T, Kessler BA, Hong Y, Bouwer EJ, Betenbaugh MJ, Allnutt FCT (2014).  Mixed Trophic State Production Process for Microalgal Biomass with High Lipid Content for Generating Biodiesel and Biogas.  Bioenergy Research.  7(4).
  • Xiao S, Shiloach J, Betenbaugh MJ (2014).  Engineering cells to improve protein expression.  Current Opinion in Structural Biology.  26(1).
  • Rogers JN, Rosenberg JN, Guzman BJ, Oh VH, Mimbela LE, Ghassemi A, Betenbaugh MJ, Oyler GA, Donohue MD (2014).  A critical analysis of paddlewheel-driven raceway ponds for algal biofuel production at commercial scales.  Algal Research.  4(1).
  • Templeton N, Lewis A, Dorai H, Qian EA, Campbell MP, Smith KD, Lang SE, Betenbaugh MJ, Young JD (2014).  The impact of anti-apoptotic gene Bcl-2Δ expression on CHO central metabolism.  Metabolic Engineering.  25.
  • Kildegaard HF, Baycin-Hizal D, Lewis NE, Betenbaugh MJ (2013).  The emerging CHO systems biology era: Harnessing the 'omics revolution for biotechnology.  Current Opinion in Biotechnology.  24(6).
  • Jadhav V, Hackl M, Druz A, Shridhar S, Chung CY, Heffner KM, Kreil DP, Betenbaugh M, Shiloach J, Barron N, Grillari J, Borth N (2013).  CHO microRNA engineering is growing up: Recent successes and future challenges.  Biotechnology Advances.  31(8).
  • Gramlich PA, Remington MP, Amin J, Betenbaugh MJ, Fishman PS (2013).  Tat-tetanus toxin fragment C: A novel protein delivery vector and its use with photochemical internalization.  Journal of Drug Targeting.  21(7).
  • Lewis NE, Liu X, Li Y, Nagarajan H, Yerganian G, O'Brien E, Bordbar A, Roth AM, Rosenbloom J, Bian C, Xie M, Chen W, Li N, Baycin-Hizal D, Latif H, Forster J, Betenbaugh MJ, Famili I, Xu X, Wang J, Palsson BO (2013).  Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome.  Nature Biotechnology.  31(8).
  • Xiao S, White JF, Betenbaugh MJ, Grisshammer R, Shiloach J (2013).  Transient and Stable Expression of the Neurotensin Receptor NTS1: A Comparison of the Baculovirus-Insect Cell and the T-REx-293 Expression Systems.  PLoS ONE.  8(5).
  • Druz A, Son YJ, Betenbaugh M, Shiloach J (2013).  Stable inhibition of mmu-miR-466h-5p improves apoptosis resistance and protein production in CHO cells.  Metabolic Engineering.  16(1).
  • Bennun SV, Yarema KJ, Betenbaugh MJ, Krambeck FJ (2013).  Integration of the Transcriptome and Glycome for Identification of Glycan Cell Signatures.  PLoS Computational Biology.  9(1).
  • Druz A, Chen YC, Guha R, Betenbaugh M, Martin SE, Shiloach J (2013).  Large-scale screening identifies a novel microRNA, miR-15a-3p, which induces apoptosis in human cancer cell lines.  RNA Biology.  10(2).
  • Wan M, Faruq J, Rosenberg JN, Xia J, Oyler GA, Betenbaugh MJ (2013).  Achieving high throughput sequencing of a cDNA library utilizing an alternative protocol for the bench top next-generation sequencing system.  Journal of Microbiological Methods.  92(2).
  • Ghassemi A, Betenbaugh M, Oyler G, Donohue M (2013).  Algal Research.
  • Baycin-Hizal D, Tabb DL, Chaerkady R, Chen L, Lewis NE, Nagarajan H, Sarkaria V, Kumar A, Wolozny D, Colao J, Jacobson E, Tian Y, O'Meally RN, Krag SS, Cole RN, Palsson BO, Zhang H, Betenbaugh M (2012).  Proteomic analysis of chinese hamster ovary cells.  Journal of Proteome Research.  11(11).
  • Wan MX, Wang RM, Xia JL, Rosenberg JN, Nie ZY, Kobayashi N, Oyler GA, Betenbaugh MJ (2012).  Physiological evaluation of a new Chlorella sorokiniana isolate for its biomass production and lipid accumulation in photoautotrophic and heterotrophic cultures.  Biotechnology and Bioengineering.  109(8).
  • Druz A, Betenbaugh M, Shiloach J (2012).  Glucose depletion activates mmu-miR-466h-5p expression through oxidative stress and inhibition of histone deacetylation.  Nucleic Acids Research.  40(15).
  • Ohsfeldt E, Huang SH, Baycin-Hizal D, Kristoffersen L, Le TMT, Li E, Hristova K, Betenbaugh MJ (2012).  Increased expression of the integral membrane proteins EGFR and FGFR3 in anti-apoptotic Chinese hamster ovary cell lines.  Biotechnology and Applied Biochemistry.  59(3).
  • Dorai H, Corisdeo S, Ellis D, Kinney C, Chomo M, Hawley-Nelson P, Moore G, Betenbaugh MJ, Ganguly S (2012).  Early prediction of instability of chinese hamster ovary cell lines expressing recombinant antibodies and antibody-fusion proteins.  Biotechnology and Bioengineering.  109(4).
  • Ohsfeldt E, Huang S, Baycin-Hizal D, Kristoffersen L, Le TT, Li E, Hristova K, Betenbaugh M (2012).  Increased expression of the integral membrane proteins EGFR and FGFR3 in anti-apoptotic Chinese hamster ovary cell lines.  Biotechnology and Applied Biochemistry.  59(3).  155-162.
  • Majors BS, Chiang GG, Pederson NE, Betenbaugh MJ (2012).  Directed evolution of mammalian anti-apoptosis proteins by somatic hypermutation.  Protein Engineering, Design and Selection.  25(1).
  • Zustiak MP, Dorai H, Betenbaugh MJ, Sauerwald TM (2012).  Controlling apoptosis to optimize yields of proteins from mammalian cells.  Methods in Molecular Biology.  801.
  • Granell AEVB, Palter KB, Akan I, Aich U, Yarema KJ, Betenbaugh MJ, Thornhill WB, Recio-Pinto E (2011).  Dm SAS is required for sialic acid biosynthesis in cultured Drosophila third instar larvae CNS neurons.  ACS Chemical Biology.  6(11).
  • Rosenberg JN, Mathias A, Korth K, Betenbaugh MJ, Oyler GA (2011).  Microalgal biomass production and carbon dioxide sequestration from an integrated ethanol biorefinery in Iowa: A technical appraisal and economic feasibility evaluation.  Biomass and Bioenergy.  35(9).
  • Wan M, Rosenberg JN, Faruq J, Betenbaugh MJ, Xia J (2011).  An improved colony PCR procedure for genetic screening of Chlorella and related microalgae.  Biotechnology Letters.  33(8).
  • Wan M, Liu P, Xia J, Rosenberg JN, Oyler GA, Betenbaugh MJ, Nie Z, Qiu G (2011).  The effect of mixotrophy on microalgal growth, lipid content, and expression levels of three pathway genes in Chlorella sorokiniana.  Applied Microbiology and Biotechnology.  91(3).
  • Xu X, Nagarajan H, Lewis NE, Pan S, Cai Z, Liu X, Chen W, Xie M, Wang W, Hammond S, Andersen MR, Neff N, Passarelli B, Koh W, Fan HC, Wang J, Gui Y, Lee KH, Betenbaugh MJ, Quake SR, Famili I, Palsson BO, Wang J (2011).  The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.  Nature Biotechnology.  29(8).
  • Baycin-Hizal D, Tian Y, Akan I, Jacobson E, Clark D, Wu A, Jampol R, Palter K, Betenbaugh M, Zhang H (2011).  GlycoFish: A database of zebrafish N -linked glycoproteins identified using SPEG method coupled with LC/MS.  Analytical Chemistry.  83(13).
  • Druz A, Chu C, Majors B, Santuary R, Betenbaugh M, Shiloach J (2011).  A novel microRNA mmu-miR-466h affects apoptosis regulation in mammalian cells.  Biotechnology and Bioengineering.  108(7).
  • Baycin-Hizal D, Tian Y, Akan I, Jacobson E, Clark D, Chu J, Palter K, Zhang H, Betenbaugh MJ (2011).  GlycoFly: A database of Drosophila N-linked Glycoproteins identified using SPEG-MS techniques.  Journal of Proteome Research.  10(6).
  • Hayashi T, Lewis A, Hayashi E, Betenbaugh MJ, Su TP (2011).  Antigen retrieval to improve the immunocytochemistry detection of sigma-1 receptors and ER chaperones.  Histochemistry and Cell Biology.  135(6).
  • Gillmeister MP, Betenbaugh MJ, Fishman PS (2011).  Cellular trafficking and photochemical internalization of cell penetrating peptide linked cargo proteins: A dual fluorescent labeling study.  Bioconjugate Chemistry.  22(4).
  • Jones MB, Chu CH, Pendleton JC, Betenbaugh MJ, Shiloach J, Baljinnyam B, Rubin JS, Shamblott MJ (2010).  Proliferation and pluripotency of human embryonic stem cells maintained on type i collagen.  Stem Cells and Development.  19(12).
  • Chu C, Lugovtsev V, Lewis A, Betenbaugh M, Shiloach J (2010).  Production and antigenic properties of influenza virus from suspension MDCK-siat7e cells in a bench-scale bioreactor.  Vaccine.  28(44).
  • Kantardjieff A, Jacob NM, Yee JC, Epstein E, Kok YJ, Philp R, Betenbaugh M, Hu WS (2010).  Transcriptome and proteome analysis of Chinese hamster ovary cells under low temperature and butyrate treatment.  Journal of Biotechnology.  145(2).
  • Jones MB, Tomiya N, Betenbaugh MJ, Krag SS (2010).  Analysis and metabolic engineering of lipid-linked oligosaccharides in glycosylation-deficient CHO cells.  Biochemical and Biophysical Research Communications.  395(1).
  • Dorai H, Ellis D, Keung YS, Campbell M, Zhuang M, Lin C, Betenbaugh MJ (2010).  Combining high-throughput screening of caspase activity with anti-apoptosis genes for development of robust CHO production cell lines..  Biotechnology progress.  26(5).
  • Gillmeister MP, Tomiya N, Jacobia SJ, Lee YC, Gorfien SF, Betenbaugh MJ (2009).  An HPLC-MALDI MS method for N-glycan analyses using smaller size samples: Application to monitor glycan modulation by medium conditions.  Glycoconjugate Journal.  26(9).
  • Krambeck FJ, Bennun SV, Narang S, Choi S, Yarema KJ, Betenbaugh MJ (2009).  A mathematical model to derive N-glycan structures and cellular enzyme activities from mass spectrometric data.  Glycobiology.  19(11).
  • O'Connor S, Li E, Majors BS, He L, Placone J, Baycin D, Betenbaugh MJ, Hristova K (2009).  Increased expression of the integral membrane protein ErbB2 in Chinese hamster ovary cells expressing the anti-apoptotic gene Bcl-xL.  Protein Expression and Purification.  67(1).
  • Chu C, Lugovtsev V, Golding H, Betenbaugh M, Shiloach J (2009).  Conversion of MDCK cell line to suspension culture by transfecting with human siat7e gene and its application for influenza virus production.  Proceedings of the National Academy of Sciences of the United States of America.  106(35).
  • Majors BS, Betenbaugh MJ, Pederson NE, Chiang GG (2009).  Mcl-1 overexpression leads to higher viabilities and increased production of humanized monoclonal antibody in Chinese hamster ovary cells.  Biotechnology Progress.  25(4).
  • Dorai H, Yun SK, Ellis D, Kinney CA, Lin C, Jan D, Moore G, Betenbaugh MJ (2009).  Expression of anti-apoptosis genes alters lactate metabolism of Chinese Hamster ovary cells in culture.  Biotechnology and Bioengineering.  103(3).
  • Majors BS, Chiang GG, Betenbaugh MJ (2009).  Protein and genome evolution in mammalian cells for biotechnology applications.  Molecular Biotechnology.  42(2).
  • Jones MB, Rosenberg JN, Betenbaugh MJ, Krag SS (2009).  Structure and synthesis of polyisoprenoids used in N-glycosylation across the three domains of life.  Biochimica et Biophysica Acta - General Subjects.  1790(6).
  • Nivitchanyong T, Tsai YC, Betenbaugh MJ, Oyler GA (2009).  An improved in vitro and in vivo Sindbis virus expression system through host and virus engineering.  Virus Research.  141(1).
  • O’Connor S, Li E, Majors BS, He L, Placone J, Baycin D, Betenbaugh M, Hristova K (2009).  Increased expression of the integral membrane protein ErbB2 in Chinese hamster ovary cells expressing the anti-apoptotic gene Bcl-x(L).  Protein Expression and Purification.  67(1).  41-47.
  • Majors BS, Arden N, Oyler GA, Chiang GG, Pederson NE, Betenbaugh MJ (2008).  E2F-1 overexpression increases viable cell density in batch cultures of Chinese hamster ovary cells.  Journal of Biotechnology.  138(3-4).
  • Majors BS, Betenbaugh MJ, Pederson NE, Chiang GG (2008).  Enhancement of transient gene expression and culture viability using chinese hamster ovary cells overexpressing Bcl-XL.  Biotechnology and Bioengineering.  101(3).
  • Rosenberg JN, Oyler GA, Wilkinson L, Betenbaugh MJ (2008).  A green light for engineered algae: redirecting metabolism to fuel a biotechnology revolution.  Current Opinion in Biotechnology.  19(5).
  • Zustiak MP, Pollack JK, Marten MR, Betenbaugh MJ (2008).  Feast or famine: autophagy control and engineering in eukaryotic cell culture.  Current Opinion in Biotechnology.  19(5).
  • Betenbaugh M, Bentley W (2008).  Metabolic engineering in the 21st century: meeting global challenges of sustainability and health.  Current Opinion in Biotechnology.  19(5).
  • Jaluria P, Chu C, Betenbaugh M, Shiloach J (2008).  Cells by design: A mini-review of targeting cell engineering using DNA microarrays.  Molecular Biotechnology.  39(2).
  • Jaluria P, Konstantopoulos K, Betenbaugh M, Shiloach J (2008).  Egr1 and Gas6 facilitate the adaptation of HEK-293 cells to serum-free media by conferring enhanced viability and higher growth rates.  Biotechnology and Bioengineering.  99(6).
  • Hancock K, Narang S, Pattabhi S, Yushak ML, Khan A, Lin Sc, Plemons R, Betenbaugh MJ, Tsang VCW (2008).  False positive reactivity of recombinant, diagnostic, glycoproteins produced in High Five™ insect cells: Effect of glycosylation.  Journal of Immunological Methods.  330(1-2).
  • Jaluria P, Konstantopoulos K, Betenbaugh M, Shiloach J (2008).  Egr1 and Gas6 facilitate the adaptation of HEK-293 cells to serum-free media by conferring enhanced viability and higher growth rates.  Biotechnol Bioeng.  99(6).  1443-52.
  • Nivitchanyong T, Martinez A, Ishaque A, Murphy JE, Konstantinov K, Betenbaugh MJ, Thrift J (2007).  Anti-apoptotic genes aven and E1B-19K enhance performance of BHK cells engineered to express recombinant factor VIII in batch and low perfusion cell culture.  Biotechnology and Bioengineering.  98(4).
  • Jaluria P, Betenbaugh M, Konstantopoulos K, Shiloach J (2007).  Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog.  BMC Biotechnology.  7.
  • Figueroa B, Ailor E, Osborne D, Hardwick JM, Reff M, Betenbaugh MJ (2007).  Enhanced cell culture performance using inducible anti-apoptotic genes E1B-19K and Aven in the production of a monoclonal antibody with Chinese Hamster Ovary cells.  Biotechnology and Bioengineering.  97(4).
  • Arden N, Majors BS, Ahn SH, Oyler G, Betenbaugh MJ (2007).  Inhibiting the apoptosis pathway using MDM2 in mammalian cell cultures.  Biotechnology and Bioengineering.  97(3).
  • Jaluria P, Betenbaugh M, Konstantopoulos K, Frank B, Shiloach J (2007).  Application of microarrays to identify and characterize genes involved in attachment dependence in HeLa cells.  Metabolic Engineering.  9(3).
  • Jaluria P, Konstantopoulos K, Betenbaugh M, Shiloach J (2007).  A perspective on microarrays: Current applications, pitfalls, and potential uses.  Microbial Cell Factories.  6.
  • Arden N, Ahn SH, Vaz W, Rhodes M, Hancock C, Abitorabi MA, Betenbaugh MJ (2007).  Chemical caspase inhibitors enhance cell culture viabilities and protein titer.  Biotechnology Progress.  23(2).
  • O’Connor SK, He L, Li E, Betenbaugh M, Hristova K (2007).  Membrane protein expression in anti-apoptotic mammalian cells.  Biophysical Journal.  392A-392A.
  • Jaluria P, Betenbaugh M, Konstantopoulos K, Shiloach J (2007).  Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog.  BMC Biotechnol.  7.  71.
  • Jaluria P, Betenbaugh M, Konstantopoulos K, Frank B, Shiloach J (2007).  Application of microarrays to identify and characterize genes involved in attachment dependence in HeLa cells.  Metab Eng.  9(3).  241-51.
  • Jaluria P, Konstantopoulos K, Betenbaugh M, Shiloach J (2007).  A perspective on microarrays: current applications, pitfalls, and potential uses.  Microb Cell Fact.  6.  4.
  • Tomiya N, Narang S, Park J, Abdul-Rahman B, Choi O, Singh S, Hiratake J, Sakata K, Betenbaugh MJ, Palter KB, Lee YC (2006).  Purification, characterization, and cloning of a Spodoptera frugiperda Sf9 β-N-acetylhexosaminidase that hydrolyzes terminal N-acetylglucosamine on the N-glycan core.  Journal of Biological Chemistry.  281(28).
  • Viswanathan K, Tomiya N, Park J, Singh S, Lee YC, Palter K, Betenbaugh MJ (2006).  Expression of a functional Drosophila melanogaster CMP-sialic acid synthetase: Differential localization of the drosophila and human enzymes.  Journal of Biological Chemistry.  281(23).
  • Sauerwald TM, Figueroa B, Hardwick JM, Oyler GA, Betenbaugh MJ (2006).  Combining caspase and mitochondrial dysfunction inhibitors of apoptosis to limit cell death in mammalian cell cultures.  Biotechnology and Bioengineering.  94(2).
  • Arden N, Betenbaugh MJ (2006).  Regulating apoptosis in mammalian cell cultures.  Cytotechnology.  50(1-3).
  • Krambeck FJ, Betenbaugh MJ (2005).  A mathematical model of N-linked glycosylation.  Biotechnology and Bioengineering.  92(6).
  • Jaluria P, Betenbaugh M, Konstantopoulos K, Shiloach J (2005).  Application of microarrays to reverse engineer attachment dependence in mammalian cell lines.  AIChE Annual Meeting, Conference Proceedings.
  • Kim YK, Shin HS, Tomiya N, Lee YC, Betenbaugh MJ, Cha HJ (2005).  Production and N-glycan analysis of secreted human erythropoietin glycoprotein in stably transfected Drosophila S2 cells.  Biotechnology and Bioengineering.  92(4).
  • Jones J, Krag SS, Betenbaugh MJ (2005).  Controlling N-linked glycan site occupancy.  Biochimica et Biophysica Acta - General Subjects.  1726(2).
  • Jones J, Nivitchanyong T, Giblin C, Ciccarone V, Judd D, Gorfien S, Krag SS, Betenbaugh MJ (2005).  Optimization of tetracycline-responsive recombinant protein production and effect on cell growth and ER stress in mammalian cells.  Biotechnology and Bioengineering.  91(6).
  • Jones J, Viswanathan K, Krag SS, Betenbaugh MJ (2005).  Polyprenyl lipid synthesis in mammalian cells expressing human cis-prenyl transferase.  Biochemical and Biophysical Research Communications.  331(2).
  • Viswanathan K, Narang S, Hinderlich S, Lee YC, Betenbaugh MJ (2005).  Engineering intracellular CMP-sialic acid metabolism into insect cells and methods to enhance its generation.  Biochemistry.  44(20).
  • Pfister B, Oyler G, Betenbaugh M, Bao G (2004).  The effects of BclXL and Bax over-expression on stretch-injury induced neural cell death..  Mechanics & chemistry of biosystems : MCB..  1(4).
  • Tomiya N, Narang S, Lee YC, Betenbaugh MJ (2004).  Comparing N-glycan processing in mammalian cell lines to native and engineered lepidopteran insect cell lines.  Glycoconjugate Journal.  21(6).
  • Betenbaugh MJ, Tomiya N, Narang S, Hsu JTA, Lee YC (2004).  Biosynthesis of human-type N-glycans in heterologous systems.  Current Opinion in Structural Biology.  14(5).
  • Sundaram AK, Pitts L, Muhammad K, Wu J, Betenbaugh M, Woodard RW, Vann WF (2004).  Characterization of N-acetylneuraminic acid synthase isoenzyme 1 from Campylobacter jejuni.  Biochemical Journal.  383(1).
  • Arden N, Betenbaugh MJ (2004).  Life and death in mammalian cell culture: Strategies for apoptosis inhibition.  Trends in Biotechnology.  22(4).
  • Figueroa B, Chen S, Oyler GA, Hardwick JM, Betenbaugh MJ (2004).  Aven and Bcl-xL Enhance Protection Against Apoptosis for Mammalian Cells Exposed to Various Culture Conditions.  Biotechnology and Bioengineering.  85(6).
  • Viswanathan K, Lawrence S, Hinderlich S, Yarema KJ, Lee YC, Betenbaugh MJ (2003).  Engineering Sialic Acid Synthetic Ability into Insect Cells: Identifying Metabolic Bottlenecks and Devising Strategies to Overcome Them.  Biochemistry.  42(51).
  • Tomiya N, Betenbaugh MJ, Lee YC (2003).  Humanization of lepidopteran insect-cell-produced glycoproteins.  Accounts of Chemical Research.  36(8).
  • Choi O, Tomiya N, Kim JH, Slavicek JM, Betenbaugh MJ, Lee YC (2003).  N-glycan structures of human transferrin produced by Lymantria dispar (gypsy moth) cells using the LdMNPV expression system.  Glycobiology.  13(7).
  • Pfister BJ, Weihs TP, Betenbaugh M, Bao G (2003).  An in vitro uniaxial stretch model for axonal injury.  Annals of Biomedical Engineering.  31(5).
  • Sauerwald TM, Oyler GA, Betenbaugh MJ (2003).  Study of caspase inhibitors for limiting death in mammalian cell culture.  Biotechnology and Bioengineering.  81(3).
  • Figueroa B, Sauerwald TM, Oyler GA, Hardwick JM, Betenbaugh MJ (2003).  A comparison of the properties of a Bcl-xLvariant to the wild-type anti-apoptosis inhibitor in mammalian cell cultures.  Metabolic Engineering.  5(4).
  • Tomiya N, Howe D, Aumiller JJ, Pathak M, Park J, Palter KB, Jarvis DL, Betenbaugh MJ, Lee YC (2003).  Complex-type biantennary N-glycans of recombinant human transferrin from Trichoplusia ni insect cells expressing mammalian β-1,4-galactosyltransferase and β-1,2-N-acetylglucosaminyltransferase II.  Glycobiology.  13(1).
  • Betenbaugh M, Auninš J (2003).  Cell Culture Engineering VIII.  Biotechnology Progress.  19(1).
  • Pfister BJ, Weihs T, Betenbaugh M, Bao G (2003).  An in vitro uniaxial stretch model for axonal injury.  Annals of Biomedical Engineering.  31(5).  589-598.
  • Abdul-Rahman B, Ailor E, Jarvis D, Betenbaugh M, Lee YC (2002).  β-(1→4)-Galactosyltransferase activity in native and engineered insect cells measured with time-resolved europium fluorescence.  Carbohydrate Research.  337(21-23).
  • Fussenegger M, Betenbaugh MJ (2002).  Metabolic engineering II. Eukaryotic systems.  Biotechnology and Bioengineering.  79(5).
  • Sauerwald TM, Betenbaugh MJ, Oyler GA (2002).  Inhibiting apoptosis in mammalian cell culture using the caspase inhibitor XIAP and deletion mutants.  Biotechnology and Bioengineering.  77(6).
  • Kim K, Lawrence SM, Park J, Pitts L, Vann WF, Betenbaugh MJ, Palter KB (2002).  Expression of a functional Drosophila melanogaster N-acetylneuraminic acid (Neu5Ac) phosphate synthase gene: Evidence for endogenous sialic acid biosynthetic ability in insects.  Glycobiology.  12(2).
  • Lawrence SM, Huddleston KA, Tomiya N, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ (2001).  Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells.  Glycoconjugate Journal.  18(3).
  • Tomiya N, Ailor E, Lawrence SM, Betenbaugh MJ, Lee YC (2001).  Determination of nucleotides and sugar nucleotides involved in protein glycosylation by high-performance anion-exchange chromatography: Sugar nucleotide contents in cultured insect cells and mammalian cells.  Analytical Biochemistry.  293(1).
  • Figueroa B, Sauerwald TM, Mastrangelo AJ, Hardwick JM, Betenbaugh MJ (2001).  Comparison of Bcl-2 to a Bcl-2 deletion mutant for mammalian cells exposed to culture insults.  Biotechnology and Bioengineering.  73(3).
  • Pfister B, Bao G, Weihs T, Betenbaugh M (2000).  Neural cell death following mechanical stretch injury.  Annals of Biomedical Engineering.  28(SUPPL. 1).
  • LeDuc PR, Whiteley EM, Bao G, Betenbaugh MJ (2000).  Investigating the secretory pathway of the baculovirus-insect cell system using a secretory green fluorescent protein.  Biotechnology Progress.  16(5).
  • Lawrence SM, Huddleston KA, Pitts LR, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ (2000).  Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid biosynthetic ability.  Journal of Biological Chemistry.  275(23).
  • Mastrangelo AJ, Hardwick JM, Zou S, Betenbaugh MJ (2000).  Part II. Overexpression of bcl-2 family members enhances survival of mammalian cells in response to various culture insults.  Biotechnology and Bioengineering.  67(5).
  • Mastrangelo AJ, Hardwick JM, Bex F, Betenbaugh MJ (2000).  Part I. Bcl-2 and Bcl-X(L) limit apoptosis upon infection with alphavirus vectors.  Biotechnology and Bioengineering.  67(5).
  • Ailor E, Takahashi N, Tsukamoto Y, Masuda K, Rahman BA, Jarvis DL, Lee YC, Betenbaugh MJ (2000).  N-glycan patterns of human transferrin produced in Trichoplusia ni insect cells: Effects of mammalian galactosyltransferase.  Glycobiology.  10(8).
  • Pfister BJ, Betenbaugh M, Weihs T, Bao G (2000).  Neural cell necrosis following mechanical stretch injury.  Journal of Neurotrauma.  17(10).  952-952.
  • Mastrangelo AJ, Zou S, Hardwick JM, Betenbaugh MJ (1999).  Antiapoptosis chemicals prolong productive lifetimes of mammalian cells upon sindbis virus vector infection.  Biotechnology and Bioengineering.  65(3).
  • Tate CG, Whiteley E, Betenbaugh MJ (1999).  Molecular chaperones stimulate the functional expression of the cocaine- sensitive serotonin transporter.  Journal of Biological Chemistry.  274(25).
  • Ailor E, Pathmanathan J, Jongbloed JDH, Betenbaugh MJ (1999).  A bacterial signal peptidase enhances processing of a recombinant single chain antibody fragment in insect cells.  Biochemical and Biophysical Research Communications.  255(2).
  • Tate CG, Whiteley E, Betenbaugh MJ (1999).  Molecular chaperones improve functional expression of the serotonin (5-hydroxytryptamine) transporter in insect cells.  Biochemical Society Transactions.  27(6).
  • Tsai AM, Van Zanten JH, Betenbaugh MJ (1998).  II. Electrostatic effect in the aggregation of heat-denatured RNase A and implications for protein additive design.  Biotechnology and Bioengineering.  59(3).
  • Tsai AM, Van Zanten JH, Betenbaugh MJ (1998).  I. Study of protein aggregation due to heat denaturation: A structural approach using circular dichroism spectroscopy, nuclear magnetic resonance, and static light scattering.  Biotechnology and Bioengineering.  59(3).
  • Ailor E, Betenbaugh MJ (1998).  Overexpression of a cytosolic chaperone to improve solubility and secretion of a recombinant IgG protein in insect cells.  Biotechnology and Bioengineering.  58(2-3).
  • Mastrangelo AJ, Betenbaugh MJ (1998).  Overcoming apoptosis: New methods for improving protein-expression systems.  Trends in Biotechnology.  16(2).
  • LeDuc PR, Betenbaugh MJ (1997).  Implementation of a pharmocokinetic approach to a baculovirus system for analytic solutions to virus and cell interactions.  American Society of Mechanical Engineers, Bioengineering Division (Publication) BED.  36.
  • Whiteley EM, Hsu TA, Betenbaugh MJ (1997).  Modeling assembly, aggregation, and chaperoning of immunoglobulin G production in insect cells.  Biotechnology and Bioengineering.  56(1).
  • Whiteley EM, Hsu TA, Betenbaugh MJ (1997).  Thioredoxin domain non-equivalence and anti-chaperone activity of protein disulfide isomerase mutants in vivo.  Journal of Biological Chemistry.  272(36).
  • Hsu TA, Takahashi N, Tsukamoto Y, Kato K, Shimada I, Masuda K, Whiteley EM, Fan JQ, Lee YC, Betenbaugh MJ (1997).  Differential N-glycan patterns of secreted and intracellular IgG produced in Trichoplusia ni cells.  Journal of Biological Chemistry.  272(14).
  • Hsu TA, Betenbaugh MJ (1997).  Coexpression of molecular chaperone BiP improves immunoglobulin solubility and IgG secretion from trichoplusia ni insect cells.  Biotechnology Progress.  13(1).
  • Mastrangelo AJ, Marie Hardwick J, Betenbaugh MJ (1996).  Bcl-2 inhibits apoptosis and extends recombinant protein production in cells infected with Sindbis viral vectors.  Cytotechnology.  22(1-3).
  • Betenbaugh MJ, Ailor E, Whiteley E, Hinderliter P, Hsu TA (1996).  Chaperone and foldase coexpression in the baculovirus-insect cell expression system.  Cytotechnology.  20(1-3).
  • Hsu TA, Watson S, Eiden JJ, Betenbaugh MJ (1996).  Rescue of immunoglobulins from insolubility is facilitated by PDI in the baculovirus expression system.  Protein Expression and Purification.  7(3).
  • Mastrangelo AJ, Betenbaugh MJ (1995).  Implications and applications of apoptosis in cell culture.  Current Opinion in Biotechnology.  6(2).
  • Betenbaugh M, Yu M, Kuehl K, White J, Pennock D, Spik K, Schmaljohn C (1995).  Nucleocapsid- and virus-like particles assemble in cells infected with recombinant baculoviruses or vaccinia viruses expressing the M and the S segments of Hantaan virus.  Virus Research.  38(2-3).
  • Tsai AM, Betenbaugh MJ, Shiloach J (1995).  The kinetics of RCC1 inclusion body formation in Escherichia Coli.  Biotechnology and Bioengineering.  48(6).
  • HSU T-, EIDEN JJ, BETENBAUGH MJ (1994).  Engineering the Assembly Pathway of the Baculovirus‐Insect Cell Expression Systema.  Annals of the New York Academy of Sciences.  721(1).
  • Hsu TA, Eiden JJ, Bourgarel P, Meo T, Betenbaugh MJ (1994).  Effects of co-expressing chaperone bip on functional antibody production in the baculovirus system.  Protein Expression and Purification.  5(6).
  • Lindsay DA, Vonderfecht SL, Betenbaugh MJ, Eiden JJ (1993).  Baculovirus expression of gene 6 of the IDIR strain of group B rotavirus (GBR): Coding assignment of the major inner capsid protein.  Virology.  193(1).
  • Juarbe-Osorio LG, Gorziglia M, Betenbaugh MJ (1993).  Recovery and characterization of a rotavirus outer capsid protein expressed in a recombinant insect cell system.  Protein Expression and Purification.  4(3).
  • Lindsay DA, Vonderfecht SS, Willoughby R, Betenbaugh MJ, Eiden JJ (1993).  Identification and expression of the outer capsid protein (VP4) of the IDIR strain of group B rotavirus.  Virology.  194(2).
  • Juarbe-Osorio LG, Betenbaugh MJ (1992).  Application of hemagglutinating properties for purification of recombinant viral antigens from baculovirus-infected insect cell cultures.  AIChE Symposium Series.  88(290).
  • BETENBAUGH MJ, LINDSAY DA, JUARBE-OSORIO LG, GORZIGLIA M, VONDERFECHT S, EIDEN JJ (1992).  Genetically Engineered Viral Antigens from Insect Cell Culture.  Annals of the New York Academy of Sciences.  665(1).
  • Lindsay DA, Betenbaugh MJ (1992).  Quantification of cell culture factors affecting recombinant protein yields in baculovirus‐infected insect cells.  Biotechnology and Bioengineering.  39(6).
  • Betenbaugh MJ, Balog L, Lee P- (1991).  Production of Recombinant Proteins by Baculovirus‐Infected Gypsy Moth Cells.  Biotechnology Progress.  7(5).
  • Betenbaugh MJ, Dhurjati P (1990).  A comparison of mathematical model predictions to experimental measurements for growth and recombinant protein production in induced cultures of Escherichia coli.  Biotechnology and Bioengineering.  36(2).
  • BETENBAUGH MJ, DHURJATI P (1990).  Effects of Promoter Induction and Copy Number Amplification on Cloned Gene Expression and Growth of Recombinant Cell Cultures.  Annals of the New York Academy of Sciences.  589(1).
  • Betenbaugh MJ, Beaty C, Dhurjati P (1989).  Effects of plasmid amplification and recombinant gene expression on the growth kinetics of recombinant E. coli.  Biotechnology and Bioengineering.  33(11).
  • diPasquantonio VM, Betenbaugh MJ, Dhurjati P (1987).  Improvement of product yields by temperature‐shifting of Escherichia coli cultures containing plasmid pOU140.  Biotechnology and Bioengineering.  29(4).
  • Betenbaugh MJ, diPasquantonio VM, Dhurjati P (1987).  Growth kinetics of Eschericia coli containing temperature‐sensitive plasmid pOU140.  Biotechnology and Bioengineering.  29(9).
  • Hopkins DJ, Betenbaugh MJ, Dhurjati P (1987).  Effects of dissolved oxygen shock on the stability of recombinant Escherichia coli containing plasmid pKN401.  Biotechnology and Bioengineering.  29(1).
  • DiPasquantonio VM, Betenbaugh MJ, Dhurjati P (1986).  IMPROVEMENT OF PRODUCT YIELDS BY TEMPERATURE-SHIFTING OF ESCHERICHIA COLI CULTURES CONTAINING PLASMID pOU140..  American Institute of Chemical Engineers, National Meeting.
Book Chapters
  • Betenbaugh MJ, Heffner KM, Wang Q, Hizal DB, Can O (2018).  Glycoengineering of Mammalian Expression Systems on a Cellular Level.  Advances in Biochemical Engineering/Biotechnology.
  • Inwood S, Betenbaugh MJ, Lal M, Shiloach J (2018).  Genome-wide high-throughput RNAi screening for identification of genes involved in protein production.  Methods in Molecular Biology.  1850.
  • Wang Q, Chung CY, Rosenberg JN, Yu G, Betenbaugh MJ (2018).  Application of the CRISPR/Cas9 gene editing method for modulating antibody fucosylation in CHO cells.  Methods in Molecular Biology.  1850.
  • Betenbaugh MJ, Yin B, Wang Q, Chung CY, Ren X, Bhattacharya R, Yarema KJ (2017).  Glycoengineering of CHO Cells to Improve Product Quality.  Heterologous Protein Production in CHO Cells.  Humana Press.  Methods in Molecular Biology, Vol 1603.
  • Wang Q, Yin B, Chung CY, Betenbaugh MJ (2017).  Glycoengineering of CHO cells to improve product quality.  Methods in Molecular Biology.  1603.
  • Sauerwald T, Betenbaugh M (2016).  Recombinant DNA technology using mammalian cells.  Tissue Engineering and Artificial Organs.
  • Wang Q, Stuczynski M, Gao Y, Betenbaugh MJ (2015).  Strategies for engineering protein N-glycosylation pathways in mammalian cells.  Glyco-Engineering: Methods and Protocols.
  • Viswanathan K, Narang S, Betenbaugh MJ (2015).  Engineering sialic acid synthesis ability in insect cells.  Glyco-Engineering: Methods and Protocols.
  • Rosenberg JN, Oh VH, Yu G, Guzman BJ, Oyler GA, Betenbaugh MJ (2015).  Chapter 22 - Exploiting the Molecular Genetics of Microalgae: From Strain Development Pipelines to the Uncharted Waters of Mass Production.  Handbook of Marine Microalgae: Biotechnology Advances.
  • Bennun SV, Heffner KM, Blake E, Chung A, Betenbaugh MJ (2014).  Engineering of the product: Control of biotheraputics glycosylation.  Animal Cell Biotechnology: In Biologics Production.
  • Betenbaugh MJ, Yin B, Blake E, Kristoffersen L, Narang S, Viswanathan K (2014).  N-Acetylneuraminic acid synthase (NANS).  Handbook of Glycosyltransferases and Related Genes, Second Edition.  2.
  • Shiloach J, Druz A, Betenbaugh M (2012).  MicroRNAs as engineering targets: Pathway manipulation to impact bioprocess phenotypes.  MicroRNAs as Tools in Biopharmaceutical Production.  9789400751286.
  • Sauerwald TM, Lewis A, Dorai H, Betenbaugh MJ (2011).  Apoptosis: The Signaling Pathways and Their Control.  Comprehensive Biotechnology, Second Edition.  1.
  • Hizal DB, Ohsfeldt E, Mai S, Betenbaugh MJ (2011).  Membrane Protein Expression in Mammalian Cells.  Production of Membrane Proteins: Strategies for Expression and Isolation.
  • Betenbaugh MJ, Tomiya N, Narang S (2007).  Glycoengineering: Recombinant Glycoproteins.  Comprehensive Glycoscience: From Chemistry to Systems Biology.  4-4.
  • Viswanathan K, Betenbaugh MJ (2005).  Glycosylation in native and engineered insect cells.  Handbook of Carbohydrate Engineering.
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