EN.540.101. Chemical Engineering Today. 1.00 Credit.

A series of weekly lectures to introduce students to chemical and biomolecular engineering and its role as a profession in addressing contemporary technological, social, ethical, and economic issues in today’s world. The lectures will include examples of how chemical and biomolecular engineers apply the principles of physics and chemistry to develop new products, improve process efficiencies, and alleviate the strain on the ecosystem through the design of novel environmentally conscious processes. In addition, the lectures will highlight exciting new areas now being advanced by chemical and biomolecular engineers, such as biochemical engineering, tissue engineering, nanoparticle fabrication, and processing smart polymers for applications in computer technology and as sensors. Freshmen Only.
Instructor(s): L. Dahuron
Area: Engineering.

EN.540.111. Introduction to Programming for ChemBEs: Matlab Made Easy. 1.00 Credit.

Computer programming is as crucial a tool for modern engineering as calculus. Engineers use computers for almost everything: from design and manufacturing in industry to data collection and analysis in research. In this course, students will use a piece of popular engineering software, Matlab, to learn the fundamentals of programming. We will start simple, exploring such questions as: What is a program? How can we use loops and branches to accomplish a task? What exactly is Matlab doing when it’s running a script? Finally, we will build upon the fundamentals of programming to tackle relevant engineering problems This course will help ChemBE students excel in subsequent engineering courses, such as Modeling and Statistics for ChemBEs, Separations, and Chemical Kinetics, by giving students’ knowledge of the tool that helps solve complex engineering problems.
Instructor(s): Staff
Area: Engineering.

EN.540.202. Introduction to Chemical & Biological Process Analysis. 4.00 Credits.

Introduction to chemical and biomolecular engineering and the fundamental principles of chemical process analysis. Formulation and solution of material and energy balances on chemical processes. Reductionist approaches to the solution of complex, multi-unit processes will be emphasized. Introduction to the basic concepts of thermodynamics as well as chemical and biochemical reactions.
Prerequisites: (AS.030.101 OR AS.030.103) AND ( AS.171.101 OR AS.171.107 ) AND ( AS.030.102 OR AS.030.103 ORAS.110.109 OR AS.171.102 )
Instructor(s): J. Gray
Area: Engineering.

EN.540.203. Engineering Thermodynamics. 3.00 Credits.

Formulation and solution of material, energy, and entropy balances with an emphasis on open systems. A systematic problem-solving approach is developed for chemical and biomolecular process-related systems. Extensive use is made of classical thermodynamic relationships and constitutive equations for one and two component systems. Applications include the analysis and design of engines, refrigerators, heat pumps, compressors, and turbines.
Prerequisites: EN.540.202;AS.110.202
Instructor(s): J. Frechette; M. Bevan
Area: Engineering.

EN.540.204. Applied Physical Chemistry. 3.00 Credits.

The topics in this course include thermodynamic models for multicomponent phase equilibrium including vapor liquid equilibrium, phase diagrams, activity models and colligative properties in both non-electrolyte and electrolyte solutions. . A link between average thermodynamic properties and microstates and molecular interactions is made via a discussion of intermolecular forces and the partition function. Also covered are thermodynamic relationships to describe chemical equilibria, and basic concepts in quantum mechanics and statistical mechanics.
Prerequisites: EN.540.203.
Instructor(s): D. Gracias
Area: Engineering.

EN.540.290. Chemical Engineering Modeling and Design for Sophomores. 3.00 Credits.

The courses EN.540.290, 291, 390, and 391 guide the students through the open-ended problems in product and process design. Product design concerns the recognition of customer needs, the creation of suitable specifications, and the creation of new products to fulfill a societal need. Process design concerns the quantitative description of processes which serve to produce chemically-derived materials and the estimation of process profitability. Students work in small teams to complete a major project demonstrating their understanding of and proficiency in the principles of unit operations and design. Students report weekly both orally and in writing on their accomplishments. Some projects are single semester, but others can be multi-semester. Students can start in any semester and can work on projects for as many semesters as they want.
Instructor(s): M. Donohue
Area: Engineering.

EN.540.291. Chemical Engineering Modeling and Design for Sophomores. 3.00 Credits.

The courses 540.290, 291, 390, and 391 guide the students through the open-ended problems in product and process design. Product design concerns the recognition of customer needs, the creation of suitable specifications, and the creation of new products to fulfill a societal need. Process design concerns the quantitative description of processes which serve to produce chemically-derived materials and the estimation of process profitability. Students work in small teams to complete a major project demonstrating their understanding of and proficiency in the principles of unit operations and design. Students report weekly both orally and in writing on their accomplishments. Some projects are single semester, but others can be multi-semester. Students can start in any semester and can work on projects for as many semesters as they want.
Instructor(s): M. Donohue
Area: Engineering.

EN.540.301. Kinetic Processes. 3.00 Credits.

Review of numerical methods applied to kinetic phenomena and reactor design in chemical and biological processes. Homogeneous kinetics and interpretation of reaction rate data. Batch, plug flow, and stirred tank reactor analyses, including reactors in parallel and in series. Selectivity and optimization considerations in multiple reaction systems. Non isothermal reactors. Elements of heterogeneous kinetics, including adsorption isotherms and heterogeneous catalysis. Coupled transport and chemical/biological reaction rates.
Prerequisites: EN.540.203 AND EN.540.303;EN.540.305
Instructor(s): H. Cui
Area: Engineering.

EN.540.303. Transport Phenomena I. 3.00 Credits.

Molecular mechanisms of momentum transport (viscous flow), energy transport (heat conduction), and mass transport (diffusion). Isothermal equations of change (continuity, motion, and energy). The development of the Navier Stokes equation. The development of non isothermal and multi component equations of change for heat and mass transfer. Exact solutions to steady state, isothermal unidirectional flow problems, to steady state heat and mass transfer problems. The analogies between heat, mass, and momentum transfer are emphasized throughout the course.
Prerequisites: AS.110.302
Instructor(s): J. Frechette
Area: Engineering.

EN.540.304. Transport Phenomena II. 4.00 Credits.

Dimensional analysis and dimensionless groups. Laminar boundary layers, introduction to turbulent flow. Definition of the friction factor. Macroscopic mass, momentum and mechanical energy balances (Bernouilli’s equation). Metering of fluids. Convective heat and mass transfer. Heat and mass transfer in boundary layers. Correlations for convective heat and mass transfer. Boiling and condensation. Interphase mass transfer.
Prerequisites: EN.540.303.
Instructor(s): Z. Gagnon
Area: Engineering.

EN.540.305. Modeling and Statistical Analysis of Data for Chemical and Biomolecular Engineers. 3.00 Credits.

This course seeks to build the student’s strength in Chemical Engineering computing and data analysis. To this end, in the first part of the course, we will become familiar with the Matlab/Octave computing environment and solve problems in Chemical Engineering that involve concepts from Process Analysis, Thermodynamics, Transport Phenomena, and Kinetics. In the subsequent part, we will build on the skills learnt earlier and tackle problems in Data Analysis and Hypothesis testing.
Prerequisites: EN.540.202 AND AS.110.302
Instructor(s): R. Schulman
Area: Engineering.

EN.540.306. Chemical & Biomolecular Separation. 4.00 Credits.

This course covers staged and continuous-contacting separations processes critical to the chemical and biochemical industries. Separations technologies studied include distillation, liquid-liquid extraction, gas absorption, membrane ultrafiltration, reverse osmosis, dialysis, adsorption, and chromatography. Particular emphasis is placed on the biochemical uses of these processes and consequently on how the treatment of these processes differs from the more traditional approach.
Prerequisites: EN.540.203 AND EN.540.305 or programming course.
Instructor(s): M. Betenbaugh
Area: Engineering.

EN.540.307. Cell Biology for Engineers. 3.00 Credits.

This course explores fundamental structural details and molecular functions of different parts of the cell. Considerable emphasis is placed on experimental/quantitative approaches to answering these questions. Topics include Central dogma and the nucleus; protein trafficking; ion transporters; cytoskeleton; molecular motors; cell cycle and cell division; signal transduction, cell growth and cancer; cell death, the extracellular matrix; cell adhesion, cell junctions and epithelium; and muscle contraction, cell motility and morphogenesis.
Prerequisites: Cell Biology restriction: students who have completed AS.020.306 may not enroll.
Instructor(s): J. Yang; X. Chan
Area: Natural Sciences.

EN.540.309. Product Design Part 1. 2.00 Credits.

This course guides the student through the steps of product design. Product design concerns the recognition of customer needs, the creation of suitable specifications, and the selection of best products to fulfill the needs. Students work in small teams to complete a major project demonstrating their understanding of and proficiency in the primary objectives of the course. Students report several times both orally and in writing on their accomplishments. This course is the first part of a two-semester sequence that optionally can be taken instead of EN.540.314 Chemical and Biomolecular Engineering Product Design. The material covered is the same as in EN.540.314, but more time is allowed so that laboratory tests can be performed and/or prototypes can be made. Note that students must take 540.310 to complete this sequence and before receiving credits for 540.309.
Prerequisites: EN.540.306;EN.540.301 AND EN.540.303 AND EN.540.490
Instructor(s): M. Donohue
Area: Engineering.

EN.540.310. Product Design Part 2. 2.00 Credits.

This course is one part of a two semester sequence that optionally can be taken instead of for This course is the second part of a two semester sequence (with EN.540.309) that optionally can be taken instead of EN.540.314 Chemical and Biomolecular Engineering Product Design. Students continue to work with their team on their product design project. Students report several times both orally and in writing on their accomplishments. The material covered is the same as in EN.540.314, but more time is allowed so that laboratory tests can be performed and/or prototypes can be made. Note that both courses, EN.540.309and EN.540.310 must be taken to satisfy the Undergraduate degree requirement of the Chemical and Biomolecular Engineering program. The two courses can be started in any term.
Prerequisites: EN.540.309
Instructor(s): M. Donohue
Area: Engineering.

EN.540.311. Chemical Engineering Lab I. 6.00 Credits.

This course challenges students with laboratory projects that are not well-defined. Students work in groups to develop an effective approach to experiments. They identify the important operating variables, decide how best to obtain them using measured or calculated values. Based on their results they predict, carryout, analyze and improve experiments. Each student analyzes three of the following projects: distillation, gas absorption, and one of the projects in EN.540.313. In addition to technical objectives, this course stresses oral and written communication. Students will have additional meeting times with the instructors and some writing professors outside of class.
Prerequisites: Students must have completed Lab Safety training prior to registering for this class. Prerequisites:EN.540.301, EN.540.304, EN.540.306, EN.540.490 and EN.661.315
Instructor(s): A. Goffin; L. Dahuron; S. Gerecht
Area: Engineering
Writing Intensive.

EN.540.312. Chemical and Biomolecular Engineering Lab: Part 2. 3.00 Credits.

Students who, as a part of an exchange program, participated in a laboratory course at the Technical University of Denmark at Copenhagen during the summer are required to register for this course to complete their equivalency requirement for the Chemical and Biomolecular Engineering Laboratory course offered in fall at JHU. The final grade for this course will incorporate the DTU grade. In addition, students perform one experimental project and submit a full professional report along with the current Senior Lab students. Students make a 15-min presentation to the junior class about their projects and of their experience in Denmark.
Prerequisites: Students must have completed Lab Safety training prior to registering for this class.;EN.540.301 ANDEN.540.304 AND EN.540.306 AND EN.540.490 AND EN.661.315
Instructor(s): L. Dahuron
Area: Engineering
Writing Intensive.

EN.540.313. Chemical and Biomolecular Engineering Lab. 6.00 Credits.

This course challenges students with laboratory projects that are not well-defined. Students work in groups to develop an effective approach to experiments. They identify the important operating variables, decide how best to obtain them using measured or calculated values. Based on their results they predict, carryout, analyze and improve experiments. Each student analyzes at least two of the following biomolecular projects: bioreactor, biocatalysis and membrane separation and one of the projects in EN.540.311. In addition to technical objectives, this course stresses oral and written communication. Students will have additional meeting times with the instructors and some writing professors outside of class.
Prerequisites: Students must have completed Lab Safety training prior to registering for this class.;EN.540.301 ANDEN.540.304 AND EN.540.306 AND EN.540.490 AND EN.661.315
Instructor(s): A. Goffin; L. Dahuron; M. Ostermeier; S. Gerecht
Area: Engineering
Writing Intensive.

EN.540.314. ChemBE Product Design. 2.00 Credits.

This course guides the student through the contrasting aspects of product design and of process design. Product design concerns the recognition of customer needs, the creation of suitable specifications, and the selection of best products to fulfill the needs. Process design concerns the quantitative description of processes, which serve to produce many commodity chemicals, the estimation of process profitability, and the potential for profitability improvement through incremental changes in the process. Students work in small teams to complete a major project demonstrating their understanding of and proficiency in the primary objectives of the course. Students report several times both orally and in writing on their accomplishments.
Prerequisites: EN.540.301 AND EN.540.306;EN.540.303
Instructor(s): A. Goffin; L. Dahuron
Area: Engineering.

EN.540.315. Process Design with Aspen. 2.00 Credits.

Prerequisites: EN.540.301 AND EN.540.303 AND EN.540.306
Instructor(s): A. Goffin; L. Dahuron
Area: Engineering.

EN.540.390. Chemical Engineering Modeling and Design for Juniors. 3.00 Credits.

The courses EN.540.290, 291, 390, and 391 guide the students through the open-ended problems in product and process design. Product design concerns the recognition of customer needs, the creation of suitable specifications, and the creation of new products to fulfill a societal need. Process design concerns the quantitative description of processes which serve to produce chemically-derived materials and the estimation of process profitability. Students work in small teams to complete a major project demonstrating their understanding of and proficiency in the principles of unit operations and design. Students report weekly both orally and in writing on their accomplishments. Some projects are single semester, but others can be multi-semester. Students can start in any semester and can work on projects for as many semesters as they want.
Instructor(s): M. Donohue
Area: Engineering.

EN.540.391. Chemical Engineering Modeling and Design for Juniors. 3.00 Credits.

The courses 540.290, 291, 390, and 391 guide the students through the open-ended problems in product and process design. Product design concerns the recognition of customer needs, the creation of suitable specifications, and the creation of new products to fulfill a societal need. Process design concerns the quantitative description of processes which serve to produce chemically-derived materials and the estimation of process profitability. Students work in small teams to complete a major project demonstrating their understanding of and proficiency in the principles of unit operations and design. Students report weekly both orally and in writing on their accomplishments. Some projects are single semester, but others can be multi-semester. Students can start in any semester and can work on projects for as many semesters as they want.
Instructor(s): M. Donohue
Area: Engineering.

EN.540.400. Project in Design: Pharmacokinetics. 3.00 Credits.

This design project will be to develop a chemical process model of the human body that can be used to understand the temporal distribution, spatial distribution and bioavailability of pharmaceutical drugs. The course (and software to be developed) will cover the spectrum of factors affecting pharmaceutical bioavailability including drug formulation, mode of dosing and dosing rate, metabolism and metabolic cascades, storage in fatty tissues, and diffusional limitations (such as in crossing the blood-brain barrier or diffusional differences between normal and cancerous cells). The goal is to develop a process model of the human body that will predict pharmaceutical bioavailability as a function of time and organ (or cell) type that will work for a wide variety of pharmaceuticals including small molecules, biologics, and chemotherapy agents.
Instructor(s): M. Donohue
Area: Engineering, Natural Sciences.

EN.540.401. Projects in Design: Alternative Energy. 3.00 Credits.

This course is a group design project (i.e. not a lecture course) to use chemical processing simulation tools (Aspen) to model a real-world process of interest to Chemical and Biomolecular Engineers. The goal of the project will be to develop a process model that is sufficiently complete and robust that it can be used to understand the important factors in the process design and/or operation. This design project is focused on the role alternative energy will play in our country’s future. About a third of the course will be devoted to understanding the role of energy and alternative energy in the US and world economies. The remainder of the course will be devoted to a technical and economic analysis of the feasibility of making biofuel from algae.
Instructor(s): M. Donohue
Area: Engineering.

EN.540.402. Metabolic Systems Biotechnology. 3.00 Credits.

The aim of this course is to provide a fundamental understanding of the quantitative principles and methodologies of systems biology and biochemical engineering of metabolism. This includes concepts of cellular growth, cellular stoichiometric models, metabolic networks, metabolite fluxes, and genome-scale metabolic models. Quantitative methods and systems biology approaches for metabolic flux analysis and metabolic control theory will be included as well as an analysis of biochemical systems and bioreactors including a consideration of mass transport processes.
Prerequisites: AS.020.306 OR ( EN.580.440 OR EN.580.441 ) OR EN.540.307
Instructor(s): M. Betenbaugh
Area: Engineering.

EN.540.403. Colloids and Nanoparticles. 3.00 Credits.

Fundamental principles related to interactions, dynamics, and structure in colloidal, nanoparticle, and interfacial systems. Concepts covered include hydrodynamics, Brownian motion, diffusion, sedimentation, electrophoresis, colloidal and surface forces, polymeric forces, aggregation, deposition, and experimental methods. Modern topics related to colloids in nano- science and technology will be discussed throughout the course with frequent references to recent literature. Meets withEN.540.603
Instructor(s): M. Bevan
Area: Engineering.

EN.540.405. The Design of Biomolecular Systems. 3.00 Credits.

This course covers new topics in the design of systems of biomolecules, both in vitro and in vivo, for decision making and control. The course will begin with an overview of how logical decision making and control with biomolecules as is achieved in biology and then proceed to consider various strategies of engineering similar systems. The focus of the course will be on systems level principles rather than the biochemistry of molecule design. Topics will include engineering of transcriptional networks and genetic control for logically programming of cells, the design of in vitro mimics of genetic controls, molecular computing and systems aspects of metabolic engineering. The course will also cover quantitative and computational techniques for the simulation and analysis of biomolecular systems. Co-listed with EN.540.605
Instructor(s): R. Schulman.

EN.540.409. Dynamic Modeling and Control. 4.00 Credits.

Introduction to modeling, dynamics, and control. Unsteady state analysis of biomolecular and chemical process control systems. State space and Laplace transform techniques, block diagram algebra, and transfer functions. Feedback and feedforward control. Frequency response and stability analysis. Applications in chemical engineering (chemical reactors and separative processes) as well as biomolecular engineering (biosynthesis, pharmacokinetic modeling and biomolecular modeling based upon central dogma/gene expression). Introduction to nonlinear dynamics.
Prerequisites: EN.540.301 AND EN.540.306
Instructor(s): A. Goffin
Area: Engineering, Quantitative and Mathematical Sciences.

EN.540.414. Computational Protein Structure Prediction and Design. 3.00 Credits.

This class will introduce the fundamental concepts in protein structure, biophysics, optimization and informatics that have enabled the breakthroughs in computational structure prediction and design. Problems covered will include protein folding and docking, design of ligand-binding sites, design of turns and folds, design of protein interfaces. Class will consist of lectures and hands-on computer workshops. Students will learn to use molecular visualization tools and write programs with the PyRosetta protein structure software suite, including a computational project. Programming experience is recommended.
Instructor(s): J. Gray
Area: Engineering.

EN.540.415. Interfacial Science with Applications to Nanoscale Systems. 3.00 Credits.

Nanostructured materials intrinsically possess large surface area (interface area) to volume ratios. It is this large interfacial area that gives rise to many of the amazing properties and technologies associated with nanotechnology. In this class we will examine how the properties of surfaces, interfaces, and nanoscale features differ from their macroscopic behavior. We will compare and contrast fluid-fluid interfaces with solid-fluid and solid-solid interfaces, discussing fundamental interfacial physics and chemistry, as well as touching on state-of-the-art technologies.
Instructor(s): J. Frechette
Area: Engineering.

EN.540.418. Projects in the Design of a Chemical Car. 2.00 Credits.

Ready to put those concepts from class into practice? Members work over the course of the semester to design and build a chemically powered vehicle that will compete with other college teams at the American Institute of Chemical Engineers ( AIChE) Regional Conference. In this course, the students work in small groups to design and construct the chassis along with chemically powered propulsion and break mechanisms within the constraints of the competition. In addition, students will give oral presentation, write reports, and do thorough safety analysis of their prototypes. Both semesters (EN.540.418 andEN.540.419) must be completed with passing grades to receive credit. This course may be repeated.
Instructor(s): L. Dahuron
Area: Engineering.

EN.540.419. Projects in the Design of a Chemical Car. 2.00 Credits.

Ready to put those concepts from class into practice? Members work over the course of the semester to design and build a chemically powered vehicle that will compete with other college teams at the American Institute of Chemical Engineers ( AIChE) Regional Conference. In this course, the students work in small groups to design and construct the chassis along with chemically powered propulsion and break mechanisms within the constraints of the competition. In addition, students will give oral presentation, write reports, and do thorough safety analysis of their prototypes. Both semesters (EN.540.418 andEN.540.419) must be completed with passing grades to receive credit.
Instructor(s): L. Dahuron
Area: Engineering.

EN.540.421. Project in Design: Pharmacodynamics. 3.00 Credits.

This course covers pharmacodynamics, i.e. how pharmaceuticals affect biological processes. The course will use MatLab to aid in the design of new drug formulations.
Instructor(s): M. Donohue
Area: Engineering, Natural Sciences.

EN.540.422. Introduction to Polymeric Materials. 3.00 Credits.

Polymeric materials are ubiquitous in our society from Nature-made proteins and polysaccharides to synthetic plastics and fibers. Their applications range from day-to-day consumables to high performance materials used in critically demanding areas, such as aviation, aerospace and medical devices. The objective of this course is to provide an introductory overview on the field of polymer science and engineering. Students will learn some basic concepts in polymer synthesis, characterization, and processing. With the basic concepts established, industrial applications of polymeric materials will be discussed in two categories: structural polymers and functional polymers. Structural polymers, including plastics, fibers, rubbers, coatings, adhesives, and composites, will be discussed in terms of their structure, processing, and property relationship with a flavor of industrial relevant products and applications. Future trends in developing environmentally friendly polymers from renewable resources (“green polymer chemistry”) will also be covered. Lectures on functional polymers will be focused on their unique properties that are enabled by rational molecular design, controlled synthesis and processing (e.g. supramolecular assembly, and microfabrication). This class of specialty materials can find their use in high performance photovoltaics, batteries, membranes, and composites, and can also serve as “smart” materials for use in coatings, sensors, medical devices, and biomimicry.
Prerequisites: AS.030.205 or by instructor permission.
Instructor(s): H. Cui; K. Qi
Area: Engineering.

EN.540.428. Supramolecular Materials and Nanomedicine. 3.00 Credits.

Nanomedicine is a quickly growing area that exploits the novel chemical, physical, and biological properties of nanostructures and nanostructured materials for medical treatments. This course presents basic design principles of constructing nanomaterials for use in drug delivery, disease diagnosis and imaging, and tissue engineering. Three major topics will be discussed, including 1) nanocarriers for drug delivery that are formed through soft matter assembly (e.g., surfactants, lipids, block copolymers, DNA, polyelectrolytes, peptides), 2) inorganic nanostructures for disease diagnosis and imaging (e.g., nanoparticles of gold and silver, quantum dots and carbon nanotubes), and 3) supramolecular scaffolds for tissue engineering and regenerative medicine. Students are expected to learn the physical, chemical and biological properties of each nanomaterial, the underlying physics and chemistry of fabricating such material, as well as their advantages and potential issues when used for biomedical applications. This course will also provide students opportunities for case studies on commercialized nanomedicine products. After this class, students should gain a deeper understanding of current challenges in translating nanoscience and nanotechnology.
Instructor(s): H. Cui
Area: Engineering.

EN.540.436. Design: Pharmacokinetics/Dynamics. 3.00 Credits.

One semester overview of year long course, students that want a comprehensive understanding of pharmacokinetics and pharmacodynamics should take the 2 courses EN.540.400 and EN.540.421. This course covers the principles of pharmacokinetics and pharmacodynamics. Computer models of pharmacokinetic and pharmacodynamics behavior will be developed and then used to design better drug delivery regimens and to analyze drug chemistry modifications.
Instructor(s): M. Donohue
Area: Engineering, Natural Sciences.

EN.540.437. Application of Molecular Evolution to Biotechnology. 3.00 Credits.

One of the most promising strategies for successfully designing complex biomolecular functions is to exploit nature’s principles of evolution. This course provides an overview of the basics of molecular evolution as well as its experimental implementation. Current research problems in evolution-based biomolecular engineering will be used to illustrate principles in the design of biomolecules (i.e. protein engineering, RNA/DNA engineering), genetic circuits and complex biological systems including cells. Meets with EN.540.637
Instructor(s): M. Ostermeier
Area: Engineering, Natural Sciences.

EN.540.438. Advanced Topics in Pharmacokinetics and Pharmacodynamics I. 3.00 Credits.

This course involves a semester-long project in pharmacodynamics. Topics are chosen in consultation with instructor.
Prerequisites: EN.540.421 OR EN.540.436
Instructor(s): M. Donohue
Area: Engineering, Natural Sciences.

EN.540.440. Micro/Nanotechnology: The Science and Engineering of Small Structures. 3.00 Credits.

The field of micro / nanotechnology has been gaining tremendous momentum as evidenced by an explosive rise in the number of publications, patents and commercial activities. This is an introductory course intended to expose students to the field as well as real world applications. Lectures will include an overview of scaling of material properties at the nanoscale, micro and nanofabrication methods and essential analytical tools of relevance to the field. All through the course, we will go over electronic, optical and biological applications of emerging micro and nanoscale devices and materials. Co-listed withEN.540.640.
Instructor(s): D. Gracias
Area: Engineering.

EN.540.452. Eukaryotic Cell Biotechnology. 2.00 Credits.

This course involves integrated lecture/discussion and laboratory components to review and participate in current and emerging topics involving eukaryotic biotechnology. Lectures and discussions review how fundamentals of biochemical kinetics and biomolecular engineering are connected to emerging problems in mammalian, algal, and stem cell biotechnology. Laboratory activities are connected to diverse scientific and technological fundamental topics on these same themes. Journal article and research presentations provide a context for laboratory activities with respect to emerging industrial applications for eukaryotic cell types. Research design and strategy is discussed in terms of its ultimate implementation in laboratory, pilot plant, and eventually manufacturing facilities. Methodologies implemented include cell and metabolic engineering for improving yields and production rates of proteins, cells, and tissues. Example topics include expansion of mammalian, stem cells, and algae for the production of membrane proteins, biologics, biofuels, and complex metabolites.
Instructor(s): M. Betenbaugh.

EN.540.462. Polymer Design and Bioconjugation. 3.00 Credits.

This course will focus on conventional to most recent inventions on polymer and conjugation chemistry. The weekly lectures will include the reaction strategy, designs and characterization techniques, structure-property relationship, simplistic approaches and versatile application oriented-solutions to Biomaterials and Tissue engineering related challenges. Students will learn how to devise creative strategies, process design and product development. Preliminary knowledge of organic chemistry is expected.
Instructor(s): A. Singh
Area: Engineering, Natural Sciences.

EN.540.490. Chemical Laboratory Safety. 1.00 Credit.

This course is meant to provide the student with a basic knowledge of laboratory safety; hazards, regulations, personal protective equipment, good laboratory practice, elementary toxicology, and engineering controls. It has been developed by the Department of Chemical and Biomolecular Engineering to assist with regulatory compliance, minimize hazards, and reduce the severity of any incidents that may occur in the department’s laboratories. The course is a prerequisite ofEN.540.311/EN.540.313. It is required of all Chemical and Biomolecular Engineering undergraduates. In addition once per year a three-hour refresher seminar must be taken by all students involved in laboratory research.
Instructor(s): D. Kuespert
Area: Engineering.