{"id":1376,"date":"2021-06-30T13:57:54","date_gmt":"2021-06-30T17:57:54","guid":{"rendered":"https:\/\/engineering.jhu.edu\/chembe\/faculty\/jamie-spangler\/"},"modified":"2026-05-28T12:39:07","modified_gmt":"2026-05-28T16:39:07","slug":"jamie-spangler","status":"publish","type":"people","link":"https:\/\/engineering.jhu.edu\/chembe\/faculty\/jamie-spangler\/","title":{"rendered":"Jamie Spangler"},"content":{"rendered":"

Jamie Spangler<\/a> is the William R. Brody Faculty Scholar and an associate professor of biomedical engineering and chemical and biomolecular engineering at the Whiting School of Engineering. She is the director of the Spangler Lab at the Johns Hopkins School of Medicine and serves as Department of Chemical and Biomolecular Engineering director of PhD studies.<\/p>\n

Spangler\u2019s research aims to expand the repertoire of protein therapeutics by redesigning naturally occurring proteins and engineering new molecules to overcome the deficiencies of existing drugs. Integrating cutting-edge tools from structural biophysics, biomolecular engineering, and translational immunology, her research focuses on developing innovative platforms for the discovery and design of proteins that recruit novel mechanisms for disease therapy.<\/p>\n

In particular, Spangler\u2019s lab is interested in engineering antibody-based molecules that reshape immune cell behavior for targeted treatment of cancer, infectious diseases, and autoimmune disorders. The overarching goal of her interdisciplinary research program is to establish new insights into protein behavior and the extent to which it can be manipulated for medically relevant applications. She was named an AIMBE Fellow in 2026. In 2025, she received the Protein Science<\/em> Young Investigator Award and the Curtis W. McGraw Research Award.<\/p>\n

Spangler earned her BS in biomedical engineering from Johns Hopkins University in 2006 and her PhD in biological engineering from MIT in 2011. After completing postdoctoral training at Stanford University School of Medicine, she joined the faculty at Johns Hopkins in 2017.<\/p>\n","protected":false},"template":"","class_list":["post-1376","people","type-people","status-publish","hentry"],"acf":[],"yoast_head":"\nJamie Spangler - Department of Chemical and Biomolecular Engineering<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/engineering.jhu.edu\/faculty\/jamie-spangler\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jamie Spangler - Department of Chemical and Biomolecular Engineering\" \/>\n<meta property=\"og:description\" content=\"Jamie Spangler is the William R. 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