{"id":38128,"date":"2021-12-20T15:24:30","date_gmt":"2021-12-20T20:24:30","guid":{"rendered":"https:\/\/engineering.jhu.edu\/chembe\/?post_type=news&p=38128"},"modified":"2021-12-20T15:24:30","modified_gmt":"2021-12-20T20:24:30","slug":"science-advances-research-article-regarding-cancer","status":"publish","type":"news","link":"https:\/\/engineering.jhu.edu\/chembe\/news\/science-advances-research-article-regarding-cancer\/","title":{"rendered":"Science Advances | Research Article Regarding Cancer"},"content":{"rendered":"

ssDNA nanotubes for selective targetingof glioblastoma and delivery of doxorubicin for enhanced survival<\/strong><\/a><\/p>\n

Authors: Michael A. Harris, Huihui Kuang, Zachary Schneiderman, Maple L. Shiao, Andrew T. Crane, Matthew R. Chrostek, Alexandru-Flaviu T\u0103b\u0103ran, Thomas Pengo, Kevin Liaw, Beibei Xu, Lucy Lin, Clark C. Chen, M. Gerard O’Sullivan, Rangaramanujam M. Kannan, Walter C. Low, Efrosini Kokkoli<\/span><\/p>\n

Effective treatment of glioblastoma remains a daunting challenge. One of the major hurdles in the development
\nof therapeutics is their inability to cross the blood-brain tumor barrier (BBTB). Local delivery is an alternative approach that can still suffer from toxicity in the absence of target selectivity. Here, we show that nanotubes formed
\nfrom self-assembly of ssDNA-amphiphiles are stable in serum and nucleases. After bilateral brain injections, nanotubes show preferential retention by tumors compared to normal brain and are taken up by glioblastoma cells
\nthrough scavenger receptor binding and macropinocytosis. After intravenous injection, they cross the BBTB and
\ninternalize in glioblastoma cells. In a minimal residual disease model, local delivery of doxorubicin showed signs
\nof toxicity in the spleen and liver. In contrast, delivery of doxorubicin by the nanotubes resulted in no systemic
\ntoxicity and enhanced mouse survival. Our results demonstrate that ssDNA nanotubes are a promising drug
\ndelivery vehicle to glioblastoma.<\/p>\n

Click here to see the whole article.<\/a><\/p>\n","protected":false},"template":"","class_list":["post-38128","news","type-news","status-publish","hentry"],"acf":[],"yoast_head":"\nScience Advances | Research Article Regarding Cancer - Department of Chemical and Biomolecular Engineering<\/title>\n<meta name=\"description\" content=\"Effective treatment of glioblastoma remains a daunting challenge. Our results demonstrate that ssDNA nanotubes are a promising drugdelivery vehicle to glioblastoma.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/engineering.jhu.edu\/chembe\/news\/science-advances-research-article-regarding-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Science Advances | Research Article Regarding Cancer - Department of Chemical and Biomolecular Engineering\" \/>\n<meta property=\"og:description\" content=\"Effective treatment of glioblastoma remains a daunting challenge. 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