Our efforts are focused on quantitative analysis and design of custom proteins, nucleic acids, and biomolecular complexes. Participating faculty members are creators of new tools and approaches for engineering biomolecules and they apply these new technologies to solve some of the most pressing problems in biotechnology, pharmaceuticals, medicine and bioengineering. These approaches range from rational and computational methods to evolutionary design approaches, and the products span customized enzymes, molecular switches, therapeutic antibodies, and DNA assemblies. Several studies use the designed biomolecular components to drive processes at greater length and time scales, such as cellular decision-making, synthetic biology, and materials formation. Jeffrey Gray is using computational structure prediction and design methods for antibody structure prediction, protein-protein docking, design of protein-surface interactions, and engineering of membrane proteins and glycoproteins. Marc Ostermeier applies directed evolution and synthetic biology approaches to engineer proteins for biomedical and biotechnological applications. Rebecca Schulman’s work uses techniques from molecular programming to rationally design complex, environmentally-adaptive DNA nanostructures. Michael Betenbaugh’s work is directed at engineering mammalian cell factories to produce glycoprotein therapeutics with altered glycosylation patterns that exhibit extended circulatory lifetimes in patients.
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Michael Betenbaugh’s work is directed at developing protein evolutionary technologies for implementation into mammalian cell lines.
Honggang Cui is working on the molecular engineering and functional assembly of small molecule peptides, with the aim of developing biologically active and fully biodegradable nanomaterials capable of offering specific chemical, physical and mechanical signals to targeted cells.
Jeffrey Gray is using computational structure prediction and design methods for antibody structure prediction, protein- protein docking, and design of protein-surface interactions.
Marc Ostermeier seeks insight into the principles of natural evolution and applies laboratory evolution and synthetic biology principles to engineer proteins for biomedical and biotechnological applications.
Rebecca Schulman’s work uses techniques from molecular programming to rationally design complex, environmentally-adaptive DNA nanostructures.
Stavroula Sofou‘s group is utilizing different presentation geometries of functional ligands on nanoparticles with the aim of altering the apparent activities of these biomolecules.
Fusing together structural insights and molecular evolution,Jamie Spangler is interested in modifying the specificity and ultimately the activity of endogenous proteins as well as in the design of new targeted compounds that selectively stimulate and tune cellular responses..