Faculty

Margarita Herrera-Alonso

Assistant Professor

Research Interests

Nanomaterials, Biomaterials, and Polymer Self Assembly

Education
  • Ph.D. 2004, University of Massachusetts
  • M.S. 1999, Universidad Nacional Autónoma de México
  • B.S. 1997, Universidad Nacional Autónoma de México
Experience
  • 2010 - Present:  Assistant Professor, Materials Science and Engineering, Johns Hopkins University, Baltimore, MD
  • 2009 - 2010:  Lecturer, Chemical Engineering, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
  • 2008 - 2010:  Postdoctoral Fellow, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
  • 2004 - 2007:  Postdoctoral Fellow, Princeton University, Princeton, NJ
  • 1999 - 2004:  Research Assistant, University of Massachusetts, Amherst, MA
Research Areas
  • Kinetic control of polymer-based solution assemblies
  • Polymer design and synthesis
  • Architecturally complex polymer amphiphiles
  • Molecular brushes
  • Nanoparticle surface chemistry
  • Drug delivery carriers
  • Biomimetics
Awards
  • 2012:  NSF CAREER Faculty Young Investigator Award
  • 2008:  CONACYT (Consejo Nacional de Ciencia y Tecnologia) Postdoctoral Scholarship
  • 1999:  Fulbright/Garcia-Robles Scholarship
  • 1999:  Solutia Fellowship
  • 1997:  CONACYT (Consejo Nacional de Ciencia y Tecnologia) Graduate Scholarship
  • Differences in particle-cell interaction during transport and internalization processes has lead to the design of carriers with variable spatial and/or temporal characteristics to optimize and enhance the pharmacological activity of therapeutics.

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  • Design and construction of nanoparticles with regions of distinct chemical surface heterogeneity to elucidate the synergism of ligand/receptor co-localization and multivalency on particle-cell interaction efficiency and selectivity.

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Journal Articles
  • Aguilar-Castillo, B. A., Santos, J. L., Luo, H., Aguirre-Chagala, Y. E., Palacios-Hernandez, T., Herrera-Alonso, M. (2015).  Nanoparticle stability in biologically relevant media: influence of polymer architecture.  Soft Matter.  11(37).  7296-7307.
  • Santos, J. L., Li, Y., Culver, H. R., Yu, M., Herrera-Alonso, M. (2014).  Conducting polymer nanoparticles decorated with collagen mimetic peptides for collagen targeting.  Chemical Communications.  50(95).  15045-15048.
  • Santos, J. L., Herrera-Alonso, M. (2014).  Kinetically Arrested Assemblies of Architecturally Distinct Block Copolymers.  Macromolecules.  47(1).  137-145.
  • Herrera-Alonso, M., Aguirre-Chagala, Y. E., Santos, J. L., Huang, Y. (2014).  Phenylboronic acid-installed polycarbonates for the pH-dependent release of diol-containing molecules.  ACS Macro Letters.  3(12).  1249-1253.
  • Aguirre-Chagala, Y. E., Santos, J. L., Aguilar-Castillo, B. A., Herrera-Alonso, M. (2014).  Synthesis of Copolymers from Phenylboronic Acid-Installed Cyclic Carbonates.  Acs Macro Letters.  3(4).  353-358.
  • Luo, H., Santos, J. L., Herrera-Alonso, M. (2014).  Toroidal structures from brush amphiphiles.  Chemical Communications.  50(5).  536-538.
  • Herrera-Alonso, M., Santos, J. L. (2013).  "Patchy" nanoparticles via kinetically arrested co-assembly of block copolymers.  Abstracts of Papers of the American Chemical Society.  245.
  • Elised Aguirre-Chagala, Y., Santos, J. L., Herrera-Najera, R., Herrera-Alonso, M. (2013).  Organocatalytic Copolymerization of a Cyclic Carbonate Bearing Protected 2,2-bis(hydroxymethyl) Groups and D,L-lactide. Effect of Hydrophobic Block Chemistry on Nanoparticle Properties.  Macromolecules.  46(15).  5871-5881.
  • D’Addio, S. M., Saad, W., Ansell, S. M., Squiers, J. J., Adamson, D. H., Herrera-Alonso, M., Wohl, A. R., Hoye, T. R., Macosko, C. W., Mayer, L. D., Vauthier, C., Prud’homme, R. K. (2012).  Effects of block copolymer properties on nanocarrier protection from in vivo clearance.  Journal of Controlled Release.  162(1).  208-217.
  • Martinez-Estrada, A., Enrique Chavez-Castellanos, A., Herrera-Alonso, M., Herrera-Najera, R. (2010).  Comparative Study of the Effect of Sulfur on the Morphology and Rheological Properties of SB- and SBS-Modified Asphalt.  Journal of Applied Polymer Science.  115(6).  3409-3422.
  • Ramanathan, T., Abdala, A. A., Stankovich, S., Dikin, D. A., Herrera-Alonso, M., Piner, R. D., Adamson, D. H., Schniepp, H. C., Chen, X., Ruoff, R. S., Nguyen, S. T., Aksay, I. A., Prud’homme, R. K., Brinson, L. C. (2008).  Functionalized graphene sheets for polymer nanocomposites.  Nature Nanotechnology.  3(6).  327-331.
  • Herrera-Alonso, M., Abdala, A. A., McAllister, M. J., Aksay, I. A., Prud’homme, R. K. (2007).  Intercalation and stitching of graphite oxide with diaminoalkanes.  Langmuir.  23(21).  10644-10649.
  • McAllister, M. J., Li, J., Adamson, D. H., Schniepp, H. C., Abdala, A. A., Liu, J., Herrera-Alonso, M., Milius, D. L., Car, R., Prud’homme, R. K., Aksay, I. A. (2007).  Single sheet functionalized graphene by oxidation and thermal expansion of graphite.  Chemistry of Materials.  19(18).  4396-4404.
  • Schniepp, H. C., Li, J. L., McAllister, M. J., Sai, H., Herrera-Alonso, M., Adamson, D. H., Prud’homme, R. K., Car, R., Saville, D. A., Aksay, I. A. (2006).  Functionalized single graphene sheets derived from splitting graphite oxide.  Journal of Physical Chemistry B.  110(17).  8535-8539.
  • Jia, X., Herrera-Alonso, M., McCarthy, T. J. (2006).  Nylon surface modification. Part 1. Targeting the amide groups for selective introduction of reactive functionalities.  Polymer.  47(14).  4916-4924.
  • Herrera-Alonso, M., McCarthy, T. J., Jia, X. Q. (2006).  Nylon surface modification: 2. Nylon-supported composite films.  Langmuir.  22(4).  1646-1651.
  • Herrera-Alonso, M., Prud’homme, R. K. (2006).  POLY 684-Poly(ethylene glycol)-b-polycaprolactone nanoparticles and their use as drug delivery vehicles.  Abstracts of Papers of the American Chemical Society.  232.
  • Guo, X. H., Herrera-Alonso, M., Tinsley, L., Prud’homme, R. K. (2005).  How poly(1-olefin-co-maleic anhydride amide) improves flow of cold crude oils.  Abstracts of Papers of the American Chemical Society.  230.  U2316-U2317.
  • Herrera-Alonso, M., McCarthy, T. J. (2004).  Chemical surface modification of poly(p-xylylene) thin films.  Langmuir.  20(21).  9184-9189.
Conference Proceedings
  • Herrera-Alonso, M., Prud’homme, R. K. (2006).  Poly(ethylene glycol)-b-polycaprolactone nanoparticles and their use as drug delivery vehicles.  Abstracts of Papers of the American Chemical Society.  232.  9-9.
  • Jia, X. Q., Herrera-Alonso, M., McCarthy, T. J. (2005).  Nylon surface modification: Targeting the amide groups for selective introduction of reactive functionalities.  Abstracts of Papers of the American Chemical Society.  229.  U739-U739.
  • Herrera-Alonso, M., McCarthy, T. J. (2004).  Chemical reduction of nylons: Synthesis of polyalkyleneimines with controlled charge density.  Abstracts of Papers of the American Chemical Society.  227.  U374-U374.
  • Herrera-Alonso, M., Garcia-Leiner, M., McCarthy, T. J., Lesser, A. J. (2004).  Semicrystalline polymer nanocomposites using chemically designed compatibilizers and supercritical CO2-assisted polymer processing.  Abstracts of Papers of the American Chemical Society.  228.  U506-U506.
  • Herrera-Alonso, M., McCarthy, T. J. (2003).  Adsorption of polyelectrolytes to surface-modified nylon films.  Abstracts of Papers of the American Chemical Society.  226.  U380-U380.
  • Herrera-Alonso, M., McCarthy, T. J. (2002).  Surface modification of poly(p-xylylene) films.  Abstracts of Papers of the American Chemical Society.  224.  U479-U479.
Patents
  • Herrera-Alonso, M., Aksay, I., Prud'homme, R.  "Separation medium containing thermally exfoliated graphite oxide", 2012.
  • Herrera-Alonso, M., Aksay, I., McAllister, M., Prud'homme, R.  "Bridged graphite oxide material for e.g. polymer composite material in article or selective adsorption medium in adsorption device, comprises graphite oxide sheets bridged to other graphite oxide sheet(s) by diamine bridging group(s)", 2010.
  • Herrera-Alonso, M., Garcia-Leiner, M., Mehlmann, F., Prud'homme, R., Fu, L.  "Use of cyclodextrins in controlled architecture polymer synthesis", 2008.
  • Molecular and process determinants of solution based polymer self-assemblies.  Storrs, CT.  November 6, 2015
  • "Molecular brush amphiphiles", 250th ACS National Meeting.  Boston, MA.  August 19, 2015
  • Molecular and process determinants of solution assemblies.  May 13, 2015
  • Kinetic effects in solution assemblies for drug delivery applications.  January 23, 2015
  • Molecular and process determinants of solution assemblies.  December 2, 2014
  • Functional polycarbonates as environmentally responsive materials.  November 21, 2014
  • Functional polycarbonates as environmentally responsive materials.  October 9, 2014
  • International Symposium on Polymer Chemistry 2014.  Shanghai, China.  June 4, 2014
  • "Polycarbonates with pendant boronic acids: nanoparticles for controlled drug release", 247th ACS National Meeting and Exposition, Division of Polymer Chemistry.  Dallax, TX.  March 18, 2014
  • "Targeting kinetically arrested states of polymer assembly for the formation of drug carriers", PMSE Young Investigator (biannual session), ACS Spring 2014 National Meeting.  Dallas, TX.  March 16, 2014
  • Solvophobically-driven self-assembly: kinetics and structures from novel amphiphiles.  April 23, 2012
  • Solvophobically-driven self-assembly: kinetics and structures from novel amphiphiles.  March 7, 2012
  • Block copolymer nanoparticles by flash nanoprecipitation: prodrug strategies.  April 7, 2010
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