September 12, 2019 @ 3:00 pm – 4:15 pm
Title: Modeling Cellular Events: Chemotaxis and Aneuploidy
Abstract: Biology is the ‘study of complex natural things’ and the biologists are mostly interested in details of those complexity in a system. But often a simpler mathematical model is proved to be very efficient in deciphering the underlying basic working principle of the system. Despite the usefulness, these models are often criticized for not being able to explain the sufficient details of the wide range of experimental observations of different cases of pharmacological/genetic perturbations.
To fill this gap, in the present study we are proposing biochemically detailed models of signaling events during chemotaxis in soil-living social amoebae Dictyostelium discoideum and the structural aneuploidy in mammalian cells. In the chemotaxis model, we replaced the existing activator-inhibitor system with a detailed stochastic reaction-diffusion model of different phospholipids and proteins. In the case of the structural aneuploidy, we came up with two possible models involving tumor protein, Tp53. We believe that these models will not only elucidate the role of different entities in the signaling network but also are able to explain their functions in response to various genetic mutations and drug treatments.