Whiting School of Engineering, Johns Hopkins University



Leadership Through Innovation

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Research

Kevin Yarema

Assistant Professor of Biomedical Engineering
Biomedical Engineering

Assistant Information

Bohyun Cho
Clark Hall 106
(410) 516 - 4913
Bohyun Cho [bcho5@jhu.edu]

Awards

  • Distinguished Junior Faculty Award, The Midwest Carbohydrate and Glycobiology Symposium October 06, 2007 - October 06, 2007
  • Beckman Young Investigator Award (The Arnold and Mabel Beckman Foundation, Irvine, CA) September 01, 2003 - August 31, 2006
  • Outstanding Thesis Award, The Drug Information Association April 01, 1995

Courses

Spring 2009
540.451/580.421 Cell and Tissue Engineering Laboratory
Undergraduate Students: 13

Spring 2008
540.451/580.421 Cell and Tissue Engineering Laboratory
Undergraduate Students: 15

Fall 2008
540.451/580.421 Cell and Tissue Engineering Laboratory
Undergraduate Students: 16

Fall 2008
580.221 Molecules and Cells
Provided 6 hours of lectures (and generated accompanying homework and exam questions)
Undergraduate Students: 105

Fall 2008
580.440/580.640 Cell and Tissue Engineering
Undergraduate Students: 40
Graduate Students: 15

Spring 2007
540.451/580.421 Cell and Tissue Engineering Laboratory
Undergraduate Students: 11

Fall 2007
540.451/580.421 Cell and Tissue Engineering Laboratory
Undergraduate Students: 7
Graduate Students: 3

Fall 2007
580.221 Molecules and Cells
Provided 6 hours of lectures (and generated accompanying homework and exam questions)
Undergraduate Students: 120

Fall 2007
580.440/580.640 Cell and Tissue Engineering
Undergraduate Students: 45
Graduate Students: 20

Spring 2006
540.451/580.421 Cell and Tissue Engineering Laboratory
Undergraduate Students: 8
Graduate Students: 3

Fall 2006
540.451/580.421 Cell and Tissue Engineering Laboratory
Undergraduate Students: 13

Fall 2006
580.440/580.640 Cell and Tissue Engineering
Undergraduate Students: 45
Graduate Students: 25

Spring 2005
540.451/580.421 Cell and Tissue Engineering Laboratory
Undergraduate Students: 16

Fall 2005
540.451/580.421 Cell and Tissue Engineering Laboratory
Undergraduate Students: 16

Fall 2005
580.440/580.640 Cell and Tissue Engineering
Undergraduate Students: 70
Graduate Students: 35

Spring 2004
540.451/580.421 Cell and Tissue Engineering Laboratory
Undergraduate Students: 9
Graduate Students: 2

Fall 2004
540.441/641 Topics in Cellular Engineering
Undergraduate Students: 55
Graduate Students: 20

Fall 2004
540.451/580.421 Cell and Tissue Engineering Laboratory
Undergraduate Students: 13

Spring 2003
540.451/580.421 Cell and Tissue Engineering Laboratory
Undergraduate Students: 3

Fall 2003
540.441/641 and Topics in Cellular Engineering
Undergraduate Students: 25
Graduate Students: 15

Fall 2002
540.441/580.441 Topics in Cellular Engineering
Undergraduate Students: 65
Graduate Students: 35

Fall 2002
540.451/580.421 Cell and Tissue Engineering Laboratory
Undergraduate Students: 1
Graduate Students: 2

Education

Ph.D. Biological Chemistry, MIT, September, 1988 - February, 1994
B.S. Bioengineering, Walla Walla College, September, 1984 - June, 1988

Experience

  • Associate Professor, Department of Biomedical Engineering, The Johns Hopkins University. July 01, 2008 - Present
  • Assistant Professor, Department of Biomedical Engineering, The Johns Hopkins University. July 01, 2001 - June 30, 2008
  • Research Assistant Specialist, University of California @ Berkeley. January, 1999 - June, 2001
  • Postdoctoral Associate, Lawrence Berkeley National Laboratory. April, 1996 - December, 1998
  • Postdoctoral Associate, Massachusetts Institute of Technology, . February, 1994 - March, 1996

Grants and Contracts

Metabolic Control Analysis of Sialic Acid Metabolism (QSB-0425668), The National Science Foundation $509,174
Status: Awarded/Terminated
December 01, 2004 - November 30, 2006

Probing the Connections between Monosaccharide Analogs, Sialic Acid Metabolism, and Apoptosis, The National Institutes of Health (NCI) $1,595,430
Status: Awarded/Active
September 01, 2005 - June 30, 2009

Glycosylation Engineering Applications In Stem Cell Research, Charles E. Culpeper Foundation Inc. $25,000
Status: Awarded/Terminated
September 01, 2002 - August 31, 2003

Development of glycosylation-based therapies for breast cancer: Targeting sialic acid-mediated, Komen Foundation $250,000
Status: Awarded/Terminated
May 01, 2005 - April 30, 2007

Beckman Young Investigator, Arnold and Mabel Beckman Foundation $240,000
Status: Awarded/Terminated
September 01, 2003 - August 31, 2006

Investigating the Role of GNE Mutations in Hereditary Inclusion Body Myopathy (HIBM), ARM (Advancement in Research for Myopathies) $177,129
Status: Awarded/Terminated
July 01, 2003 - December 31, 2005

Animal testing of short chain fatty acid-hexomamine hybrid molecules as cancer drugs, TEDCO $50,000
Status: Awarded/Terminated
January 01, 2007 - December 31, 2007

Engineering a carbohydrate-biomaterial interface for the control of Wnt signaling, The National Institutes of Health (NIBIB) $1,295,600
Status: Awarded/Active
April 01, 2007 - March 31, 2011

In Vivo Evaluation of Sugar-SCFA Nanoparticles, Institute for NanoBioTechnology (JHU) $20,000
Status: Awarded/Terminated
April 01, 2007 - November 30, 2007

Presentations

Srinivasa-Gopalan Sampathkumar, Mark B. Jones and Kevin J. Yarema: Engineering of cell surface sialic acids: Synthesis of analogs of 2-N-acylamino-2-deoxy-a,b-D-mannopyranose and studies on their efficacy of cellular uptake and toxicity The 23rd Gordon Research Conference on Carbohydrates. Tilden, New Hampshire. June 22, 2003.

Hao Chen, Mark B. Jones, Howard Teng, Jun Kyu Rhee, Gautam Baskaran, Nick Lahar, and Kevin J. Yarema: Sialic Acid Engineering: Optimizing the flux of acetylated ManNAc analogs through the sialic acid biosynthetic pathway  Society for Glycobiology Annual Meeting. Boston, Massachusetts. November 10, 2002.

Srinivasa-Gopalan Sampathkumar, Mark B. Jones and Kevin J. Yarema: Engineering of cell surface sialic acids: Synthesis of analogs of 2-N-acylamido-2-deoxy-ab-D-mannopyranose and studies on their efficacy of uptake and toxicity The 226th ACS National Meeting. New York, NY. September 07, 2003.

Eun Jeong Kim, Jun Kyu Rhee, Srinivasa-Gopalan Sampathkumar, Mark B. Jones, Gautam Baskaran, and Kevin J. Yarema: Characterization of the apoptotic effects of N-acetylmannosamine (ManNAc) analogs in Jurkat (human T-lymphoma-derived) cells Society for Glycobiology 2003 National Meeting. San Diego, CA. December 03, 2003.

Hao Chen, Zhonghui Sun, and Kevin J. Yarema: Establishing a correlation between mutant forms of GNE found in HIBM and the expression of neurotrophic factors Society for Glycobiology 2003 National Meeting. San Diego, California. December 03, 2003.

Srinivasa-Gopalan Sampathkumar, Mark B. Jones and Kevin J. Yarema: Engineering of cell surface sialic acid. Synthesis of analogs of 2-N-Acylamino-2-deoxy-á,â-D-mannopyranose and studies on their efficacy of uptake and toxicity. Society for Glycobiology 2003 National Meeting. San Diego, California. December 03, 2003.

Kevin J. Yarema: Mutant Forms of Recombinant UDP-GlcNAc 2-epimerase/ManNAc  Hereditary Inclusion Body Myopathy Meeting . Lawton Chiles International Center. November 21, 2003. (Invited)

Kevin J. Yarema: A Systems Biology Approach to the Study of Sialic Acid Metabolism Beckman Young Investigator Symposium . Newport Beach, California. August 22, 2003. (Invited)

Srinivasa-Gopalan Sampathkumar, Mark B. Jones and Kevin J. Yarema: Metabolic substrate based engineering of cell surface sialic acids: synthesis of peracylated N-acyl-D mannosamine analogs containing pendant thiol groups and studies on their efficacy of cellular uptake and toxicity The 228th ACS National Meeting, . Philadelphia, PA . August 22, 2004.

Srinivasa-Gopalan Sampathkumar, Mark B. Jones and Kevin J. Yarema: Substrate based metabolic engineering of cell surface sialic acids: Synthesis and applications of novel N-acylmannosamine analogs possessing pendant thiol groups as metabolic precursors Society for Glycobiology 2004 National Meeting. Honolulu, Hawaii. November 17, 2004.

Adrienne Li, Zhiyun Wang, Michael P. Murrell, Brent Cameron, Gautam Baskaran, Nicholas M. Stamatos, Hao-Quan Mao, & Kevin J. Yarema: The sialic acid biology of human stem cells: Basic steps towards the characterization and manipulation of glycosylation to control their differentiation and proliferation Society for Glycobiology 2004 National Meeting. Honolulu, Hawaii. November 17, 2004.

Mark B. Jones, Srinivasa-Gopalan Sampathkumar, and Kevin J. Yarema: Monosaccharides provide an efficient delivery method for butyrate, a short chain fatty acid (SCFA) with anti-cancer activity Society for Glycobiology 2004 National Meeting. Honolulu, Hawaii. November 17, 2004.

Hao Chen, Stephan Hinderlich, & Kevin J. Yarema: Recombinant GNE alters the expression of proteins important for muscle functions and provides insights into the cellular basis of HIBM Society for Glycobiology 2004 National Meeting. Honolulu, Hawaii. November 17, 2004.

Zhiyun Wang, Zhonghui Sun, Hao Chen, Stephan Hinderlich, & Kevin J. Yarema: Feedback control mechanisms, not the potential catalytic epimerization activity of GNE, determines bulk metabolic flux through the sialic acid biosynthetic pathway Society for Glycobiology 2004 National Meeting. Honolulu, Hawaii. November 17, 2004.

Salama, I., Hinderlich, S., Shlomai, Z., Eisenberg, I., Krause, S., Yarema, K., Argov, Z., Reutter, W., Lochmuller, H., Dabby, R., Sadeh, M., Ben-Bassat, H., & Mitrani-Rosenbaum, S. : Biochemical characterization of myoblasts from Hereditary Inclusion Body myopathy patients with various mutations in GNE Society for Glycobiology 2004 National Meeting. Honolulu, Hawaii. November 17, 2004.

Kevin J. Yarema: A Systems Biology Approach to the Study of Sialic Acid Metabolism Beckman Young Investigator Symposium. Irvine, CA. August 23, 2004. (Invited)

Kevin J. Yarema: Metabolic Connections between Sialic Acid Biosynthesis, Human Disease, and Apoptosis JHU Glycobiology Interest Group . Baltimore, Maryland. October 12, 2004. (Invited)

Kevin J. Yarema: Chemical-Biology Methods to Manipulate Glycosylation: Applications and Challenges for the Metabolic Engineering of Sialic Acids The 21st Century COE Young Scientist Network Symposium: Toward a Fusion of Bioscience and Nanotechnology. Hokkaido University, Sapporo, Japan. August 06, 2004. (Invited)

Kevin J. Yarema: Metabolic Labeling of Sialic Acid in Neurons  Neuro2004: Glycobiology and the Plasticity of the Nervous System. Osaka, Japan. September 23, 2004. (Invited)

Kevin J. Yarema: Cell Surface Oligosaccharide Engineering: New Methods for Cell Adhesion, Tissue Engineering, and Medicine Invited Lecture. Osaka Prefecture University, Osaka, Japan. September 22, 2004. (Invited)

Kevin J. Yarema: Cell Surface Oligosaccharide Engineering: New Directions for Cancer Therapy and Tissue Engineering  Invited Lecture. Osaka University, Osaka, Japan. September 21, 2004. (Invited)

Kevin J. Yarema: Monosaccharide-based Modulation of Sialic Acid Metabolism: Prospects for Therapeutic Applications Food and Drug Admistration Seminar Series. Bethesda, Maryland. April 22, 2004. (Invited)

Srinivasa-Gopalan Sampathkumar, Mark B. Jones and Kevin J. Yarema: Novel method for the expression of thiols on cell surface carbohydrates with applications to tissue engineering Gordon Research Conference on Carbohydrates. Tilton School, Tilton, New Hampshire. June 19, 2005.

S-Gopalan Sampathkumar, Mark B. Jones, Kaoru Hida, Prasra Gomutputra, Tony H. Sheh and Kevin J. Yarema: Design and synthesis of novel SCFA carbohydrate hybrids with anti-cancer properties American Chemical Society Meeting & Exposition. Washington, District of Columbia. August 28, 2005.

Kevin J. Yarema: Development of therapeutic applications for N-acetylmannosamine (ManNAc) analogues used for the manipulation of sialic acid metabolism GLYCO XVIII: The International Symposium on Glycoconjugates. Firenze, Italy. September 04, 2005. (Invited)

Kevin J. Yarema: Connections between apoptosis and sialic acid metabolism: Application to new cancer therapies GLYCO XVIII: The International Symposium on Glycoconjugates. Firenze, Italy. September 04, 2005.

S-Gopalan Sampathkumar, Adrienne V. Li, Mark B. Jones, Kaoru Hida, and Kevin J. Yarema: Metabolic engineering novel adhesive properties into cell surface carbohydrates 2005 BMES (Biomedical Engineering Society) Fall Meeting. Baltimore, Maryland. September 28, 2005.

Srinivasa-Gopalan Sampathkumar, Mark B. Jones, M. Adam Meledeo, Koaru Hida, Anthony H. Sheh, Pam Gomutputra and Kevin J. Yarema: Carbohydrate-based small molecules as anti-cancer drugs: Short chain fatty acid-hexosamine hybrids Society for Glycobiology 2005 National Meeting. Boston, Massachusetts. November 09, 2005.

Zhiyun Wang, Zhonghui Sun and Kevin J. Yarema: GNE is involved in cell growth via modulation of ganglioside metabolism Society for Glycobiology 2005 National Meeting. Boston, Massachusetts. November 09, 2005.

Srinivasa-Gopalan Sampathkumar, Christopher T. Campbell, Adrienne V. Li, Mark B. Jones, Zonghui Sun, Anshu Sarje, Nitish V. Thakor and Kevin J. Yarema: Modulation of cell adhesion or attachment using sialic acid engineering methods Society for Glycobiology 2005 National Meeting. Boston, Massachusetts. November 09, 2005.

Srinivasa-Gopalan Sampathkumar, Adrienne V. Li, Mark B. Jones, Prabhani U. Atukorale, Christopher T. Campbell, and Kevin J. Yarema: A carbohydrate based small molecule induces beta-catenin accumulation and neural differentiation in human stem cells Keystone Symposia on Wnt and beta-catenin signaling in development and disease. Snowbird, Utah. April 07, 2006.

Srinivasa-Gopalan Sampathkumar, Anshu Sarje, Adrienne V. Li, Mark B. Jones, Prabhani U. Atukorale, Zhonghui Sun, and Kevin J. Yarema: Metabolic substrate-based oligosaccharide engineering: A new tool for tissue engineering and stem cell biology World Congress on Tissue Engineering and Regenerative Medicine. Pittsburg, Pennsylvania. April 25, 2006.

Zhiyun Wang, Hao Chen, Zhonghui Sun and Kevin J. Yarema: Systems Biology Approach to the Study of Sialic Acid Metabolism: Is HIBM caused by Abnormal Sialic Acid Production? Beckman Young Investigators Symposium. Irvine, California. August 26, 2005. (Invited)

Kevin J. Yarema: Sialic acid engineering – A new method for controlling cell adhesion and stem cell fate Department of Chemical Engineering Seminar Series. University of Maryland, Baltimore County. May 15, 2006. (Invited)

Kevin J. Yarema: Metabolic oligosaccharide engineering: Developing new tools for tissue engineering The Interdisciplinary Translational Glycobiology Symposium. Arizona State University, Tempe. May 11, 2006. (Invited)

Yihua Loo, S-Gopalan Sampathkumar, Prabhani U. Atukorale, Kevin J. Yarema, Kam W. Leong: Engineering of Cell Surface Sialic Acids for Polymeric Gene Delivery American Society for Gene Therapy 9th Annual Meeting. Baltimore, Maryland. June 01, 2006.

Christopher Campbell, S-Gopalan Sampathkumar, Mary Wen, Jean Wang, Christopher Weier, Kevin Yarema: Sialic acid engineering for modifying invasiveness of breast cancer The Susan G. Komen Foundation's ninth annual Mission Conference. Washington, District of Columbia. June 12, 2006.

Kevin J. Yarema: Sialic acid: A regulator of apoptosis, proliferation, and differentiation in cancer and stem cells Symposium on Chemical Biology. National Cancer Institute at Frederick. June 20, 2006. (Invited)

Kevin Yarema: Metabolic engineering of mammalian glycosylation with monosaccharide analogues. GLUPOR VI: 6th International Meeting of the Portuguese Carbohydrate Group | 3rd Iberian Carbohydrate Meeting . Coimbra, Portugal. September 11, 2005. (Invited)

Kevin J. Yarema: Engineering glycosylation pathwasy in human cells Johns Hopkins University Glycobiology Interest Group. Baltimore, Maryland. December 04, 2001. (Invited)

Kevin J. Yarema: Sialic acid: A regulator of apoptosis, proliferation, and differentiation Johns Hopkins University Glycobiology Interest Group. Baltimore, Maryland. February, 2006. (Invited)

Prabhani U. Atukorale, S-Gopalan Sampathkumar, Adrienne V. Li, Mark B. Jones, Anshu Sarje, Gregory Christopherson, Zhonghui Sun, Andrew Lewis, Hai-Quan Mao, and Kevin J. Yarema: Metabolic installation of thiols into sialic acid modulates adhesion and stem cell biology XXIIIrd International Carbohydrate Symposium. Whistler, British Columbia, Canada. July 23, 2006.

S.-Gopalan Sampathkumar, Christopher T. Campbell, Mark B. Jones, M. Adam Meledeo, Jie Fu, Kaoru Hida, Anthony Sheh, Pam Gomatputra, Sean S. Choi, Jean Wang, Mary Wen, Christopher A. Weier, Matthew David, Justin Hanes, and Kevin J. Yarema: Carbohydrate-n-butyrate hybrid prodrugs: Sugar-dependent anti-cancer activity XXIIIrd International Carbohydrate Symposium. Whistler, British Columbia, Canada. July 23, 2006.

Kevin J. Yarema: A systems biology approach to the study of sialic acid metabolism Beckman Young Investigator's Symposium. Newport Beach, California. August 25, 2006. (Invited)

Zhiyun Wang, Zhonghui Sun, & Kevin J. Yarema: Tissue-specific roles for GNE in cell growth Society for Glycobiology 2006 National Meeting. Los Angeles, California. November 15, 2006.

Srinivasa-Gopalan Sampathkumar, Christopher T. Campbell, M. Adam Meledeo, Sean S. Choi, Mathew David, M., Jie Fu, Justin Hanes, & Kevin J. Yarema: Carbohydrate-short chain fatty acid hybrids as anti-cancer prodrugs: The sugar matters Society for Glycobiology 2006 National Meeting. Los Angeles, California. November 15, 2006. (Invited)

Prabhani U. Atukorale, Srinivasa-Gopalan Sampathkumar, Mark B. Jones, Adrienne V. Li, & Kevin J. Yarema: Neural differentiation of human stem cells via metabolic sialic acid engineering Society for Glycobiology 2006 National Meeting. Los Angeles, California. November 15, 2006.

Kevin J. Yarema: Systems biology of glycosylation Chemistry/Biology Interface Symposium Series. University of Maryland, Baltimore County, Maryland. October 18, 2006. (Invited)

Kevin J Yarema: Metabolic oligosaccharide engineering of sialic acid: Links between tissue engineering, stem cells, and cancer Chemistry Department Symposium Series. University of Texas at Austin. January 26, 2007. (Invited)

Kevin J. Yarema: Metabolic oligosaccharide engineering: Developing applications ranging from control of stem cell fate to cancer therapies Biological Chemistry and Chemistry Seminar. Grinnell College. February 21, 2007. (Invited)

Kevin J. Yarema: Metabolic oligosaccharide engineering: Sialic acid-based tools for tissue engineering and cancer research Department of Chemistry Seminar. Wayne State University, Detroit, Michigan. February 28, 2007. (Invited)

Kevin J. Yarema: Metabolic oligosaccharide engineering: Links between stem cells and cancer Department of Biological Engineering Seminar. Massachusetts Institute of Technology. April 12, 2007. (Invited)

Prabhani U. Atukorale, Srinivasa-Gopalan Sampathkumar, Mark B. Jones, Adrienne V. Li, & Kevin J. Yarema: Neural differentiation of human stem cells via metabolic sialic acid engineering The Institute for NanoBiotechnology Spring Symposium. Baltimore, Maryland . April 27, 2007. (Invited)

Christopher T. Campbell, H. Zaidi, Jie Fu, Christopher Weier, S.-G. Sampathkumar, K.-W. Li, Betty M. Tyler, Mark B. Jones, Justin Hanes, Kevin J. Yarema, and Henry J. Brem: Treatment of CNS tumors with N-acetylmannosamine tetrabutyrate 2007 American Association of Neurological Surgeons Annual Meeting. Washington, D.C.. April 15, 2007.

Udayanath Aich; Christopher T. Campbell; Srinivasa-Gopalan Sampathkumar; Christopher Weier; Sean S. Choi; Adam M. Meledeo; Francisco Contijoch; Kevin J. Yarema: Regiospecific attachment of short chain fatty acid (SCFA) groups to ‘core’ amino sugars decouples metabolic flux from toxicity Society for Glycobiology 2007 National Meeting. Boston, Massachusetts. November 11, 2006.

Christopher T. Campbell; Noha Elmouelhi; Christopher A. Weier; M. Adam Meledeo; Udayanath Aich; Jean J. Wang; Mary M. Wen ; Srinivasa-Gopalan Sampathkumar; and Kevin J. Yarema: SCFA-monosaccharide analogs: New tools to deconvolute the influence of HDACi and NF-ęB over invasion in metastatic breast cancer cells  Society for Glycobiology 2007 National Meeting. Boston, Massachusetts. November 11, 2007.

Prabhani U. Atukorale; S.-Gopalan Sampathkumar; Pao-Lin Che; Anshu Sarje; Udayanath Aich; and Kevin J. Yarema: Development of novel tissue engineering technologies: Metabolic engineering of thiol groups into the surface sialic acids of human stem cells Society for Glycobiology 2007 National Meeting. Boston, Massachusetts. November 11, 2007.

Udayanath Aich; Christopher T. Campbell; Srinivasa-Gopalan Sampathkumar; Christopher Weier; Sean S. Choi; Adam M. Meledeo; Francisco Contijoch; Kevin J. Yarema: Regiospecific attachment of short chain fatty acid (SCFA) groups to ‘core’ amino sugars decouples metabolic flux from toxicity 2007 Midwest Carbohydrate and Glycobiology Symposium. Ohio State University, Columbus, Ohio. October 05, 2007.

Yarema, K.J.: Chemical glycobiology: Control of pro-invasive oncogenes in metastatic breast cancer cells with hexosamine analogs 2007 Midwest Carbohydrate and Glycobiology Symposium. Ohio State University, Columbus, Ohio. October 06, 2007. (Invited)

Zhiyun Wang, Anshu Sarje, Pao-lin Che and Kevin J. Yarema: Gangliosides govern signaling networks activated in human embryonic cells by moderate strength static magnetic field (SMF) exposure Society for Glycobiology 2007 National Meeting. Boston, Massachusetts. November 11, 2007.

Prabhani U. Atukorale; S.-Gopalan Sampathkumar; Pao-Lin Che; Anshu Sarje; Udayanath Aich; and Kevin J. Yarema: Development of novel tissue engineering technologies: Metabolic engineering of thiol groups into the surface sialic acids of human stem cells Johns Hopkins Brain Science Institute - 2007 Fall Symposium. Baltimore, Maryland. December 14, 2007.

Zhiyun Wang, Anshu Sarje, Pao-lin Che and Kevin J. Yarema: Static magnetic fields (SMF) activate signaling networks in human embryonic cell leading to expression of oligodendrocyte markers Johns Hopkins Brain Science Institute - 2007 Fall Symposium. Baltimore, Maryland. December 14, 2007.

Udayanath Aich, Christopher T. Campbell, S-Gopalan Sampathkumar, Noha Elmouelhi, M. Adam Meledeo, Francisco Contijoch, & Kevin J. Yarema: Design of SCFA-ManNAc hybrid molecules for the selective control of sialic acid biosynthesis and toxicity Division of Carbohydrate Chemistry, The 235th ACS National Meeting. New Orleans, LA. April 06, 2008.

Kevin J. Yarema: Combined effects of magnetic exposure, interleukin-6 signaling, and ganglioside regulation on stem cell differentiation Department of Biology Seminar. The Johns Hopkins University, Baltimore, MD. March 06, 2008. (Invited)

Udayanath Aich, M. Adam Meledeo, Jie Fu, Justin Hanes, & Kevin J. Yarema: Encapsulation of SCFA-hexosamine prodrugs in degradable polymers and formulation into nanoparticles for controlled release and cancer targeting The Institute for NanoBiotechnology Spring Symposium, The Johns Hopkins University. Baltimore, MD. May 02, 2008.

Jian Du, Pao-Lin Che, Zhiyun Wang, Udayanath Aich, & Kevin J Yarema: Electrospun nanofibers enhance glycoengineered cell adhesion The Institute for NanoBiotechnology Spring Symposium, The Johns Hopkins University. Baltimore, MD. May 02, 2008.

Kevin J. Yarema: Metabolic glycoengineering: Steps towards the construction of an artificial stem cell niche National Institutes of Health Glycosciences Day. Bethesda, MD. May 09, 2008. (Invited)

M. Adam Meledeo, Noha Elmouelhi, Christopher T. Campbell, & Kevin J. Yarema: Differential effects of tri-O-butyl N-acetyl sugar analogs on cancer progression pathways National Institutes of Health Glycosciences Day. Bethesda, MD. May 09, 2008.

Prabhani U. Atukorale, S-Gopalan Sampathkumar, Pao-Lin Che, Anshu Sarje, Udayanath Aich, & Kevin J. Yarema: Development of novel tissue engineering technologies: Metabolic engineering of thiol groups into the surface sialic acids of human stem cells National Institutes of Health Glycosciences Day. Bethesda, MD. May 09, 2008.

Udayanath Aich, Christopher T. Campbell, S-Gopalan Sampathkumar, Christopher A. Weier, Sean S. Choi, M. Adam Meledeo, Fransico Contijoch, & Kevin J. Yarema: Regiospecific attachment of short chain fatty acid (SCFA) groups to ‘core’ amino sugars decouples metabolic flux from toxicity National Institutes of Health Glycosciences Day. Bethesda, MD. May 09, 2008.

Udayanath Aich, S-Gopalan Srinivasa, M. Adam Meledeo, Hargun S. Khanna, Christopher T. Campbell, & Kevin J. Yarema: Insights into esterase processing and anti-cancer properties of SCFA-hexosamine analogs obtained through AutoDock modeling NIH Chemical Biology Symposium. Bethesda, MD. August 16, 2008.

Kevin J. Yarema: Metabolic glycoengineering – developing new tools for the modification of glycans in living cells. Synthetic Biology Workshop, University of Groningen Centre for Synthetic Biology. The Netherlands. November 07, 2008. (Invited)

Jian Du, Pao-Lin Che, Zhiyun Wang, Udayanath Aich, Rohan R. Agrawal, & Kevin J. Yarema: Exploiting sialic acid-displayed thiols for tissue engineering Society for Glycobiology 2008 National Meeting. Dallas, TX. November 12, 2008.

M. Adam Meledeo, Kyle J. Price, Mike Sheng, Nina Xu, Udayanath Aich, & Kevin J. Yarema: Treatment of a mouse cancer model with 3,4,6-O-Bu3ManNAc: understanding how tri-O-butanoyl ManNAc analogs drive apoptosis Society for Glycobiology 2008 National Meeting. Dallas, TX. November 12, 2008.

Udayanth Aich, Raja Srinivasa, M. Adam Meledeo, Hargun S. Khanna, Christopher T. Campbell, & Kevin J. Yarema: Insights into esterase processing and anti-cancer properties of SCFA-hexosamine analogs obtained through AutoDock modeling Society for Glycobiology 2008 National Meeting. Dallas, TX. November 12, 2008.

Venkata D. P. Paruchuri, Noha Elmouelhi, Udayanath Aich, M. Adam Meledeo, Christopher T. Campbell, & Kevin J. Yarema: Hexosamines as scaffolds for drug discovery: Exploration of the cellular effects of acylated ManNAc, GlcNAc, and GalNAc analogs Society for Glycobiology 2008 National Meeting. Dallas, TX. November 12, 2008.

Metabolic glycoengineering: Developing tools to modify cell surface chemistry in living cells Department of Cell Biology Seminar Series. Baltimore, MD. February 05, 2009. (Invited)

Kevin J. Yarema: Metabolic glycoengineering: Developing tools to modify cell surface chemistry in living cells Baltimore-Washington Glycobiology Interest Group. Baltimore, MD. February 10, 2009. (Invited)

Kevin J. Yarema: Sugar-based drug discovery: The hexosamine platform Carbohydrates Gordon Research Conference. The Tilton School,Tilton, New Hampshire. June 18, 2009. (Invited)

Jian Du, Pao-Lin Che, Zhi-Yun Wang, Udayanath Aich, and Kevin J. Yarema: Electrospun nanofibers enhance glycoengineered cell adhesion The Institute for NanoBiotechnology Spring Symposium. The Johns Hopkins University, Baltimore, MD. May 02, 2009.

Jian Du, Elaine Tan, Pao-Lin Che, Zhi-Yun Wang, and Kevin J. Yarema: Electrospun nanofibers for neural promotion (Poster #27) The Institute for NanoBiotechnology Spring Symposium-Nanoscience for Neuroscience & Neurosurgery. The Johns Hopkins University, Baltimore, MD. May 18, 2009.

Jian Du and Kevin J. Yarema: Exploring stem cell and cancer cell biology with sugar analogs NIH/FDA Glycoscience Research Day. Bethesda, MD. May 28, 2009. (Invited)

Jian Du, Pao-Lin Che, Elaine Tan, Zhi-Yun Wang, and Kevin J. Yarema: Exploring stem cell biology and tissue engineering with sugar analogs NIH/FDA Glycoscience Research Day . Bethesda, MD . May 28, 2009. Poster presentation and Abstract #32

Pao-Lin Che, Jian Du, Elaine Tan, Zhi-Yun Wang, and Kevin J. Yarema: Studies on the combined effects of sugar analogs and three dimensional growth substrates in modulating immune and cancer cell behavior NIH/FDA Glycoscience Research Day . Bethesda, MD . May 28, 2009. Poster presentation and Abstract #19; winner of “Outstanding Poster” award

Professional Activities

Consultant for BioAbility, LLC (Research Triangle Park, NC), StemNetics (Hanover, PA), and AMRi (Towson, MD).

Small group facilitator for the Introduction to Research Ethics seminar for JHMI Graduate Students (Fall, 2007 and Spring, 2008)

Ad Hoc reviewer for research grants for the National Science Foundation, Barry M. Goldwater Scholarship for Undergraduates, and internal research awards in the School of Chemical & Biomedical Engineering, Nanyang Technological University, Singapore

Ad Hoc reviewer for research grants for the National Science Foundation, and the Israel Science Foundation's FIRST (Focal Initiatives in Research in Science and Technology) program.

Grant application review for the Research Corporation's Science Advancement Programs

Ad Hoc reviewer for research grants for the National Science Foundation, and the Israel Science Foundation's FIRST (Focal Initiatives in Research in Science and Technology) program.

Special Emphasis Panel (SEP) for the NIBIB Career Development, Institutional Training Grant, Residency Supplement Review, ZEB1 OSR B, June 29-30, 2005.

Ad hoc member of the National Institute of Biomedical Imaging and Bioengineering review panel (headed by Manana Sukhareva, Ph.D., met on June 19, 2006)

Ad hoc reviewer fo the NIH Special Emphasis Panel/Scientific Review Group 2008/01 for ZRG1 BCMB-A (02) S - Synthetic and Biological Chemistry, October 3-4, 2007.

NIH Special Emphasis Panel/Scientific Review Group 2009/05 ZHD1 DSR-Z (04) meeting, scheduled for February 26, 2009

Editor for the "Handbook of Carbohydrate Engineering" published on May 27, 2005 by the CRC Press (Francis & Taylor, Boca Raton, FL).

Reviewed manuscripts under consideration for publication in ACS Chemical Biology, Acta Biomaterialia, Biochemistry, Biochimica et Biophysica Acta, Bioconjugate Chemistry, Biomacromolecules, Biomaterials, Bioorganic & Medicinal Chemistry, Biotechnology and Bioengineering, Biotechnology Progress, Cell Metabolism, Chemistry & Biology, Current Bioactive Compounds, Expert Opinion on Drug Discovery, FEBS Letters, FEBS Journal, Genome Biology, Glycobiology, Indian Journal of Medical Research, Journal of Biotechnology, Journal of Environmental Engineering, Journal of Medicinal Chemistry, Journal of Molecular Biology, Journal of Organic Chemistry, Journal of the American Chemical Society, Medicinal Research Reviews, Molecular Biosystems, Nature Biotechnology, Nature Cell Biology, Nature Chemical Biology, PLOS ONE, and Regenerative Medicine

Serves on the Editorial Board of "Current Bioactive Compounds"

Served on the Westgate Scholar selection committee (April 2007).

Member of the Health Professions Committee (April 2007 to present).

Member of the Whiting School of Engineering Graduate Committee (2007 to 2010)

Member of the Committee on Study Abroad of The Johns Hopkins Unversity (Fall 2007 - Summer 2009)

Research Interests

Carbohydrate engineering; Cell surface engineering; Glycosylation related diseases; Sialic acid biosynthetic pathway; Tissue engineering; Cell adhesion; Impact of glycosylation on stem cell fate; Development of therapies for HIBM (hereditary inclusion body myopathy); Study of the cellular and biomedical effects of moderate strength static magnetic fields

Publications: All Publications

  1. Yarema, K.J.. "Comparative toxicities and mutagenicities of platinum anticancer drugs". Drug Information Journal 29 (1995):1633S-1644S (Published)
  2. Paige, L.A., Yarema, K.J., Rink, S., Essigmann, J.M., & Croy, R.G.. "Programmable therapeutics: A strategy that can selectively direct the cytotoxic effects of anticancer compounds to tumor cells. ". Massachusetts Biotechnology Council 4th Annual Symposium, at MIT, Cambridge, MA (1995) (Published)
  3. Yarema, K.J., Mahal, L.K., & Bertozzi, C.R. . "Engineering novel cell surface chemistry using the pathways for oligosaccharide biosynthesis". Glycobiology 6 (1996):754 (Published)
  4. Mahal, L.K., Yarema, K.J., & Bertozzi, C.R.. "Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis.". Science 276 (1997):1125-1128 (Published)
  5. Yarema, K.J., Mahal. L.K., & Bertozzi, C.R.. "Applications of unnatural oligosaccharide biosynthesis to selective drug delivery.". 213th ACS National Meeting at San Fransisco, CA, April 13-17, 1997 (1997) (Published)
  6. Yarema, K. J., Mahal, L.K., Bruehl, R. E. Rodriguez, E.C., & Bertozzi, C.R. . "Metabolic delivery of ketone groups to sialic acid residues. Application to cell surface engineering. ". J. Biol. Chem. 273 (1998):31168-31179 (Published)
  7. Yarema, K.J. & Bertozzi, C.R. . "Chemical approaches to glycobiology and emerging carbohydrate-based therapeutic agents". Curr. Opin. Chem. Biol 2 (1998):49-61 (Published)
  8. Mahal, L.K., Yarema, K.J., Lemieux, G.A., & Bertozzi, C.R. "Chemical approaches to glycobiology: Engineering cell surface sialic acids for tumor targeting ." Sialobiology and Other Novel Forms of Glycosylation. Gakushin Publishing Company, 1999. 273-280. (Published)
  9. Essigmann, John M.; Croy, Robert G.; Yarema, Kevin J.; and Morningstar, Marshall. "Programmable genotoxic agents and uses therefor. ". United States Patent 5,879,917. (1999) (Published)
  10. Lemieux, G.A., Yarema, K.J., Jacobs, C.L., & Bertozzi, C.R.. "Exploiting differences in sialoside expression for selective targeting of MRI contrast reagents". J. Am. Chem. Soc. 121 (1999):4278-4279 (Published)
  11. Jacobs, C.L., Yarema, K.J., Mahal., L.K., Nauman, D.A., Charters, N., & Bertozzi, C.R. . "Metabolic labeling of glycoproteins with chemical tags through unnatural sialic acid biosynthesis." Meth. Enzymol. , 2000. 260-275. (Published)
  12. Bertozzi, Carolyn; Yarema, Kevin J.; Mahal; Lara K. "Glycoconjugates and methods. ". United States Patent 6,075,134 (2000) (Published)
  13. Yarema, K.J., Goon, S., & Bertozzi, C.R. . "Metabolic selection of cells with glycosylation defects found in human disease.". International Carbohydrate Symposium at Hamburg, Germany, August 26-29, 2000. (2000) (Published)
  14. Jacobs, C.L., Goon, S., Yarema, K.J., Hinderlich, S., Hang, H.C., Chai, D.H., and Bertozzi, C.R.. "Exploration of the mechanism for substrate selection by the sialic acid pathway". Biochemistry 40 (2001):12864-12874 (Published)
  15. Yarema, K.J., Goon, S., & Bertozzi., C.R. . "Metabolic selection of glycosylation defects in human cells". Nature Biotechnology 6 (2001):553-558 (Published)
  16. Yarema, K.J. "New directions in carbohydrate engineering: A metabolic substrate-based approach to modify the cell surface display of sialic acids". Biotechniques. 31 (2001):384-393 (Published)
  17. Yarema, K.J. & Bertozzi, C.R. "Characterizing glycosylation defects". GenomeBiology REVIEWS004 (2001):004.1-10 (Published)
  18. Yarema, K.J., Goon, S., & Bertozzi, C.R. . "Metabolic selection of cells with glycosylation defects found in human disease". 4th Annual San Diego Glycobiology Symposium at San Diego, CA, January 12 and 13, 2001. (2001) (Published)
  19. Yarema, K.J. "A metabolic substrate-based approach to engineering new chemical reactivity into cellular sialoglycoconjugates." Cell Engineering, Volume 3. Kluwer Academic Publishers, 2002. 171-196. (Published)
  20. Chen, H., Jones, M.B., Teng, H., Rhee, J.K., Baskaran, G., Lahar, N., & Yarema, K.J., . " Evaluation of the metabolic flux of acetylated ManNAc analogs through the sialic acid biosynthetic pathway.". Glycobiology 12. 11 (2002):700 (Published)
  21. Tong, L., Baskaran, G., Jones, M.B., Rhee, J.K., and Yarema, K.J. "Glycosylation changes as disease markers." Bioengineering and Genetic Engineering Reviews. Intercept Scientific Technical Medical Publishers, 2003. 199-246. (Published)
  22. Luchansky, S.J., Yarema, K.J., Takahashi, S., Bertozzi, C.R. "GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism". J. Biol. Chem. 278 (2003):8035-8042 (Published)
  23. Viswanathan, K., Lawrence, S., Hinderlich, S., Yarema, K.J., Lee, Y.C, & Betenbaugh, M. J.. "Engineering the sialic acid synthetic activity into insect cells: Identifying metabolic bottlenecks and devising strategies to overcome them". Biochemistry 42 (2003):15215-15225 (Published)
  24. Kim, E.J., Rhee, J.K., Sampathkamur, S. G., Jones, M.B., Baskaran, G. & Yarema, K.J.. "Characterization of the apoptotic effects of N-acetylmannosamine (ManNAc) analogs in Jurkat (human T-lymphoma-derived) cells". Glycobiology 13 (2003):856 (Published)
  25. Chen, H., Sun, Z., & Yarema, K.J.. "Establishing a correlation between mutant forms of GNE found in HIBM and the expression of neurotrophic factors". Glycobiology 13. 11 (2003):901 (Published)
  26. Sampathkamur, S. G., Jones, M. B., & Yarema, K.J .. "Engineering of cell surface sialic acid. Synthesis of analogs of 2-N-Acylamino-2-deoxy-á,â-D-mannopyranose and studies on their efficacy of uptake and toxicity.". Glycobiology 13. 11 (2003):891 (Published)
  27. Murrell, M.P., Yarema, K.J., & Levchenko, A.. "The systems biology of glycosylation". ChemBioChem 5 (2004):1334-1347 (Published)
  28. Kim, E. J., Sampathkamur, S.-G., Jones, M. B., Rhee, J. K., Baskaran, G., Goon, S., and Yarema, K. J.. "Characterization of the metabolic flux and apoptotic effects of O-hydroxyl and N-acyl-modified N-acetylmannosamine (ManNAc) analogs in Jurkat (human T-lymphoma-derived) cells". J. Biol. Chem. 279 (2004):18342-18352 (Published)
  29. Jones, M.B., Teng, H., Rhee, J.K., Baskaran, G., Lahar, N., and Yarema, K.J.. "Characterization of the cellular uptake and metabolic conversion of acetylated N-acetylmannosamine (ManNAc) analogs to sialic acids". Biotechnol Bioeng 85 (2004):394-405 (Published)
  30. Kim, E. J., Jones, M. B., Rhee, J. K., Sampathkumar, S.-G., Yarema, K. J. ") Establishment of ManNAc analog-resistant cell lines as improved hosts for sialic acid engineering applications". Biotechnol Prog 20 (2004):1674-1682 (Published)
  31. Hinderlich, S., Salama, I., Eisenberg, I., Potikha, T., Manteya, L., Yarema, K.J., Horstkorte, R., Argov, A., Sadeh, M., Reutter, W., & Mitrani-Rosenbaum, S. "The M712T mutant of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase results in reduced enzyme activities but not in altered overall cellular sialylation in hereditary inclusion body myopathy". FEBS Lett 566 (2004):105-109 (Published)
  32. Sampathkumar, S.G., Jones, M.B., and Yarema, K.J. . "Substrate based metabolic engineering of cell surface sialic acids: Synthesis and applications of novel N-acylmannosamine analogs possessing pendant thiol groups as metabolic precursors.". Glycobiology 14. 11 (2004):Abstract #126 (Published)
  33. Li, A., Wang, Z., Murrell, M.P., Cameron, B., Baskaran, G., Stamatos, N.M., Mao, H.-Q., and Yarema, K.J. . "The sialic acid biology of human stem cells: Basic steps towards the characterization and manipulation of glycosylation to control their differentiation and proliferation. ". Glycobiology 14. 11 (2004):Abstract #347 (Published)
  34. Jones, M.B., Sampathkumar, S.-G., and Yarema, K.J. . "Monosaccharides provide an efficient delivery method for butyrate, a short chain fatty acid (SCFA) with anti-cancer activity". Glycobiology 14. 11 (2004):Abstract #426 (Published)
  35. Chen, C., Hinderlich, S. and Yarema, K.J. . "Recombinant GNE alters the expression of proteins important for muscle functions and provides insights into the cellular basis of HIBM". Glycobiology 14. 11 (2004):Abstract #440 (Published)
  36. Chen, H., Wang, Z., Sun, Z., Kim, E.K., & Yarema, K.J., . "., Mammalian glycosylation: An overview of carbohydrate biosynthesis." Handbook of Carbohydrate Engineering. CRC Press (Taylor & Francis Group), Boca Raton, FL, 2005. 1-48. (Published)
  37. Murrell, M.P., Yarema, K.J., & Levchenko, A. "Computational modeling of glycosylation." Handbook of Carbohydrate Engineering. CRC Press (Taylor & Francis Group), Boca Raton, FL, 2005. 247-288. (Published)
  38. Sun, Z., & Yarema, K.J. Introduction. Handbook of Carbohydrate Engineering. CRC Press (Taylor & Francis Group), Boca Raton, FL, 2005. v-xxiii. (Published)
  39. Sampathkumar, S. G. & Yarema, K.J.. "Targeting cancer cells with dendrimers". Chem. Biol. 12 (2005):5-6 (Published)
  40. Sun, Z., & Yarema, K.J.. "A Photochemical snapshot of CD22 binding". Nat. Chem. Biol. 1. 2 (2005):69-70 (Published)
  41. Campbell, C.T. & Yarema, K.J.. "Large-scale approaches for glycobiology". Genome Biology 6 (2005):236-244 (Published)
  42. Salama, I., Hinderlich, S., Shlomai, Z., Eisenberg, I., Krause, S., Yarema, K., Argov, Z., Lochmuller, H., Reutter, W., Dabby, R., Sadeh, M., Ben-Bassat, H., Mitrani-Rosenbaum, S.. "No overall hyposialylation in hereditary inclusion body myopathy myoblasts carrying the homozygous M712T GNE mutation". Biochem. Biophys. Res. Commun. (2005):221-226 (Published)
  43. Sampathkumar, S. G., Jones, M.B., Hida, K., Gomutputra, P., Sheh, T. H., & Yarema, K.J. "Design and synthesis of novel SCFA carbohydrate hybrids with anti-cancer properties". American Chemical Society Meeting & Exposition, Washington, DC, USA, August 28 – September 1, 2005 (2005) (Published)
  44. Yarema, K. J. . "Development of therapeutic applications for N-acetylmannosamine (ManNAc) analogues used for the manipulation of sialic acid metabolism.". GLYCO XVIII: The International Symposium on Glycoconjugates (2005) (Published)
  45. Sampathkumar, S.G., Li, A. V., Jones, M.B., Hida, K., & Yarema, K.J. "Metabolic engineering novel adhesive properties into cell surface carbohydrates". Biomedical Engineering Society Baltimore, MD, USA, September 28 - October 1, 2005 (2005):Abstract # 767 (Published)
  46. Sampathkumar, S. G., Campbell, C. T., Li, A. V., Jones, M. B., Sun, Z., Sarje, A., Thakor, N. V. & Yarema, K.J. . "Modulation of cell adhesion or attachment using sialic acid engineering methods". Glycobiology 15. 11 (2005):1210 (Published)
  47. Wang, Z., Sun, Z., & Yarema, K.J.. "GNE is involved in cell growth via modulation of ganglioside metabolism". Glycobiology 15. 11 (2005):1248 (Published)
  48. Sampathkumar, S. G., Jones, M.B., Meledeo, M. A., Hida, K., Sheh, T. H., Gomutputra, P., & Yarema, K.J. . "Carbohydrate-based small molecules as anti-cancer drugs: Short chain fatty acid-hexosamine hybrids". Glycobiology 15. 11 (2005):1249 (Published)
  49. Sampathkumar, S.-G., Campbell, C.T., Weier, C., & Yarema, K.J. "Short-chain fatty acid-hexosamine cancer prodrugs: The sugar matters!". Drugs of the Future 31. 12 (2006):1099-1116 (Published)
  50. Sampathkumar, S.-G., A. V. Li, M. B. Jones, Z. Sun & K.J. Yarema. "Metabolic installation of thiols into sialic acid modulates adhesion and stem cell biology ". Nat. Chem. Biol. 2. 3 (2006):149-152 (Published)
  51. Sampathkumar, S.-G., A. V. Li, & K.J. Yarema. "Sialic Acid and the Central Nervous System: Perspectives on Biological Functions, Detection and Imaging Methods, and Manipulation ". Curr Drug Targets CNS Neurol Disord 5 (2006):425-440 (Published)
  52. Wang, Z., Sun, Z., Li, A.V., & Yarema, K.J. "Roles for gne outside of sialic acid biosynthesis: modulation of sialyltransferase and BiP expression, GM3 and GD3 biosynthesis, proliferation and apoptosis, and ERK1/2 phosphorylation". J. Biol. Chem. 281 (2006):27016-27028 (Published)
  53. Sampathkumar, S.-G., Jones, M.B., Meledeo, M.A., Campbell, C.T., Choi, S.S., Hida, K., Gomutputra, P., Sheh, A., Gilmartin, T., Head, S. R., & Yarema, K.J. "Targeting glycosylation pathways and the cell cycle: Sugar-dependent activity of butyrate-carbohydrate cancer prodrugs". Chemistry & Biology 13. 12 (2006):1265-1275 (Published)
  54. Sampathkumar, S.-G., Jones, M.B., & Yarema, K.J. . "Metabolic expression of thiol-derivatized sialic acids on the cell surface and their quantitative estimation by flow cytometry". Nature Protocols 1. 4 (2006):1840-1851 (Published)
  55. Sampathkumar, S.-G., Li, A.V., & Yarema, K.J.. "Synthesis of non-natural ManNAc analogs for the expression of thiols on cell surface sialic acids". Nature Protocols 1. 5 (2006):2377-2385 (Published)
  56. Yarema, K. J., Sampathkumar, S.-G., Jones, M. B.,, and Campbell, C.T.. "Short Chain Fatty Acid (SCFA) - Carbohydrate Bifunctional Hybrid Molecules with Novel Anti-cancer Properties ". Application No. 60/683,839 submitted on 24 May 2006 (2006) (Published)
  57. Wang, Z., Sun, Z, & Yarema, K. J. . "Tissue-specific roles for GNE in cell growth". Glycobiology 16 (2006):1116-(abstract #69) (Published)
  58. Sampathkumar, S. -G., Campbell, C. T., Meledeo, M. A., Choi, S. S., David, M., Fu, J., Hanes, J., & Yarema, K. J. . "Carbohydrate-short chain fatty acid hybrids as anti-cancer prodrugs: The sugar matters". Glycobiology 16 (2006):1154-(abstract #262) (Published)
  59. Atukorale, P. U., Sampathkumar, S. -G., Jones, M. B., Li, A.V., & Yarema, K. J. . "Neural differentiation of human stem cells via metabolic sialic acid engineering". Glycobiology 16 (2006):1148-(abstract #231) (Published)
  60. Sampathkumar, S.-G. & Yarema, K.J. . "Chapter 1: Dendrimers in cancer treatment & diagnosis." Nanotechnologies for the Lifesciences - Vol. 06: Nanomaterials for Cancer Diagnosis and Therapy. John Wiley & Sons, Hoboken NJ, 2007. 1-43. (Published)
  61. Campbell, C.T., Sampathkumar, S.-G., & Yarema, K.J. "Metabolic oligosaccharide engineering: perspectives, applications, and future directions". Molecular BioSystems 3 (2007):187-194 (Published)
  62. Varghese, S., Theprungsirikul, P., Sahani, S., Hwang, N., Yarema, K.J., & Elisseeff, J.H. "Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression". Osteoarthritis Cartilage 15. 1 (2007):59-68 (Published)
  63. Daubeuf, S., Aucher, A., Sampathkumar, S.-G., Yarema, K.J. & Hudrisier, D. "Chemical labels metabolically installed into the glycoconjugates of the target cell surface can be used to track lymphocyte/target cell interplay via trogocytosis. Comparisons with PKH and biotin". Immunological Investigations 36 (2007):687-712 (Published)
  64. Aich, U., Campbell, C. T., Sampathkumar, S.-G., Weier, C., Choi, S. S., Meledeo, M. A., Contijoch, F., & Yarema, K. J.. "Regiospecific attachment of short chain fatty acid (SCFA) groups to 'core' amino sugars decouples metabolic flux from toxicity". Glycobiology 17. 11 (2007):1267-(abstract #247) (Published)
  65. Atukorale, P. U., Sampathkumar, S.-G., Che, P.-L., Sarje, A., Aich, U., & Yarema, K. Y.. "Development of novel tissue engineering technologies: Metabolic engineering of thiol groups into the surface sialic acids of human stem cells". Glycobiology 17. 11 (2007):1240-(abstract # 140) (Published)
  66. Wang, Z., Sarje, A., Che, P.-L., & Yarema, K. J.. "Gangliosides govern signaling networks activated in human embryonic cells by moderate strength static magnetic field (SMF) exposure". Glycobiology 17. 11 (2007):1244-(abstract #156) (Published)
  67. Campbell, C. T., Elmouelhi, N., Weier, C. A., Meledeo, M. A., Aich, U., Wang, J. J., Wen, M. M., Sampathkumar, S.-G., Yarema, K. J.. "SCFA-monosaccharide analogs: New tools to deconvolute the influence of HDACi and NF-ęB over invasion in metastatic breast cancer cells ". Glycobiology 17. 11 (2007):1261-(abstract #224) (Published)
  68. Meledeo, M.A. & Yarema, K.J. "Glycan biosynthesis and glycosylation in mammals (Available online at 10.1002/9780470048672.wecb190)." Wiley Encyclopedia of Chemical Biology. John Wiley & Sons, Inc., 2008. 1-16. (Published)
  69. Campbell, C.T., Aich, U., Weier, C.A, Wang, J.J., Choi, S.S., Wen, M.M., Maisel, K., Sampathkumar, S.-G., & Yarema, K.J. . "Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogs inhibits the mobility of metastatic MDA-MB-231 breast cancer cells". Journal of Medicinal Chemistry 51 (2008):8135-8147 (Published)
  70. Aich, U., & Yarema K.J. "Non-natural sugar analogues: Chemical probes for metabolic oligosaccharide engineering." Glycoscience – Chemistry and Chemical Biology, 2nd Edition. Springer-Verlag, 2008. 2133-2190. (Published)
  71. Kim, E.J., Shin, H.Y., Park, S., Sung, D., Jon, S., Sampathkumar, S.G., Yarema, K.J., Choi, S.Y., and Kim, K. "Electrochemically active, anti-biofouling polymer adlayers on indium-tin-oxide electrodes". Chemical Communications 14 (2008):3543-3545 (Published)
  72. Elmouelhi, N., & Yarema, K.J. "Building on what nature gave us: Engineering cell glycosylation pathways." Biotechnology and Bioengineering Research Trends. Nova Publishers, Hauppauge, NY, 2008. 37-73. (Published)
  73. Aich, U., Campbell, C. T., Elmouelhi, Weier, C., Sampathkumar, S.-G., Choi, S. S., & Yarema, K. J.. "Regioisomeric SCFA attachment to hexosamine separates metabolic flux from cytotoxicity and MUC1 suppression". ACS Chemical Biology 3 (2008):230-240 (Published)
  74. Meledeo, M. A., Price, K. J., Sheng, M., Xu, N., Aich, U., & Yarema, K.J. . "Treatment of a mouse cancer model with 3,4,6-O-Bu3ManNAc: understanding how tri-O-butanoyl ManNAc analogs drive apoptosis". Glycobiology 18. 11 (2008):962-(abstract #89) (Published)
  75. Aich, U., Raja Srinivasa, R., Meledeo, M. A., Khanna, H. S., Campbell, C. T., & Yarema, K.J. . "Insights into esterase processing and anti-cancer properties of SCFA-hexosamine analogs obtained through AutoDock modeling". Glycobiology 18. 11 (2008):964-(Abstract #98) (Published)
  76. Paruchuri, V. D. P., Elmouelhi, N., Aich, U., Meledeo, M. A., Campbell, C. T., & Yarema, K.J. . "Hexosamines as scaffolds for drug discovery: Exploration of the cellular effects of acylated ManNAc, GlcNAc, and GalNAc analogs". Glycobiology 18. 11 (2008):997-(Abstract #230). (Published)
  77. Du, J., Che, P.-L, Wang, Z., Aich, U., Agrawal, R.R., & Yarema, K.J. . "Exploiting sialic acid-displayed thiols for tissue engineering ". Glycobiology 18. 11 (2008):997-(Abstract #231). (Published)
  78. Wang, Z., Sarje, A., Che, P., and Yarema, K.J. "Moderate strength (0.23-0.28 T) static magnetic fields (SMF) modulate signaling and differentiation in human embryonic cells". BMC Genomics (2009) (In Press)
  79. Atukorale, P.U., Choi, S.S., Aich, U., Campbell, C.T., Meledeo, M.A., & Yarema, K.J. "Chemical biology of glycosylation: Therapeutic prospects of metabolic oligosaccharide engineering." Small Molecules Targeting Proteins. John Wiley & Sons, 2009. 189-221. (Published)
  80. Aich, U., & Yarema, K. J. "Glycobiology & Immunology." Carbohydrate-Based Vaccines in "The Wiley Series in Drug Discovery and Development". John Wiley & Sons, 2009. (In Press)
  81. Du, J., Meledeo, M. A., Wang, Z., Khanna, H.S., and Yarema, K. J. . "Metabolic glycoengineering: Sialic acid and beyond". Glycobiology (2009) (Accepted)
  82. Meledeo, M.A., Wang., Z., Du., J., and Yarema, K. J. "Mammalian glycan biosynthesis: Building a template for biological recognition." Carbohydrate Recognition: Biological Problems, Methods, and Applications. John Wiley & Sons, Hoboken, NJ, 2009. (Invited Chapter) (In Press)
  83. Wang, Z., Du, J., Che, P.-L., Meledeo, M.A., and Yarema, K.J. . "Hexosamine analogs: From metabolic glycoengineering to drug discovery". Current Opinion in Chemical Biology (2009) (Accepted)
  84. Elmouelhi, N., Aich, U., Paruchuri, V. D. P., Meledeo, M. A., Campbell, C. T., Wang, J. J., Srinivas, R., Khanna, H. S., and Yarema, K. J.. "The hexosamine template – A platform for modulating gene expression and for sugar-based drug discovery". Journal of Medicinal Chemistry (2009):2515-2530 (Published)
  85. Krambeck, F.J., Bennun, S.V., Narang, S., Choi, S., Yarema, K.J., & Betenbaugh, M.J. "A mathematical model to derive N-glycan structures and cellular enzyme activities from mass spectrometric data". Glycobiology (2009):Epub ahead of press-June 8, 2009 (Published)
  86. Aich, U., Meledeo, M.A., Sampathkumar, S.G., Fu, J., Jones, M.B., Weier, C.A., Chung, S.Y., Tang, B.C., Yang, M., Justin Hanes, J., and Yarema, K.J. . "Development of delivery methods for carbohydrate-based drugs: Controlled release of biologically-active short chain fatty acid-hexosamine analogs". Glycoconjugate Journal (2009) (Submitted)
  87. Du, J., Che, P.-L., Wang, Z.-Y., Aich, U., Meledeo, M.A., and Yarema, K.J. . "Electrospun 3D fibrous growth substrates enhance glycoengineered cell adhesion". (2009) (In Preparation)
  88. Wang, Z.-Y., Che, P.-L., and Yarema, K.J. . "Exposure of PC12 cells to static magnetic fields mimics responses to Parkinsons Disease drug candidates". (2009) (In Preparation)

Publications: Abstracts

  1. Meledeo, M. A., Price, K. J., Sheng, M., Xu, N., Aich, U., & Yarema, K.J. . "Treatment of a mouse cancer model with 3,4,6-O-Bu3ManNAc: understanding how tri-O-butanoyl ManNAc analogs drive apoptosis". Glycobiology 18. 11 (2008):962-(abstract #89) (Published)
  2. Aich, U., Raja Srinivasa, R., Meledeo, M. A., Khanna, H. S., Campbell, C. T., & Yarema, K.J. . "Insights into esterase processing and anti-cancer properties of SCFA-hexosamine analogs obtained through AutoDock modeling". Glycobiology 18. 11 (2008):964-(Abstract #98) (Published)
  3. Paruchuri, V. D. P., Elmouelhi, N., Aich, U., Meledeo, M. A., Campbell, C. T., & Yarema, K.J. . "Hexosamines as scaffolds for drug discovery: Exploration of the cellular effects of acylated ManNAc, GlcNAc, and GalNAc analogs". Glycobiology 18. 11 (2008):997-(Abstract #230). (Published)
  4. Du, J., Che, P.-L, Wang, Z., Aich, U., Agrawal, R.R., & Yarema, K.J. . "Exploiting sialic acid-displayed thiols for tissue engineering ". Glycobiology 18. 11 (2008):997-(Abstract #231). (Published)
  5. Aich, U., Campbell, C. T., Sampathkumar, S.-G., Weier, C., Choi, S. S., Meledeo, M. A., Contijoch, F., & Yarema, K. J.. "Regiospecific attachment of short chain fatty acid (SCFA) groups to 'core' amino sugars decouples metabolic flux from toxicity". Glycobiology 17. 11 (2007):1267-(abstract #247) (Published)
  6. Atukorale, P. U., Sampathkumar, S.-G., Che, P.-L., Sarje, A., Aich, U., & Yarema, K. Y.. "Development of novel tissue engineering technologies: Metabolic engineering of thiol groups into the surface sialic acids of human stem cells". Glycobiology 17. 11 (2007):1240-(abstract # 140) (Published)
  7. Wang, Z., Sarje, A., Che, P.-L., & Yarema, K. J.. "Gangliosides govern signaling networks activated in human embryonic cells by moderate strength static magnetic field (SMF) exposure". Glycobiology 17. 11 (2007):1244-(abstract #156) (Published)
  8. Campbell, C. T., Elmouelhi, N., Weier, C. A., Meledeo, M. A., Aich, U., Wang, J. J., Wen, M. M., Sampathkumar, S.-G., Yarema, K. J.. "SCFA-monosaccharide analogs: New tools to deconvolute the influence of HDACi and NF-ęB over invasion in metastatic breast cancer cells ". Glycobiology 17. 11 (2007):1261-(abstract #224) (Published)
  9. Wang, Z., Sun, Z, & Yarema, K. J. . "Tissue-specific roles for GNE in cell growth". Glycobiology 16 (2006):1116-(abstract #69) (Published)
  10. Sampathkumar, S. -G., Campbell, C. T., Meledeo, M. A., Choi, S. S., David, M., Fu, J., Hanes, J., & Yarema, K. J. . "Carbohydrate-short chain fatty acid hybrids as anti-cancer prodrugs: The sugar matters". Glycobiology 16 (2006):1154-(abstract #262) (Published)
  11. Atukorale, P. U., Sampathkumar, S. -G., Jones, M. B., Li, A.V., & Yarema, K. J. . "Neural differentiation of human stem cells via metabolic sialic acid engineering". Glycobiology 16 (2006):1148-(abstract #231) (Published)
  12. Sampathkumar, S. G., Campbell, C. T., Li, A. V., Jones, M. B., Sun, Z., Sarje, A., Thakor, N. V. & Yarema, K.J. . "Modulation of cell adhesion or attachment using sialic acid engineering methods". Glycobiology 15. 11 (2005):1210 (Published)
  13. Wang, Z., Sun, Z., & Yarema, K.J.. "GNE is involved in cell growth via modulation of ganglioside metabolism". Glycobiology 15. 11 (2005):1248 (Published)
  14. Sampathkumar, S. G., Jones, M.B., Meledeo, M. A., Hida, K., Sheh, T. H., Gomutputra, P., & Yarema, K.J. . "Carbohydrate-based small molecules as anti-cancer drugs: Short chain fatty acid-hexosamine hybrids". Glycobiology 15. 11 (2005):1249 (Published)
  15. Sampathkumar, S.G., Jones, M.B., and Yarema, K.J. . "Substrate based metabolic engineering of cell surface sialic acids: Synthesis and applications of novel N-acylmannosamine analogs possessing pendant thiol groups as metabolic precursors.". Glycobiology 14. 11 (2004):Abstract #126 (Published)
  16. Li, A., Wang, Z., Murrell, M.P., Cameron, B., Baskaran, G., Stamatos, N.M., Mao, H.-Q., and Yarema, K.J. . "The sialic acid biology of human stem cells: Basic steps towards the characterization and manipulation of glycosylation to control their differentiation and proliferation. ". Glycobiology 14. 11 (2004):Abstract #347 (Published)
  17. Jones, M.B., Sampathkumar, S.-G., and Yarema, K.J. . "Monosaccharides provide an efficient delivery method for butyrate, a short chain fatty acid (SCFA) with anti-cancer activity". Glycobiology 14. 11 (2004):Abstract #426 (Published)
  18. Chen, C., Hinderlich, S. and Yarema, K.J. . "Recombinant GNE alters the expression of proteins important for muscle functions and provides insights into the cellular basis of HIBM". Glycobiology 14. 11 (2004):Abstract #440 (Published)
  19. Kim, E.J., Rhee, J.K., Sampathkamur, S. G., Jones, M.B., Baskaran, G. & Yarema, K.J.. "Characterization of the apoptotic effects of N-acetylmannosamine (ManNAc) analogs in Jurkat (human T-lymphoma-derived) cells". Glycobiology 13 (2003):856 (Published)
  20. Chen, H., Sun, Z., & Yarema, K.J.. "Establishing a correlation between mutant forms of GNE found in HIBM and the expression of neurotrophic factors". Glycobiology 13. 11 (2003):901 (Published)
  21. Sampathkamur, S. G., Jones, M. B., & Yarema, K.J .. "Engineering of cell surface sialic acid. Synthesis of analogs of 2-N-Acylamino-2-deoxy-á,â-D-mannopyranose and studies on their efficacy of uptake and toxicity.". Glycobiology 13. 11 (2003):891 (Published)
  22. Chen, H., Jones, M.B., Teng, H., Rhee, J.K., Baskaran, G., Lahar, N., & Yarema, K.J., . " Evaluation of the metabolic flux of acetylated ManNAc analogs through the sialic acid biosynthetic pathway.". Glycobiology 12. 11 (2002):700 (Published)
  23. Yarema, K.J., Mahal, L.K., & Bertozzi, C.R. . "Engineering novel cell surface chemistry using the pathways for oligosaccharide biosynthesis". Glycobiology 6 (1996):754 (Published)

Publications: Book Chapters

  1. Atukorale, P.U., Choi, S.S., Aich, U., Campbell, C.T., Meledeo, M.A., & Yarema, K.J. "Chemical biology of glycosylation: Therapeutic prospects of metabolic oligosaccharide engineering." Small Molecules Targeting Proteins. John Wiley & Sons, 2009. 189-221. (Published)
  2. Aich, U., & Yarema, K. J. "Glycobiology & Immunology." Carbohydrate-Based Vaccines in "The Wiley Series in Drug Discovery and Development". John Wiley & Sons, 2009. (In Press)
  3. Meledeo, M.A., Wang., Z., Du., J., and Yarema, K. J. "Mammalian glycan biosynthesis: Building a template for biological recognition." Carbohydrate Recognition: Biological Problems, Methods, and Applications. John Wiley & Sons, Hoboken, NJ, 2009. (Invited Chapter) (In Press)
  4. Meledeo, M.A. & Yarema, K.J. "Glycan biosynthesis and glycosylation in mammals (Available online at 10.1002/9780470048672.wecb190)." Wiley Encyclopedia of Chemical Biology. John Wiley & Sons, Inc., 2008. 1-16. (Published)
  5. Aich, U., & Yarema K.J. "Non-natural sugar analogues: Chemical probes for metabolic oligosaccharide engineering." Glycoscience – Chemistry and Chemical Biology, 2nd Edition. Springer-Verlag, 2008. 2133-2190. (Published)
  6. Elmouelhi, N., & Yarema, K.J. "Building on what nature gave us: Engineering cell glycosylation pathways." Biotechnology and Bioengineering Research Trends. Nova Publishers, Hauppauge, NY, 2008. 37-73. (Published)
  7. Sampathkumar, S.-G. & Yarema, K.J. . "Chapter 1: Dendrimers in cancer treatment & diagnosis." Nanotechnologies for the Lifesciences - Vol. 06: Nanomaterials for Cancer Diagnosis and Therapy. John Wiley & Sons, Hoboken NJ, 2007. 1-43. (Published)
  8. Chen, H., Wang, Z., Sun, Z., Kim, E.K., & Yarema, K.J., . "., Mammalian glycosylation: An overview of carbohydrate biosynthesis." Handbook of Carbohydrate Engineering. CRC Press (Taylor & Francis Group), Boca Raton, FL, 2005. 1-48. (Published)
  9. Murrell, M.P., Yarema, K.J., & Levchenko, A. "Computational modeling of glycosylation." Handbook of Carbohydrate Engineering. CRC Press (Taylor & Francis Group), Boca Raton, FL, 2005. 247-288. (Published)
  10. Sun, Z., & Yarema, K.J. Introduction. Handbook of Carbohydrate Engineering. CRC Press (Taylor & Francis Group), Boca Raton, FL, 2005. v-xxiii. (Published)
  11. Tong, L., Baskaran, G., Jones, M.B., Rhee, J.K., and Yarema, K.J. "Glycosylation changes as disease markers." Bioengineering and Genetic Engineering Reviews. Intercept Scientific Technical Medical Publishers, 2003. 199-246. (Published)
  12. Yarema, K.J. "A metabolic substrate-based approach to engineering new chemical reactivity into cellular sialoglycoconjugates." Cell Engineering, Volume 3. Kluwer Academic Publishers, 2002. 171-196. (Published)
  13. Jacobs, C.L., Yarema, K.J., Mahal., L.K., Nauman, D.A., Charters, N., & Bertozzi, C.R. . "Metabolic labeling of glycoproteins with chemical tags through unnatural sialic acid biosynthesis." Meth. Enzymol. , 2000. 260-275. (Published)
  14. Mahal, L.K., Yarema, K.J., Lemieux, G.A., & Bertozzi, C.R. "Chemical approaches to glycobiology: Engineering cell surface sialic acids for tumor targeting ." Sialobiology and Other Novel Forms of Glycosylation. Gakushin Publishing Company, 1999. 273-280. (Published)

Publications: Journals

  1. Wang, Z., Sarje, A., Che, P., and Yarema, K.J. "Moderate strength (0.23-0.28 T) static magnetic fields (SMF) modulate signaling and differentiation in human embryonic cells". BMC Genomics (2009) (In Press)
  2. Du, J., Meledeo, M. A., Wang, Z., Khanna, H.S., and Yarema, K. J. . "Metabolic glycoengineering: Sialic acid and beyond". Glycobiology (2009) (Accepted)
  3. Wang, Z., Du, J., Che, P.-L., Meledeo, M.A., and Yarema, K.J. . "Hexosamine analogs: From metabolic glycoengineering to drug discovery". Current Opinion in Chemical Biology (2009) (Accepted)
  4. Elmouelhi, N., Aich, U., Paruchuri, V. D. P., Meledeo, M. A., Campbell, C. T., Wang, J. J., Srinivas, R., Khanna, H. S., and Yarema, K. J.. "The hexosamine template – A platform for modulating gene expression and for sugar-based drug discovery". Journal of Medicinal Chemistry (2009):2515-2530 (Published)
  5. Krambeck, F.J., Bennun, S.V., Narang, S., Choi, S., Yarema, K.J., & Betenbaugh, M.J. "A mathematical model to derive N-glycan structures and cellular enzyme activities from mass spectrometric data". Glycobiology (2009):Epub ahead of press-June 8, 2009 (Published)
  6. Aich, U., Meledeo, M.A., Sampathkumar, S.G., Fu, J., Jones, M.B., Weier, C.A., Chung, S.Y., Tang, B.C., Yang, M., Justin Hanes, J., and Yarema, K.J. . "Development of delivery methods for carbohydrate-based drugs: Controlled release of biologically-active short chain fatty acid-hexosamine analogs". Glycoconjugate Journal (2009) (Submitted)
  7. Du, J., Che, P.-L., Wang, Z.-Y., Aich, U., Meledeo, M.A., and Yarema, K.J. . "Electrospun 3D fibrous growth substrates enhance glycoengineered cell adhesion". (2009) (In Preparation)
  8. Wang, Z.-Y., Che, P.-L., and Yarema, K.J. . "Exposure of PC12 cells to static magnetic fields mimics responses to Parkinsons Disease drug candidates". (2009) (In Preparation)
  9. Campbell, C.T., Aich, U., Weier, C.A, Wang, J.J., Choi, S.S., Wen, M.M., Maisel, K., Sampathkumar, S.-G., & Yarema, K.J. . "Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogs inhibits the mobility of metastatic MDA-MB-231 breast cancer cells". Journal of Medicinal Chemistry 51 (2008):8135-8147 (Published)
  10. Kim, E.J., Shin, H.Y., Park, S., Sung, D., Jon, S., Sampathkumar, S.G., Yarema, K.J., Choi, S.Y., and Kim, K. "Electrochemically active, anti-biofouling polymer adlayers on indium-tin-oxide electrodes". Chemical Communications 14 (2008):3543-3545 (Published)
  11. Aich, U., Campbell, C. T., Elmouelhi, Weier, C., Sampathkumar, S.-G., Choi, S. S., & Yarema, K. J.. "Regioisomeric SCFA attachment to hexosamine separates metabolic flux from cytotoxicity and MUC1 suppression". ACS Chemical Biology 3 (2008):230-240 (Published)
  12. Campbell, C.T., Sampathkumar, S.-G., & Yarema, K.J. "Metabolic oligosaccharide engineering: perspectives, applications, and future directions". Molecular BioSystems 3 (2007):187-194 (Published)
  13. Varghese, S., Theprungsirikul, P., Sahani, S., Hwang, N., Yarema, K.J., & Elisseeff, J.H. "Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression". Osteoarthritis Cartilage 15. 1 (2007):59-68 (Published)
  14. Daubeuf, S., Aucher, A., Sampathkumar, S.-G., Yarema, K.J. & Hudrisier, D. "Chemical labels metabolically installed into the glycoconjugates of the target cell surface can be used to track lymphocyte/target cell interplay via trogocytosis. Comparisons with PKH and biotin". Immunological Investigations 36 (2007):687-712 (Published)
  15. Sampathkumar, S.-G., Campbell, C.T., Weier, C., & Yarema, K.J. "Short-chain fatty acid-hexosamine cancer prodrugs: The sugar matters!". Drugs of the Future 31. 12 (2006):1099-1116 (Published)
  16. Sampathkumar, S.-G., A. V. Li, M. B. Jones, Z. Sun & K.J. Yarema. "Metabolic installation of thiols into sialic acid modulates adhesion and stem cell biology ". Nat. Chem. Biol. 2. 3 (2006):149-152 (Published)
  17. Sampathkumar, S.-G., A. V. Li, & K.J. Yarema. "Sialic Acid and the Central Nervous System: Perspectives on Biological Functions, Detection and Imaging Methods, and Manipulation ". Curr Drug Targets CNS Neurol Disord 5 (2006):425-440 (Published)
  18. Wang, Z., Sun, Z., Li, A.V., & Yarema, K.J. "Roles for gne outside of sialic acid biosynthesis: modulation of sialyltransferase and BiP expression, GM3 and GD3 biosynthesis, proliferation and apoptosis, and ERK1/2 phosphorylation". J. Biol. Chem. 281 (2006):27016-27028 (Published)
  19. Sampathkumar, S.-G., Jones, M.B., Meledeo, M.A., Campbell, C.T., Choi, S.S., Hida, K., Gomutputra, P., Sheh, A., Gilmartin, T., Head, S. R., & Yarema, K.J. "Targeting glycosylation pathways and the cell cycle: Sugar-dependent activity of butyrate-carbohydrate cancer prodrugs". Chemistry & Biology 13. 12 (2006):1265-1275 (Published)
  20. Sampathkumar, S.-G., Jones, M.B., & Yarema, K.J. . "Metabolic expression of thiol-derivatized sialic acids on the cell surface and their quantitative estimation by flow cytometry". Nature Protocols 1. 4 (2006):1840-1851 (Published)
  21. Sampathkumar, S.-G., Li, A.V., & Yarema, K.J.. "Synthesis of non-natural ManNAc analogs for the expression of thiols on cell surface sialic acids". Nature Protocols 1. 5 (2006):2377-2385 (Published)
  22. Sampathkumar, S. G. & Yarema, K.J.. "Targeting cancer cells with dendrimers". Chem. Biol. 12 (2005):5-6 (Published)
  23. Sun, Z., & Yarema, K.J.. "A Photochemical snapshot of CD22 binding". Nat. Chem. Biol. 1. 2 (2005):69-70 (Published)
  24. Campbell, C.T. & Yarema, K.J.. "Large-scale approaches for glycobiology". Genome Biology 6 (2005):236-244 (Published)
  25. Salama, I., Hinderlich, S., Shlomai, Z., Eisenberg, I., Krause, S., Yarema, K., Argov, Z., Lochmuller, H., Reutter, W., Dabby, R., Sadeh, M., Ben-Bassat, H., Mitrani-Rosenbaum, S.. "No overall hyposialylation in hereditary inclusion body myopathy myoblasts carrying the homozygous M712T GNE mutation". Biochem. Biophys. Res. Commun. (2005):221-226 (Published)
  26. Sampathkumar, S. G., Jones, M.B., Hida, K., Gomutputra, P., Sheh, T. H., & Yarema, K.J. "Design and synthesis of novel SCFA carbohydrate hybrids with anti-cancer properties". American Chemical Society Meeting & Exposition, Washington, DC, USA, August 28 – September 1, 2005 (2005) (Published)
  27. Murrell, M.P., Yarema, K.J., & Levchenko, A.. "The systems biology of glycosylation". ChemBioChem 5 (2004):1334-1347 (Published)
  28. Kim, E. J., Sampathkamur, S.-G., Jones, M. B., Rhee, J. K., Baskaran, G., Goon, S., and Yarema, K. J.. "Characterization of the metabolic flux and apoptotic effects of O-hydroxyl and N-acyl-modified N-acetylmannosamine (ManNAc) analogs in Jurkat (human T-lymphoma-derived) cells". J. Biol. Chem. 279 (2004):18342-18352 (Published)
  29. Jones, M.B., Teng, H., Rhee, J.K., Baskaran, G., Lahar, N., and Yarema, K.J.. "Characterization of the cellular uptake and metabolic conversion of acetylated N-acetylmannosamine (ManNAc) analogs to sialic acids". Biotechnol Bioeng 85 (2004):394-405 (Published)
  30. Kim, E. J., Jones, M. B., Rhee, J. K., Sampathkumar, S.-G., Yarema, K. J. ") Establishment of ManNAc analog-resistant cell lines as improved hosts for sialic acid engineering applications". Biotechnol Prog 20 (2004):1674-1682 (Published)
  31. Hinderlich, S., Salama, I., Eisenberg, I., Potikha, T., Manteya, L., Yarema, K.J., Horstkorte, R., Argov, A., Sadeh, M., Reutter, W., & Mitrani-Rosenbaum, S. "The M712T mutant of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase results in reduced enzyme activities but not in altered overall cellular sialylation in hereditary inclusion body myopathy". FEBS Lett 566 (2004):105-109 (Published)
  32. Luchansky, S.J., Yarema, K.J., Takahashi, S., Bertozzi, C.R. "GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism". J. Biol. Chem. 278 (2003):8035-8042 (Published)
  33. Viswanathan, K., Lawrence, S., Hinderlich, S., Yarema, K.J., Lee, Y.C, & Betenbaugh, M. J.. "Engineering the sialic acid synthetic activity into insect cells: Identifying metabolic bottlenecks and devising strategies to overcome them". Biochemistry 42 (2003):15215-15225 (Published)
  34. Jacobs, C.L., Goon, S., Yarema, K.J., Hinderlich, S., Hang, H.C., Chai, D.H., and Bertozzi, C.R.. "Exploration of the mechanism for substrate selection by the sialic acid pathway". Biochemistry 40 (2001):12864-12874 (Published)
  35. Yarema, K.J., Goon, S., & Bertozzi., C.R. . "Metabolic selection of glycosylation defects in human cells". Nature Biotechnology 6 (2001):553-558 (Published)
  36. Yarema, K.J. "New directions in carbohydrate engineering: A metabolic substrate-based approach to modify the cell surface display of sialic acids". Biotechniques. 31 (2001):384-393 (Published)
  37. Yarema, K.J. & Bertozzi, C.R. "Characterizing glycosylation defects". GenomeBiology REVIEWS004 (2001):004.1-10 (Published)
  38. Lemieux, G.A., Yarema, K.J., Jacobs, C.L., & Bertozzi, C.R.. "Exploiting differences in sialoside expression for selective targeting of MRI contrast reagents". J. Am. Chem. Soc. 121 (1999):4278-4279 (Published)
  39. Yarema, K. J., Mahal, L.K., Bruehl, R. E. Rodriguez, E.C., & Bertozzi, C.R. . "Metabolic delivery of ketone groups to sialic acid residues. Application to cell surface engineering. ". J. Biol. Chem. 273 (1998):31168-31179 (Published)
  40. Yarema, K.J. & Bertozzi, C.R. . "Chemical approaches to glycobiology and emerging carbohydrate-based therapeutic agents". Curr. Opin. Chem. Biol 2 (1998):49-61 (Published)
  41. Mahal, L.K., Yarema, K.J., & Bertozzi, C.R.. "Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis.". Science 276 (1997):1125-1128 (Published)
  42. Yarema, K.J.. "Comparative toxicities and mutagenicities of platinum anticancer drugs". Drug Information Journal 29 (1995):1633S-1644S (Published)

Publications: Conference Proceedings

  1. Yarema, K. J. . "Development of therapeutic applications for N-acetylmannosamine (ManNAc) analogues used for the manipulation of sialic acid metabolism.". GLYCO XVIII: The International Symposium on Glycoconjugates (2005) (Published)
  2. Sampathkumar, S.G., Li, A. V., Jones, M.B., Hida, K., & Yarema, K.J. "Metabolic engineering novel adhesive properties into cell surface carbohydrates". Biomedical Engineering Society Baltimore, MD, USA, September 28 - October 1, 2005 (2005):Abstract # 767 (Published)
  3. Yarema, K.J., Goon, S., & Bertozzi, C.R. . "Metabolic selection of cells with glycosylation defects found in human disease". 4th Annual San Diego Glycobiology Symposium at San Diego, CA, January 12 and 13, 2001. (2001) (Published)
  4. Yarema, K.J., Goon, S., & Bertozzi, C.R. . "Metabolic selection of cells with glycosylation defects found in human disease.". International Carbohydrate Symposium at Hamburg, Germany, August 26-29, 2000. (2000) (Published)
  5. Yarema, K.J., Mahal. L.K., & Bertozzi, C.R.. "Applications of unnatural oligosaccharide biosynthesis to selective drug delivery.". 213th ACS National Meeting at San Fransisco, CA, April 13-17, 1997 (1997) (Published)
  6. Paige, L.A., Yarema, K.J., Rink, S., Essigmann, J.M., & Croy, R.G.. "Programmable therapeutics: A strategy that can selectively direct the cytotoxic effects of anticancer compounds to tumor cells. ". Massachusetts Biotechnology Council 4th Annual Symposium, at MIT, Cambridge, MA (1995) (Published)

Publications: Patents

  1. Yarema, K. J., Sampathkumar, S.-G., Jones, M. B.,, and Campbell, C.T.. "Short Chain Fatty Acid (SCFA) - Carbohydrate Bifunctional Hybrid Molecules with Novel Anti-cancer Properties ". Application No. 60/683,839 submitted on 24 May 2006 (2006) (Published)
  2. Bertozzi, Carolyn; Yarema, Kevin J.; Mahal; Lara K. "Glycoconjugates and methods. ". United States Patent 6,075,134 (2000) (Published)
  3. Essigmann, John M.; Croy, Robert G.; Yarema, Kevin J.; and Morningstar, Marshall. "Programmable genotoxic agents and uses therefor. ". United States Patent 5,879,917. (1999) (Published)

Supervised Students

Rohan Agrawal
Masters
Graduate

Udayanath Aich
Postdoc

Ebony Ashey-Bey
High School
Other
Ebony is a student working in the lab through the Ingenuity Project at Baltimore Polytechnic

Prabhani Atukorale
Masters
Graduate

Gautam Baskaran
Undergraduate

Christopher T. Campbell
M. D. / Ph. D.
Graduate

Pao-lin Che
Undergraduate

Pao-lin Che
Masters
Graduate

Hao Chen
Postdoc

Donavan Cheng
Graduate
Ph.D. Rotation Student

Helen Choi
Undergraduate

Sean S. Choi
Masters
Graduate

Francisco Jose Contijoch
Undergraduate

Matt David
Undergraduate

Noha Elmouelhi
Masters
Graduate

Jie Fu
Postdoc
Dr. Fu is participating in a collaborative project with Dr. Justin Hanes' laboratory (ChemBE, JHU).

Ambhighainath Ganesan
Graduate
Ph. D. Rotation Student

Prasra Gomutputra
Undergraduate

Kaoru Hida
Graduate
Ph.D. Rotation Student

Rohan Hughes
High School
Other
Rohan is a student working in the lab through the Ingenuity Project at Baltimore Polytechnic

Mark B. Jones
Undergraduate

Mark B. Jones
Masters
Graduate

Kiren Khanduja
Undergraduate

Harry Khanna
Masters
Graduate

Jennifer Kim
Undergraduate

Eun Jeong Kim
Postdoc

Grace Koo
Undergraduate

Nick Lahar
Undergraduate

Andrew Lewis
Undergraduate

Adrienne V. Li
Undergraduate

Adrienne V. Li
Masters
Graduate

Dann Martin
Undergraduate

M. Adam Meledeo
Ph. D.
Graduate

Jeffrey Millman
Undergraduate
Summer REU student

Michael Murrell
Undergraduate

Suzanne Nizza
Undergraduate

Venkata Durga Prasad Paruchuri
Masters
Graduate

Kyle Price
Undergraduate

Robin Rhee
Undergraduate

Brandon Roane
High School
Other
Brandon is a student working in the lab through the Ingenuity Project at Baltimore Polytechnic

Srinivasa-Gopalan Sampathkumar
Postdoc
Current position: Faculty at the National Institute of Immunology, New Dehli, India

Anshu Sarje
Research Associate
Other

Shivam Shah
Undergraduate

Anthony Sheh
Undergraduate

Mike Sheng
Undergraduate

Chuck Shih
Undergraduate

Zhonghui Sun
Undergraduate

Howard Teng
Undergraduate

Lily Tong
Undergraduate
Summer REU student

Zhiyun Wang
Postdoc

Jean J. Wang
Undergraduate

Nina Xu
Undergraduate

Diversity and Climate