BLOOMBERG DISTINGUISHED PROFESSOR
Ph.D. Genetics and Cell Biology, University of California, San Francisco (’92)
Professor, Department of Cell Biology, Johns Hopkins University School of Medicine
Director, Center for Cell Dynamics, Institute for Basic Biomedical Sciences, Johns Hopkins University
Cellular dynamics in space, time, and adaptation
The goal of our research is to understand how eukaryotic cells polarize, divide, move, and vary their genomes to adapt to the changing environment. We strive for integrated analyses on the systems level that combines whole-cell quantitative observation and mathematical modeling with cutting-edge molecular genetics approaches. We are intrigued about how cells generate patterns through self-organization in response to environmental signals, accomplish division or motility through coordinated structural rearrangements and force production, and, when challenged with hostile environments or genetic perturbations, evolve innovative solutions to maintain vitality and functionality. In addition to the goal of identifying fundamental principles, we actively seek opportunities to apply basic-research insights to the improvement of human health.