Eric C. Frey


Primary Appointment: Radiology and Radiological Science

Research Interests

  • Quantitative imaging
  • Cancer response imaging
  • Targeted radionuclide cancer therapy
  • SPECT and PET Imaging
  • Task-based image quality evaluation
  • Tomographic reconstruction

Primary Appointment: Johns Hopkins Medicine Medical Imaging Physics

Dr. Frey’s areas of expertise are SPECT and PET imaging, task-based image quality evaluation, tomographic reconstruction, and photon transport simulations. He applies these to solve medical problems in cardiology, oncology, and neurology. Current research projects include: developing and evaluating improved quantitative imaging for targeted radionuclide cancer therapy treatment planning; developing and validating multi-modality (PET/CT, SPECT/CT, and MRI) quantitative imaging metrics for assessment of response to cancer therapy; developing, optimizing and validating simultaneous dual isotope SPECT methods for assessing rest-stress myocardial perfusion and myocardial perfusion-innervation mismatch; optimizing pediatric nuclear medicine procedures to optimize dose while maintaining adequate diagnostic image quality; and optimizing instrumentation, acquisition, and reconstruction methods and parameters for  myocardial perfusion SPECT.

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