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Applied Mathematics and Statistics

You should not see this data Random Dot Product Graphs

  • Edward Scheinerman
  • Applied Mathematics and Statistics
  • Research Objective:  Develop a new model of random graphs in which vertices are represented by vectors in Euclidean space and the probability of adjacency is determined by the dot product of the vectors. Approach:  Use graph theory, probability theory, and matrix analysis to prove...
    ...more...

(Nugget last updated 21-Jul-2005)

Biomedical Engineering

You should not see this data An Algebraic Geometric Approach to Hybrid Systems Identification

  • Rene Vidal
  • Biomedical Engineering
  • Research objectives: Develop theory and algorithms for identifying  the model parameters and estimating the continuous and discrete states of hybrid systems with interac-ting continuous and discrete dynamics Approach: Configuration space of a hybrid system is represented as an algebraic...
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(Nugget last updated 1-Feb-2006)

You should not see this data The Computational Neuropsychiatry of Brain Diseases: Schizophrenia, Depression and Aging

  • Michael I. Miller
  • Biomedical Engineering
  • The Computational Neuropsychiatry of Brain Diseases: Schizophrenia, Depression and Aging Michael I. Miller, Department of Biomedical Engineering, Johns Hopkins University NIH P01 AG003991-21 The field of Computational Neuropsychiatry has been exploding with large deformation brain mapping technology...
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(Nugget last updated 9-Feb-2006)

You should not see this data Metabolic Control Analysis of Sialic Acid Metabolism

  • Kevin Yarema
  • Biomedical Engineering
  • Research Objectives: To develop MCA and MFA computation models of sialic acid biosynthesis as a first step in applying a ‘Systems Biology’ approach to the study of glycosylation. Approach: Initial models will be constructed by using information currently in the literature.                                    ...
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(Nugget last updated 22-Jul-2005)

You should not see this data Segmenting Rigid Motions from Dynamic Textures

  • Rene Vidal
  • Biomedical Engineering
  • Research objectives: Develop theory and algorithms for detecting, tracking and recognizing multiple rigid and deforming motions in dynamically changing environments with a minimum level of supervision Approach: We model scenes containing rigid motions and dynamic textures as the output of...
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(Nugget last updated 1-Feb-2006)

You should not see this data Targeted Integration of Tissue Engineered Cartilage

  • Jennifer Elisseeff
  • Biomedical Engineering
  • Research Objectives: Development of an efficient and biocompatible method to directly bond a biomaterial to cartilage tissue. Approach: Collagen fibers will be exposed on the cartilage surface and oxidized to generate a radical and initiate photopolymerization to form a hydrogel directly bonded to...
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(Nugget last updated 8-Aug-2005)

Chemical and Biomolecular Engineering

You should not see this data Biophysical and Biochemical Characterization

  • Konstantinos Konstantopoulos
  • Chemical and Biomolecular Engineering
  • Research Objective: To develop a mechanistic understanding of selectin-ligand interactions pertinent to cancer metastasis Approach: Utilize biophysical tools to characterize selectin-tumor cell interactions at the molecular levelImplement novel and standard biochemical techniques to identify and characterize...
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(Nugget last updated 5-Aug-2005)

You should not see this data Engineering Protein Molecular Switches

  • Marc Ostermeier
  • Chemical and Biomolecular Engineering
  • Research Objectives: To create protein molecular switches and exploit their properties for sensing, biotechnological and biomedical applications.  Approach: Use natural evolution as a model for how to engineer new protein properties.Combine molecular biological and engineering approaches.Elucidate...
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(Nugget last updated 5-Aug-2005)

You should not see this data Polymeric Nanoparticle Therapeutics

  • Justin Hanes
  • Chemical and Biomolecular Engineering
  • Research Objective:Develop “nanomedicines” that use new biodegradable plastics to target large drug and gene doses to selective locations in the body. Approach: Synthesize new plastic biomaterials (“polymers). Use biodegradable polymers  to encapsulate drugs/genes into therapeutic nanoparticles....
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(Nugget last updated 5-Aug-2005)

Civil Engineering

You should not see this data Field Testing Method to Help Design a Pile Foundation System for Buildings and Bridges that can Withstand Even the Strongest Earthquake Imaginable

  • Annalingam Anandarajah
  • Civil Engineering
  • As we all now know, earthquakes cause significant damage to structures and loss of lives. One way to prevent structural failures is to build them on strong, earthquake-resistant foundation systems. However, the current methods are inadequate to design such a foundation system. With research funds...
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(Nugget last updated 8-Aug-2005)

You should not see this data Optimal Structural System Design for Catastrophic Unforeseen Events

  • Benjamin W. Schafer
  • Civil Engineering
  •  Research Objectives: Characterize probability of failure (Pf) for buildings under catastrophic unforeseen events. Explore decision-making methods for low-probability, high-risk, high-uncertainty, catastrophic events. Approach: Develop an efficient new computational tool for assessing the stability...
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(Nugget last updated 9-Aug-2005)

You should not see this data Random Loadings and Materials on the Reliability of Structures

  • Lori L. Graham-Brady
  • Civil Engineering
  • NSF has sponsored research at Johns Hopkins University studying the effects of random loadings and materials on the reliability of structures. By better understanding structural safety, the costs and benefits of improved building design can be more rationally balanced through consideration...
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(Nugget last updated 9-Aug-2005)

Computer Science

You should not see this data BitC: A Programming Language for Secure Systems

  • Jonathan S. Shapiro
  • Computer Science
  • Research Objectives: Create a programming language and proving environment for verifiable, practical, complex software systems. Approach: Design a systems programming language with a well-defined semantics. Language should include means for specifying both theorems and invariants about...
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(Nugget last updated 9-Aug-2005)

You should not see this data Coyotos: A Secure, Reliable Operating System

  • Jonathan S. Shapiro
  • Computer Science
  • Research Objectives: Create a robust, scalable, real-time operating system that can support secure, defensible applications and services. Approach: Build on earlier EROS work, providing improved multithreading and IPC and adopting an embeddable, microkernel design. Leverage our prior work with MOPS...
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(Nugget last updated 9-Aug-2005)

You should not see this data ERC for Computer Integrated Surgical Systems and Technologies

  • Russell H. Taylor
  • Computer Science
  • Objectives: Captivate enthusiasm of students at high school age for Computer Assisted Surgery Teach the basic themes of the field Attract female students to biomed engineering Approach: Emphasize multi-disciplinary concepts through state-of-the-art clinical systems developed at ERC Involve advanced...
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(Nugget last updated 11-Aug-2005)

You should not see this data Eros: A High Performance Capability System

  • Jonathan S. Shapiro
  • Computer Science
  • Research Objectives: Demonstrate that a capability-based operating system can be both high-performance and secure Approach: Create a high-performance microkernel designed to support capability-based security. Solve some hard challenge problems using the mechanisms and idioms that capabilities...
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(Nugget last updated 10-Aug-2005)

You should not see this data Software Systems for Vision-Based Spatial Interaction

  • Gregory D. Hager
  • Computer Science
  • Research Objectives: To explore the use of local-based vision algorithms to augment human-computer interaction. We are interesting in developing and studying algorithms that may be used to create pluggable interaction components for modern, video-enabled interfaces. Approach: Analyze the local...
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(Nugget last updated 10-Aug-2005)

Electrical and Computer Engineering

You should not see this data Color-Based Object Recognition on a Chip

  • Ralph Etienne-Cummings
  • Electrical and Computer Engineering
  • Implemented chip that contains a camera and a recognition engine Decomposes the image into Hue, Saturation and Intensity (HSI) Creates a template of HIS for learned template Identifies part of the scene that match a template Used by interactive toys, aides to the blind and Robots ...
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(Nugget last updated 28-Jun-2005)

You should not see this data Dynamic Control of Locomotion Central Pattern Generators (CPG): Towards a Spinal Neuroprosthesis

  • Ralph Etienne-Cummings
  • Electrical and Computer Engineering
  • Research Objectives: To develop a neuroprosthetic device that will help restore locomotion to spinal cord injury (SCI) patients with lower spine trauma. Approach: Develop devices and methods to interact with the spinal cord in a closed-loop manner. Determine the phase transition curves...
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(Nugget last updated 11-Aug-2005)

You should not see this data VLSI Implementation of Central Pattern Generators (CPG) for Legged Locomotion

  • Ralph Etienne-Cummings
  • Electrical and Computer Engineering
  • Implemented a general purpose CPG chip Contains 10 Neurons Allows 10 fully connected neurons Allows 10 inputs from off-chip Allows Spike and Graded neuron inputs Allows digitally programmable synapses Operates on microwatts of power Used to control legged locomotion ...
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(Nugget last updated 12-Jul-2005)

You should not see this data VLSI Implementation of Robotic Vision System: Single Chip Micro-Stereo System

(Nugget last updated 11-Aug-2005)

You should not see this data VLSI Implementation of Robotic Vision System: Ultrasonic Imaging and Tracking

  • Ralph Etienne-Cummings
  • Electrical and Computer Engineering
  • •Implemented ultrasonic bearing estimation chip and change detection chip •Uses sonic flow across microphone array to measure bearing of target •Creates internal map of environment •Detects changes in the structure of the environment •Operates on milliwatts...
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(Nugget last updated 11-Aug-2005)

You should not see this data VLSI Implementation of Robotic Vision System: Visual Tracking

(Nugget last updated 11-Aug-2005)

Geography and Environmental Engineering

You should not see this data Collaboration in Mathematical Geosciences

  • Markus Hilpert
  • Geography and Environmental Engineering
  • Objectives: Build models of porous media that accurately represent their geometry and topology Be able to use non-voxelized images as an input in order to avoid losses in spatial resolution Obtain mathematically unique network models of porous media Approach: Employ concept of duality...
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(Nugget last updated 1-Feb-2006)

You should not see this data The Role of Surface Characteristics in Determining Sorption Properties of Char and Soot

(Nugget last updated 11-Aug-2005)

Materials Science and Engineering

You should not see this data Building a "Better Mousetrap": Bimetallic Reductants to Mitigate Pollution

  • Robert E. Green, Jr.
  • Materials Science and Engineering
  • Motivation: Bimetallic reductants, in which a second metal is plated onto Fe0, offer great promise in treating organic solvents present as groundwater contaminants. One popular such reductant is Pd/Fe, which has been shown to be much more reactive than Fe0 toward common chlorinated organic compounds,...
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(Nugget last updated 11-Aug-2005)

You should not see this data Development of Nondestructive Evaluation Techniques to Detect Defects in Electrical Insulation Writing

  • Robert E. Green, Jr.
  • Materials Science and Engineering
  • Research Objectives: To develop nondestructive evaluation techniques for detection of defects in wiring on aircraft and space vehicles in order to insure their safety. Approach: Blow hot air on sections of electrical wiring so that defects in the insulation will cause the metal wires inside to heat...
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(Nugget last updated 11-Aug-2005)

You should not see this data Development of Nondestructive Evaluation Techniques to Detect Defects in Thermal Insulation Foams

  • Robert E. Green, Jr.
  • Materials Science and Engineering
  • Research Objectives: To develop nondestructive evaluation techniques to detect defects in the thermal insulation ceramic foam on the space shuttle main fuel tank to insure a safe return to flight. Approach: Space Shuttle Main Fuel Thermal Insulation Apply a variety of nondestructive techniques...
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(Nugget last updated 11-Aug-2005)

You should not see this data Nanometer-scale Structure and Properties of Amorphous Alloys

  • Todd C. Hufnagel
  • Materials Science and Engineering
  • Research Objectives: Amorphous alloys (also called metallic glasses) combine the outstanding mechanical properties of metals with the ease of processing of glasses. We seek to understand the relationship between the structure of these materials and their properties. Approach: Combine advanced...
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(Nugget last updated 11-Aug-2005)

You should not see this data Sources and Sinks for Dissolved Chromium

(Nugget last updated 11-Aug-2005)

Mechanical Engineering

You should not see this data Force Generation in Biological Systems

  • Sean Sun
  • Mechanical Engineering
  • Research Objectives: Amorphous alloys (also called metallic glasses) combine the outstanding mechanical properties of metals with the ease of processing of glasses. We seek to understand the relationship between the structure of these materials and their properties. Approach: Combine advanced structural...
    ...more...

(Nugget last updated 11-Aug-2005)

You should not see this data ITR: Collaborative Research: Modeling and Display of Haptic Information for Enhanced Performance of Computer Integrated Surgery

  • Allison M. Okamura
  • Mechanical Engineering
  • Project Description: The goal of this project is to significantly improve the information-enhanced operating room through the sensing and acquisition of models representing haptic information during tool-tissue interactions in minimally invasive surgery. This research will significantly impact:...
    ...more...

(Nugget last updated 11-Aug-2005)

You should not see this data New Computational Method Based on Scale-Invariance (Fractals) for Multi-Scale, Complex Systems

  • Charles Meneveau
  • Mechanical Engineering
  • Many systems in the natural and man-made world display a wide range of dynamically linked length-scales. Turbulent flow in a plant canopy is one example, where vortices of sizes ranging from tens of meters down to fractions of millimeters interact with fractal-like objects such as trees. Describing...
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(Nugget last updated 11-Aug-2005)

You should not see this data Quantification of Biomolecules Based on Flow Cytometric Single-Molecule Detection and Sorting on a Microchip

  • Jeff Tza-Huei Wang
  • Mechanical Engineering
  • Research Objective: To develop a molecular detection and sorting platform for high throughput quantitative screening of biomoelcules. Approach: Using confocal laser-induced fluorescence spectroscopy to achieve detection of single-molecule fluorescence. Develop a nanocrystal quantum dots-based...
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(Nugget last updated 12-Aug-2005)

You should not see this data Testing of Silicon Carbide

  • William N. Sharpe, Jr.
  • Mechanical Engineering
  • Professor Sharpe is testing silicon carbide microspecimens at 1000 degrees C for the NASA Glenn Research Center in Cleveland. Silicon carbide in its bulk form maintains its strength at high temperatures, which makes it a good candidate for microelectromechanical systems (MEMS) to be used in jet...
    ...more...

(Nugget last updated 12-Aug-2005)

Other

You should not see this data Engineering Enhanced Anti-Apoptosis Activity for Mammalian Cell Culture

  • Research Objectives: To develop cell lines with improved survival against insults that trigger the death (apoptosis) of cells producing biopharmaceuticals in bioreactors. Approach: Examine induction of apoptosis in cell cultures Identify anti-apoptosis genes available in nature Mutate these...
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(Nugget last updated 5-Aug-2005)

You should not see this data Tissue Deformation Modeling and Needle Steering

  • Researchers at the Engineering Research Center for Computer-Integrated Surgical Systems and Technology are developing dynamically updated geometric models of internal organs.  These models will help solve one of the major complications in current surgical procedures, namely the fact that the...
    ...more...

(Nugget last updated 11-Aug-2005)