Research Project

In Vivo Laser Tissue Ablation using 6.1 µm Quantum Cascade Laser

Novel mid-infrared quantum cascade laser based surgical tool for precise eye surgery

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Dry bovine cornea ablation: (a) ablation line observed under digital optical microscope with 300 magnification and feature size measured (111 µm and 152 µm); (b) OCT en-face projection image of the ablation line; (c) cross sectional OCT image of the dashed yellow line in (b).

OCT is an established noninvasive optical imaging technology that can provide high-speed, high-resolution, 3-D images of biological samples. Since the early 1990s, it has been widely used for diagnosis, therapy monitoring and ranging.8 In this study, we performed QCL-based laser thermal therapy with real-time feedback from an OCT system to monitor the laser treatment. In particular, we performed tissue ablation and coagulation using a 6.12-µm QCL with real-time OCT monitoring.  The purpose of this project is to develop a novel mid-infrared quantum cascade laser based surgical tool for precise eye surgery.

OCT_Figure3 OCT_Figure4

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