Bio: Sharon C. Glotzer is the Anthony C. Lembke Department Chair of Chemical Engineering at the University of Michigan in Ann Arbor. Glotzer is also the John Werner Cahn Distinguished University Professor of Engineering and the Stuart W. Churchill Collegiate Professor of Chemical Engineering, and Professor of Materials Science and Engineering, Physics, Applied Physics, and Macromolecular Science and Engineering. She is a member of the National Academy of Sciences, the National Academy of Engineering, and the American Academy of Arts and Sciences, and a fellow of the American Association for the Advancement of Science, the American Physical Society, the American Institute of Chemical Engineers, the Materials Research Society, and the Royal Society of Chemistry. Professor Glotzer’s research on computational assembly science and engineering aims toward predictive materials design of colloidal and soft matter, and is sponsored by the NSF, DOE, DOD, and Simons Foundation. Using computation, geometrical concepts, and statistical mechanics, her group seeks to understand complex behavior emerging from simple rules and forces, and use that knowledge to design new classes of materials. Her introduction of the notion of “patchy particles,” a conceptual approach to nanoparticle design, has informed wide-ranging investigations of self-assembly. She showed that entropy alone can assemble shapes into many structures, which has implications for materials science, thermodynamics, mathematics, nanotechnology, biology and more. Her group’s “shape space diagram” shows how matter self-organizes based on the shapes of the constituent elements, making it possible to predict what kind of ordered material will emerge from disorder. Her group also develops and disseminates powerful open-source software, including the particle simulation toolkit, HOOMD-blue, which allows for fast simulation of materials on graphics processors. Glotzer has published over 240 refereed papers and presented over 350 plenary, keynote and invited talks around the world. She has served on boards and advisory committees of the National Science Foundation, the U.S. Department of Energy, and the National Academies, and is currently a member of the National Academies Board on Chemical Sciences and Technology. She is a Simons Investigator, a former National Security Science and Engineering Faculty Fellow, and the recipient of numerous other awards and honors, including the 2019 Aneesur Rahman Prize for Computational Physics from the American Physical Society, the 2018 Nanoscale Science and Engineering Forum Award and the 2016 Alpha Chi Sigma Award both from the American Institute of Chemical Engineers, and the 2014 MRS Medal from the Materials Research Society.
Development of Pharmacologically Active Delivery Systems to Target Chemokine Networks in Metastatic Cancer and Organ Fibrosis
Chemokine networks control cell movement to specific locations throughout the body as part of normal homeostasis and during pathological processes such as cancer, inflammation, and fibrogenesis. In tumors, a complex chemokine network controls cell trafficking into and out of the tumor microenvironment. The tumor chemokine network also participates in angiogenesis and generation of the fibroblast stroma. Importantly, chemokine networks are directly involved in the molecular control of metastasis and govern organ-specific homing of metastatic cells, which makes them promising targets for the development of antimetastatic therapies. The CXCR4 axis is also involved in mediating the infiltration and migration of inflammatory cells during pulmonary fibrosis. I will present our progress in the development of polymer drugs that target chemokine receptor CXCR4 as part of combination therapies in the treatment of metastatic pancreatic cancer and pulmonary fibrosis.
Bio: David Oupický is a Parke-Davis Professor of Pharmaceutics at the University of Nebraska Medical Center (UNMC). He obtained his MS degree in Polymer Engineering from the University of Chemical Technology in Prague in 1993 and his Ph.D. degree in Macromolecular Chemistry (1999) with Prof. Karel Ulbrich at the Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic. He was a postdoctoral fellow with Prof. Len Seymour at the CRC Institute for Cancer Studies at the University of Birmingham, UK from 1999 until 2002, when he became an Assistant Professor and then an Associate Professor of Pharmaceutical Sciences at Wayne State University, Detroit. After 10 years as a faculty at Wayne State University in Detroit, he joined UNMC. His research interests include synthesis of novel polymers and development of drug and nucleic acid delivery systems.