Biomaterials

Projects

  • This DTRA (Defense Threat Reduction Agency) project develops a combination of reactive materials and biocidal compounds for the purpose of bioagent defeat. The reactive material is nano-layered metallic particles that reach very high temperatures when reacted and produce a significant amount of heat in the process. This heat is used to decompose an iodine-containing compound, resulting in a release of iodine gas, which is a known biocide.

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  • We have been developing a biochemically functionalized electrospun fiber platform serving as an artificial stem cell niche that presents topographical and biochemical cues to impact the local regulation of stem cells.

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  • We investigate the assembly and function of channel forming membrane proteins with the use of electrochemical techniques, such as impedance spectroscopy, and fluorescence. This work serves to elucidate the behavior and selectivity of protein channels that may play significant roles in cell trafficking and communication.

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  • We are using microfluidic platforms, microfabrication tools, soft-lithography, and transwell assays to study how physical and chemical parameters influence the properties of the endothelium.

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  • We are using a microfluidic platform to study the influence of electric field on motility, directionality, shape factor, and cell orientation.

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  • We are using quantum dot conjugates to track the G protein-coupled receptor (GPCR), a membrane protein that acts as a gatekeeper of information and is the target of one-third of all drugs.

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  • Quantum dots are inorganic semiconductor nanoparticles that possess unique optical and electronic properties, which make them suitable for advanced molecular and cellular imaging, drug delivery, and highly sensitive bioassays.

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  • We are using imprinted hydrogels to study molecular recognition of proteins and enzymes relevant to the development of biosensors, diagnostics, and the development of prevention and treatment of disease.

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  • The overall objective of this research is to develop biofunctional polymeric scaffolds that can mimic the extracellular matrix microenvironment and support the desired cellular behaviors such as adhesion, migration and proliferation of adult stem cells, while maintaining their phenotype.

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  • The aim of this study is to investigate the structure-transfection efficiency relationship of PPA gene carriers; and to investigate the effect of PPA structure on DNA compaction ability of PPA, stability of PPA/DNA nanoparticles in physiological medium, cellular uptake efficiency, intracellular trafficking, DNA unpacking, and nuclear translocation.

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