Understanding how cells sense and interpret forces, and how this mechanosensation influences various physiological processes.
The sensing of mechanical stresses is fundamental to a wide range of cellular and tissue functions, including hearing, bone remodeling, blood pressure regulation and embryonic and tumor development. Our lab carries out research aimed at understanding how cells sense and interpret these forces, and how this mechanosensation influences various physiological processes. This research is carried out in collaboration with Doug Robinson, of the Department of Cell Biology in the JH School of Medicine.
Some publications related to this work are:
1. Luo T, Mohan K, Iglesias PA, Robinson DN. Molecular mechanisms of cellular mechanosensing. Nat Mater. 12:1064-71, 2013.
2. Luo T, Mohan K, Srivastava V, Ren Y, Iglesias PA, Robinson DN. Understanding the cooperative interaction between myosin II and actin cross-linkers mediated by actin filaments during mechanosensation. Biophys J. 102:238-47, 2012.
3. Kee YS, Ren Y, Dorfman D, Iijima M, Firtel R, Iglesias PA, Robinson DN. A mechanosensory system governs myosin II accumulation in dividing cells. Mol Biol Cell. 23:1510-23, 2012.
4. Zhou Q, Kee YS, Poirier CC, Jelinek C, Osborne J, Divi S, Surcel A, Will ME, Eggert US, Müller-Taubenberger A, Iglesias PA, Cotter RJ, Robinson DN.14-3-3 coordinates microtubules, Rac, and myosin II to control cell mechanics and cytokinesis. Curr Biol. 20:1881-9, 2010.
5. Effler JC, Kee YS, Berk JM, Tran MN, Iglesias PA, Robinson DN. Mitosis-specific mechanosensing and contractile-protein redistribution control cell shape. Curr Biol. 16:1962-7, 2006.